WormBase Tree Display for Gene: WBGene00020917

WBGene00020917 SMap: S_parent: Sequence: W01B11
  Identity: Version: 1
    Name: Sequence_name: W01B11.6
      Molecular_name: W01B11.6
        W01B11.6.1
        CE26952
      Other_name: CELE_W01B11.6 Accession_evidence: NDB BX284601
      Public_name: W01B11.6
    DB_info: Database: AceView gene 1D862
        WormQTL gene WBGene00020917
        WormFlux gene WBGene00020917
        NDB locus_tag CELE_W01B11.6
        Panther gene CAEEL|WormBase=WBGene00020917|UniProtKB=O45017
          family PTHR10438
        NCBI gene 171903
        RefSeq protein NM_058738.7
        TrEMBL UniProtAcc O45017
        UniProt_GCRP UniProtAcc O45017
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:03 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
    Status: Live
  Gene_info: Biotype: SO:0001217
    Allele (31)
    RNASeq_FPKM (74)
    Ortholog (34)
    Paralog: WBGene00007099 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00015062 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00021548 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00021826 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00021933 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Automated_description: Enriched in several structures, including AIZ; coelomocyte; germline precursor cell; head mesodermal cell; and sensory neurons based on microarray; tiling array; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including daf-16; daf-2; and glp-1 based on microarray; proteomic; and RNA-seq studies. Is affected by twenty-five chemicals including rotenone; 4-bromodiphenyl ether; and levamisole based on RNA-seq and microarray studies. Human ortholog(s) of this gene implicated in male infertility. Human TXNDC2 enables thioredoxin-disulfide reductase (NADP) activity. Is predicted to encode a protein with the following domains: Thioredoxin-like superfamily; Thioredoxin domain; and Thioredoxin. Is an ortholog of human TXNDC2 (thioredoxin domain containing 2) and TXNDC8 (thioredoxin domain containing 8). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:12336 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:31454)
  Molecular_info: Corresponding_CDS: W01B11.6
    Corresponding_CDS_history: W01B11.6b:wp112
    Corresponding_transcript: W01B11.6.1
    Corresponding_transcript_history: W01B11.6b:wp251
    Associated_feature: WBsf664026
      WBsf219119
  Experimental_info: RNAi_result: WBRNAi00093043 Inferred_automatically: RNAi_primary
      WBRNAi00054501 Inferred_automatically: RNAi_primary
      WBRNAi00004362 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1018113
      Expr1158048
      Expr2006657
      Expr2024874
    Microarray_results (24)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032425:down_in_alg-1
      WBPaper00032425:down_in_zfp-1
      WBPaper00034761:hlh-30_downregulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:BAG-neuron_embryo_enriched
      WBPaper00037950:BAG-neuron_embryo_SelectivelyEnriched
      WBPaper00037950:coelomocytes_embryo_enriched
      WBPaper00037950:coelomocytes_embryo_SelectivelyEnriched
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:germline-precursors_embryo_enriched
      WBPaper00037950:germline-precursors_embryo_SelectivelyEnriched
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:Harposporium_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00042561:smgl-1(RNAi)_downregulated
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044736:oscillating_dev_expression
      WBPaper00045050:csr-1(hypomorph)_downregulated
      WBPaper00045314:S.aureus-induced_N2
      WBPaper00045316:prg-1_downregulated_L2
      WBPaper00045316:prg-1_downregulated_L3
      WBPaper00045521:Gender_Neutral
      WBPaper00045934:wrn-1(gk99)_upregulated
      WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_downregulated
      WBPaper00046337:polysomal_N2_vs_daf-2_downregulated
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00047132:glp-1(ts)-25C_upregulated
      WBPaper00048971:daf-16(mgDf50)_downregulated_L1
      WBPaper00048988:neuron_expressed
      WBPaper00049325:CB4856_vs_N2_DEG
      WBPaper00049498:npr-1(ur89)_regulated_8
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr)
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050053:muscle_enriched_Day12
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_100-cell-embryo
      WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo
      WBPaper00050163:chd-3(eh4)_downregulated_100-cell-embryo
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050903:mir-35-41(nDf50)_25C_upregulated
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051021:4-bromodiphenyl-ether_upregulated
      WBPaper00051245:body-wall-muscle_nucleus_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051257:Levamisole_upregulated
      WBPaper00051265:F4_morc-1(tm6048)_downregulated
      WBPaper00051388:Glucose-diet_upregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:zidovudine_24h_regulated
      WBPaper00053388:dauer_regulated_Cluster2
      WBPaper00053599:female_vs_male_downregulated
      WBPaper00053599:oocyte_vs_mitosis_upregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053792:Ochrobactrum_downregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053814:OP50_vs_PY79_upregulated_PY79
      WBPaper00054493:hpl-2(tm1489)_downregulated
      WBPaper00055013:hmg-4(RNAi)_upregulated
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055482:Tunicamycin_upregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00056009:propionate_upregulated_vitamin-B12_downregulated
      WBPaper00056039:efa-6(tm3124)_downregulated
      WBPaper00056073:NHR-86_interacting_promoter
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056617:adr-1(tm668)_upregulated_L4_protein
      WBPaper00056617:adr-2(ok735)_upregulated_L4_protein
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00056826:hmc_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057154:HeatShock_downregulated_mRNA
      WBPaper00057154:HeatShock_upregulated_miRNA-target
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00058725:sftb-1(cer39)_downregulated
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059421:daf-1(m40);daf-3(mgDf90)_upregulated
      WBPaper00059421:daf-1(m40)_upregulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00059604:fluvastatin_downregulated_dlk-1(km12)
      WBPaper00059604:fluvastatin_downregulated_N2
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00060100:SiNP_downregulated_mRNA
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060434:pH4.33_vs_pH6.33_downrgulated
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061007:HB115_downregulated
      WBPaper00061007:M.braciatum_downregulated
      WBPaper00061274:microgravity_downregulated
      WBPaper00061340:AIZ
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061409:neuronal-fzo-1(RNAi)_upregulated
      WBPaper00061479:ubc-9(ne4833)_upregulated
      WBPaper00061527:172183_at-176110_at
      WBPaper00061527:W01F3.2_1554-Y106G6D.8
      WBPaper00061651:ADF_enriched
      WBPaper00061651:AIZ_enriched
      WBPaper00061651:ASER_enriched
      WBPaper00061651:ASK_enriched
      WBPaper00061651:IL2_LR_enriched
      WBPaper00061651:PDE_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:etr-1(lq61)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062440:crh-1(n3315)_downregulated
      WBPaper00062440:crh-1(syb385)_downregulated
      WBPaper00062446:nhr-8(hd117)_downregulated
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064107:lin-35(n745)_downregulated
      WBPaper00064122:vulva_transcriptome
      WBPaper00064130:Beta-Amyloid_24h_upregulated_mRNA
      WBPaper00064158:xpo-1(RNAi)_upregulated
      WBPaper00064539:nhr-114(gk849)_downregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00065288:mdt-15(tm2182)_downregulated
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065373:sek-1(km4)_downregulated_cisplatin
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065841:76_0
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066110:Doxorubicin_upregulated_diploid
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      WBPaper00066232:ash-2(RNAi)_downregulated_WT
      cgc4386_cluster_2_2
      cgc4489_group_9
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00028789:PA14_vs_gacA_upregulated_4hr
      WBPaper00029437:dcr-1_upregulated
      WBPaper00032062:age_regulated_genes
      WBPaper00032165:differentially_expressed_with_age_medoid_6
      WBPaper00032948:StarveUp1
      WBPaper00034757:up_by_oxidative_stress
      WBPaper00035227:heat_shock_regulated
      WBPaper00035560:ahr-1_downregulated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036286:Pattern_I
      WBPaper00038172:tax-6null_up_regulated
      WBPaper00039866:ClassComp_daf-19_downregulated
      WBPaper00039866:SAM_daf-19_downregulated
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
      WBPaper00040876:mir-35_downregulated
      WBPaper00041002:HF_11d_2.0mM_Down
      WBPaper00041002:HQ_3d_2.0mM_Down
      WBPaper00041211:RPW-24_Up
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_3h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00045294:50uM_DBAA_downregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00045960:L4-lethargus_upregulated
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00047070:xpa-1_UV_upregulated
      WBPaper00048989:eat-2(ad465)_downregulated_in-DMSO
      WBPaper00048989:N2_rapamycin_downregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00053550:daf-19(m86)_downregulated_3-fold-embryo
      WBPaper00053550:daf-19(m86)_downregulated_L1
      WBPaper00055435:MUA-AuNP-0.5_downregulated
      WBPaper00055435:MUA-AuNP-3_downregulated
      WBPaper00055899:nitroguanidine_regulated
      WBPaper00057098:SiO2-nanoparticles_downregulated
      [cgc5976]:class_1
    Interaction: WBInteraction000240358
      WBInteraction000259629
      WBInteraction000268191
      WBInteraction000271114
      WBInteraction000277227
      WBInteraction000293790
      WBInteraction000294042
      WBInteraction000305484
      WBInteraction000312111
      WBInteraction000315072
      WBInteraction000317831
      WBInteraction000324375
      WBInteraction000327006
      WBInteraction000327627
      WBInteraction000328910
      WBInteraction000329259
      WBInteraction000332719
      WBInteraction000338013
      WBInteraction000339431
      WBInteraction000342330
      WBInteraction000343161
      WBInteraction000345432
      WBInteraction000346801
      WBInteraction000347289
      WBInteraction000348930
      WBInteraction000355337
      WBInteraction000358545
      WBInteraction000361274
      WBInteraction000362657
      WBInteraction000365655
      WBInteraction000365968
      WBInteraction000371386
      WBInteraction000377133
      WBInteraction000396627
      WBInteraction000399281
      WBInteraction000407259
      WBInteraction000411962
      WBInteraction000415807
      WBInteraction000421836
      WBInteraction000423220
      WBInteraction000423987
      WBInteraction000431025
      WBInteraction000432444
      WBInteraction000433227
      WBInteraction000439259
      WBInteraction000440001
      WBInteraction000441149
      WBInteraction000456661
      WBInteraction000457545
      WBInteraction000460992
      WBInteraction000472591
      WBInteraction000472895
      WBInteraction000504262
  Map_info: Positive: Positive_clone: W01B11 Inferred_automatically: From sequence, transcript, pseudogene data
    Interpolated_map_position: I -3.92076
  Reference: WBPaper00035663
    WBPaper00064898
    WBPaper00065331
  Method: Gene