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WormBase Tree Display for Gene: WBGene00003774

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Name Class

WBGene00003774SMapS_parentSequenceF07F6
IdentityVersion1
NameCGC_namenmr-1Person_evidenceWBPerson404
Sequence_nameF07F6.6
Molecular_nameF07F6.6
F07F6.6.1
CE30128
Other_nameF56D1.bCurator_confirmedWBPerson1983
RemarkOld cosmid naming mapped via unique overlapping PCR_product on CDSs
F56D1.cCurator_confirmedWBPerson1983
RemarkOld cosmid naming mapped via unique overlapping PCR_product on CDSs
CELE_F07F6.6Accession_evidenceNDBBX284602
Public_namenmr-1
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:32WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classnmr
AlleleWBVar00732045
WBVar01499702
WBVar00732046
WBVar00732047
WBVar01912135
WBVar00732048
WBVar00732049
WBVar00732050
WBVar00732051
WBVar00732052
WBVar01373033
WBVar00732053
WBVar01719735
WBVar01719736
WBVar00732054
WBVar01719737
WBVar00732055
WBVar00732056
WBVar00732057
WBVar00732058
WBVar01603863
WBVar00732059
WBVar00732060
WBVar00732061
WBVar00732062
WBVar00732063
WBVar00732064
WBVar00732065
WBVar00732066
WBVar01498435
WBVar00103908
WBVar00732067
WBVar00732068
WBVar00732069
WBVar01666069
WBVar01666070
WBVar00732070
WBVar01666071
WBVar00732071
WBVar01666072
WBVar00732072
WBVar01666073
WBVar00732073
WBVar00732074
WBVar01666074
WBVar00732075
WBVar00732076
WBVar00732077
WBVar00732078
WBVar00000109
WBVar01499376
WBVar00366181
WBVar01783417
WBVar01783418
WBVar00366182
WBVar00366183
WBVar00550587
WBVar00366184
WBVar00550588
WBVar00550593
WBVar00366185
WBVar00550598
WBVar00366186
WBVar00366187
WBVar00366188
WBVar00366189
WBVar00366190
WBVar00366191
WBVar00366192
WBVar00366193
WBVar00366194
WBVar02002672
WBVar00366195
WBVar01437799
WBVar01240196
WBVar01437800
WBVar01240201
WBVar02129946
WBVar01792167
WBVar01891703
WBVar00223809
WBVar00598364
WBVar00598365
WBVar00240658
WBVar00172130
WBVar00172131
WBVar00172132
WBVar00172133
WBVar00172134
WBVar00172135
WBVar00172136
WBVar00172137
WBVar00172138
WBVar00172139
WBVar00172140
WBVar00172141
WBVar00172142
WBVar00172143
WBVar00067749
StrainWBStrain00040167
WBStrain00002755
WBStrain00040168
WBStrain00040666
WBStrain00040171
WBStrain00040796
WBStrain00054658
WBStrain00054659
RNASeq_FPKM (74)
GO_annotation (32)
Ortholog (37)
ParalogWBGene00001612Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00001613Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00001614Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00001615Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00001616Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00001617Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00001618Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00001619Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00003775Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00012190Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionnmr-1 encodes an NMDA-type ionotropic glutamate receptor subunit that affects the duration of forward movement which is important during foraging behavior, and also affects osmotic avoidance; the slow kinetics typical of NMDA-dependent currents are likely important for its effect on forward movement.Paper_evidenceWBPaper00004836
WBPaper00005622
Curator_confirmedWBPerson48
Date_last_updated04 Mar 2005 00:00:00
Automated_descriptionPredicted to enable ligand-gated monoatomic ion channel activity and signaling receptor activity. Predicted to contribute to NMDA glutamate receptor activity. Involved in locomotory behavior and regulation of forward locomotion. Located in neuron projection; plasma membrane; and synapse. Expressed in several structures, including ganglia; gonadal sheath cell; head mesodermal cell; nerve ring neurons; and oocyte. Used to study neurodegenerative disease. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; alcohol use disorder; autosomal dominant intellectual developmental disorder 8; and developmental and epileptic encephalopathy 101. Is an ortholog of human GRIN1 (glutamate ionotropic receptor NMDA type subunit 1).Paper_evidenceWBPaper00065943
Curator_confirmed (2)
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:1289Homo sapiensPaper_evidenceWBPaper00057034
Curator_confirmedWBPerson324
Date_last_updated30 Mar 2021 00:00:00
Potential_modelDOID:10652Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4584)
DOID:0070038Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4584)
DOID:8725Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4584)
DOID:0070387Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4584)
DOID:3526Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4584)
DOID:1574Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4584)
DOID:11206Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:4584)
Models_disease_assertedWBDOannot00000907
WBDOannot00000908
Molecular_infoCorresponding_CDSF07F6.6
Corresponding_transcriptF07F6.6.1
Other_sequenceOden_isotig22559
JI250035.1
Tcol_isotig18961
Associated_featureWBsf987884
WBsf987885
WBsf1012228
WBsf1012229
WBsf223054
Experimental_infoRNAi_resultWBRNAi00022320Inferred_automaticallyRNAi_primary
WBRNAi00043920Inferred_automaticallyRNAi_primary
WBRNAi00030612Inferred_automaticallyRNAi_primary
Expr_pattern (11)
Drives_construct (42)
Construct_productWBCnstr00000022
WBCnstr00006168
WBCnstr00010811
WBCnstr00011656
WBCnstr00013203
WBCnstr00035874
Microarray_results (19)
Expression_clusterWBPaper00032528:L3_depleted
WBPaper00037950:AVE-neuron_embryo_enriched
WBPaper00037950:AVE-neuron_embryo_SelectivelyEnriched
WBPaper00037950:germline-precursors_blastula-embryo_expressed
WBPaper00037950:glr-1(+)-neurons_larva_enriched
WBPaper00037950:glr-1(+)-neurons_larva_SelectivelyEnriched
WBPaper00037950:hypodermis_L1-larva_expressed
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
WBPaper00038438:Harposporium_24hr_upregulated_RNAseq
WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
WBPaper00038438:S.marcescens_24hr_downregulated_RNAseq
WBPaper00040285:H2S_12hr_downregulated
WBPaper00042194:nhr-114(RNAi)_downregulated
WBPaper00042215:wdr-23(tm1817)_upregulated
WBPaper00044743:wdr-23_neuron_upregulated
WBPaper00047131:daf-2(e1370)_upregulated_N2-background
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_enriched
WBPaper00048988:neuron_expressed
WBPaper00050370:dpy-21(e428)_L3_downregulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050726:OsmoticStress_regulated_NoFood
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00052856:Cadmium_regulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053308:SMG-2_associated_NMD(-)_unaltered_ClassII
WBPaper00054758:alg-1(gk204)_upregulated
WBPaper00055103:thoc-5(wy822)_upregulated
WBPaper00055226:adr-1(tm668)_upregulated
WBPaper00055354:eat-2(ad1116)_downregulated
WBPaper00055354:Psora-Allantoin_downregulated
WBPaper00055354:Rapamycin-Allantoin_downregulated
WBPaper00055354:Rapamycin-Metformin_downregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
WBPaper00055354:Rapamycin_downregulated
WBPaper00055354:Rifampicin-Allantoin_downregulated
WBPaper00058711:skn-1(lax188)_upregulated
WBPaper00058948:PA14_downregulated
WBPaper00058969:RIS_depleted
WBPaper00059027:neuron-synapses_depleted
WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
WBPaper00059664:srbc-48(ac23)_upregulated
WBPaper00059987:Wounding_upregulated
WBPaper00060014:set-2(tm1630)_downregulated
WBPaper00060459:bcat-1(RNAi)_upregulated
WBPaper00060661:sensory-neuron_enriched
WBPaper00060764:swsn-1(os22ts)_upregulated
WBPaper00060811:L1_vs_adult_upregulated_neural
WBPaper00060909:atfs-1(cmh15)_downregulated
WBPaper00061340:AVA
WBPaper00061340:mu_sph
WBPaper00061340:RMD
WBPaper00061341:28C_24h_upregulated
WBPaper00061341:28C_48h_upregulated
WBPaper00061424:Diet_MYb120_upregulated
WBPaper00061527:ckr-1-T09B9.3
WBPaper00061651:AVD_enriched
WBPaper00061995:mter-4(syb3662syb3403)_downregulated
WBPaper00062103:neuron_enriched
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062456:doxycycline_upregulated_CB4856_protein
WBPaper00062456:doxycycline_upregulated_N2_protein
WBPaper00062585:hlh-26(ok1453)_upregulated_E.faecium
WBPaper00062590:Aging_downregulated_neuron
WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064721:fasn-1(g14)_downregulated_starved
WBPaper00065096:25C_vs_20C_downregulated
WBPaper00065841:22_0
WBPaper00065841:49_0
WBPaper00065841:61_0
WBPaper00065841:73_0
WBPaper00065841:98_0
WBPaper00065841:102_0
WBPaper00065841:118_0
WBPaper00065841:120_0
WBPaper00065841:131_0
cgc4489_group_9
WBPaper00026929:Resveratrol_regulated_daf-16
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00030839:Larval_Pan_Neuronal
WBPaper00031252:AIN-1_IP_enriched
WBPaper00031252:AIN-2_IP_enriched
WBPaper00036123:Cadmium_regulated
WBPaper00040858:eQTL_regulated_old
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00048989:N2_rapamycin_downregulated
Interaction (71)
Map_infoMapIIPosition-1.52008Error0.016815
PositivePositive_cloneF07F6Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point4253
4538
5279
Pseudo_map_position
Reference (105)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene