WormBase Tree Display for Gene: WBGene00004055
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| WBGene00004055 | SMap | S_parent | Sequence | B0218 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | pmk-1 | Person_evidence | WBPerson1315 | |||||
| Sequence_name | B0218.3 | ||||||||
| Molecular_name | B0218.3 | ||||||||
| B0218.3.1 | |||||||||
| CE06686 | |||||||||
| Other_name | CELE_B0218.3 | Accession_evidence | NDB | BX284604 | |||||
| Public_name | pmk-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:34 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info (12) | |||||||||
| Disease_info | Experimental_model | DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00035592 | ||||
| Accession_evidence | OMIM | 607060 | |||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Date_last_updated | 15 Apr 2013 00:00:00 | ||||||||
| Potential_model | DOID:1993 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6876) | |||||
| DOID:9261 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6876) | ||||||
| DOID:3717 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6876) | ||||||
| DOID:219 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6876) | ||||||
| DOID:0080199 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6876) | ||||||
| Disease_relevance | pmk-1 is orthologous to the human Mitogen-activated protein kinases, MAPK14 (p38 MAP kinase) and MAPK11 (p38-beta); studies in C. elegans indicate that the elegans genes pmk-1 and sek-1 (orthologous to human MAP2K3 and MAP2K6) are required for the normal protective role of LRRK2 (leucine-rich repeat kinase 2), during conditions of cellular stress; mutations in human LRRK2 are implicated in late-onset Parkinson''s disease (PD); in an elegans model for human LRRK2 function in vivo, wild-type human LRRK2 complements the function of it''s elegans ortholog, lrk-1, strongly protecting against cellular stress phenotypes in a rotenone (a mitochondrial complex I inhibitor) protection assay; knockdown of sek-1 and pmk-1 in this model, completely abolished the ability of LRRK2 to protect animals against rotenone, this and similar studies with lrk-1, indicate that lrk-1/LRRK2 requires sek-1 and pmk-1 for normal function, linking these MAP kinases to pathologies like PD. | Homo sapiens | Paper_evidence | WBPaper00035592 | |||||
| Accession_evidence | OMIM | 607060 | |||||||
| 600289 | |||||||||
| 602898 | |||||||||
| Curator_confirmed | WBPerson324 | ||||||||
| Models_disease_in_annotation | WBDOannot00000142 | ||||||||
| Molecular_info | Corresponding_CDS | B0218.3 | |||||||
| Corresponding_transcript | B0218.3.1 | ||||||||
| Other_sequence (33) | |||||||||
| Associated_feature | WBsf660378 | ||||||||
| WBsf228633 | |||||||||
| WBsf228634 | |||||||||
| Experimental_info | RNAi_result (46) | ||||||||
| Expr_pattern (11) | |||||||||
| Drives_construct | WBCnstr00015810 | ||||||||
| WBCnstr00019245 | |||||||||
| WBCnstr00035721 | |||||||||
| WBCnstr00042639 | |||||||||
| Construct_product | WBCnstr00015810 | ||||||||
| WBCnstr00015844 | |||||||||
| WBCnstr00020594 | |||||||||
| WBCnstr00020595 | |||||||||
| WBCnstr00035721 | |||||||||
| WBCnstr00040291 | |||||||||
| Regulate_expr_cluster | WBPaper00028789:pmk-1_downregulated | ||||||||
| WBPaper00028789:pmk-1_upregulated | |||||||||
| WBPaper00046083:pmk-1(km25)_OP50_downregulated | |||||||||
| WBPaper00046083:pmk-1(km25)_OP50_upregulated | |||||||||
| WBPaper00050515:pmk-1(km25)_downregulated | |||||||||
| WBPaper00050515:pmk-1(km25)_upregulated | |||||||||
| WBPaper00056275:P.aeruginosa_downregulated_pmk-1(km25)_dependent | |||||||||
| WBPaper00056275:P.aeruginosa_upregulated_pmk-1(km25)_dependent | |||||||||
| WBPaper00065823:pmk-1(km25)_downregulated | |||||||||
| WBPaper00065823:pmk-1(km25)_upregulated | |||||||||
| Antibody | WBAntibody00000535 | ||||||||
| WBAntibody00001023 | |||||||||
| WBAntibody00001650 | |||||||||
| WBAntibody00001699 | |||||||||
| WBAntibody00002861 | |||||||||
| Microarray_results (25) | |||||||||
| Expression_cluster (110) | |||||||||
| Interaction (384) | |||||||||
| WBProcess | WBbiopr:00000001 | ||||||||
| WBbiopr:00000008 | |||||||||
| WBbiopr:00000014 | |||||||||
| WBbiopr:00000039 | |||||||||
| Map_info | Map | IV | Position | 3.64389 | Error | 0.001545 | |||
| Positive | Positive_clone | B0218 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4594 | |||||||
| 4994 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (304) | |||||||||
| Picture | WBPicture0000013079 | ||||||||
| WBPicture0000013081 | |||||||||
| WBPicture0000013093 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
