WormBase Tree Display for Gene: WBGene00013308

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WBGene00013308	SMap	S_parent	Sequence	Y57G11C
	Identity	Version	4
		Name	CGC_name	nuo-3	Person_evidence	WBPerson1157
			Sequence_name	Y57G11C.12
			Molecular_name	Y57G11C.12
				Y57G11C.12.1
				CE14948
				Y57G11C.12.2
			Other_name	ndua-6	Person_evidence	WBPerson555
				CELE_Y57G11C.12	Accession_evidence	NDB	BX284604
			Public_name	nuo-3
		DB_info	Database	WormQTL	gene	WBGene00013308
				WormFlux	gene	WBGene00013308
				NDB	locus_tag	CELE_Y57G11C.12
				Panther	gene	CAEEL\|WormBase=WBGene00013308\|UniProtKB=O18236
					family	PTHR12964
				NCBI	gene	36805062
				RefSeq	protein	NM_001392444.1
				TrEMBL	UniProtAcc	O18236
				UniProt_GCRP	UniProtAcc	O18236
				OMIM	gene	602138
		Species	Caenorhabditis elegans
		History	Version_change	1	26 May 2004 16:54:54	WBPerson1971	Event	Imported	Initial conversion from CDS class of WS125
				2	31 Aug 2005 14:07:05	WBPerson2970	Name_change	CGC_name	nuo-3
				3	06 Mar 2018 14:43:22	WBPerson4025	Event	Split_into	WBGene00303007
				4	16 Jan 2023 18:37:21	WBPerson51134	Name_change	Other_name	ndua-6
			Split_into	WBGene00303007
		Status	Live
	Gene_info	Biotype	SO:0001217
		Gene_class	nuo
		Allele (27)
		Strain	WBStrain00003089
			WBStrain00055406
		RNASeq_FPKM (74)
		GO_annotation	00031815
			00031816
			00031817
			00031818
			00031819
			00031820
			00031821
			00031822
			00031823
		Contained_in_operon	CEOP5614
		Ortholog (28)
		Structured_description	Concise_description	The nuo-3 locus encodes two distinct, non-overlapping proteins: Y57G11C.12a (homologous to human C3orf10/BRICK1, a component of the WAVE1 complex) and Y57G11C.12b (a putativeNADH-ubiquinone oxidoreductase alpha subunit, homologous to human NDUFA6 [OMIM:602138]).	Person_evidence	WBPerson242
					Curator_confirmed	WBPerson567
					Date_last_updated	12 May 2008 00:00:00
			Automated_description	Predicted to be involved in response to oxidative stress. Predicted to be located in mitochondrial inner membrane and respirasome. Predicted to be part of mitochondrial respiratory chain complex I. Human ortholog(s) of this gene implicated in Alzheimer's disease and nuclear type mitochondrial complex I deficiency 33. Is an ortholog of human NDUFA6 (NADH:ubiquinone oxidoreductase subunit A6).	Paper_evidence	WBPaper00065943
					Curator_confirmed	WBPerson324
						WBPerson37462
					Inferred_automatically	This description was generated automatically by a script based on data from the WS291 version of WormBase
					Date_last_updated	29 Nov 2023 00:00:00
	Disease_info	Potential_model	DOID:0112097	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:7690)
			DOID:10652	Homo sapiens	Inferred_automatically	Inferred by orthology to human genes with DO annotation (HGNC:7690)
	Molecular_info	Corresponding_CDS	Y57G11C.12
		Corresponding_CDS_history	Y57G11C.12a:wp264
			Y57G11C.12b:wp264
		Corresponding_transcript	Y57G11C.12.1
			Y57G11C.12.2
		Corresponding_transcript_history	Y57G11C.12c:wp264
		Associated_feature	WBsf652383
			WBsf981851
			WBsf998642
			WBsf231227
	Experimental_info	RNAi_result (35)
		Expr_pattern	Chronogram977
			Expr7077
			Expr1012642
			Expr1035936
			Expr1161096
			Expr2014529
			Expr2032768
		Drives_construct	WBCnstr00003574
			WBCnstr00029696
		Construct_product	WBCnstr00029696
		Microarray_results (32)
		Expression_cluster	WBPaper00028451:Low_abundance_spermatogenesis_enriched
			WBPaper00032528:L3_enriched
			WBPaper00035073:mitochondria_protein
			WBPaper00037086:biotin_regulated
			WBPaper00037950:BAG-neuron_blastula-embryo_expressed
			WBPaper00037950:bodywall-muscle_L2-larva_expressed
			WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
			WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
			WBPaper00037950:excretory-cell_L2-larva_expressed
			WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
			WBPaper00037950:germline-precursors_blastula-embryo_expressed
			WBPaper00037950:hypodermis_L3-L4-larva_expressed
			WBPaper00037950:hypodermis_larva_enriched
			WBPaper00037950:hypodermis_larva_SelectivelyEnriched
			WBPaper00037950:intestine_L1-larva_expressed
			WBPaper00037950:intestine_L2-larva_expressed
			WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
			WBPaper00038289:oocyte_protein
			WBPaper00040221:DAF-12_target_ALF4
			WBPaper00040965:lipid-droplet_associated_protein
			WBPaper00044501:gld-1_let-7_regulated
			WBPaper00044736:flat_dev_expression
			WBPaper00045521:Gender_Neutral
			WBPaper00045571:germline-ablation_downregulated
			WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
			WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
			WBPaper00048923:Aging_regulated
			WBPaper00048988:neuron_expressed
			WBPaper00049217:TCER-1_downregulated
			WBPaper00049545:jmjd-3.1(+)_downregulated
			WBPaper00050488:adult_vs_dauer_regulated_N2_20C
			WBPaper00050726:OsmoticStress_regulated_Food
			WBPaper00050990:arcade_intestinal-valve_expressed
			WBPaper00050990:body-muscle_expressed
			WBPaper00050990:GABAergic-neuron_expressed
			WBPaper00050990:hypodermis_expressed
			WBPaper00050990:intestine_expressed
			WBPaper00050990:NMDA-neuron_expressed
			WBPaper00050990:pharynx_expressed
			WBPaper00050990:seam_expressed
			WBPaper00051039:germline_enriched
			WBPaper00053184:sma-4(rax3)_downregulated
			WBPaper00053295:lin-22(ot269)_downregulated
			WBPaper00053388:dauer_regulated_Cluster6
			WBPaper00053713:Pheromone-induced_postdauer_vs_control_downregulated
			WBPaper00053810:daf-2(e1370)_downregulated
			WBPaper00053810:nuo-6(qm200)_upregulated
			WBPaper00055049:S.gordonii_downregulated
			WBPaper00055354:Rifampicin-Allantoin_upregulated
			WBPaper00055648:germline_expressed
			WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
			WBPaper00056501:P.aeruginosa_downregulated_mitochondria-protein
			WBPaper00056900:PID-3_interacting
			WBPaper00057288:iff-1(RNAi)_downregulated_transcript
			WBPaper00059254:CSR-1_interacting
			WBPaper00059328:mrps-5(RNAi)_downregulated_protein
			WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
			WBPaper00059471:EGL-43_interacting
			WBPaper00060100:SiNP_downregulated_mRNA
			WBPaper00060811:L1_vs_adult_downregulated_neural
			WBPaper00060911:prx-5(RNAi)_downregulated_protein
			WBPaper00061341:28C_24h_downregulated
			WBPaper00061341:28C_48h_downregulated
			WBPaper00061377:MYRF-2_interacting
			WBPaper00061527:B0495.9-ZK1128.1
			WBPaper00061527:dld-1-skn-1_16701
			WBPaper00062325:muscle_enriched_coding-RNA
			WBPaper00062498:PPM-1.D_interacting
			WBPaper00064055:trl-1(cas1077)_downregulated_non-starved
			WBPaper00064055:trl-1(cas1077)_downregulated_starved
			WBPaper00064071:NHR-49_interacting
			WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
			WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
			WBPaper00064130:Beta-Amyloid_downregulated_protein
			WBPaper00065120:body-muscle-transcriptome
			WBPaper00065835:Day5_vs_Day1_downregulated
			WBPaper00065835:Day11_vs_Day1_downregulated
			cgc4386_cluster_1_5
			WBPaper00025032:cluster_152
			WBPaper00025032:cluster_157
			WBPaper00025141:N2_Expressed_Genes
			WBPaper00025141:unc-4::GFP_Enriched_Genes
			WBPaper00025141:unc-4::GFP_Expressed_Genes
			WBPaper00026929:sir-2.1_overexpression_regulated
			WBPaper00026980:intestine_enriched
			WBPaper00030839:Embryo_A_Class
			WBPaper00030839:Embryo_Pan_Neuronal
			WBPaper00035905:FBF-1_Associated
			WBPaper00036286:Pattern_H
			WBPaper00037147:heatshock_upregulated
			WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
			WBPaper00041606:CE_B.thuringiensis-DB27_regulated
			WBPaper00041606:CE_S.marcescens_regulated
			WBPaper00041606:CE_X.nematophila_regulated
			WBPaper00041939:control_vs_EtBr-exposed_48h
			WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
			WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
			WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
			WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
			WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
			WBPaper00048637:lin-35(n745)_starvation_downregulated
			[cgc5767]:cluster_29
			[cgc5767]:expression_class_M
			[cgc5767]:expression_class_MD
			[cgc5767]:expression_class_MD_pd(66_min)
			[cgc5767]:expression_class_SM
			[cgc5767]:expression_class_SMD
		Interaction (87)
	Map_info	Map	IV	Position	12.5086	Error	0.002306
		Positive	Positive_clone	Y57G11C	Inferred_automatically	From sequence, transcript, pseudogene data
		Pseudo_map_position
	Reference	WBPaper00005928
		WBPaper00026715
		WBPaper00031194
		WBPaper00033840
		WBPaper00037471
		WBPaper00038491
		WBPaper00041233
		WBPaper00048636
		WBPaper00055090
	Remark	Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.	CGC_data_submission
	Method	Gene