WormBase Tree Display for Gene: WBGene00004357

WBGene00004357 SMap: S_parent: Sequence: Y51H4A
  Identity: Version: 1
    Name: CGC_name: rho-1 Person_evidence: WBPerson237
      Sequence_name: Y51H4A.3
      Molecular_name: Y51H4A.3a
        Y51H4A.3a.1
        CE25369
        Y51H4A.3b
      Other_name: RhoA Accession_evidence: EMBL L36965
        Y51H4A.B Paper_evidence: WBPaper00004196
        CELE_Y51H4A.3 Accession_evidence: NDB BX284604
      Public_name: rho-1
    DB_info: Database: AceView gene 4R428
        WormQTL gene WBGene00004357
        WormFlux gene WBGene00004357
        NDB locus_tag CELE_Y51H4A.3
        Panther gene CAEEL|WormBase=WBGene00004357|UniProtKB=Q22038
          family PTHR24072
        NCBI gene 178458
        RefSeq protein NR_131670.1
            NM_070558.9
        SwissProt UniProtAcc Q22038
        UniProt_GCRP UniProtAcc Q22038
        RNAcentral URSid URS00007B0C17
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:35 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: rho
    Allele (155)
    Strain: WBStrain00036907
      WBStrain00047246
    RNASeq_FPKM (74)
    GO_annotation (40)
    Ortholog (58)
    Paralog: WBGene00000390 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00000424 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00003239 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00004287 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00012532 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00022177 Caenorhabditis elegans From_analysis: Panther
      WBGene00009059 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00019544 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: rho-1 encodes a Rho GTPase; rho-1 activity is required for regulation of a number of actin filament-based processes including embryonic polarity, cell migration, cell shape changes, muscle contraction, and neurite outgrowth; in addition, RHO-1 is required for both DGK-1- and UNC-13-dependent and independent regulation of synaptic signaling at neuromuscular junctions; as RHO-1 binds DGK-1 in vitro, its regulation of DGK-1-mediated signaling may be direct; in vitro RHO-1 GTPase activity is enhanced by the RGA-3 and RGA-4 GAP proteins, consistent with genetic studies showing that, in the early embryo, RHO-1 activity is required for expression of the rga-3/4(RNAi) hypercontractibility phenotype; RHO-1 is ubiquitously expressed throughout development with notably high expression seen in head neurons and asymmetric expression seen in the anterior cortex of one-cell embryos. Paper_evidence: WBPaper00002066
            WBPaper00004340
            WBPaper00004959
            WBPaper00013415
            WBPaper00027016
            WBPaper00028358
            WBPaper00028408
            WBPaper00031005
          Curator_confirmed: WBPerson1843
          Date_last_updated: 13 Sep 2007 00:00:00
      Automated_description: Enables several functions, including GTP binding activity; GTPase activating protein binding activity; and GTPase activity. Involved in several processes, including actomyosin structure organization; positive regulation of acetylcholine secretion, neurotransmission; and positive regulation of locomotion. Located in cell cortex and cleavage furrow. Expressed widely. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; multiple sclerosis; and ovarian carcinoma. Is an ortholog of human RHOA (ras homolog family member A). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:9256 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:667)
      DOID:11054 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:667)
      DOID:2377 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:667)
      DOID:3459 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:667)
      DOID:4001 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:667,HGNC:669)
      DOID:1612 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:667,HGNC:668,HGNC:669)
  Molecular_info: Corresponding_CDS: Y51H4A.3a
    Corresponding_transcript: Y51H4A.3b
      Y51H4A.3a.1
    Other_sequence (67)
    Associated_feature (14)
  Experimental_info: RNAi_result (53)
    Expr_pattern (11)
    Construct_product (11)
    Antibody: WBAntibody00000091
      WBAntibody00001137
    Microarray_results (18)
    Expression_cluster (119)
    Interaction (279)
  Map_info: Map: IV Position: 15.09 Error: 0.001168
    Positive: Positive_clone: Y51H4A Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (126)
  Remark: Sequence connection from [Spencer AG, Han M]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene