WormBase Tree Display for Gene: WBGene00004287

WBGene00004287 SMap: S_parent: Sequence: K03D3
  Identity: Version: 2
    Name: CGC_name: rac-2
      Sequence_name: K03D3.10
      Molecular_name: K03D3.10
        K03D3.10.1
        CE25698
      Other_name: CELE_K03D3.10 Accession_evidence: NDB BX284604
      Public_name: rac-2
    DB_info: Database: WormQTL gene WBGene00004287
        WormFlux gene WBGene00004287
        NDB locus_tag CELE_K03D3.10
        Panther gene CAEEL|WormBase=WBGene00004287|UniProtKB=Q94124
          family PTHR24072
        NCBI gene 186939
        RefSeq protein NM_001047496.1
        SwissProt UniProtAcc Q94124
        UniProt_GCRP UniProtAcc Q94124
        OMIM gene 602048
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:34 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 14 Nov 2005 08:32:55 WBPerson1983 Event: Split_into: WBGene00044670
      Split_into: WBGene00044670
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: rac
    Allele (55)
    Strain: WBStrain00035523
      WBStrain00035892
    RNASeq_FPKM (74)
    GO_annotation (37)
    Ortholog (31)
    Paralog: WBGene00000390 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000424 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003239 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00004357 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00019544 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00044670 Caenorhabditis elegans From_analysis: modENCODE_Pseudogenes
      WBGene00022177 Caenorhabditis elegans From_analysis: Panther
      WBGene00009059 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00012532 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: rac-2 encodes a small Rho family GTPase that, along with CED-10 and MIG-2, is one of three C. elegans Rac-related proteins; genetic studies indicate that rac-2 functions redundantly with mig-2 and ced-10 to regulate CAN and PDE axon pathfinding and CAN cell migration; in addition, rac-2 functions slightly redundant with mig-2 during distal tip cell movement and slightly redundant with ced-10 during cell-corpse phagocytosis; as unc-73 mutations enhance rac-2 defects in axon pathfinding and CAN cell migration, UNC-73/Trio is a likely candidate to act upstream of RAC-2 and positively regulate its GTPase activity in vivo; further, as UNC-115 activity is required to mediate the morphogenetic effects of constitutively active RAC-2(G12V), UNC-115, an actin-binding protein, is likely to be a downstream effector of RAC-2; GFP::RAC-2 reporters expressed in neurons and neuroblasts reveal localization at cell margins and the nerve ring, the latter suggesting that GFP::RAC-2 associates with the axonal plasma membrane. Paper_evidence: WBPaper00005004
            WBPaper00005607
          Curator_confirmed: WBPerson1843
          Date_last_updated: 18 Jan 2007 00:00:00
      Automated_description: Enables GTP binding activity and GTPase activity. Involved in actin filament organization; axon guidance; and neuron migration. Located in axon and plasma membrane. Expressed in nerve ring and neurons. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant intellectual developmental disorder 48; colon adenoma; and gastrointestinal system cancer (multiple). Is an ortholog of human RAC1 (Rac family small GTPase 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (15)
  Molecular_info: Corresponding_CDS: K03D3.10
    Corresponding_CDS_history: K03D3.10b:wp144
      K03D3.10c:wp151
      K03D3.10d:wp144
    Corresponding_transcript: K03D3.10.1
    Other_sequence: OF00746
      TSC06947_1
      ES564234.1
    Associated_feature: WBsf998845
      WBsf998846
      WBsf1018854
  Experimental_info: RNAi_result (56)
    Expr_pattern: Expr2278
      Expr1011573
      Expr1153530
      Expr2015236
      Expr2033470
    Drives_construct: WBCnstr00035585
    Construct_product: WBCnstr00007682
      WBCnstr00010748
      WBCnstr00035585
    Microarray_results (18)
    Expression_cluster (31)
    Interaction (197)
    WBProcess: WBbiopr:00000015
      WBbiopr:00000107
      WBbiopr:00000111
  Map_info: Map: IV Position: 14.9995 Error: 0.003782
    Positive: Positive_clone: K03D3 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4406
        4621
    Pseudo_map_position
  Reference (44)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene