WBGene00003003 | SMap | S_parent | Sequence | T25C12 |
| Identity | Version | 1 |
| | Name | CGC_name | lin-14 | Person_evidence | WBPerson261 |
| | | Sequence_name | T25C12.1 |
| | | Molecular_name | T25C12.1a |
| | | | T25C12.1a.1 |
| | | | CE43285 |
| | | | T25C12.1b |
| | | | CE03734 |
| | | | T25C12.1b.1 |
| | | Other_name | CELE_T25C12.1 | Accession_evidence | NDB | BX284606 |
| | | Public_name | lin-14 |
| | DB_info | Database | AceView | gene | XM103 |
| | | | WormQTL | gene | WBGene00003003 |
| | | | WormFlux | gene | WBGene00003003 |
| | | | NDB | locus_tag | CELE_T25C12.1 |
| | | | NCBI | gene | 181337 |
| | | | RefSeq | protein | NM_077515.5 |
| | | | | | NM_077516.7 |
| | | | SwissProt | UniProtAcc | Q21446 |
| | | | TREEFAM | TREEFAM_ID | TF316913 |
| | | | UniProt_GCRP | UniProtAcc | Q21446 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | lin |
| | Reference_allele | WBVar00089301 |
| | | WBVar00089587 |
| | Allele | WBVar00089450 | Inferred_automatically | From strain object: MT1848 |
| | | | | From strain object: MT862 |
| | | WBVar00089496 | Inferred_automatically | From strain object: MT925 |
| | | WBVar00088773 | Inferred_automatically | From strain object: VT284 |
| | | WBVar00089447 |
| | | WBVar00089448 |
| | | WBVar00089592 |
| | | WBVar00089446 |
| | | WBVar00089449 |
| | | WBVar00275046 |
| | | WBVar00089709 |
| | | WBVar00275050 |
| | | WBVar00089589 |
| | | WBVar00089801 |
| | | WBVar00143283 |
| | | WBVar00089584 |
| | | WBVar00089799 |
| | | WBVar00089586 |
| | | WBVar00275051 |
| | | WBVar00089802 |
| | | WBVar00089588 |
| | | WBVar00089590 |
| | | WBVar00089797 |
| | | WBVar00275047 |
| | | WBVar00275043 |
| | | WBVar02153550 |
| | | WBVar02157624 |
| | | WBVar02157626 |
| | | WBVar02157627 |
| | | WBVar02157628 |
| | | WBVar01188254 |
| | | WBVar00300565 |
| | | WBVar01188255 |
| | | WBVar01188256 |
| | | WBVar02112319 |
| | | WBVar02027426 |
| | | WBVar01499887 |
| | | WBVar01188257 |
| | | WBVar02027427 |
| | | WBVar01188258 |
| | | WBVar01499888 |
| | | WBVar01602195 |
| | | WBVar01188259 |
| | | WBVar01602196 |
| | | WBVar01188260 |
| | | WBVar01602197 |
| | | WBVar01188261 |
| | | WBVar01188262 |
| | | WBVar01188263 |
| | | WBVar01499710 |
| | | WBVar01188264 |
| | | WBVar01897932 |
| | | WBVar01188265 |
| | | WBVar01897933 |
| | | WBVar01188266 |
| | | WBVar02032861 |
| | | WBVar01188267 |
| | | WBVar00274531 |
| | | WBVar01188268 |
| | | WBVar00274533 |
| | | WBVar00260216 |
| | | WBVar00089301 |
| | | WBVar01987711 |
| | | WBVar01987712 |
| | | WBVar02072669 |
| | | WBVar01987713 |
| | | WBVar02068023 |
| | | WBVar01987714 |
| | | WBVar01489247 |
| | | WBVar00601538 |
| | | WBVar01188114 |
| | | WBVar01188115 |
| | | WBVar01188116 |
| | | WBVar01188117 |
| | | WBVar01188118 |
| | | WBVar00089445 |
| | | WBVar01188119 |
| | | WBVar01188120 |
| | | WBVar01188121 |
| | | WBVar01188123 |
| | | WBVar01188124 |
| | | WBVar01188125 |
| | | WBVar01188126 |
| | | WBVar01188127 |
| | | WBVar01188128 |
| | | WBVar01188129 |
| | | WBVar01188130 |
| | | WBVar01188131 |
| | | WBVar01188132 |
| | | WBVar01188133 |
| | | WBVar01188134 |
| | | WBVar01188135 |
| | | WBVar01188136 |
| | | WBVar01188137 |
| | | WBVar01188138 |
| | | WBVar02152597 |
| | | WBVar01188139 |
| | | WBVar01188140 |
| | | WBVar01188141 |
| | | WBVar02009144 |
| | | WBVar01188142 |
| | | WBVar02009145 |
| | | WBVar01188143 |
| | | WBVar02009146 |
| | | WBVar01188144 |
| | | WBVar01188145 |
| | | WBVar01188146 |
| | | WBVar02093439 |
| | | WBVar01188147 |
| | | WBVar01188148 |
| | | WBVar01188149 |
| | | WBVar01188150 |
| | | WBVar01188151 |
| | | WBVar01188152 |
| | | WBVar01188153 |
| | | WBVar01188154 |
| | | WBVar01498128 |
| | | WBVar01188155 |
| | | WBVar01188156 |
| | | WBVar01188157 |
| | | WBVar00089582 |
| | | WBVar01188158 |
| | | WBVar00089583 |
| | | WBVar01188159 |
| | | WBVar00089585 |
| | | WBVar00089587 |
| | | WBVar01188160 |
| | | WBVar01497582 |
| | | WBVar01188161 |
| | | WBVar00089591 |
| | | WBVar01188162 |
| | | WBVar00089593 |
| | | WBVar00083186 |
| | | WBVar00089594 |
| | | WBVar01188163 |
| | | WBVar00083187 |
| | | WBVar01703416 |
| | | WBVar01494274 |
| | | WBVar01188164 |
| | | WBVar01188165 |
| | | WBVar00083188 |
| | | WBVar01703417 |
| | | WBVar01820533 |
| | | WBVar01188166 |
| | | WBVar00083189 |
| | | WBVar01188167 |
| | | WBVar00083190 |
| | | WBVar01188168 |
| | | WBVar00083191 |
| | | WBVar01493175 |
| | | WBVar01188169 |
| | | WBVar00083192 |
| | | WBVar01188170 |
| | | WBVar00083193 |
| | | WBVar00083194 |
| | | WBVar01188171 |
| | | WBVar00083195 |
| | | WBVar01188172 |
| | | WBVar01188173 |
| | | WBVar01188174 |
| | | WBVar01188175 |
| | | WBVar01188176 |
| | | WBVar01188177 |
| | | WBVar01188178 |
| | | WBVar01690508 |
| | | WBVar01188179 |
| | | WBVar01690509 |
| | | WBVar01188180 |
| | | WBVar01188181 |
| | | WBVar01690510 |
| | | WBVar01188182 |
| | | WBVar01690511 |
| | | WBVar01690512 |
| | | WBVar01188183 |
| | | WBVar01690513 |
| | | WBVar01188185 |
| | | WBVar01620587 |
| | | WBVar01188186 |
| | | WBVar01620588 |
| | | WBVar01500001 |
| | | WBVar01620589 |
| | | WBVar01188187 |
| | | WBVar01620590 |
| | | WBVar01500002 |
| | | WBVar01188188 |
| | | WBVar01188189 |
| | | WBVar01188190 |
| | | WBVar01188191 |
| | | WBVar00089668 |
| | | WBVar01188192 |
| | | WBVar01188193 |
| | | WBVar01759469 |
| | | WBVar01759470 |
| | | WBVar01188194 |
| | | WBVar01188195 |
| | | WBVar01759471 |
| | | WBVar01188196 |
| | | WBVar01487681 |
| | | WBVar01759472 |
| | | WBVar02051082 |
| | | WBVar01188197 |
| | | WBVar00517475 |
| | | WBVar00517476 |
| | | WBVar01188198 |
| | | WBVar02051083 |
| | | WBVar00517477 |
| | | WBVar01188199 |
| | | WBVar01188200 |
| | | WBVar00517478 |
| | | WBVar00517479 |
| | | WBVar01188201 |
| | | WBVar01188202 |
| | | WBVar00517480 |
| | | WBVar00517481 |
| | | WBVar01188203 |
| | | WBVar01188204 |
| | | WBVar00517482 |
| | | WBVar00517483 |
| | | WBVar01188205 |
| | | WBVar00089710 |
| | | WBVar01188206 |
| | | WBVar00517484 |
| | | WBVar00517485 |
| | | WBVar01188207 |
| | | WBVar01188208 |
| | | WBVar00517486 |
| | | WBVar01825919 |
| | | WBVar01188209 |
| | | WBVar00517487 |
| | | WBVar00517488 |
| | | WBVar01188210 |
| | | WBVar01188211 |
| | | WBVar00517489 |
| | | WBVar01188212 |
| | | WBVar00517490 |
| | | WBVar00517491 |
| | | WBVar01188213 |
| | | WBVar01981336 |
| | | WBVar00517492 |
| | | WBVar01188214 |
| | | WBVar01981337 |
| | | WBVar00517493 |
| | | WBVar01188215 |
| | | WBVar00517494 |
| | | WBVar01981338 |
| | | WBVar01188216 |
| | | WBVar01981339 |
| | | WBVar01188217 |
| | | WBVar00517495 |
| | | WBVar01981340 |
| | | WBVar01188218 |
| | | WBVar00517496 |
| | | WBVar01188219 |
| | | WBVar01981341 |
| | | WBVar00517497 |
| | | WBVar00517498 |
| | | WBVar02140121 |
| | | WBVar01188220 |
| | | WBVar00517499 |
| | | WBVar02140122 |
| | | WBVar01188221 |
| | | WBVar01188222 |
| | | WBVar02140123 |
| | | WBVar00517500 |
| | | WBVar01188223 |
| | | WBVar00517501 |
| | | WBVar01188224 |
| | | WBVar01787034 |
| | | WBVar00517502 |
| | | WBVar01188225 |
| | | WBVar00517503 |
| | | WBVar00517504 |
| | | WBVar01188226 |
| | | WBVar00517505 |
| | | WBVar01471181 |
| | | WBVar01188227 |
| | | WBVar00517506 |
| | | WBVar01188228 |
| | | WBVar01471182 |
| | | WBVar01188229 |
| | | WBVar00517507 |
| | | WBVar01471183 |
| | | WBVar00517508 |
| | | WBVar01471184 |
| | | WBVar01493787 |
| | | WBVar01188230 |
| | | WBVar01471185 |
| | | WBVar01188231 |
| | | WBVar00517509 |
| | | WBVar01493788 |
| | | WBVar01471186 |
| | | WBVar00517510 |
| | | WBVar01188232 |
| | | WBVar01188233 |
| | | WBVar01471187 |
| | | WBVar00517511 |
| | | WBVar01188234 |
| | | WBVar01471188 |
| | | WBVar00517512 |
| | | WBVar01188235 |
| | | WBVar01471189 |
| | | WBVar00517513 |
| | | WBVar00089798 |
| | | WBVar00517514 |
| | | WBVar01188236 |
| | | WBVar01471190 |
| | | WBVar00089800 |
| | | WBVar00517515 |
| | | WBVar01471191 |
| | | WBVar01188237 |
| | | WBVar00517516 |
| | | WBVar01188238 |
| | | WBVar00517517 |
| | | WBVar01188239 |
| | | WBVar01188240 |
| | | WBVar00517518 |
| | | WBVar00517519 |
| | | WBVar01188241 |
| | | WBVar01188242 |
| | | WBVar00517520 |
| | | WBVar01188243 |
| | | WBVar00517521 |
| | | WBVar00517522 |
| | | WBVar01188244 |
| | | WBVar00517523 |
| | | WBVar01188245 |
| | | WBVar00517524 |
| | | WBVar01188246 |
| | | WBVar01188247 |
| | | WBVar01188248 |
| | | WBVar01188249 |
| | | WBVar01188250 |
| | | WBVar01498960 |
| | | WBVar01188251 |
| | | WBVar01188252 |
| | | WBVar01494914 |
| | | WBVar01500067 |
| | | WBVar01188253 |
| | Legacy_information | Class 1 alleles (loss-of-function) n526n540ird : precocious heterochronic lineage alterations in ectoderm; abnormal development of vulva endoderm and mesoderm; abnormal cuticle formation; ES2; male more severely affected only three molts gonadal development abnormal. Similar phenotype in n536n540/Df. NA > 10 (n179ts etc.; also Class 1a n355n679ird ts (only early events precocious); Class 1b n360ts (only late events precocious). Class 2 alleles (gain-of-function) n536sd : retarded heterochronic alterations in many lineages abnormal vulval development cuticle formation supernumerary molts extra divisions in sex mesoblasts intestine etc.; gonadal lineages normal. ES3. ME0? NA2 (n355sd). For both Class 1 and Class 2 mutations late lineages are less affected if animal develops via dauer stage. |
| | | See also n179, n355, n360, n407, n530, n531, n532, n534, n535, n536, n539, n540, n679, n726, n727, n837, n838, n839, n840, n841, n842 |
| | | [C.elegansII] n526n540ird : lf allele (Class II, a-b-), precocious heterochronic lineage alterations in ectoderm; abnormal development of vulva,endoderm and mesoderm; abnormal cuticle formation; precocious dauer entry at L1 molt; ES2; male more severely affected, only three molts, gonadal development abnormal. Similar phenotype in n536n540/Df. OA>10: n179ts, etc.; also n355n679ird,ts (Class V, a-b+, only early events precocious); n360ts(Class III, a+b-, only late events precocious). Also gain-of-function alleles: n536sd (Class I, retarded heterochronic alterations in many lineages; abnormal vulval development, cuticle formation, supernumerary molts, extra divisions in sex mesoblasts, intestine etc.; gonadal lineages normal. ES3), n355sd(similar). Numerous intragenic revertants. For both lf and gf mutations, late lineages are less affected if animal develops via dauer stage. Cloned: two 3.5 kb transcripts, differing 5',encoding 70 kD novel proteins; antibodies stain nuclei; protein levels high in L1, reduced or absent later. Gain-of-function mutations affect3' UTR. [Ruvkun and Giusto 1989; Wightman et al. 1993; GR; VT] |
| | Strain (20) |
| | RNASeq_FPKM (74) |
| | GO_annotation (16) |
| | Ortholog | WBGene00058282 | Caenorhabditis remanei | From_analysis | OMA |
| | | | | | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | | WBGene00036988 | Caenorhabditis briggsae | From_analysis | Hillier-set |
| | | | | | OrthoMCL |
| | | | | | OMA |
| | | | | | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | | WBGene00150927 | Caenorhabditis brenneri | From_analysis | OMA |
| | | | | | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | | WBGene00131217 | Caenorhabditis japonica | From_analysis | OMA |
| | | | | | TreeFam |
| | | | | | Inparanoid_8 |
| | | | | | WormBase-Compara |
| | | WBGene00226262 | Brugia malayi | From_analysis | WormBase-Compara |
| | | CBOVI.g3932 | Caenorhabditis bovis | From_analysis | WormBase-Compara |
| | | CSP21.g9157 | Caenorhabditis parvicauda | From_analysis | WormBase-Compara |
| | | CSP26.g1842 | Caenorhabditis zanzibari | From_analysis | WormBase-Compara |
| | | CSP28.g18779 | Caenorhabditis panamensis | From_analysis | WormBase-Compara |
| | | CSP29.g15814 | Caenorhabditis becei | From_analysis | WormBase-Compara |
| | | CSP31.g10044 | Caenorhabditis uteleia | From_analysis | WormBase-Compara |
| | | CSP32.g2871 | Caenorhabditis sulstoni | From_analysis | WormBase-Compara |
| | | CSP38.g554 | Caenorhabditis quiockensis | From_analysis | WormBase-Compara |
| | | CSP39.g28774 | Caenorhabditis waitukubuli | From_analysis | WormBase-Compara |
| | | CSP40.g12614 | Caenorhabditis tribulationis | From_analysis | WormBase-Compara |
| | | Cang_2012_03_13_00320.g9145 | Caenorhabditis angaria | From_analysis | WormBase-Compara |
| | | Cni-lin-14 | Caenorhabditis nigoni | From_analysis | WormBase-Compara |
| | | Csp11.Scaffold49.g290 | Caenorhabditis tropicalis | From_analysis | WormBase-Compara |
| | | Csp5_scaffold_00026.g1518 | Caenorhabditis sinica | From_analysis | WormBase-Compara |
| | | FL83_01114 | Caenorhabditis latens | From_analysis | WormBase-Compara |
| | | GCK72_023795 | Caenorhabditis remanei | From_analysis | WormBase-Compara |
| | | OTIPU.nOt.2.0.1.g00985 | Oscheius tipulae | From_analysis | WormBase-Compara |
| | | Pan_g16864 | Panagrellus redivivus | From_analysis | WormBase-Compara |
| | | Sp34_X0089610 | Caenorhabditis inopinata | From_analysis | WormBase-Compara |
| | | chrX_pilon.g20075 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00241199 | Onchocerca volvulus | From_analysis | WormBase-Compara |
| | | WBGene00109949 | Pristionchus pacificus | From_analysis | WormBase-Compara |
| | | WBGene00266869 | Strongyloides ratti | From_analysis | WormBase-Compara |
| | Structured_description | Concise_description | lin-14 encodes a novel protein whose activity is required for specifying the division timings of a specific group of cells during postembryonic development; lin-14 loss-of-function mutations result in the premature appearance of later larval lineages, while gain-of-function mutations result in reiteration of L1 larval stages lineages; in addition, lin-14 acts as a positive regulator of AVM, PVM, and FLP touch cell development; in regulating developmental timing, lin-14 acts, in part, by positively regulating the activity of lin-28, which encodes a cytoplasmic protein also required for proper developmental timing; at hatching, LIN-14 is detected in the nuclei of blast cells and neurons; later, from the late L1 to adult stages, LIN-14 levels are negatively regulated by translational repression mediated by lin-4, a 22-nt small temporal RNA (stRNA) that is complementary to sequences in the lin-14 3' UTR. | Paper_evidence | WBPaper00000620 |
| | | | | | WBPaper00001137 |
| | | | | | WBPaper00001468 |
| | | | | | WBPaper00001829 |
| | | | | | WBPaper00001848 |
| | | | | | WBPaper00003931 |
| | | | | | WBPaper00005159 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 02 Sep 2005 00:00:00 |
| | | Automated_description | Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and single-stranded DNA binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; regulation of cell fate specification; and regulation of nematode larval development, heterochronic. Located in condensed nuclear chromosome. Expressed in several structures, including QL; QR; neurons; oocyte; and somatic nervous system. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | T25C12.1a |
| | | T25C12.1b |
| | Corresponding_CDS_history | T25C12.1a:wp196 |
| | Corresponding_transcript | T25C12.1a.1 |
| | | T25C12.1b.1 |
| | Other_sequence (11) |
| | Associated_feature (55) |
| | Transcription_factor | WBTranscriptionFactor000395 |
| Experimental_info | RNAi_result (17) |
| | Expr_pattern (13) |
| | Drives_construct | WBCnstr00000926 |
| | | WBCnstr00007336 |
| | | WBCnstr00007627 |
| | | WBCnstr00015030 |
| | | WBCnstr00015050 |
| | | WBCnstr00015780 |
| | | WBCnstr00015781 |
| | | WBCnstr00036292 |
| | Construct_product | WBCnstr00000967 |
| | | WBCnstr00007627 |
| | | WBCnstr00019563 |
| | | WBCnstr00019564 |
| | | WBCnstr00021119 |
| | | WBCnstr00021910 |
| | | WBCnstr00036292 |
| | Regulate_expr_cluster | WBPaper00026952:class_A |
| | | WBPaper00026952:class_B |
| | | WBPaper00026952:class_C |
| | | WBPaper00026952:class_D |
| | | WBPaper00026952:class_E |
| | | WBPaper00026952:class_F |
| | | WBPaper00026952:class_G |
| | | WBPaper00026952:class_H |
| | Antibody | WBAntibody00000046 |
| | | WBAntibody00000337 |
| | | WBAntibody00000338 |
| | | WBAntibody00001031 |
| | | WBAntibody00001569 |
| | | WBAntibody00001873 |
| | Microarray_results | SMD_LIN-14__#2 |
| | | SMD_T25C12.1 |
| | | 174510_at |
| | | 193913_s_at |
| | | A_12_P105208 |
| | | A_12_P161556 |
| | | A_12_P161557 |
| | | Aff_T25C12.1A |
| | | GPL13394_WBGene00003003 |
| | | GPL13914_T25C12.1 |
| | | GPL14144_T25C12.1a_1103-1162_0.919_5_C |
| | | GPL14144_T25C12.1a_1138-1197_0.927_3_A |
| | | GPL14144_T25C12.1a_1258-1317_0.909_9_B |
| | | GPL19516_CGZ0036766 |
| | | GPL19516_CGZ0036767 |
| | | GPL21109_T25C12.11 |
| | | GPL21109_T25C12.12 |
| | | GPL21109_T25C12.1a |
| | | GPL3518_CE03733 |
| | | GPL3518_CE03734 |
| | | GPL8304_CE_WBGene00003003_A |
| | | GPL8304_CE_WBGene00003003_B |
| | | GPL8673_T25C12_1aP00062 |
| | | GPL8673_T25C12_1aP00065 |
| | | GPL8673_T25C12_1aP00068 |
| | | GPL8673_T25C12_1bP00131 |
| | | GPL8673_T25C12_1bP00144 |
| | | GPL8673_T25C12_1bP00382 |
| | | GPL9450_T25C12.1a |
| | | GPL9450_T25C12.1b |
| | | cea2.3.24991 |
| | | cea2.d.05942 |
| | | cea2.d.05944 |
| | Expression_cluster (173) |
| | Interaction (256) |
| | WBProcess | WBbiopr:00000031 |
| | | WBbiopr:00000057 |
| | | WBbiopr:00000083 |
| Map_info | Map | X | Position | 3.78431 | Error | 0.060767 |
| | Well_ordered |
| | Positive | Inside_rearr | nDf19 |
| | | | yDp8 |
| | | | yDp10 |
| | | Positive_clone | PPE4 |
| | | | T25C12 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 251 |
| | | | 492 |
| | | | 636 |
| | | | 637 |
| | | | 688 |
| | | | 3648 |
| | | | 3652 |
| | | Multi_point (22) |
| | | Pos_neg_data | 3918 |
| | | | 3920 |
| | | | 654 |
| | | | 668 |
| | | | 3155 |
| | | | 294 |
| | | | 1831 |
| | | | 8427 |
| Reference (365) |
| Method | Gene |