| WBGene00000176 | Evidence | Person_evidence | WBPerson548 |
|---|
| SMap | S_parent | Sequence | K02G10 |
| Identity | Version | 1 |
| | Name | CGC_name | aqp-8 | Person_evidence | WBPerson300 |
| | | Sequence_name | K02G10.7 |
| | | Molecular_name (13) |
| | | Other_name | CELE_K02G10.7 | Accession_evidence | NDB | BX284606 |
| | | Public_name | aqp-8 |
| | DB_info | Database | AceView | gene | XF322 |
| | | | WormQTL | gene | WBGene00000176 |
| | | | WormFlux | gene | WBGene00000176 |
| | | | NDB | locus_tag | CELE_K02G10.7 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00000176|UniProtKB=Q7Z137 |
| | | | | family | PTHR43829 |
| | | | NCBI | gene | 180744 |
| | | | RefSeq | protein | NM_001361799.3 |
| | | | | | NM_001029587.3 |
| | | | | | NM_001361800.3 |
| | | | | | NM_001373283.3 |
| | | | TREEFAM | TREEFAM_ID | TF313173 |
| | | | TrEMBL | UniProtAcc | Q7Z138 |
| | | | | | A0A2K5AU16 |
| | | | | | A0A2K5AU20 |
| | | | | | Q7Z137 |
| | | | UniProt_GCRP | UniProtAcc | Q7Z138 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:20 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | aqp |
| | Allele (46) |
| | Strain | WBStrain00032798 |
| | RNASeq_FPKM (74) |
| | GO_annotation (13) |
| | Ortholog (40) |
| | Paralog | WBGene00000169 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00000170 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00000171 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00000175 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00013272 | Caenorhabditis elegans | From_analysis | Panther |
| | | WBGene00000172 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00000173 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00000174 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | Structured_description | Concise_description | aqp-8 encodes, by alternative splicing, two isoforms of a putative aquaglyceroporin with no known substrate, since AQP-8 expressed in Xenopus oocytes has no effect on water, glycerol, or urea permeability; loss of AQP-8 activity via mutation or RNAi results in no obvious defects; however, AQP-8, in conjunction with AQP-2, AQP-3, and AQP-4, is weakly required for recovery from hypotonic stress; AQP-8 is expressed in the excretory cell. | Paper_evidence | WBPaper00029039 |
| | | | | | WBPaper00030907 |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | Date_last_updated | 12 Aug 2007 00:00:00 |
| | | Automated_description | Predicted to enable glycerol channel activity and water channel activity. Predicted to be involved in glycerol transmembrane transport and water transport. Located in cell surface. Expressed in several structures, including excretory system; germ line; intestinal cell; non-striated muscle; and ray. Human ortholog(s) of this gene implicated in several diseases, including brain edema; inflammatory bowel disease (multiple); and morbid obesity. Is an ortholog of several human genes including AQP3 (aquaporin 3 (Gill blood group)); AQP7 (aquaporin 7); and AQP9 (aquaporin 9). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:4724 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:636) |
| | | DOID:8577 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:640) |
| | | DOID:8778 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:640) |
| | | DOID:9352 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:640) |
| | | DOID:0060180 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:640) |
| | | DOID:11981 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:640) |
| Molecular_info | Corresponding_CDS | K02G10.7a |
| | | K02G10.7b |
| | | K02G10.7c |
| | | K02G10.7d |
| | Corresponding_CDS_history | K02G10.7:wp101 |
| | | K02G10.7a:wp271 |
| | Corresponding_transcript | K02G10.7a.1 |
| | | K02G10.7b.1 |
| | | K02G10.7b.2 |
| | | K02G10.7c.1 |
| | | K02G10.7d.1 |
| | Other_sequence (33) |
| | Associated_feature | WBsf034361 |
| | | WBsf216759 |
| | | WBsf718571 |
| | | WBsf1005038 |
| | | WBsf1005039 |
| | | WBsf1022838 |
| | | WBsf237306 |
| | | WBsf237307 |
| Experimental_info | RNAi_result (7) |
| | Expr_pattern | Expr4778 |
| | | Expr4818 |
| | | Expr10636 |
| | | Expr13456 |
| | | Expr1012328 |
| | | Expr1030100 |
| | | Expr1153486 |
| | | Expr2009385 |
| | | Expr2027621 |
| | Drives_construct | WBCnstr00004199 |
| | | WBCnstr00012238 |
| | | WBCnstr00017213 |
| | | WBCnstr00017563 |
| | | WBCnstr00017564 |
| | | WBCnstr00037685 |
| | Construct_product | WBCnstr00017136 |
| | | WBCnstr00017213 |
| | | WBCnstr00017563 |
| | | WBCnstr00017565 |
| | | WBCnstr00037685 |
| | Microarray_results | SMD_K02G10.7 |
| | | 192076_at |
| | | A_12_P120370 |
| | | Aff_K02G10.7 |
| | | GPL13394_WBGene00000176 |
| | | GPL13914_K02G10.7 |
| | | GPL14144_K02G10.7b_492-551_0.770_36_C |
| | | GPL14144_K02G10.7b_687-746_0.800_26_B |
| | | GPL14144_K02G10.7b_772-831_0.954_1_A |
| | | GPL19516_CGZ0027500 |
| | | GPL19516_CGZ0027501 |
| | | GPL21109_K02G10.7a |
| | | GPL21109_K02G10.7b |
| | | GPL3518_CE30087 |
| | | GPL8304_CE_WBGene00000176_A |
| | | GPL8673_K02G10_7aP00152 |
| | | GPL8673_K02G10_7aP00393 |
| | | GPL8673_K02G10_7aP00689 |
| | | GPL8673_K02G10_7bP00466 |
| | | GPL8673_K02G10_7bP00475 |
| | | GPL8673_K02G10_7bP00484 |
| | Expression_cluster | WBPaper00032031:DConiospora_downregulated_OligoArray_24h |
| | | WBPaper00036738:500uM_Heme_upregulated |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_adult_enriched |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:coelomocytes_embryo_enriched |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:excretory-cell_L2-larva_expressed |
| | | WBPaper00037950:excretory-cell_larva_enriched |
| | | WBPaper00037950:germline-precursors_blastula-embryo_expressed |
| | | WBPaper00037950:hypodermis_L1-larva_expressed |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:hypodermis_larva_enriched |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:intestine_L2-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_larva_enriched |
| | | WBPaper00038118:aak-2(gt33)_upregulated |
| | | WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq |
| | | WBPaper00038438:Harposporium_24hr_downregulated_RNAseq |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray |
| | | WBPaper00040990:PA14_upregulated |
| | | WBPaper00044260:nicotinc-acid_upregulated |
| | | WBPaper00044736:oscillating_dev_expression |
| | | WBPaper00045017:blmp-1(tm548)_upregulated |
| | | WBPaper00045521:Gender_Neutral |
| | | WBPaper00045571:germline-ablation_upregulated |
| | | WBPaper00046012:tdp-1(ok803)_upregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00047132:glp-1(ts)-25C_upregulated |
| | | WBPaper00048611:MnCl2_downregulated |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048952:glucose_induced |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049018:ham-3(RNAi)_downregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049736:daf-2(e1370)_downregulated_15deg-then-25deg(12hr) |
| | | WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031) |
| | | WBPaper00049920:Glucose-Diet_upregulated_N2 |
| | | WBPaper00049942:HeatShock_upregulated_hsf-1(+) |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050080:rbr-2(tm3141)_downregulated |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C |
| | | WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050522:mafr-1(tm6082)_downregulated |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050726:starvation_regulated_LowSalt |
| | | WBPaper00050801:DAF-16_dauer_regulome |
| | | WBPaper00050801:DPY-21_dauer_regulome |
| | | WBPaper00050990:hypodermis_enriched |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00051245:cytoplasm_specific |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:epidermis_specific |
| | | WBPaper00051265:F1_hrde-1(tm1200)_upregulated |
| | | WBPaper00051371:Orsay-virus-infection_upregulated_rde-1(ne219) |
| | | WBPaper00051388:Glucose-diet_upregulated |
| | | WBPaper00051404:alg-1(gk214)_upregulated |
| | | WBPaper00051404:alg-2(ok304)_upregulated |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053388:dauer_regulated_Cluster1 |
| | | WBPaper00053402:his-3(RNAi)_upregulated |
| | | WBPaper00053599:female_vs_male_downregulated |
| | | WBPaper00053771:up_at_dpy-7(e88) |
| | | WBPaper00054410:set-9(rw5)_upregulated |
| | | WBPaper00054493:hpl-2(tm1489)_downregulated |
| | | WBPaper00055354:Psora-Allantoin_downregulated |
| | | WBPaper00055354:Psora_downregulated |
| | | WBPaper00055354:Rapamycin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Metformin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_downregulated |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055354:Rifampicin-Psora_downregulated |
| | | WBPaper00055354:Rifampicin_downregulated |
| | | WBPaper00055482:Tunicamycin_downregulated |
| | | WBPaper00055648:male-vas-deferens_expressed |
| | | WBPaper00055827:daf-2(e1370)_downregulated |
| | | WBPaper00056034:pals-25(jy9)_downregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_upregulated_N2 |
| | | WBPaper00056167:Cry5B_downregulated |
| | | WBPaper00056169:rrf-3(pk1426)_upregulated_L3 |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056471:S.aureus-4h_upregulated_N2 |
| | | WBPaper00056826:SGP_biased |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057154:HeatShock_downregulated_mRNA |
| | | WBPaper00057154:HeatShock_upregulated_miRNA-target |
| | | WBPaper00057265:metaformin_upregulated_OP50 |
| | | WBPaper00057265:metaformin_upregulated_OP50-MR |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058678:DAF-12_upregulated_PVD |
| | | WBPaper00058711:paraquat_downregulated |
| | | WBPaper00058711:skn-1(lax188)_upregulated |
| | | WBPaper00058725:sftb-1(cer6)_downregulated |
| | | WBPaper00059231:alh-6(lax105)_L4_downregulated |
| | | WBPaper00059253:stearic-acid_downregulated |
| | | WBPaper00059421:daf-3(mgDf90)_upregulated |
| | | WBPaper00059566:wdr-23(mac32)_upregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059728:5ug_cholesterol_upregulated |
| | | WBPaper00059728:20ug_cholesterol_upregulated |
| | | WBPaper00059735:glucose_upregulated_lpin-1(RNAi) |
| | | WBPaper00059735:glucose_upregulated_N2 |
| | | WBPaper00059754:E.faecalis_OG1RF_upregulated |
| | | WBPaper00059816:crh-1(n3315)_downrgulated |
| | | WBPaper00059895:wounding_downregulated |
| | | WBPaper00059987:Wounding_downregulated |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060014:set-2(zr2012)_downregulated |
| | | WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi) |
| | | WBPaper00060445:nfki-1(cer1)_downregulated_L1 |
| | | WBPaper00060661:sensory-neuron_depleted |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00061081:E.faecalis_upregulated_skpo-1(ok1640) |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061340:Coelomocyte |
| | | WBPaper00061340:DA |
| | | WBPaper00061340:DB |
| | | WBPaper00061340:RID |
| | | WBPaper00061424:Diet_MYb120_upregulated |
| | | WBPaper00061527:tars-1-AFFX-r2-3026-5_at |
| | | WBPaper00061530:nhr-49(e2144)_upregulated |
| | | WBPaper00061613:human-amyloid-beta_alpha-Synuclein(A53T)_downregulated |
| | | WBPaper00061699:daf-18(ok480)_upregulated |
| | | WBPaper00061753:csr-1(tor159)_upregulated_20C |
| | | WBPaper00061800:miR-85(n4117)_downregulated_20C |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062184:PA14_downregulated |
| | | WBPaper00062193:daf-16(RNAi)_upregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062345:bortezomib_4h_downregulated_zip-1(jy13) |
| | | WBPaper00062347:blmp-1(tm548)_upregulated |
| | | WBPaper00062354:H.zoospora_6h_regulated |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20) |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064403:Heat-killed-E.Coli_upregulated |
| | | WBPaper00064539:nhr-114(gk849)_upregulated |
| | | WBPaper00064632:daf-2(e1370)_downregulated_intestine |
| | | WBPaper00065074:glna(-)_upregulated |
| | | WBPaper00065096:25C_vs_20C_upregulated |
| | | WBPaper00065096:npr-8(ok1439)_upregulated_Day1_20C |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065149:lin-52(n771)_downregulated |
| | | WBPaper00065315:mating_upregulated_Day2-7 |
| | | WBPaper00065373:Cisplatin_downregulated_WT |
| | | WBPaper00065373:sek-1(km4)_upregulated_cisplatin |
| | | WBPaper00065373:sek-1(km4)_upregulated_Ref |
| | | WBPaper00065392:Lb.rhamnosus_upregulated |
| | | WBPaper00065749:Heat-Shock_upregulated_endu-2(tm4977) |
| | | WBPaper00065835:Day5_vs_Day1_downregulated |
| | | WBPaper00065841:0_0 |
| | | WBPaper00065926:pgph-2(overepxreesion)_upregulated_glucose |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00066005:RAGA-1_degradation_somatic_upregulated |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | WBPaper00066085:sin-3(tm1276)_downregulated |
| | | cgc4386_cluster_1_3 |
| | | cgc4489_group_2 |
| | | WBPaper00005124:progesterone_10-7M_regulated |
| | | WBPaper00006465:IV_ethanol_late_repression |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00031703:heme_responsive_7 |
| | | WBPaper00032948:FedUp |
| | | WBPaper00034739:N2lessDR1350 |
| | | WBPaper00035227:heat_shock_regulated |
| | | WBPaper00035873:dpy-9_regulated |
| | | WBPaper00035873:dpy-10_regulated |
| | | WBPaper00035873:osm-7_regulated |
| | | WBPaper00035873:osm-8_regulated |
| | | WBPaper00035873:osm-11_regulated |
| | | WBPaper00035873:osmotically_regulated |
| | | WBPaper00036464:S.aureus-RN6390_regulated |
| | | WBPaper00037695:CC_3-day |
| | | WBPaper00038172:crh-1null_up_regulated |
| | | WBPaper00038172:tax-6null_up_regulated |
| | | WBPaper00040426:CYD-1_CDK-4_downregulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00041002:HF_3d_2.0mM_Up |
| | | WBPaper00041002:HQ_3d_0.2mM_Up |
| | | WBPaper00041002:HQ_3d_2.0mM_Up |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_24h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_51h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_24h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041960:N2_fasting_upregulated_anytime |
| | | WBPaper00042178:hlh-29(tm284)_upregulated |
| | | WBPaper00042258:DA1877_upregulated_GravidAdult |
| | | WBPaper00042331:a-SWCNTs_downregulated |
| | | WBPaper00045263:isp-1(qm150)_downregulated |
| | | WBPaper00045263:nuo-6(qm200)_downregulated |
| | | WBPaper00046083:pmk-1(km25)_OP50_upregulated |
| | | WBPaper00047070:N2_UV_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_upregulated |
| | | WBPaper00050515:nipi-3(fr4)_upregulated |
| | | WBPaper00050538:Fasting_upregulated |
| | | WBPaper00050538:Fasting_upregulated_cholesterol-dependent |
| | | WBPaper00050767:Octopamine_induced |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | Interaction (115) |
| Map_info | Map | X | Position | -6.86689 | Error | 0.013931 |
| | Positive | Positive_clone | K02G10 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 5264 |
| | | | 4264 |
| | | | 5494 |
| | Pseudo_map_position |
| Reference (12) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
