WormBase Tree Display for Gene: WBGene00020917

WBGene00020917 SMap: S_parent: Sequence: W01B11
  Identity: Version: 1
    Name: Sequence_name: W01B11.6
      Molecular_name: W01B11.6
        W01B11.6.1
        CE26952
      Other_name: CELE_W01B11.6 Accession_evidence: NDB BX284601
      Public_name: W01B11.6
    DB_info: Database: AceView gene 1D862
        WormQTL gene WBGene00020917
        WormFlux gene WBGene00020917
        NDB locus_tag CELE_W01B11.6
        Panther gene CAEEL|WormBase=WBGene00020917|UniProtKB=O45017
          family PTHR10438
        NCBI gene 171903
        RefSeq protein NM_058738.7
        TrEMBL UniProtAcc O45017
        UniProt_GCRP UniProtAcc O45017
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:03 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
    Status: Live
  Gene_info: Biotype: SO:0001217
    Allele (31)
    RNASeq_FPKM (74)
    Ortholog (34)
    Paralog: WBGene00007099 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00015062 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00021548 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00021826 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00021933 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Automated_description: Enriched in several structures, including AIZ; coelomocyte; germline precursor cell; head mesodermal cell; and sensory neurons based on microarray; tiling array; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including daf-16; daf-2; and glp-1 based on microarray; proteomic; and RNA-seq studies. Is affected by twenty-five chemicals including rotenone; 4-bromodiphenyl ether; and levamisole based on RNA-seq and microarray studies. Human ortholog(s) of this gene implicated in male infertility. Human TXNDC2 enables thioredoxin-disulfide reductase (NADP) activity. Is predicted to encode a protein with the following domains: Thioredoxin-like superfamily; Thioredoxin domain; and Thioredoxin. Is an ortholog of human TXNDC2 (thioredoxin domain containing 2) and TXNDC8 (thioredoxin domain containing 8). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:12336 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:31454)
  Molecular_info: Corresponding_CDS: W01B11.6
    Corresponding_CDS_history: W01B11.6b:wp112
    Corresponding_transcript: W01B11.6.1
    Corresponding_transcript_history: W01B11.6b:wp251
    Associated_feature: WBsf664026
      WBsf219119
  Experimental_info: RNAi_result: WBRNAi00093043 Inferred_automatically: RNAi_primary
      WBRNAi00054501 Inferred_automatically: RNAi_primary
      WBRNAi00004362 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1018113
      Expr1158048
      Expr2006657
      Expr2024874
    Microarray_results (24)
    Expression_cluster: WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032425:down_in_alg-1
      WBPaper00032425:down_in_zfp-1
      WBPaper00034761:hlh-30_downregulated
      WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:BAG-neuron_embryo_enriched
      WBPaper00037950:BAG-neuron_embryo_SelectivelyEnriched
      WBPaper00037950:coelomocytes_embryo_enriched
      WBPaper00037950:coelomocytes_embryo_SelectivelyEnriched
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:germline-precursors_embryo_enriched
      WBPaper00037950:germline-precursors_embryo_SelectivelyEnriched
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:Harposporium_24hr_upregulated_RNAseq
      WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
      WBPaper00042561:smgl-1(RNAi)_downregulated
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044736:oscillating_dev_expression
      WBPaper00045050:csr-1(hypomorph)_downregulated
      WBPaper00045314:S.aureus-induced_N2
      WBPaper00045316:prg-1_downregulated_L2
      WBPaper00045316:prg-1_downregulated_L3
      WBPaper00045521:Gender_Neutral
      WBPaper00045934:wrn-1(gk99)_upregulated
      WBPaper00046337:polysomal_daf-2_vs_daf-2;daf-16_downregulated
      WBPaper00046337:polysomal_N2_vs_daf-2_downregulated
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00047132:glp-1(ts)-25C_upregulated
      WBPaper00048971:daf-16(mgDf50)_downregulated_L1
      WBPaper00048988:neuron_expressed
      WBPaper00049325:CB4856_vs_N2_DEG
      WBPaper00049498:npr-1(ur89)_regulated_8
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr)
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050053:muscle_enriched_Day12
      WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_100-cell-embryo
      WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo
      WBPaper00050163:chd-3(eh4)_downregulated_100-cell-embryo
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050903:mir-35-41(nDf50)_25C_upregulated
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051021:4-bromodiphenyl-ether_upregulated
      WBPaper00051245:body-wall-muscle_nucleus_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051257:Levamisole_upregulated
      WBPaper00051265:F4_morc-1(tm6048)_downregulated
      WBPaper00051388:Glucose-diet_upregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:zidovudine_24h_regulated
      WBPaper00053388:dauer_regulated_Cluster2
      WBPaper00053599:female_vs_male_downregulated
      WBPaper00053599:oocyte_vs_mitosis_upregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053792:Ochrobactrum_downregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053814:OP50_vs_PY79_upregulated_PY79
      WBPaper00054493:hpl-2(tm1489)_downregulated
      WBPaper00055013:hmg-4(RNAi)_upregulated
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Psora-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Allantoin_downregulated
      WBPaper00055354:Rapamycin-Metformin_downregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin_downregulated
      WBPaper00055482:Tunicamycin_upregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00056009:propionate_upregulated_vitamin-B12_downregulated
      WBPaper00056039:efa-6(tm3124)_downregulated
      WBPaper00056073:NHR-86_interacting_promoter
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056617:adr-1(tm668)_upregulated_L4_protein
      WBPaper00056617:adr-2(ok735)_upregulated_L4_protein
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00056826:hmc_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057154:HeatShock_downregulated_mRNA
      WBPaper00057154:HeatShock_upregulated_miRNA-target
      WBPaper00058725:sftb-1(cer6)_downregulated
      WBPaper00058725:sftb-1(cer39)_downregulated
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059421:daf-1(m40);daf-3(mgDf90)_upregulated
      WBPaper00059421:daf-1(m40)_upregulated
      WBPaper00059471:EGL-43_interacting
      WBPaper00059604:fluvastatin_downregulated_dlk-1(km12)
      WBPaper00059604:fluvastatin_downregulated_N2
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00060100:SiNP_downregulated_mRNA
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060434:pH4.33_vs_pH6.33_downrgulated
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061007:HB115_downregulated
      WBPaper00061007:M.braciatum_downregulated
      WBPaper00061274:microgravity_downregulated
      WBPaper00061340:AIZ
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061409:neuronal-fzo-1(RNAi)_upregulated
      WBPaper00061479:ubc-9(ne4833)_upregulated
      WBPaper00061527:172183_at-176110_at
      WBPaper00061527:W01F3.2_1554-Y106G6D.8
      WBPaper00061651:ADF_enriched
      WBPaper00061651:AIZ_enriched
      WBPaper00061651:ASER_enriched
      WBPaper00061651:ASK_enriched
      WBPaper00061651:IL2_LR_enriched
      WBPaper00061651:PDE_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:etr-1(lq61)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062354:H.zoospora_6h_regulated
      WBPaper00062440:crh-1(n3315)_downregulated
      WBPaper00062440:crh-1(syb385)_downregulated
      WBPaper00062446:nhr-8(hd117)_downregulated
      WBPaper00064005:starvation_downregulated_N2_mRNA
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064107:lin-35(n745)_downregulated
      WBPaper00064122:vulva_transcriptome
      WBPaper00064130:Beta-Amyloid_24h_upregulated_mRNA
      WBPaper00064158:xpo-1(RNAi)_upregulated
      WBPaper00064539:nhr-114(gk849)_downregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00065288:mdt-15(tm2182)_downregulated
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065373:sek-1(km4)_downregulated_cisplatin
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065841:76_0
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00066110:Doxorubicin_upregulated_diploid
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      WBPaper00066232:ash-2(RNAi)_downregulated_WT
      cgc4386_cluster_2_2
      cgc4489_group_9
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00028789:PA14_vs_gacA_upregulated_4hr
      WBPaper00029437:dcr-1_upregulated
      WBPaper00032062:age_regulated_genes
      WBPaper00032165:differentially_expressed_with_age_medoid_6
      WBPaper00032948:StarveUp1
      WBPaper00034757:up_by_oxidative_stress
      WBPaper00035227:heat_shock_regulated
      WBPaper00035560:ahr-1_downregulated
      WBPaper00036123:Atrazine_regulated
      WBPaper00036286:Pattern_I
      WBPaper00038172:tax-6null_up_regulated
      WBPaper00039866:ClassComp_daf-19_downregulated
      WBPaper00039866:SAM_daf-19_downregulated
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
      WBPaper00040876:mir-35_downregulated
      WBPaper00041002:HF_11d_2.0mM_Down
      WBPaper00041002:HQ_3d_2.0mM_Down
      WBPaper00041211:RPW-24_Up
      WBPaper00041606:CE_B.thuringiensis-DB27_regulated
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_3h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00045294:50uM_DBAA_downregulated
      WBPaper00045673:colistin_upregulated
      WBPaper00045960:L4-lethargus_upregulated
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00047070:xpa-1_UV_upregulated
      WBPaper00048989:eat-2(ad465)_downregulated_in-DMSO
      WBPaper00048989:N2_rapamycin_downregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00053550:daf-19(m86)_downregulated_3-fold-embryo
      WBPaper00053550:daf-19(m86)_downregulated_L1
      WBPaper00055435:MUA-AuNP-0.5_downregulated
      WBPaper00055435:MUA-AuNP-3_downregulated
      WBPaper00055899:nitroguanidine_regulated
      WBPaper00057098:SiO2-nanoparticles_downregulated
      [cgc5976]:class_1
    Interaction (53)
  Map_info: Positive: Positive_clone: W01B11 Inferred_automatically: From sequence, transcript, pseudogene data
    Interpolated_map_position: I -3.92076
  Reference: WBPaper00035663
    WBPaper00064898
    WBPaper00065331
  Method: Gene