WormBase Tree Display for Gene: WBGene00004357
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| WBGene00004357 | SMap | S_parent | Sequence | Y51H4A | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | rho-1 | Person_evidence | WBPerson237 | |||||
| Sequence_name | Y51H4A.3 | ||||||||
| Molecular_name | Y51H4A.3a | ||||||||
| Y51H4A.3a.1 | |||||||||
| CE25369 | |||||||||
| Y51H4A.3b | |||||||||
| Other_name | RhoA | Accession_evidence | EMBL | L36965 | |||||
| Y51H4A.B | Paper_evidence | WBPaper00004196 | |||||||
| CELE_Y51H4A.3 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | rho-1 | ||||||||
| DB_info | Database | AceView | gene | 4R428 | |||||
| WormQTL | gene | WBGene00004357 | |||||||
| WormFlux | gene | WBGene00004357 | |||||||
| NDB | locus_tag | CELE_Y51H4A.3 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00004357|UniProtKB=Q22038 | |||||||
| family | PTHR24072 | ||||||||
| NCBI | gene | 178458 | |||||||
| RefSeq | protein | NR_131670.1 | |||||||
| NM_070558.9 | |||||||||
| SwissProt | UniProtAcc | Q22038 | |||||||
| UniProt_GCRP | UniProtAcc | Q22038 | |||||||
| RNAcentral | URSid | URS00007B0C17 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:35 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | rho | ||||||||
| Allele (155) | |||||||||
| Strain | WBStrain00036907 | ||||||||
| WBStrain00047246 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (40) | |||||||||
| Ortholog (58) | |||||||||
| Paralog | WBGene00000390 | Caenorhabditis elegans | From_analysis | Panther | |||||
| WormBase-Compara | |||||||||
| WBGene00000424 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00003239 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00004287 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00012532 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00022177 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WBGene00009059 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00019544 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | rho-1 encodes a Rho GTPase; rho-1 activity is required for regulation of a number of actin filament-based processes including embryonic polarity, cell migration, cell shape changes, muscle contraction, and neurite outgrowth; in addition, RHO-1 is required for both DGK-1- and UNC-13-dependent and independent regulation of synaptic signaling at neuromuscular junctions; as RHO-1 binds DGK-1 in vitro, its regulation of DGK-1-mediated signaling may be direct; in vitro RHO-1 GTPase activity is enhanced by the RGA-3 and RGA-4 GAP proteins, consistent with genetic studies showing that, in the early embryo, RHO-1 activity is required for expression of the rga-3/4(RNAi) hypercontractibility phenotype; RHO-1 is ubiquitously expressed throughout development with notably high expression seen in head neurons and asymmetric expression seen in the anterior cortex of one-cell embryos. | Paper_evidence | WBPaper00002066 | |||||
| WBPaper00004340 | |||||||||
| WBPaper00004959 | |||||||||
| WBPaper00013415 | |||||||||
| WBPaper00027016 | |||||||||
| WBPaper00028358 | |||||||||
| WBPaper00028408 | |||||||||
| WBPaper00031005 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 13 Sep 2007 00:00:00 | ||||||||
| Automated_description | Enables several functions, including GTP binding activity; GTPase activating protein binding activity; and GTPase activity. Involved in several processes, including actomyosin structure organization; positive regulation of acetylcholine secretion, neurotransmission; and positive regulation of locomotion. Located in cell cortex and cleavage furrow. Expressed widely. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; multiple sclerosis; and ovarian carcinoma. Is an ortholog of human RHOA (ras homolog family member A). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:667) | ||||
| DOID:11054 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:667) | ||||||
| DOID:2377 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:667) | ||||||
| DOID:3459 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:667) | ||||||
| DOID:4001 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:667,HGNC:669) | ||||||
| DOID:1612 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:667,HGNC:668,HGNC:669) | ||||||
| Molecular_info | Corresponding_CDS | Y51H4A.3a | |||||||
| Corresponding_transcript | Y51H4A.3b | ||||||||
| Y51H4A.3a.1 | |||||||||
| Other_sequence (67) | |||||||||
| Associated_feature (14) | |||||||||
| Experimental_info | RNAi_result (53) | ||||||||
| Expr_pattern (11) | |||||||||
| Construct_product (11) | |||||||||
| Antibody | WBAntibody00000091 | ||||||||
| WBAntibody00001137 | |||||||||
| Microarray_results (18) | |||||||||
| Expression_cluster (119) | |||||||||
| Interaction (279) | |||||||||
| Map_info | Map | IV | Position | 15.09 | Error | 0.001168 | |||
| Positive | Positive_clone | Y51H4A | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00004196 | ||||||||
| WBPaper00004340 | |||||||||
| WBPaper00004959 | |||||||||
| WBPaper00010073 | |||||||||
| WBPaper00011658 | |||||||||
| WBPaper00012556 | |||||||||
| WBPaper00013415 | |||||||||
| WBPaper00017093 | |||||||||
| WBPaper00018840 | |||||||||
| WBPaper00019316 | |||||||||
| WBPaper00023327 | |||||||||
| WBPaper00023414 | |||||||||
| WBPaper00025137 | |||||||||
| WBPaper00026732 | |||||||||
| WBPaper00026774 | |||||||||
| WBPaper00026850 | |||||||||
| WBPaper00026937 | |||||||||
| WBPaper00027016 | |||||||||
| WBPaper00027071 | |||||||||
| WBPaper00027197 | |||||||||
| WBPaper00027235 | |||||||||
| WBPaper00027296 | |||||||||
| WBPaper00027345 | |||||||||
| WBPaper00027672 | |||||||||
| WBPaper00027923 | |||||||||
| WBPaper00027954 | |||||||||
| WBPaper00028001 | |||||||||
| WBPaper00028358 | |||||||||
| WBPaper00028395 | |||||||||
| WBPaper00028408 | |||||||||
| WBPaper00028856 | |||||||||
| WBPaper00030733 | |||||||||
| WBPaper00030892 | |||||||||
| WBPaper00031005 | |||||||||
| WBPaper00031968 | |||||||||
| WBPaper00032195 | |||||||||
| WBPaper00032405 | |||||||||
| WBPaper00032779 | |||||||||
| WBPaper00033015 | |||||||||
| WBPaper00033521 | |||||||||
| WBPaper00034079 | |||||||||
| WBPaper00034638 | |||||||||
| WBPaper00035488 | |||||||||
| WBPaper00036989 | |||||||||
| WBPaper00037522 | |||||||||
| WBPaper00037607 | |||||||||
| WBPaper00037900 | |||||||||
| WBPaper00038084 | |||||||||
| WBPaper00038091 | |||||||||
| WBPaper00038212 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00038635 | |||||||||
| WBPaper00038646 | |||||||||
| WBPaper00038649 | |||||||||
| WBPaper00038650 | |||||||||
| WBPaper00038668 | |||||||||
| WBPaper00038843 | |||||||||
| WBPaper00039146 | |||||||||
| WBPaper00039240 | |||||||||
| WBPaper00039254 | |||||||||
| WBPaper00040835 | |||||||||
| WBPaper00041129 | |||||||||
| WBPaper00041637 | |||||||||
| WBPaper00041771 | |||||||||
| WBPaper00041891 | |||||||||
| WBPaper00042325 | |||||||||
| WBPaper00042732 | |||||||||
| WBPaper00042733 | |||||||||
| WBPaper00042771 | |||||||||
| WBPaper00043301 | |||||||||
| WBPaper00043387 | |||||||||
| WBPaper00043426 | |||||||||
| WBPaper00043453 | |||||||||
| WBPaper00044157 | |||||||||
| WBPaper00044595 | |||||||||
| WBPaper00045955 | |||||||||
| WBPaper00046168 | |||||||||
| WBPaper00046208 | |||||||||
| WBPaper00046221 | |||||||||
| WBPaper00046313 | |||||||||
| WBPaper00046675 | |||||||||
| WBPaper00047112 | |||||||||
| WBPaper00047484 | |||||||||
| WBPaper00048213 | |||||||||
| WBPaper00048291 | |||||||||
| WBPaper00048842 | |||||||||
| WBPaper00049131 | |||||||||
| WBPaper00049309 | |||||||||
| WBPaper00049828 | |||||||||
| WBPaper00050540 | |||||||||
| WBPaper00050656 | |||||||||
| WBPaper00051821 | |||||||||
| WBPaper00052274 | |||||||||
| WBPaper00052765 | |||||||||
| WBPaper00053276 | |||||||||
| WBPaper00054438 | |||||||||
| WBPaper00055035 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00055279 | |||||||||
| WBPaper00055350 | |||||||||
| WBPaper00055566 | |||||||||
| WBPaper00056137 | |||||||||
| WBPaper00056801 | |||||||||
| WBPaper00056927 | |||||||||
| WBPaper00057747 | |||||||||
| WBPaper00057748 | |||||||||
| WBPaper00058265 | |||||||||
| WBPaper00059624 | |||||||||
| WBPaper00060754 | |||||||||
| WBPaper00060897 | |||||||||
| WBPaper00061150 | |||||||||
| WBPaper00061290 | |||||||||
| WBPaper00061388 | |||||||||
| WBPaper00061553 | |||||||||
| WBPaper00061837 | |||||||||
| WBPaper00062045 | |||||||||
| WBPaper00062488 | |||||||||
| WBPaper00062625 | |||||||||
| WBPaper00063057 | |||||||||
| WBPaper00064064 | |||||||||
| WBPaper00064561 | |||||||||
| WBPaper00064780 | |||||||||
| WBPaper00064804 | |||||||||
| WBPaper00064936 | |||||||||
| WBPaper00065275 | |||||||||
| WBPaper00066087 | |||||||||
| Remark | Sequence connection from [Spencer AG, Han M] | ||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
