WormBase Tree Display for Gene: WBGene00017699

WBGene00017699 SMap: S_parent: Sequence: F22D3
  Identity: Version: 2
    Name: CGC_name: flcn-1 Person_evidence: WBPerson15935
      Sequence_name: F22D3.2
      Molecular_name (21)
      Other_name: CELE_F22D3.2 Accession_evidence: NDB BX284602
      Public_name: flcn-1
    DB_info: Database: AceView gene 2H237
        WormQTL gene WBGene00017699
        WormFlux gene WBGene00017699
        OMIM disease 135150
          gene 607273
        NDB locus_tag CELE_F22D3.2
        Panther gene CAEEL|WormBase=WBGene00017699|UniProtKB=H2KY80
          family PTHR31441
        NCBI gene 174134
        RefSeq protein NM_001306549.4
            NM_001330952.3
            NM_001276732.2
            NM_001381469.1
            NM_001306551.3
            NM_001381470.1
            NM_001026937.5
        TrEMBL UniProtAcc S6FCY3
            S6EZM3
            K0M7B5
            J7S130
            S6F533
            Q5DX40
            S6FMZ4
        UniProt_GCRP UniProtAcc S6FMZ4
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:30:59 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 29 Jun 2012 17:03:10 WBPerson2970 Name_change: CGC_name: flcn-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: flcn
    Allele (252)
    Strain: WBStrain00031743
    RNASeq_FPKM (74)
    GO_annotation (20)
    Ortholog (40)
    Structured_description: Concise_description: F22D3.2 encodes an ortholog of human folliculin (OMIM:607273, mutated inBirt-Hogg-Dube syndrome). Paper_evidence: WBPaper00028837
          Curator_confirmed: WBPerson567
          Date_last_updated: 11 Dec 2006 00:00:00
      Automated_description: Predicted to contribute to GTPase activator activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; positive regulation of TORC1 signaling; and positive regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in cytosol. Expressed in excretory cell; nervous system; spermatheca; and vulva. Used to study Birt-Hogg-Dube syndrome. Human ortholog(s) of this gene implicated in several diseases, including Birt-Hogg-Dube syndrome; primary spontaneous pneumothorax; and renal cell carcinoma. Is an ortholog of human FLCN (folliculin). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:0050676 Homo sapiens Paper_evidence: WBPaper00048631
          Accession_evidence: OMIM 135150
          Curator_confirmed: WBPerson324
          Date_last_updated: 03 Nov 2015 00:00:00
    Potential_model: DOID:9256 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:27310)
      DOID:0080218 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:27310)
      DOID:4450 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:27310)
      DOID:0050676 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:27310)
  Models_disease_in_annotation: WBDOannot00000382
  Molecular_info: Corresponding_CDS: F22D3.2c
      F22D3.2d
      F22D3.2e
      F22D3.2f
      F22D3.2g
      F22D3.2i
      F22D3.2j
    Corresponding_CDS_history: F22D3.2:wp127
      F22D3.2a:wp206
      F22D3.2a:wp238
      F22D3.2a:wp274
      F22D3.2b:wp206
      F22D3.2b:wp238
      F22D3.2h:wp274
    Corresponding_transcript: F22D3.2c.1
      F22D3.2d.1
      F22D3.2e.1
      F22D3.2f.1
      F22D3.2g.1
      F22D3.2i.1
      F22D3.2j.1
    Other_sequence (21)
    Associated_feature (63)
  Experimental_info: RNAi_result: WBRNAi00013748 Inferred_automatically: RNAi_primary
      WBRNAi00045306 Inferred_automatically: RNAi_primary
      WBRNAi00013747 Inferred_automatically: RNAi_primary
      WBRNAi00031265 Inferred_automatically: RNAi_primary
      WBRNAi00092437 Inferred_automatically: RNAi_primary
      WBRNAi00092428 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr10985
      Expr13864
      Expr1017397
      Expr1037596
      Expr1149230
      Expr2011814
      Expr2030052
    Drives_construct: WBCnstr00017598
      WBCnstr00017614
      WBCnstr00027093
    Construct_product: WBCnstr00017614
      WBCnstr00027093
      WBCnstr00040219
    Regulate_expr_cluster: WBPaper00042236:flcn-1(ok975)_upregulated
      WBPaper00056471:flcn-1(ok975)_downregulated
      WBPaper00056471:flcn-1(ok975)_upregulated
    Antibody: WBAntibody00002522
    Microarray_results (41)
    Expression_cluster: WBPaper00036375:enriched_in_PVD_OLL
      WBPaper00037055:DAF-16_binding_DNA
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:dopaminergic-neurons_larva_enriched
      WBPaper00037950:dopaminergic-neurons_larva_SelectivelyEnriched
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038168:lin-15B(n744)_upregulated
      WBPaper00038438:Harposporium_24hr_downregulated_RNAseq
      WBPaper00040209:B.thuringiensis_upregulated_MY15
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00042561:smgl-1(RNAi)_upregulated
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045316:prg-1_upregulated_L2
      WBPaper00045390:ubc-9(RNAi)_downregulated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045521:Gender_Neutral
      WBPaper00045729:gld-2(RNAi)_downregulated
      WBPaper00048762:FOG-3_associated
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050234:lin-28(RNAi)_upregulated
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:pharynx_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051265:F4_morc-1(tm6048)_upregulated
      WBPaper00052884:emb-4(hc60)_downregulated
      WBPaper00053184:sma-4(rax3)_downregulated
      WBPaper00053295:lin-22(icb38)_upregulated
      WBPaper00053295:lin-22(ot269)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053388:dauer_regulated_Cluster4
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00054792:FOG-3_interacting
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055565:AVK_enriched
      WBPaper00055971:nhl-2(ok818)_20C_upregulated
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056139:soil-microbiota_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059471:EGL-43_interacting
      WBPaper00059763:neuron_expressed
      WBPaper00060278:atp-2(RNAi)_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00061340:ABarpaaa_lineage
      WBPaper00061340:AIN
      WBPaper00061340:AIN_parent
      WBPaper00061340:ASK_parent
      WBPaper00061340:AVH_parent
      WBPaper00061340:CEPso
      WBPaper00061340:ILsh_OLLsh_OLQsh
      WBPaper00061340:Parent_of_PVP_and_rect_V
      WBPaper00061340:Pharyngeal_neuron
      WBPaper00061340:pm8
      WBPaper00061340:RIA_parent
      WBPaper00061340:RIB
      WBPaper00061340:RIC_parent
      WBPaper00061340:RIV
      WBPaper00061340:RME_LR_parent
      WBPaper00061527:ldb-1_2877-scd-1_3086
      WBPaper00061527:nhr-46_2300-unc-108_2961
      WBPaper00061527:pkn-1_20439-tbc-12_11015
      WBPaper00061651:AIZ_enriched
      WBPaper00061651:I3_enriched
      WBPaper00061651:URB_enriched
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00064716:paraquat_upregulated
      WBPaper00064735:bet-1(RNAi)_vs_N2_upregulated
      WBPaper00064735:bet-1(uth41)_vs_N2_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065835:Day11_vs_Day1_upregulated
      WBPaper00065841:108_0
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      WBPaper00065993:glp-1(e2141)_downregulated
      WBPaper00066146:germline-inx-14(RNAi)_downregulated_PA14
      cgc4386_cluster_6_3
      cgc4489_group_21
      WBPaper00025032:cluster_44
      WBPaper00025032:cluster_74
      WBPaper00025032:cluster_104
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00030839:Larval_Pan_Neuronal
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00031252:AIN-2_IP_enriched
      WBPaper00031532:Larva_Pan_Neuronal_Enriched
      WBPaper00031832:slr-2_regulated
      WBPaper00034739:N2moreDR1350
      WBPaper00035084:embryo_enriched_AIN-2_IP
      WBPaper00035227:heat_shock_regulated
      WBPaper00035873:dpy-9_regulated
      WBPaper00035873:dpy-10_regulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036286:Pattern_B
      WBPaper00037611:RNP-8-associated
      WBPaper00037901:GLD-1_mRNA_targets
      WBPaper00038231:Cry5B_1.5-fold_upregulated
      WBPaper00040963:Q100_down
      WBPaper00040963:Q200_down
      WBPaper00040963:TA100_down
      WBPaper00040963:TA200_down
      WBPaper00040963:TA300_down
      WBPaper00040985:AIN-2_asynchronous_intestine
      WBPaper00040985:AIN-2_asynchronous_muscle
      WBPaper00040985:AIN-2_L4_intestine
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041606:CE_S.marcescens_regulated
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_EtBr-exposed_51h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00042258:DA1877_downregulated_GravidAdult
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00042548:miRISC_enriched
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00046548:dafachronic-acid_downregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(23_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
    Interaction: WBInteraction000402369
      WBInteraction000520210
      WBInteraction000520211
      WBInteraction000520212
      WBInteraction000520213
      WBInteraction000520218
      WBInteraction000521811
      WBInteraction000534849
  Map_info: Map: II Position: 0.145905
    Positive: Positive_clone: F22D3 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00042236
    WBPaper00043118
    WBPaper00048129
    WBPaper00048631
    WBPaper00049821
    WBPaper00051847
    WBPaper00055071
    WBPaper00055090
    WBPaper00061202
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene