WormBase Tree Display for Gene: WBGene00012532
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WBGene00012532 | SMap | S_parent | Sequence | Y32F6B | |||
---|---|---|---|---|---|---|---|
Identity | Version | 3 | |||||
Name | CGC_name | crp-1 | Paper_evidence | WBPaper00024905 | |||
Sequence_name | Y32F6B.3 | ||||||
Molecular_name | Y32F6B.3 | ||||||
Y32F6B.3.1 | |||||||
CE16612 | |||||||
Other_name | CELE_Y32F6B.3 | Accession_evidence | NDB | BX284605 | |||
Public_name | crp-1 | ||||||
DB_info | Database | AceView | gene | 5K959 | |||
WormQTL | gene | WBGene00012532 | |||||
WormFlux | gene | WBGene00012532 | |||||
NDB | locus_tag | CELE_Y32F6B.3 | |||||
Panther | gene | CAEEL|WormBase=WBGene00012532|UniProtKB=O62422 | |||||
family | PTHR24072 | ||||||
NCBI | gene | 179462 | |||||
RefSeq | protein | NM_073287.7 | |||||
TREEFAM | TREEFAM_ID | TF300837 | |||||
TrEMBL | UniProtAcc | O62422 | |||||
UniProt_GCRP | UniProtAcc | O62422 | |||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (3) | ||||||
Split_into | WBGene00303085 | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | crp | ||||||
Allele (32) | |||||||
Strain | WBStrain00031568 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (14) | |||||||
Ortholog (24) | |||||||
Paralog | WBGene00000390 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | |||||||
WBGene00000424 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00003239 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00004287 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00004357 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00009059 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00019544 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00022177 | Caenorhabditis elegans | From_analysis | Panther | ||||
Structured_description | Concise_description | crp-1 encodes a novel member of the Rho subfamily of Ras small GTP-binding proteins; genetic analyses indicate that CRP-1 functions in apical membrane trafficking events as well as in the DNA remodeling/transcriptional response that promotes adaptation to endoplasmic reticulum (ER) stress as part of the unfolded protein response (UPR); in regulating the UPR, CRP-1 likely functions together with the CDC-48.1 AAA+ ATPase and the HIM-6 RecQ helicase, with which it interacts in vitro; in C. elegans, a CRP-1::GFP fusion protein is first expressed in embryos in pharyngeal, rectal, and intestinal tissues; at later stage CRP-1::GFP expression is also seen in head and tail support cells (socket and sheath cells), the vulval epithelium, and the excretory cell; when expressed in NIH3T3 cells, CRP-1 localizes to the trans-Golgi network and to recycling endosomes and does not appear to affect actin cytoskeleton reorganization; in vitro assays indicate that CRP-1 is deficient in GTP hydrolysis, has a higher affinity for GDP (as opposed to GTP) binding, and exhibits low GDP-to-GTP nucleotide-exchange activity. | Paper_evidence | WBPaper00025137 | |||
WBPaper00027071 | |||||||
WBPaper00031857 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 09 Jan 2009 00:00:00 | ||||||
Automated_description | Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including Cdc42 protein signal transduction; actin filament organization; and endocytosis. Located in recycling endosome and trans-Golgi network. Expressed in several structures, including excretory cell; pharyngeal-intestinal valve; rectal epithelium; socket cell; and vulva. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | Y32F6B.3 | |||||
Corresponding_CDS_history | Y32F6B.3a:wp264 | ||||||
Y32F6B.3b:wp264 | |||||||
Corresponding_transcript | Y32F6B.3.1 | ||||||
Other_sequence (28) | |||||||
Associated_feature | WBsf647160 | ||||||
WBsf647161 | |||||||
WBsf1001122 | |||||||
WBsf1020314 | |||||||
WBsf232385 | |||||||
Experimental_info | RNAi_result (11) | ||||||
Expr_pattern | Expr8631 | ||||||
Expr8632 | |||||||
Expr1021291 | |||||||
Expr1035546 | |||||||
Expr1159322 | |||||||
Expr2010543 | |||||||
Expr2028783 | |||||||
Drives_construct | WBCnstr00013410 | ||||||
WBCnstr00029919 | |||||||
Construct_product | WBCnstr00013410 | ||||||
WBCnstr00029919 | |||||||
Antibody | WBAntibody00001414 | ||||||
Microarray_results (20) | |||||||
Expression_cluster (135) | |||||||
Interaction (12) | |||||||
WBProcess | WBbiopr:00000079 | ||||||
Map_info | Map | V | Position | 2.56937 | Error | 0.00056 | |
Positive | Positive_clone | Y32F6B | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 5081 | |||||
Pseudo_map_position | |||||||
Reference (13) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |