WormBase Tree Display for Gene: WBGene00009165
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| WBGene00009165 | SMap | S_parent | Sequence | F26E4 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | gpx-1 | Person_evidence | WBPerson261 | |||||
| Sequence_name | F26E4.12 | ||||||||
| Molecular_name | F26E4.12 | ||||||||
| F26E4.12.1 | |||||||||
| CE09696 | |||||||||
| Other_name | CELE_F26E4.12 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | gpx-1 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:49 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 20 Jul 2012 14:20:02 | WBPerson2970 | Name_change | CGC_name | gpx-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | gpx | ||||||||
| Allele (19) | |||||||||
| Strain | WBStrain00001879 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (19) | |||||||||
| Ortholog (58) | |||||||||
| Paralog | WBGene00007516 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00007517 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00020373 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00011045 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Inparanoid_8 | |||||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00022377 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00019846 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00018850 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| Structured_description | Concise_description | gpx-1 encodes a phospholipid hydroperoxide glutathione peroxidase; GPX-1 is predicted to catalyze the reduction of phospholipid hydroperoxides with glutathione; loss of gpx-1 activity via RNAi results in increased intestinal dipeptide uptake and increased cellular levels of the unsaturated aldehyde 4-hydroxynonenal (4-HNE), a lipid peroxidation product. | Paper_evidence | WBPaper00040287 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 25 Mar 2014 00:00:00 | ||||||||
| Automated_description | Enables phospholipid-hydroperoxide glutathione peroxidase activity. Involved in cellular response to reactive oxygen species and regulation of peptide transport. Located in cytosol and nucleus. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple) and spondylometaphyseal dysplasia Sedaghatian type. Is an ortholog of human GPX4 (glutathione peroxidase 4). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4556) | ||||
| DOID:3717 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4556) | ||||||
| DOID:1184 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4556) | ||||||
| DOID:219 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4556) | ||||||
| DOID:10591 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4556) | ||||||
| DOID:0112298 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4556) | ||||||
| DOID:0050861 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:4556) | ||||||
| Molecular_info | Corresponding_CDS | F26E4.12 | |||||||
| Corresponding_transcript | F26E4.12.1 | ||||||||
| Other_sequence (33) | |||||||||
| Associated_feature | WBsf643629 | ||||||||
| WBsf643630 | |||||||||
| WBsf656796 | |||||||||
| WBsf218345 | |||||||||
| WBsf218346 | |||||||||
| WBsf218347 | |||||||||
| Experimental_info | RNAi_result (17) | ||||||||
| Expr_pattern | Expr5875 | ||||||||
| Expr1013421 | |||||||||
| Expr1033997 | |||||||||
| Expr1149552 | |||||||||
| Expr2012215 | |||||||||
| Expr2030451 | |||||||||
| Drives_construct | WBCnstr00002672 | ||||||||
| WBCnstr00032407 | |||||||||
| Construct_product | WBCnstr00032407 | ||||||||
| Microarray_results (17) | |||||||||
| Expression_cluster (152) | |||||||||
| Interaction (109) | |||||||||
| Map_info | Map | I | Position | 3.89832 | |||||
| Positive | Positive_clone | F26E4 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (11) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
