WormBase Tree Display for Gene: WBGene00012907

WBGene00012907 SMap: S_parent: Sequence: Y46G5A
  Identity: Version: 2
    Name: CGC_name: cpt-1 Person_evidence: WBPerson3206
            WBPerson3205
      Sequence_name: Y46G5A.17
      Molecular_name: Y46G5A.17
        Y46G5A.17.1
        CE36414
        Y46G5A.17.2
      Other_name: CELE_Y46G5A.17 Accession_evidence: NDB BX284602
      Public_name: cpt-1
    DB_info: Database: AceView gene 2N80
        WormQTL gene WBGene00012907
        WormFlux gene WBGene00012907
        NDB locus_tag CELE_Y46G5A.17
        Panther gene CAEEL|WormBase=WBGene00012907|UniProtKB=Q9U2F2
          family PTHR22589
        NCBI gene 174912
        RefSeq protein NM_064320.6
        TrEMBL UniProtAcc Q9U2F2
        UniProt_GCRP UniProtAcc Q9U2F2
        OMIM gene 600528
            608846
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:54 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 18 Jul 2005 13:34:00 WBPerson2970 Name_change: CGC_name: cpt-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cpt
    Allele (342)
    Strain: WBStrain00001343
    RNASeq_FPKM (74)
    GO_annotation (16)
    Contained_in_operon: CEOP2721
    Ortholog (60)
    Paralog: WBGene00000481 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00007175 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00008629 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00009622 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00011122 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00011850 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00021002 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00020911 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00021703 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00019644 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: Y46G5A.17 is orthologous to the human gene SIMILAR TO CARNITINE PALMITOYLTRANSFERASE I, LIVER (CPT1A; OMIM:600528), which when mutated leads to disease. Curator_confirmed: WBPerson1823
            WBPerson567
          Date_last_updated: 06 Aug 2004 00:00:00
      Automated_description: Predicted to enable carnitine O-palmitoyltransferase activity. Predicted to be involved in carnitine metabolic process and fatty acid metabolic process. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in carnitine palmitoyltransferase I deficiency; hereditary spastic paraplegia 73; and lymphangioleiomyomatosis. Is an ortholog of human CPT1A (carnitine palmitoyltransferase 1A) and CPT1C (carnitine palmitoyltransferase 1C). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0110818 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:18540)
      DOID:0090129 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2328)
      DOID:3319 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2328)
      DOID:3146 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2328)
  Molecular_info: Corresponding_CDS: Y46G5A.17
    Corresponding_CDS_history: Y46G5A.17:wp52
      Y46G5A.17:wp119
    Corresponding_transcript: Y46G5A.17.1
      Y46G5A.17.2
    Other_sequence (115)
    Associated_feature (14)
  Experimental_info: RNAi_result: WBRNAi00056674 Inferred_automatically: RNAi_primary
      WBRNAi00000348 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram1623
      Expr6984
      Expr1011554
      Expr1035713
      Expr1160145
      Expr2010514
      Expr2028754
    Drives_construct: WBCnstr00002236
      WBCnstr00029794
    Construct_product: WBCnstr00029794
    Microarray_results (19)
    Expression_cluster: WBPaper00005700:transmembrane_protein
      WBPaper00031040:TGF-beta_adult_downregulated
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00033070:Elbe_upregulated
      WBPaper00037682:sma-2_upregulated
      WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
      WBPaper00037950:bodywall-muscle_L1-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:hypodermis_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038213:E.coli(LF82)_72h_upregulated
      WBPaper00040221:DAF-12_target_ALF4
      WBPaper00041954:ethanol_upregulated
      WBPaper00044426:rotenone_24h_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045420:fertilization_upregulated_protein
      WBPaper00045521:Gender_Neutral
      WBPaper00045729:gld-2(RNAi)_downregulated
      WBPaper00045974:NSM_enriched_totalRNA_RNAseq
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049942:HeatShock_downregulated_hsf-1(+)
      WBPaper00050412:cco-1(RNAi)_upregulated_N2
      WBPaper00050468:hlh-30-dependent_Cry5B_regulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050698:DEP-1_interacting
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:OsmoticStress_regulated_NoFood
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:body-muscle_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:germline_enriched
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051265:F4_morc-1(tm6048)_upregulated
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053302:zidovudine_72h_regulated
      WBPaper00053388:dauer_regulated_Cluster4
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00054192:cold-shock_upregulated
      WBPaper00055049:S.gordonii_upregulated
      WBPaper00055334:DLC-1_interacting
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055648:germline_expressed
      WBPaper00055971:nhl-2(ok818)_25C_upregulated
      WBPaper00056034:pals-22(jy3)_downregulated
      WBPaper00056034:pals-25(jy9)_downregulated
      WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
      WBPaper00056443:sek-1(km4)_downregulated
      WBPaper00056471:S.aureus-4h_upregulated_N2
      WBPaper00056826:SGP_biased
      WBPaper00057041:spc-1(cas971)_downregulated
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00057288:Cold_downregulated_protein
      WBPaper00057288:iff-1(RNAi)_upregulated_transcript
      WBPaper00058691:set-2(bn129)_downregulated
      WBPaper00058691:sin-3(tm1276)_upregulated
      WBPaper00059027:neuron-synapses_enriched
      WBPaper00059174:MEG-3_interacting
      WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
      WBPaper00059356:BAZ-2_SET-6_interacting
      WBPaper00059471:EGL-43_interacting
      WBPaper00059609:malt-1_ilc-17.1_nfki-1_upregulated
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060014:set-2(zr2012)_upregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060811:L1_vs_adult_upregulated_neural
      WBPaper00060909:atfs-1(cmh15)_upregulated
      WBPaper00061007:S.aquatilis_downregulated
      WBPaper00061340:T
      WBPaper00061341:28C_48h_upregulated
      WBPaper00061527:npp-8_4368-E01B7.1_7741
      WBPaper00061530:nhr-49(e2144)_upregulated
      WBPaper00061902:CAMT-1_interacting
      WBPaper00062325:muscle_enriched_coding-RNA
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00062684:pathogen_downregulated_CB4856
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064201:SNA-3_interacting
      WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated
      WBPaper00064315:mes-3(bn199)_downregulated_PGCs
      WBPaper00064315:mrg-1(qa6200)_downregulated_PGCs
      WBPaper00064539:nhr-114(gk849)_upregulated
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065199:Transgeneration-starvation_regulated_fed
      WBPaper00065746:tmc-1(rg1003)_downregulated
      WBPaper00065945:epidermis-rpoa-2(-)_downregulated_transcript
      WBPaper00065945:global-rpoa-2(-)_downregulated_transcript
      WBPaper00065975:P-body_vs_WholeAnimal_enriched
      WBPaper00065995:M.humicola-extract_downregulated_N2
      cgc4386_cluster_6_6
      WBPaper00025032:cluster_28
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00031252:AIN-1_IP_enriched
      WBPaper00031832:slr-2_regulated
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00035905:FBF-1_Associated
      WBPaper00036286:Pattern_F
      WBPaper00037901:GLD-1_mRNA_targets
      WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
      WBPaper00040858:eQTL_age_regulated_aging
      WBPaper00040858:eQTL_regulated_aging
      WBPaper00040858:eQTL_regulated_old
      WBPaper00041002:HF_3d_0.2mM_Down
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041002:HQ_3d_2.0mM_Down
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00047070:N2_UV_downregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      [cgc5767]:cluster_62
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(23_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
    Interaction: WBInteraction000558548
      WBInteraction000563740
      WBInteraction000579824
      WBInteraction000585689
  Map_info: Map: II Position: 11.205 Error: 0.026807
    Positive: Positive_clone: Y46G5A Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (12)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene