WormBase Tree Display for Gene: WBGene00012532
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| WBGene00012532 | SMap | S_parent | Sequence | Y32F6B | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | crp-1 | Paper_evidence | WBPaper00024905 | |||||
| Sequence_name | Y32F6B.3 | ||||||||
| Molecular_name | Y32F6B.3 | ||||||||
| Y32F6B.3.1 | |||||||||
| CE16612 | |||||||||
| Other_name | CELE_Y32F6B.3 | Accession_evidence | NDB | BX284605 | |||||
| Public_name | crp-1 | ||||||||
| DB_info | Database | AceView | gene | 5K959 | |||||
| WormQTL | gene | WBGene00012532 | |||||||
| WormFlux | gene | WBGene00012532 | |||||||
| NDB | locus_tag | CELE_Y32F6B.3 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00012532|UniProtKB=O62422 | |||||||
| family | PTHR24072 | ||||||||
| NCBI | gene | 179462 | |||||||
| RefSeq | protein | NM_073287.7 | |||||||
| TREEFAM | TREEFAM_ID | TF300837 | |||||||
| TrEMBL | UniProtAcc | O62422 | |||||||
| UniProt_GCRP | UniProtAcc | O62422 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:53 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 18 Feb 2005 12:07:44 | WBPerson2970 | Name_change | CGC_name | crp-1 | ||||
| 3 | 02 Mar 2018 11:09:16 | WBPerson4025 | Event | Split_into | WBGene00303085 | ||||
| Split_into | WBGene00303085 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | crp | ||||||||
| Allele (32) | |||||||||
| Strain | WBStrain00031568 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (14) | |||||||||
| Ortholog (24) | |||||||||
| Paralog | WBGene00000390 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00000424 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00003239 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00004287 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00004357 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00009059 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00019544 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00022177 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| Structured_description | Concise_description | crp-1 encodes a novel member of the Rho subfamily of Ras small GTP-binding proteins; genetic analyses indicate that CRP-1 functions in apical membrane trafficking events as well as in the DNA remodeling/transcriptional response that promotes adaptation to endoplasmic reticulum (ER) stress as part of the unfolded protein response (UPR); in regulating the UPR, CRP-1 likely functions together with the CDC-48.1 AAA+ ATPase and the HIM-6 RecQ helicase, with which it interacts in vitro; in C. elegans, a CRP-1::GFP fusion protein is first expressed in embryos in pharyngeal, rectal, and intestinal tissues; at later stage CRP-1::GFP expression is also seen in head and tail support cells (socket and sheath cells), the vulval epithelium, and the excretory cell; when expressed in NIH3T3 cells, CRP-1 localizes to the trans-Golgi network and to recycling endosomes and does not appear to affect actin cytoskeleton reorganization; in vitro assays indicate that CRP-1 is deficient in GTP hydrolysis, has a higher affinity for GDP (as opposed to GTP) binding, and exhibits low GDP-to-GTP nucleotide-exchange activity. | Paper_evidence | WBPaper00025137 | |||||
| WBPaper00027071 | |||||||||
| WBPaper00031857 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 09 Jan 2009 00:00:00 | ||||||||
| Automated_description | Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including Cdc42 protein signal transduction; actin filament organization; and endocytosis. Located in recycling endosome and trans-Golgi network. Expressed in several structures, including excretory cell; pharyngeal-intestinal valve; rectal epithelium; socket cell; and vulva. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | Y32F6B.3 | |||||||
| Corresponding_CDS_history | Y32F6B.3a:wp264 | ||||||||
| Y32F6B.3b:wp264 | |||||||||
| Corresponding_transcript | Y32F6B.3.1 | ||||||||
| Other_sequence (28) | |||||||||
| Associated_feature | WBsf647160 | ||||||||
| WBsf647161 | |||||||||
| WBsf1001122 | |||||||||
| WBsf1020314 | |||||||||
| WBsf232385 | |||||||||
| Experimental_info | RNAi_result (11) | ||||||||
| Expr_pattern | Expr8631 | ||||||||
| Expr8632 | |||||||||
| Expr1021291 | |||||||||
| Expr1035546 | |||||||||
| Expr1159322 | |||||||||
| Expr2010543 | |||||||||
| Expr2028783 | |||||||||
| Drives_construct | WBCnstr00013410 | ||||||||
| WBCnstr00029919 | |||||||||
| Construct_product | WBCnstr00013410 | ||||||||
| WBCnstr00029919 | |||||||||
| Antibody | WBAntibody00001414 | ||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (135) | |||||||||
| Interaction (12) | |||||||||
| WBProcess | WBbiopr:00000079 | ||||||||
| Map_info | Map | V | Position | 2.56937 | Error | 0.00056 | |||
| Positive | Positive_clone | Y32F6B | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5081 | |||||||
| Pseudo_map_position | |||||||||
| Reference (13) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
