WormBase Tree Display for Gene: WBGene00006786

WBGene00006786 SMap: S_parent: Sequence: Y60A3A
  Identity: Version: 2
    Name: CGC_name: unc-51 Person_evidence: WBPerson261
      Sequence_name: Y60A3A.1
      Molecular_name: Y60A3A.1
        Y60A3A.1.1
        CE24516
      Other_name: frs-2 Accession_evidence: EMBL AB096637
        atg-1 Person_evidence: WBPerson649
        CELE_Y60A3A.1 Accession_evidence: NDB BX284605
      Public_name: unc-51
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:42 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 29 Feb 2008 11:29:00 WBPerson2970 Name_change: Other_name: atg-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: unc
    Reference_allele: WBVar00143154
    Allele: WBVar00000613
      WBVar00143835
      WBVar00143318
      WBVar02125034
      WBVar00266701
      WBVar01104031
      WBVar01104032
      WBVar02079739
      WBVar01104033
      WBVar01104034
      WBVar01104035
      WBVar01897557
      WBVar01104036
      WBVar01104037
      WBVar01104038
      WBVar01104039
      WBVar01499709
      WBVar01104040
      WBVar01104041
      WBVar02105524
      WBVar00310298
      WBVar02105525
      WBVar00489216
      WBVar02105526
      WBVar00489217
      WBVar00489218
      WBVar00489219
      WBVar00489220
      WBVar00489221
      WBVar00489222
      WBVar00489223
      WBVar00489224
      WBVar01525024
      WBVar00489225
      WBVar00489226
      WBVar01525025
      WBVar00489227
      WBVar01525026
      WBVar00489228
      WBVar00300380
      WBVar01525027
      WBVar01525028
      WBVar00489229
      WBVar00489230
      WBVar02074924
      WBVar01525029
      WBVar01525030
      WBVar00489231
      WBVar00489232
      WBVar01525031
      WBVar01525032
      WBVar00489233
      WBVar00489234
      WBVar01525033
      WBVar01525034
      WBVar00489235
      WBVar01525035
      WBVar00489236
      WBVar00489237
      WBVar01525036
      WBVar00489238
      WBVar00489239
      WBVar00489240
      WBVar00489241
      WBVar00489242
      WBVar00143760
      WBVar00489243
      WBVar00489244
      WBVar01499566
      WBVar02116233
      WBVar01926264
      WBVar00302319
      WBVar01926265
      WBVar01926266
      WBVar01926267
      WBVar01926268
      WBVar02071955
      WBVar01926269
      WBVar02074398
      WBVar01926270
      WBVar01926271
      WBVar00143814
      WBVar01926272
      WBVar01926273
      WBVar02063243
      WBVar02063244
      WBVar02063245
      WBVar02026019
      WBVar02026020
      WBVar02026021
      WBVar02026022
      WBVar02026023
      WBVar02026024
      WBVar02152049
      WBVar02026025
      WBVar02138385
      WBVar02050295
      WBVar00234761
      WBVar00238630
      WBVar02122712
      WBVar01485804
      WBVar01485805
      WBVar01485806
      WBVar01485807
      WBVar01829603
      WBVar01829604
      WBVar01829605
      WBVar00253118
      WBVar01752724
      WBVar01549366
      WBVar01752725
      WBVar01752726
      WBVar01752727
      WBVar01340200
      WBVar02091625
      WBVar01752728
      WBVar02091626
      WBVar01752729
      WBVar02091627
      WBVar01752730
      WBVar01752731
      WBVar01103953
      WBVar01103954
      WBVar01752732
      WBVar01103955
      WBVar01752733
      WBVar01103956
      WBVar01752734
      WBVar00309348
      WBVar01752735
      WBVar01103957
      WBVar01752736
      WBVar01103958
      WBVar01752737
      WBVar01103959
      WBVar01103960
      WBVar01752738
      WBVar01752739
      WBVar02112799
      WBVar01103961
      WBVar01499446
      WBVar00088283
      WBVar00088284
      WBVar02112800
      WBVar02013615
      WBVar01103962
      WBVar01752740
      WBVar01103963
      WBVar01500000
      WBVar02112801
      WBVar01752741
      WBVar01752742
      WBVar01103964
      WBVar01752743
      WBVar01103965
      WBVar02085753
      WBVar01752744
      WBVar01103966
      WBVar00266025
      WBVar02085754
      WBVar01752745
      WBVar01103967
      WBVar01752746
      WBVar01103968
      WBVar01752747
      WBVar01103969
      WBVar01103970
      WBVar01752748
      WBVar01543811
      WBVar01103971
      WBVar01752749
      WBVar01543812
      WBVar01752750
      WBVar01103972
      WBVar01752751
      WBVar01543813
      WBVar01103973
      WBVar00072036
      WBVar01752752
      WBVar01103974
      WBVar00072037
      WBVar00143154
      WBVar00228986
      WBVar01103975
      WBVar00072038
      WBVar01752753
      WBVar00072039
      WBVar01752754
      WBVar01103976
      WBVar01103977
      WBVar00072040
      WBVar00143169
      WBVar01752755
      WBVar01752756
      WBVar01941076
      WBVar01103978
      WBVar00072041
      WBVar00072042
      WBVar01941077
      WBVar01752757
      WBVar01103979
      WBVar00303658
      WBVar01752758
      WBVar00072043
      WBVar01941078
      WBVar01103980
      WBVar01941079
      WBVar02118708
      WBVar01752759
      WBVar01103981
      WBVar00072044
      WBVar00266408
      WBVar01752760
      WBVar00072045
      WBVar01103982
      WBVar01466522
      WBVar01752761
      WBVar00072046
      WBVar01103983
      WBVar01103984
      WBVar01752762
      WBVar00072047
      WBVar00266411
      WBVar01466525
      WBVar01103985
      WBVar01752763
      WBVar00072048
      WBVar01466527
      WBVar01498549
      WBVar01103986
      WBVar01466528
      WBVar01752764
      WBVar00072049
      WBVar01466529
      WBVar01103987
      WBVar01752765
      WBVar00072050
      WBVar01103988
      WBVar01752766
      WBVar01466530
      WBVar00072051
      WBVar01617669
      WBVar00072052
      WBVar01498738
      WBVar01103989
      WBVar01752767
      WBVar01466531
      WBVar00072053
      WBVar01466532
      WBVar01978379
      WBVar01103990
      WBVar01752768
      WBVar01752769
      WBVar00072054
      WBVar01978380
      WBVar01466533
      WBVar01103991
      WBVar01103992
      WBVar01978381
      WBVar00143209
      WBVar01598641
      WBVar01498925
      WBVar01103993
      WBVar01598642
      WBVar01978382
      WBVar01598643
      WBVar01103994
      WBVar01978383
      WBVar01598644
      WBVar01103995
      WBVar01978384
      WBVar01598645
      WBVar01978385
      WBVar01103996
      WBVar01598646
      WBVar01978386
      WBVar01103997
      WBVar01499299
      WBVar01598647
      WBVar01978387
      WBVar01103998
      WBVar01103999
      WBVar01598648
      WBVar01978388
      WBVar01104000
      WBVar01978389
      WBVar01877162
      WBVar01598649
      WBVar01104001
      WBVar01978390
      WBVar01877163
      WBVar01598650
      WBVar02079337
      WBVar01104002
      WBVar01598651
      WBVar01978391
      WBVar01877164
      WBVar01598652
      WBVar01877165
      WBVar02121491
      WBVar01978392
      WBVar01104003
      WBVar01877166
      WBVar01598653
      WBVar01978393
      WBVar01104004
      WBVar01877167
      WBVar01598654
      WBVar01104005
      WBVar01598655
      WBVar01104006
      WBVar01877168
      WBVar01598656
      WBVar01104007
      WBVar01877169
      WBVar01877170
      WBVar01598657
      WBVar01104008
      WBVar01877171
      WBVar01104009
      WBVar01598658
      WBVar01877172
      WBVar01598659
      WBVar01104010
      WBVar01877173
      WBVar01598660
      WBVar01104011
      WBVar01598661
      WBVar01877174
      WBVar01104012
      WBVar01598662
      WBVar01104013
      WBVar01104014
      WBVar01901405
      WBVar02093345
      WBVar01598664
      WBVar01104015
      WBVar01598665
      WBVar02093346
      WBVar01104016
      WBVar01598666
      WBVar02120400
      WBVar01104017
      WBVar01598667
      WBVar01913790
      WBVar02083229
      WBVar01598668
      WBVar01104018
      WBVar01913791
      WBVar01913792
      WBVar01104019
      WBVar01913793
      WBVar01104020
      WBVar01913794
      WBVar01104021
      WBVar01913795
      WBVar01104022
      WBVar00227670
      WBVar01104023
      WBVar01488836
      WBVar01104024
      WBVar01498958
      WBVar01104025
      WBVar02124642
      WBVar01104026
      WBVar01104027
      WBVar01104028
      WBVar02123724
      WBVar01104029
      WBVar02121333
      WBVar01104030
    Legacy_information: e369 : paralysed dumpy tends to curl; Egl; dorsal extensions of DD and VD neurons grow in aberrant directions fail to connect to dorsal nerve cord; amphid phasmid PDE axons abnormal; suppressed by sup-4. ES3 ME0. NA6 (e389 e432 etc.).
      See also e432, e584, e1120, e1189, e1212
      [C.elegansII] e369amb : paralysed dumpy tends to curl; Egl; dorsal extensions of DD and VD neurons grow in aberrant directions fail to connect to dorsal nerve cord; amphid, phasmid, PDE and other axons abnormal; multiple defects in axon elongation, fasciculation,etc. Abnormal axon ultrastructure: varicosities, cisternae, abnormal vesicles.ES3 ME0. OA>10: e389, e432, e584, e1212 etc. Cloned: 3.1 kb transcript, encodes predicted 856 aa protein with similarity to Ser/Thrkinases. unc-51: lacZ expressed in neurons. [Hedgecock et al. 1985; McIntire et al. 1992; Ogura et al. 1994; FK; FR]
    Strain (20)
    RNASeq_FPKM (74)
    GO_annotation (61)
    Ortholog (54)
    Paralog: WBGene00013694 Caenorhabditis elegans From_analysis: Panther
      WBGene00013643 Caenorhabditis elegans From_analysis: Panther
    Structured_description: Concise_description: unc-51 encodes a serine/threonine protein kinase orthologous to Saccharomyces cerevisiae autophagy protein Atg1p and the vertebrate ULK proteins; unc-51 is required for axon outgrowth along the anterior-posterior axis and sex myoblast migration; in regulating axon outgrowth, UNC-51 functions together with the VAB-8 kinesin-like protein and UNC-14, both of which physically interact with, and are phosphorylated by, UNC-51, and with the UNC-5 Netrin receptor, whose subcellular localization in neurons is regulated by UNC-51 and UNC-14; in addition, UNC-51 is required for normal dauer morphogenesis of daf-2 mutant animals; UNC-51 is expressed in all C. elegans neurons and in body wall and pharyngeal muscles; in neurons, an UNC-51::GFP fusion protein shows punctate cytoplasmic localization in axons and cell bodies and partial co-localization with UNC-14 and UNC-5. Paper_evidence: WBPaper00002050
            WBPaper00002845
            WBPaper00004362
            WBPaper00006070
            WBPaper00024595
            WBPaper00028376
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 21 Jul 2008 00:00:00
      Automated_description: Enables protein serine/threonine kinase activity. Involved in several processes, including determination of adult lifespan; nematode male tail tip morphogenesis; and regulation of axon extension. Located in axon and neuronal cell body. Expressed in body wall musculature; motor neurons; pharyngeal muscle cell; and touch receptor neurons. Is an ortholog of human ULK1 (unc-51 like autophagy activating kinase 1) and ULK2 (unc-51 like autophagy activating kinase 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: Y60A3A.1
    Corresponding_transcript: Y60A3A.1.1
    Other_sequence (65)
    Associated_feature: WBsf669876
      WBsf669877
      WBsf982087
      WBsf1003406
      WBsf1021857
  Experimental_info: RNAi_result (28)
    Expr_pattern: Expr731
      Expr1492
      Expr12441
      Expr15294
      Expr1021306
      Expr1032857
      Expr1161234
      Expr2017884
      Expr2036020
    Drives_construct (17)
    Construct_product (3)
    Microarray_results (20)
    Expression_cluster (150)
    Interaction (96)
    WBProcess: WBbiopr:00000003
  Map_info: Map: V Position: 24.4326 Error: 0.019149
    Well_ordered
    Positive: Inside_rearr: ozDf1
        ozDf2
      Positive_clone: Y60A3A Inferred_automatically: From sequence, transcript, pseudogene data
        YO#KOPUF
    Mapping_data: 2_point (12)
      Multi_point (36)
      Pos_neg_data: 298
        2143
        8972
        8980
    Landmark_gene
  Reference (191)
  Method: Gene