WormBase Tree Display for Gene: WBGene00019064

WBGene00019064 SMap: S_parent: Sequence: F58G4
  Identity: Version: 2
    Name: CGC_name: myo-5 Person_evidence: WBPerson261
      Sequence_name: F58G4.1
      Molecular_name: F58G4.1
        F58G4.1.1
        CE07306
      Other_name: CELE_F58G4.1 Accession_evidence: NDB BX284605
      Public_name: myo-5
    DB_info: Database: AceView gene 5I597
        WormQTL gene WBGene00019064
        WormFlux gene WBGene00019064
        NDB locus_tag CELE_F58G4.1
        Panther gene CAEEL|WormBase=WBGene00019064|UniProtKB=Q21000
          family PTHR45615
        NCBI gene 179190
        RefSeq protein NM_072693.4
        TrEMBL UniProtAcc Q21000
        UniProt_GCRP UniProtAcc Q21000
        OMIM gene 160710
            160720
            160740
            160741
            160760
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:01 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 03 Aug 2007 17:25:12 WBPerson2970 Name_change: CGC_name: myo-5
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: myo
    Allele (102)
    Strain: WBStrain00001815
    RNASeq_FPKM (74)
    GO_annotation (20)
    Ortholog (82)
    Paralog: WBGene00002348 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003514 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00003515 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00003776 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003777 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00006789 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00009730 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00012437 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00002035 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00002036 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00002037 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00002038 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00002039 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00002040 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00002041 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00004969 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00006754 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00015356 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00015968 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00018317 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00018377 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Automated_description: Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in muscle contraction and sarcomere organization. Predicted to be located in cytoplasm and myosin filament. Predicted to be part of myosin II complex. Human ortholog(s) of this gene implicated in several diseases, including congenital heart disease (multiple); distal myopathy 1; and intrinsic cardiomyopathy (multiple). Is an ortholog of several human genes including MYH1 (myosin heavy chain 1); MYH2 (myosin heavy chain 2); and MYH3 (myosin heavy chain 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (30)
  Molecular_info: Corresponding_CDS: F58G4.1
    Corresponding_transcript: F58G4.1.1
    Other_sequence (45)
    Associated_feature (11)
  Experimental_info: RNAi_result: WBRNAi00001416 Inferred_automatically: RNAi_primary
      WBRNAi00049048 Inferred_automatically: RNAi_primary
      WBRNAi00016011 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram331
      Expr6255
      Expr1025980
      Expr1038232
      Expr1152790
      Expr2013844
      Expr2032084
    Drives_construct: WBCnstr00002611
      WBCnstr00026089
    Construct_product: WBCnstr00026089
    Microarray_results (19)
    Expression_cluster: WBPaper00024505:pharyngeal_enriched
      WBPaper00024970:GABAergic_neuron_specific
      WBPaper00029359_1135
      WBPaper00029359_1166
      WBPaper00029359_1197
      WBPaper00029359_1253
      WBPaper00029359_1291
      WBPaper00029359_1320
      WBPaper00029359_1326
      WBPaper00029359_1345
      WBPaper00029359_1439
      WBPaper00029359_1458
      WBPaper00029359_1466
      WBPaper00029359_1546
      WBPaper00029359_1549
      WBPaper00029359_1557
      WBPaper00029359_1599
      WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00037047:aging_accelerated_insoluble_protein
      WBPaper00037047:insoluble_protein
      WBPaper00037055:DAF-16_binding_DNA
      WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_embryo_enriched
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:germline-precursors_blastula-embryo_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:pharyngeal-muscle_embryo_enriched
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
      WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
      WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
      WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
      WBPaper00038438:S.marcescens_24hr_downregulated_RNAseq
      WBPaper00040134:nhr-49(RNAi)_regulated_protein
      WBPaper00040560:hpl-2_embryo_upregulated
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00042561:smgl-1(RNAi)_upregulated
      WBPaper00044037:eat-2_upregulated
      WBPaper00044736:oscillating_dev_expression
      WBPaper00044743:wdr-23_neuron_upregulated
      WBPaper00045390:tunicamycin_downregulated
      WBPaper00045390:ubc-9(RNAi)_downregulated
      WBPaper00045521:Gender_Neutral
      WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00047132:glp-1(ts)-25C_upregulated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00050080:rbr-2(tm3141)_downregulated
      WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:daf-2(e1370)_vs_daf-2(e1370);mir-34(gk437)_regulated_dauer_25C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050636:aging_regulated_insoluble_protein
      WBPaper00050698:DEP-1_interacting
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050843:sesamin_downregulated
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00051039:ash-2(RNAi)_regulated_intestine
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed
      WBPaper00051245:pharyngeal-muscle_nucleus_expressed
      WBPaper00051265:F4_hrde-1(tm1200)_upregulated
      WBPaper00051404:alg-1(gk214)_upregulated
      WBPaper00051404:alg-2(ok304)_upregulated
      WBPaper00051461:pig-1(gm344)_downregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:alovudine_72h_regulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053599:female_vs_male_upregulated
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053771:down_by_skn-1(RNAi)_at_dpy-7(e88)
      WBPaper00053771:up_at_dpy-7(e88)
      WBPaper00053810:daf-2(e1370)_downregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:eat-2(ad1116)_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rapamycin_upregulated
      WBPaper00055354:Rifampicin-Allantoin_downregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055482:pmt-2(RNAi)_upregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055648:pharynx_expressed
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056039:hda-6(ok3203)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056090:E.faecalis_upregulated_N2
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056290:hsp-6(mg585)_downregulated
      WBPaper00056443:DietaryRestriction_downregulated
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056868:P.aeruginosa_upregulated_smallRNA
      WBPaper00056900:ERH-2_interacting
      WBPaper00056900:PID-3_interacting
      WBPaper00056900:TOFU-6_interacting
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00057143:ztf-11(RNAi)_upregulated
      WBPaper00058598:mex-1(or286)_upregulated
      WBPaper00058598:mex-3(eu149)_upregulated
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058598:spn-4(tm291)_upregulated
      WBPaper00058665:graphene-oxide_downregulated_mRNA
      WBPaper00058942:henn-1(pk2295)_upregulated
      WBPaper00058969:RIS_depleted
      WBPaper00059117:B.subtilis_upregulated
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059328:mrps-5(RNAi)_upregulated_protein
      WBPaper00059421:daf-1(m40)_upregulated
      WBPaper00059421:daf-3(mgDf90)_downregulated
      WBPaper00059566:wdr-23(mac32)_upregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
      WBPaper00060100:SiNP_upregulated_mRNA
      WBPaper00060445:ikb-1(nr2027)_upregulated_L4
      WBPaper00060445:nfki-1(cer1)_upregulated_L4
      WBPaper00060459:bcat-1(RNAi)_upregulated
      WBPaper00060683:hlh-11(ko1)_upregulated
      WBPaper00060811:L1_vs_adult_downregulated_neural
      WBPaper00060909:atfs-1(et18)_downregulated
      WBPaper00061081:E.faecalis_upregulated_N2
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061377:MYRF-1_interacting
      WBPaper00061377:PAN-1_interacting
      WBPaper00061439:unc-30(ok613)_downregulated
      WBPaper00061479:hda-1(ne4747)_upregulated
      WBPaper00061479:hda-1(ne4752)_upregulated
      WBPaper00061479:mep-1(ne4629)_upregulated
      WBPaper00061479:prg-1(tm872)_upregulated
      WBPaper00061527:tnt-4-myo-1_2160
      WBPaper00061818:AFD_enriched_protein
      WBPaper00061995:mter-4(syb3662syb3403)_downregulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00064055:trl-1(cas1077)_upregulated_starved
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064201:SNA-1_interacting
      WBPaper00064201:SNA-3_interacting
      WBPaper00064306:Agaro-oligosaccharides_upregulated
      WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs
      WBPaper00064494:postdauer_upregulated_AWA
      WBPaper00064502:nhr-23(kry61);spe-44(fx110)_upregulated
      WBPaper00064502:nhr-23(kry61)_upregulated
      WBPaper00064716:paraquat_downregulated
      WBPaper00064721:fasn-1(g14)_downregulated_starved
      WBPaper00064871:hypoxia_downregulated_F2
      WBPaper00064933:bcf-1(ylf1)_upregulated_transcript
      WBPaper00064933:E.coli-binding_secret_protein
      WBPaper00064939:vit-5(RNAi)_upregulated
      WBPaper00064992:heat-shock_upregulated
      WBPaper00065149:lin-52(n771)_downregulated
      WBPaper00065158:AFD_enriched
      WBPaper00065258:anchor-cell_depleted
      WBPaper00065373:Cisplatin_downregulated_WT
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065759:dot-1.1(knu339)_upregulated
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065841:3_0
      WBPaper00065841:18_0
      WBPaper00065841:24_0
      WBPaper00065841:24_1
      WBPaper00065841:26_0
      WBPaper00065841:26_1
      WBPaper00065841:26_2
      WBPaper00065975:P-body_vs_oocyte_depleted
      WBPaper00065975:P-body_vs_WholeAnimal_depleted
      WBPaper00065984:pals-17(syb3980)_upregulated
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066038:mip-1(how5)_upregulated
      WBPaper00066118:cyclobutrifluram_upregulated
      cgc4489_group_16
      WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00034661:AgNPs_downregulated
      WBPaper00036286:Pattern_I
      WBPaper00038172:crh-1null_up_regulated
      WBPaper00040821:Au-NP_regulated
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_regulated_old
      WBPaper00040963:Q200_down
      WBPaper00040963:TA200_up
      WBPaper00040963:TA300_up
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00045865:biofilm_downregulated_B
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00047070:N2_UV_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc6390]:Cluster_B
    Interaction (109)
  Map_info: Map: V Position: 1.01421 Error: 0.000932
    Positive: Positive_clone: F58G4 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00025258
    WBPaper00032048
    WBPaper00038491
    WBPaper00040135
    WBPaper00046461
    WBPaper00055090
    WBPaper00061616
    WBPaper00064601
    WBPaper00064648
    WBPaper00065026
  Remark: This myosin heavy chain, MHC E, is expressed in body wall muscle and localized by antibodies to A-bands. Person_evidence: WBPerson261
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene