Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Gene: WBGene00001189

expand all nodes | collapse all nodes | view schema

Name Class

WBGene00001189SMapS_parentSequenceF01D4
IdentityVersion1
NameCGC_nameegl-21Person_evidenceWBPerson268
Sequence_nameF01D4.4
Molecular_nameF01D4.4
F01D4.4.1
CE09156
Other_nameCELE_F01D4.4Accession_evidenceNDBBX284604
Public_nameegl-21
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:23WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classegl
Reference_alleleWBVar00089624
Allele (43)
Legacy_informationn611ts : transient bloating at 25x Type E partially temperature sensitive uncoordinated weak coiler. ES2 (adult). NA3 (n476 n576).
[C.elegansII] n611ts : transient bloating at 25C, variable drug response; partially temperature sensitive;uncoordinated weak coiler; abnormal 5-HT signalling. ES2 (adult). ME2. OA2: n476, n576. [Trent et al. 1983; KP; MT]
StrainWBStrain00023630
WBStrain00026777
WBStrain00026813
WBStrain00026827
WBStrain00026874
RNASeq_FPKM (74)
GO_annotation (41)
Ortholog (52)
ParalogWBGene00012073Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00019074Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionConcise_descriptionegl-21 encodes a putative carboxypeptidase (whose homologs include humanenkephalin convertase/carboxypeptidase E); EGL-21 is expressedthroughout the nervous system; EGL-21 is required for normal synthesisof FMRFamide-like (FLP) and neuropeptide-like (NLP) peptides, and for normal egg-laying, locomotion, and defecation; EGL-21 promotes acetylcholine release at neuromuscular junctions; egl-21 mutant defects resemble those seen for mutants of theproprotein convertase type 2 EGL-3.Paper_evidenceWBPaper00005776
WBPaper00006103
WBPaper00030763
Curator_confirmedWBPerson48
WBPerson1843
WBPerson567
Date_last_updated10 Mar 2008 00:00:00
Automated_descriptionEnables carboxypeptidase activity. Involved in several processes, including cellular response to carbon dioxide; regulation of multicellular organismal process; and regulation of neurotransmitter levels. Located in axon; cytoplasmic vesicle; and neuronal cell body. Expressed in nervous system and uv1. Human ortholog(s) of this gene implicated in carboxypeptidase N deficiency; morbid obesity; and type 2 diabetes mellitus. Is an ortholog of human CPE (carboxypeptidase E).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0111583Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2312)
DOID:9970Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2303)
DOID:9352Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2303)
DOID:11981Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2303)
Molecular_infoCorresponding_CDSF01D4.4
Corresponding_transcriptF01D4.4.1
Other_sequence (140)
Associated_featureWBsf652133
WBsf668250
WBsf230743
WBsf230744
WBsf230745
Experimental_infoRNAi_result (16)
Expr_patternExpr2378
Expr15246
Expr1028609
Expr1030761
Expr1147706
Expr2011213
Expr2029449
Drives_constructWBCnstr00010801
WBCnstr00037040
Construct_productWBCnstr00010801
WBCnstr00021862
WBCnstr00037040
AntibodyWBAntibody00002570
Microarray_results (24)
Expression_clusterWBPaper00030922:glycosylated_protein
WBPaper00032528:L3_enriched
WBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00037682:sma-2_sma-4_upregulated
WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
WBPaper00037950:A-class-motor-neurons_larva_enriched
WBPaper00037950:all-neurons_L1-larva_expressed
WBPaper00037950:all-neurons_L2-larva_expressed
WBPaper00037950:all-neurons_larva_enriched
WBPaper00037950:AVA-neuron_L1-larva_expressed
WBPaper00037950:AVE-neuron_L1-larva_expressed
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:BAG-neuron_embryo_enriched
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:coelomocytes_L2-larva_expressed
WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:dopaminergic-neurons_larva_enriched
WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
WBPaper00037950:glr-1(+)-neurons_larva_enriched
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00037950:PVD-OLL-neurons_larva_enriched
WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
WBPaper00042215:wdr-23(tm1817)_upregulated
WBPaper00042561:smgl-1(RNAi)_upregulated
WBPaper00044037:eat-2_upregulated
WBPaper00044426:rotenone_24h_upregulated
WBPaper00044501:gld-1_let-7_regulated
WBPaper00044656:tatn-1(qd182)_upregulated
WBPaper00044736:flat_dev_expression
WBPaper00044743:wdr-23_neuron_upregulated
WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
WBPaper00045521:Gender_Neutral
WBPaper00045571:germline-ablation_upregulated
WBPaper00045861:ash-2(tm1095)_upregulated
WBPaper00045861:set-2(ok952)_upregulated
WBPaper00045861:wdr-5(ok1417)_upregulated
WBPaper00045974:NSM_enriched_DSN-treated_RNAseq
WBPaper00045974:NSM_enriched_totalRNA_RNAseq
WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_downregulated
WBPaper00046337:polysomal_N2_vs_daf-2_downregulated
WBPaper00046497:B.thuringiensis_0.1mix_upregulated_12h
WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h
WBPaper00046691:P1_enriched
WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
WBPaper00047131:daf-2(e1370)_upregulated_N2-background
WBPaper00047132:glp-1(ts)-25C_upregulated
WBPaper00048988:neuron_enriched
WBPaper00048988:neuron_expressed
WBPaper00049001:EVN_enriched
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
WBPaper00049920:Glucose-Diet_upregulated_N2
WBPaper00049942:hsf-1(RNAi)_upregulated
WBPaper00050094:mes-2(bn11)_upregulated
WBPaper00050344:AFD-neuron_enriched
WBPaper00050344:ASER-neuron_enriched
WBPaper00050344:PLM-neuron_enriched
WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_25C
WBPaper00050488:N2_vs_mir-34(gk437)_regulated_adult_20C
WBPaper00050726:OsmoticStress_regulated_NoFood
WBPaper00050726:starvation_regulated_LowSalt
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
WBPaper00050903:mir-35-41(nDf50)_25C_upregulated
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00050990:pharynx_expressed
WBPaper00050990:seam_expressed
WBPaper00051039:intestine_enriched
WBPaper00051558:aging_regulated
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053184:sma-2(rax5)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053388:dauer_regulated_Cluster2
WBPaper00053599:female_vs_male_downregulated
WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
WBPaper00053810:daf-2(e1370)_upregulated
WBPaper00053810:nuo-6(qm200)_upregulated
WBPaper00055049:S.gordonii_upregulated
WBPaper00055354:Psora-Allantoin_downregulated
WBPaper00055354:Rapamycin-Allantoin_downregulated
WBPaper00055354:Rapamycin-Metformin_downregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
WBPaper00055354:Rapamycin-Rifampicin_downregulated
WBPaper00055354:Rifampicin-Allantoin_downregulated
WBPaper00055354:Rifampicin_downregulated
WBPaper00055482:pmt-2(RNAi)_upregulated
WBPaper00055565:AVK_enriched
WBPaper00055648:nerve-ring_expressed
WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated
WBPaper00055971:nhl-2(ok818)_25C_downregulated
WBPaper00056034:pals-22(jy3)_upregulated
WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
WBPaper00056090:E.faecalis_upregulated_N2
WBPaper00056139:soil-microbiota_upregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00056471:S.aureus-4h_upregulated_N2
WBPaper00056826:hmc_biased
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00057041:unc-70(cas983)_downregulated
WBPaper00057140:meg-3(tm4259)_meg-4(ax2026)_downregulated
WBPaper00057140:pptr-1(tm3103)_downregulated
WBPaper00057162:meg-3_meg-4_downregulated_sRNA
WBPaper00057288:Cold_upregulated_transcript
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058598:sin-3(tm1276)_downregulated
WBPaper00058598:spn-4(tm291)_upregulated
WBPaper00058948:PA14_downregulated
WBPaper00058969:RIS_enriched
WBPaper00059027:neuron-synapses_depleted
WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
WBPaper00059356:BAZ-2_SET-6_interacting
WBPaper00059471:EGL-43_interacting
WBPaper00059566:wdr-23(mac32)_upregulated
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00059763:neuron_expressed
WBPaper00059895:wounding_upregulated
WBPaper00059987:Wounding_upregulated
WBPaper00060014:set-2(tm1630)_downregulated
WBPaper00060273:isp-1(qm150)_upregulated
WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
WBPaper00060459:bcat-1(RNAi)_upregulated
WBPaper00060661:sensory-neuron_enriched
WBPaper00060811:L1_vs_adult_upregulated_neural
WBPaper00061007:HB101_upregulated
WBPaper00061007:S.aquatilis_upregulated
WBPaper00061081:E.faecalis_upregulated_N2
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061274:microgravity_downregulated
WBPaper00061340:ADE
WBPaper00061340:ADL
WBPaper00061340:AFD
WBPaper00061340:AIA
WBPaper00061340:AIB
WBPaper00061340:AIM
WBPaper00061340:AIN
WBPaper00061340:AIY
WBPaper00061340:AIZ
WBPaper00061340:ALA
WBPaper00061340:ALM_PLM
WBPaper00061340:ALN
WBPaper00061340:ASG
WBPaper00061340:AUA
WBPaper00061340:AVA
WBPaper00061340:AVB
WBPaper00061340:AVD
WBPaper00061340:AVE
WBPaper00061340:AVG
WBPaper00061340:AVH
WBPaper00061340:AVJ
WBPaper00061340:AVK
WBPaper00061340:AVL
WBPaper00061340:BAG
WBPaper00061340:CEP
WBPaper00061340:DA
WBPaper00061340:DA_DB
WBPaper00061340:DD
WBPaper00061340:DVA
WBPaper00061340:DVC
WBPaper00061340:FLP
WBPaper00061340:I5
WBPaper00061340:IL1
WBPaper00061340:OLL
WBPaper00061340:OLQ
WBPaper00061340:PVP
WBPaper00061340:PVT
WBPaper00061340:RIA
WBPaper00061340:RIB
WBPaper00061340:RIC
WBPaper00061340:RIH
WBPaper00061340:RIM
WBPaper00061340:RIS
WBPaper00061340:RIV
WBPaper00061340:RMD
WBPaper00061340:RME
WBPaper00061340:SIB
WBPaper00061340:SMD
WBPaper00061340:URX
WBPaper00061341:28C_24h_upregulated
WBPaper00061439:unc-30(ok613)_upregulated
WBPaper00061439:unc-30(ok613)_upregulated_P.aeruginosa-infection
WBPaper00061479:hda-1(ne4752)_upregulated
WBPaper00061527:flp-5-F17C11.2
WBPaper00061651:ADA_enriched
WBPaper00061651:AIA_enriched
WBPaper00061651:AIB_enriched
WBPaper00061651:AIM_enriched
WBPaper00061651:AIN_enriched
WBPaper00061651:AIY_enriched
WBPaper00061651:AIZ_enriched
WBPaper00061651:ALA_enriched
WBPaper00061651:AQR_enriched
WBPaper00061651:ASG_enriched
WBPaper00061651:AUA_enriched
WBPaper00061651:AVA_enriched
WBPaper00061651:AVF_enriched
WBPaper00061651:AVH_enriched
WBPaper00061651:AVJ_enriched
WBPaper00061651:AVK_enriched
WBPaper00061651:AVL_enriched
WBPaper00061651:AVM_enriched
WBPaper00061651:AWB_enriched
WBPaper00061651:BAG_enriched
WBPaper00061651:BDU_enriched
WBPaper00061651:DVA_enriched
WBPaper00061651:DVB_enriched
WBPaper00061651:DVC_enriched
WBPaper00061651:I5_enriched
WBPaper00061651:I6_enriched
WBPaper00061651:IL2_LR_enriched
WBPaper00061651:LUA_enriched
WBPaper00061651:MI_enriched
WBPaper00061651:PDA_enriched
WBPaper00061651:PHC_enriched
WBPaper00061651:PVM_enriched
WBPaper00061651:PVP_enriched
WBPaper00061651:PVQ_enriched
WBPaper00061651:PVW_enriched
WBPaper00061651:RIB_enriched
WBPaper00061651:RIC_enriched
WBPaper00061651:RID_enriched
WBPaper00061651:RIF_enriched
WBPaper00061651:RIG_enriched
WBPaper00061651:RIH_enriched
WBPaper00061651:RIM_enriched
WBPaper00061651:RIP_enriched
WBPaper00061651:RIR_enriched
WBPaper00061651:RIS_enriched
WBPaper00061651:RIV_enriched
WBPaper00061651:RMD_LR_enriched
WBPaper00061651:RME_DV_enriched
WBPaper00061651:RME_LR_enriched
WBPaper00061651:RMF_enriched
WBPaper00061651:RMG_enriched
WBPaper00061651:RMH_enriched
WBPaper00061651:SDQ_enriched
WBPaper00061651:SMD_enriched
WBPaper00061651:URA_enriched
WBPaper00061651:URB_enriched
WBPaper00061995:mter-4(syb3662syb3403)_downregulated
WBPaper00062103:neuron_enriched
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062193:skn-1(RNAi)_upregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062669:extracellular-vesicle_protein
WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA
WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064156:lipl-4(overexpress)_upregulated
WBPaper00064306:Agaro-oligosaccharides_upregulated
WBPaper00064716:paraquat_downregulated
WBPaper00064871:hypoxia_downregulated_F2
WBPaper00065096:25C_vs_20C_downregulated
WBPaper00065096:Day10_vs_Day1_downregulated
WBPaper00065120:body-muscle-transcriptome
WBPaper00065149:lin-52(n771)_downregulated
WBPaper00065581:hpk-1(pk1393)_upregulated
WBPaper00065623:94
WBPaper00065623:100
WBPaper00065623:116
WBPaper00065841:60_0
WBPaper00065841:74_0
WBPaper00065841:109_0
WBPaper00065841:111_0
WBPaper00065841:117_0
WBPaper00065841:118_0
WBPaper00065841:123_0
WBPaper00065841:126_0
WBPaper00065841:128_0
WBPaper00065841:129_0
WBPaper00065841:139_0
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00065993:glp-1(e2141)_upregulated
cgc4386_cluster_1_6
cgc4489_group_14
WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00030839:Embryo_Pan_Neuronal
WBPaper00030839:Larval_Pan_Neuronal
WBPaper00031003:0hr_muscle_depleted
WBPaper00031003:24hr_muscle_depleted
WBPaper00031003:total_muscle_depleted
WBPaper00031252:AIN-2_IP_enriched
WBPaper00031532:Larva_Pan_Neuronal_Enriched
WBPaper00032948:StarveUp3
WBPaper00035084:L1_enriched_AIN-2_IP
WBPaper00035227:heat_shock_regulated
WBPaper00035588:alg-1(-)_upregulated
WBPaper00035873:dpy-9_regulated
WBPaper00035873:dpy-10_regulated
WBPaper00035873:osm-8_regulated
WBPaper00036286:Pattern_C
WBPaper00038060:SUMO-1_downregulated
WBPaper00038172:tax-6null_up_regulated
WBPaper00038427:lin-54_embryo_changed
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
WBPaper00040858:eQTL_age_regulated_developing
WBPaper00040858:eQTL_regulated_developing
WBPaper00040985:AIN-2_asynchronous_intestine
WBPaper00040985:AIN-2_asynchronous_muscle
WBPaper00041002:HQ_3d_2.0mM_Up
WBPaper00041174:genotypic
WBPaper00041174:genotypic_prime
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
WBPaper00042178:hlh-29(tm284)_upregulated
WBPaper00042274:tbx-2(bx59)_upregulated
WBPaper00042548:miRISC_enriched
WBPaper00045865:biofilm_upregulated_A
WBPaper00047070:N2_starvation_upregulated
WBPaper00048624:hlh-25(ok1710)_upregulated
WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
WBPaper00048989:N2_allantoin_downregulated
WBPaper00053236:Starvation_regulated_GR1307
WBPaper00053236:Starvation_regulated_N2
WBPaper00056330:mrps-5(RNAi)_upregulated
InteractionWBInteraction000004043
WBInteraction000029698
WBInteraction000030450
WBInteraction000108811
WBInteraction000111961
WBInteraction000122020
WBInteraction000124414
WBInteraction000138462
WBInteraction000150837
WBInteraction000151182
WBInteraction000152041
WBInteraction000157628
WBInteraction000170501
WBInteraction000172692
WBInteraction000178046
WBInteraction000183862
WBInteraction000184026
WBInteraction000206986
WBInteraction000209272
WBInteraction000214096
WBInteraction000215932
WBInteraction000216726
WBInteraction000217401
WBInteraction000222203
WBInteraction000222388
WBInteraction000222979
WBInteraction000224593
WBInteraction000228792
WBInteraction000229733
WBInteraction000240244
WBInteraction000250692
WBInteraction000253513
WBInteraction000254245
WBInteraction000254555
WBInteraction000259761
WBInteraction000262523
WBInteraction000264668
WBInteraction000267176
WBInteraction000267781
WBInteraction000270059
WBInteraction000280337
WBInteraction000302477
WBInteraction000302527
WBInteraction000303930
WBInteraction000313069
WBInteraction000314288
WBInteraction000319461
WBInteraction000334661
WBInteraction000335024
WBInteraction000336281
WBInteraction000339162
WBInteraction000344652
WBInteraction000345582
WBInteraction000346656
WBInteraction000348726
WBInteraction000349936
WBInteraction000352309
WBInteraction000355805
WBInteraction000359361
WBInteraction000360286
WBInteraction000366302
WBInteraction000383303
WBInteraction000384053
WBInteraction000386289
WBInteraction000386941
WBInteraction000388923
WBInteraction000396192
WBInteraction000398259
WBInteraction000399014
WBInteraction000400155
WBInteraction000401932
WBInteraction000406265
WBInteraction000406955
WBInteraction000411626
WBInteraction000414786
WBInteraction000416690
WBInteraction000420722
WBInteraction000422707
WBInteraction000428486
WBInteraction000436324
WBInteraction000437513
WBInteraction000447083
WBInteraction000448077
WBInteraction000450933
WBInteraction000452425
WBInteraction000452502
WBInteraction000459026
WBInteraction000500517
WBInteraction000501850
WBInteraction000512383
WBInteraction000512384
WBInteraction000517215
WBInteraction000517216
WBInteraction000517217
Anatomy_functionWBbtf0207
WBbtf0208
WBbtf0211
Map_infoMapIVPosition4.60123Error0.002141
PositivePositive_cloneF01D4Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point626
1829
3240
Reference (47)
MethodGene