WormBase Tree Display for Gene: WBGene00001189

WBGene00001189 SMap: S_parent: Sequence: F01D4
  Identity: Version: 1
    Name: CGC_name: egl-21 Person_evidence: WBPerson268
      Sequence_name: F01D4.4
      Molecular_name: F01D4.4
        F01D4.4.1
        CE09156
      Other_name: CELE_F01D4.4 Accession_evidence: NDB BX284604
      Public_name: egl-21
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:23 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: egl
    Reference_allele: WBVar00089624
    Allele (43)
    Legacy_information: n611ts : transient bloating at 25x Type E partially temperature sensitive uncoordinated weak coiler. ES2 (adult). NA3 (n476 n576).
      [C.elegansII] n611ts : transient bloating at 25C, variable drug response; partially temperature sensitive;uncoordinated weak coiler; abnormal 5-HT signalling. ES2 (adult). ME2. OA2: n476, n576. [Trent et al. 1983; KP; MT]
    Strain: WBStrain00023630
      WBStrain00026777
      WBStrain00026813
      WBStrain00026827
      WBStrain00026874
    RNASeq_FPKM (74)
    GO_annotation (41)
    Ortholog (52)
    Paralog: WBGene00012073 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00019074 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: egl-21 encodes a putative carboxypeptidase (whose homologs include humanenkephalin convertase/carboxypeptidase E); EGL-21 is expressedthroughout the nervous system; EGL-21 is required for normal synthesisof FMRFamide-like (FLP) and neuropeptide-like (NLP) peptides, and for normal egg-laying, locomotion, and defecation; EGL-21 promotes acetylcholine release at neuromuscular junctions; egl-21 mutant defects resemble those seen for mutants of theproprotein convertase type 2 EGL-3. Paper_evidence: WBPaper00005776
            WBPaper00006103
            WBPaper00030763
          Curator_confirmed: WBPerson48
            WBPerson1843
            WBPerson567
          Date_last_updated: 10 Mar 2008 00:00:00
      Automated_description: Enables carboxypeptidase activity. Involved in several processes, including cellular response to carbon dioxide; regulation of multicellular organismal process; and regulation of neurotransmitter levels. Located in axon; cytoplasmic vesicle; and neuronal cell body. Expressed in nervous system and uv1. Human ortholog(s) of this gene implicated in carboxypeptidase N deficiency; morbid obesity; and type 2 diabetes mellitus. Is an ortholog of human CPE (carboxypeptidase E). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0111583 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2312)
      DOID:9970 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2303)
      DOID:9352 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2303)
      DOID:11981 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2303)
  Molecular_info: Corresponding_CDS: F01D4.4
    Corresponding_transcript: F01D4.4.1
    Other_sequence (140)
    Associated_feature: WBsf652133
      WBsf668250
      WBsf230743
      WBsf230744
      WBsf230745
  Experimental_info: RNAi_result (16)
    Expr_pattern: Expr2378
      Expr15246
      Expr1028609
      Expr1030761
      Expr1147706
      Expr2011213
      Expr2029449
    Drives_construct: WBCnstr00010801
      WBCnstr00037040
    Construct_product: WBCnstr00010801
      WBCnstr00021862
      WBCnstr00037040
    Antibody: WBAntibody00002570
    Microarray_results (24)
    Expression_cluster: WBPaper00030922:glycosylated_protein
      WBPaper00032528:L3_enriched
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00037682:sma-2_sma-4_upregulated
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:A-class-motor-neurons_larva_enriched
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_larva_enriched
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:AVE-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:BAG-neuron_embryo_enriched
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:dopaminergic-neurons_larva_enriched
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_larva_enriched
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_larva_enriched
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00042561:smgl-1(RNAi)_upregulated
      WBPaper00044037:eat-2_upregulated
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044656:tatn-1(qd182)_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044743:wdr-23_neuron_upregulated
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00045521:Gender_Neutral
      WBPaper00045571:germline-ablation_upregulated
      WBPaper00045861:ash-2(tm1095)_upregulated
      WBPaper00045861:set-2(ok952)_upregulated
      WBPaper00045861:wdr-5(ok1417)_upregulated
      WBPaper00045974:NSM_enriched_DSN-treated_RNAseq
      WBPaper00045974:NSM_enriched_totalRNA_RNAseq
      WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_downregulated
      WBPaper00046337:polysomal_N2_vs_daf-2_downregulated
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h
      WBPaper00046691:P1_enriched
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00047132:glp-1(ts)-25C_upregulated
      WBPaper00048988:neuron_enriched
      WBPaper00048988:neuron_expressed
      WBPaper00049001:EVN_enriched
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050094:mes-2(bn11)_upregulated
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050344:PLM-neuron_enriched
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_25C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_adult_20C
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050903:mir-35-41(nDf50)_25C_upregulated
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:intestine_enriched
      WBPaper00051558:aging_regulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053388:dauer_regulated_Cluster2
      WBPaper00053599:female_vs_male_downregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Rifampicin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055565:AVK_enriched
      WBPaper00055648:nerve-ring_expressed
      WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056826:hmc_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00057140:meg-3(tm4259)_meg-4(ax2026)_downregulated
      WBPaper00057140:pptr-1(tm3103)_downregulated
      WBPaper00057162:meg-3_meg-4_downregulated_sRNA
      WBPaper00057288:Cold_upregulated_transcript
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00058969:RIS_enriched
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059471:EGL-43_interacting
      WBPaper00059566:wdr-23(mac32)_upregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059763:neuron_expressed
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060014:set-2(tm1630)_downregulated
      WBPaper00060273:isp-1(qm150)_upregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061007:HB101_upregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061081:E.faecalis_upregulated_N2
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061274:microgravity_downregulated
      WBPaper00061340:ADE
      WBPaper00061340:ADL
      WBPaper00061340:AFD
      WBPaper00061340:AIA
      WBPaper00061340:AIB
      WBPaper00061340:AIM
      WBPaper00061340:AIN
      WBPaper00061340:AIY
      WBPaper00061340:AIZ
      WBPaper00061340:ALA
      WBPaper00061340:ALM_PLM
      WBPaper00061340:ALN
      WBPaper00061340:ASG
      WBPaper00061340:AUA
      WBPaper00061340:AVA
      WBPaper00061340:AVB
      WBPaper00061340:AVD
      WBPaper00061340:AVE
      WBPaper00061340:AVG
      WBPaper00061340:AVH
      WBPaper00061340:AVJ
      WBPaper00061340:AVK
      WBPaper00061340:AVL
      WBPaper00061340:BAG
      WBPaper00061340:CEP
      WBPaper00061340:DA
      WBPaper00061340:DA_DB
      WBPaper00061340:DD
      WBPaper00061340:DVA
      WBPaper00061340:DVC
      WBPaper00061340:FLP
      WBPaper00061340:I5
      WBPaper00061340:IL1
      WBPaper00061340:OLL
      WBPaper00061340:OLQ
      WBPaper00061340:PVP
      WBPaper00061340:PVT
      WBPaper00061340:RIA
      WBPaper00061340:RIB
      WBPaper00061340:RIC
      WBPaper00061340:RIH
      WBPaper00061340:RIM
      WBPaper00061340:RIS
      WBPaper00061340:RIV
      WBPaper00061340:RMD
      WBPaper00061340:RME
      WBPaper00061340:SIB
      WBPaper00061340:SMD
      WBPaper00061340:URX
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061527:flp-5-F17C11.2
      WBPaper00061651:ADA_enriched
      WBPaper00061651:AIA_enriched
      WBPaper00061651:AIB_enriched
      WBPaper00061651:AIM_enriched
      WBPaper00061651:AIN_enriched
      WBPaper00061651:AIY_enriched
      WBPaper00061651:AIZ_enriched
      WBPaper00061651:ALA_enriched
      WBPaper00061651:AQR_enriched
      WBPaper00061651:ASG_enriched
      WBPaper00061651:AUA_enriched
      WBPaper00061651:AVA_enriched
      WBPaper00061651:AVF_enriched
      WBPaper00061651:AVH_enriched
      WBPaper00061651:AVJ_enriched
      WBPaper00061651:AVK_enriched
      WBPaper00061651:AVL_enriched
      WBPaper00061651:AVM_enriched
      WBPaper00061651:AWB_enriched
      WBPaper00061651:BAG_enriched
      WBPaper00061651:BDU_enriched
      WBPaper00061651:DVA_enriched
      WBPaper00061651:DVB_enriched
      WBPaper00061651:DVC_enriched
      WBPaper00061651:I5_enriched
      WBPaper00061651:I6_enriched
      WBPaper00061651:IL2_LR_enriched
      WBPaper00061651:LUA_enriched
      WBPaper00061651:MI_enriched
      WBPaper00061651:PDA_enriched
      WBPaper00061651:PHC_enriched
      WBPaper00061651:PVM_enriched
      WBPaper00061651:PVP_enriched
      WBPaper00061651:PVQ_enriched
      WBPaper00061651:PVW_enriched
      WBPaper00061651:RIB_enriched
      WBPaper00061651:RIC_enriched
      WBPaper00061651:RID_enriched
      WBPaper00061651:RIF_enriched
      WBPaper00061651:RIG_enriched
      WBPaper00061651:RIH_enriched
      WBPaper00061651:RIM_enriched
      WBPaper00061651:RIP_enriched
      WBPaper00061651:RIR_enriched
      WBPaper00061651:RIS_enriched
      WBPaper00061651:RIV_enriched
      WBPaper00061651:RMD_LR_enriched
      WBPaper00061651:RME_DV_enriched
      WBPaper00061651:RME_LR_enriched
      WBPaper00061651:RMF_enriched
      WBPaper00061651:RMG_enriched
      WBPaper00061651:RMH_enriched
      WBPaper00061651:SDQ_enriched
      WBPaper00061651:SMD_enriched
      WBPaper00061651:URA_enriched
      WBPaper00061651:URB_enriched
      WBPaper00061995:mter-4(syb3662syb3403)_downregulated
      WBPaper00062103:neuron_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA
      WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
      WBPaper00064156:lipl-4(overexpress)_upregulated
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064871:hypoxia_downregulated_F2
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065149:lin-52(n771)_downregulated
      WBPaper00065581:hpk-1(pk1393)_upregulated
      WBPaper00065623:94
      WBPaper00065623:100
      WBPaper00065623:116
      WBPaper00065841:60_0
      WBPaper00065841:74_0
      WBPaper00065841:109_0
      WBPaper00065841:111_0
      WBPaper00065841:117_0
      WBPaper00065841:118_0
      WBPaper00065841:123_0
      WBPaper00065841:126_0
      WBPaper00065841:128_0
      WBPaper00065841:129_0
      WBPaper00065841:139_0
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      cgc4386_cluster_1_6
      cgc4489_group_14
      WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00030839:Embryo_Pan_Neuronal
      WBPaper00030839:Larval_Pan_Neuronal
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00031532:Larva_Pan_Neuronal_Enriched
      WBPaper00032948:StarveUp3
      WBPaper00035084:L1_enriched_AIN-2_IP
      WBPaper00035227:heat_shock_regulated
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035873:osm-8_regulated
      WBPaper00036286:Pattern_C
      WBPaper00038060:SUMO-1_downregulated
      WBPaper00038172:tax-6null_up_regulated
      WBPaper00038427:lin-54_embryo_changed
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040858:eQTL_age_regulated_developing
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040985:AIN-2_asynchronous_intestine
      WBPaper00040985:AIN-2_asynchronous_muscle
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_prime
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00042178:hlh-29(tm284)_upregulated
      WBPaper00042274:tbx-2(bx59)_upregulated
      WBPaper00042548:miRISC_enriched
      WBPaper00045865:biofilm_upregulated_A
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00048624:hlh-25(ok1710)_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00048989:N2_allantoin_downregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00056330:mrps-5(RNAi)_upregulated
    Interaction (94)
    Anatomy_function (3)
  Map_info: Map: IV Position: 4.60123 Error: 0.002141
    Positive: Positive_clone: F01D4 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 626
        1829
        3240
  Reference (47)
  Method: Gene