WormBase Tree Display for Gene: WBGene00004055
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WBGene00004055 | SMap | S_parent | Sequence | B0218 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info (12) | |||||||
Disease_info | Experimental_model | DOID:14330 | Homo sapiens | Paper_evidence | WBPaper00035592 | ||
Accession_evidence | OMIM | 607060 | |||||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 15 Apr 2013 00:00:00 | ||||||
Potential_model | DOID:1993 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6876) | |||
DOID:9261 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6876) | ||||
DOID:3717 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6876) | ||||
DOID:219 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6876) | ||||
DOID:0080199 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:6876) | ||||
Disease_relevance | pmk-1 is orthologous to the human Mitogen-activated protein kinases, MAPK14 (p38 MAP kinase) and MAPK11 (p38-beta); studies in C. elegans indicate that the elegans genes pmk-1 and sek-1 (orthologous to human MAP2K3 and MAP2K6) are required for the normal protective role of LRRK2 (leucine-rich repeat kinase 2), during conditions of cellular stress; mutations in human LRRK2 are implicated in late-onset Parkinson''s disease (PD); in an elegans model for human LRRK2 function in vivo, wild-type human LRRK2 complements the function of it''s elegans ortholog, lrk-1, strongly protecting against cellular stress phenotypes in a rotenone (a mitochondrial complex I inhibitor) protection assay; knockdown of sek-1 and pmk-1 in this model, completely abolished the ability of LRRK2 to protect animals against rotenone, this and similar studies with lrk-1, indicate that lrk-1/LRRK2 requires sek-1 and pmk-1 for normal function, linking these MAP kinases to pathologies like PD. | Homo sapiens | Paper_evidence | WBPaper00035592 | |||
Accession_evidence | OMIM | 607060 | |||||
600289 | |||||||
602898 | |||||||
Curator_confirmed | WBPerson324 | ||||||
Models_disease_in_annotation | WBDOannot00000142 | ||||||
Molecular_info | Corresponding_CDS | B0218.3 | |||||
Corresponding_transcript | B0218.3.1 | ||||||
Other_sequence (33) | |||||||
Associated_feature | WBsf660378 | ||||||
WBsf228633 | |||||||
WBsf228634 | |||||||
Experimental_info | RNAi_result (46) | ||||||
Expr_pattern (11) | |||||||
Drives_construct | WBCnstr00015810 | ||||||
WBCnstr00019245 | |||||||
WBCnstr00035721 | |||||||
WBCnstr00042639 | |||||||
Construct_product | WBCnstr00015810 | ||||||
WBCnstr00015844 | |||||||
WBCnstr00020594 | |||||||
WBCnstr00020595 | |||||||
WBCnstr00035721 | |||||||
WBCnstr00040291 | |||||||
Regulate_expr_cluster | WBPaper00028789:pmk-1_downregulated | ||||||
WBPaper00028789:pmk-1_upregulated | |||||||
WBPaper00046083:pmk-1(km25)_OP50_downregulated | |||||||
WBPaper00046083:pmk-1(km25)_OP50_upregulated | |||||||
WBPaper00050515:pmk-1(km25)_downregulated | |||||||
WBPaper00050515:pmk-1(km25)_upregulated | |||||||
WBPaper00056275:P.aeruginosa_downregulated_pmk-1(km25)_dependent | |||||||
WBPaper00056275:P.aeruginosa_upregulated_pmk-1(km25)_dependent | |||||||
WBPaper00065823:pmk-1(km25)_downregulated | |||||||
WBPaper00065823:pmk-1(km25)_upregulated | |||||||
Antibody | WBAntibody00000535 | ||||||
WBAntibody00001023 | |||||||
WBAntibody00001650 | |||||||
WBAntibody00001699 | |||||||
WBAntibody00002861 | |||||||
Microarray_results (25) | |||||||
Expression_cluster (110) | |||||||
Interaction (384) | |||||||
WBProcess | WBbiopr:00000001 | ||||||
WBbiopr:00000008 | |||||||
WBbiopr:00000014 | |||||||
WBbiopr:00000039 | |||||||
Map_info | Map | IV | Position | 3.64389 | Error | 0.001545 | |
Positive | Positive_clone | B0218 | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Mapping_data | Multi_point | 4594 | |||||
4994 | |||||||
Pseudo_map_position | |||||||
Reference (304) | |||||||
Picture | WBPicture0000013079 | ||||||
WBPicture0000013081 | |||||||
WBPicture0000013093 | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |