WormBase Tree Display for Expr_pattern: Expr2278
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| Expr2278 | Expression_of | Gene | WBGene00004287 | |
|---|---|---|---|---|
| Reflects_endogenous_expression_of | WBGene00004287 | |||
| Expression_data | Anatomy_term | WBbt:0003679 | Certain | |
| WBbt:0006749 | Certain | |||
| GO_term | GO:0005886 | |||
| GO:0030424 | ||||
| Subcellular_localization | Animals harboring the unc-115::gfp::rac-2 transgene showed expression of GFP::RAC-2 that accumulate at the cell margins of neuroblasts and neurons as well as in the nerve ring. Nerve ring accumulation suggests that GFP::RAC-2 localized to the plasma membranes of axons. | |||
| Type | Reporter_gene | |||
| Picture | WBPicture0000007523 | |||
| Remark | Wild-type rac-2 and rac-2(G12V)-coding regions displayed indistinguishable localization, and gfp::rac-2(G12V) caused dominant effects on PDE development. Expression of GFP from a transgene that contained a frameshift between the gfp- and rac-2-coding regions failed to accumulate at the cell margins and in the nerve ring and instead was uniformly distributed in the cytoplasm, indicating that RAC-2 sequences mediate accumulation of GFP::RAC-2 at the plasma membrane, presumably via C-terminal CAAX motif. | |||
| Reference | WBPaper00005607 | |||
| Transgene | WBTransgene00027979 |
