WormBase Tree Display for Gene: WBGene00009165

WBGene00009165 SMap: S_parent: Sequence: F26E4
  Identity: Version: 2
    Name: CGC_name: gpx-1 Person_evidence: WBPerson261
      Sequence_name: F26E4.12
      Molecular_name: F26E4.12
        F26E4.12.1
        CE09696
      Other_name: CELE_F26E4.12 Accession_evidence: NDB BX284601
      Public_name: gpx-1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:49 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 20 Jul 2012 14:20:02 WBPerson2970 Name_change: CGC_name: gpx-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: gpx
    Allele (19)
    Strain: WBStrain00001879
    RNASeq_FPKM (74)
    GO_annotation (19)
    Ortholog (58)
    Paralog: WBGene00007516 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00007517 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00020373 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00011045 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00022377 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00019846 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00018850 Caenorhabditis elegans From_analysis: Panther
    Structured_description: Concise_description: gpx-1 encodes a phospholipid hydroperoxide glutathione peroxidase; GPX-1 is predicted to catalyze the reduction of phospholipid hydroperoxides with glutathione; loss of gpx-1 activity via RNAi results in increased intestinal dipeptide uptake and increased cellular levels of the unsaturated aldehyde 4-hydroxynonenal (4-HNE), a lipid peroxidation product. Paper_evidence: WBPaper00040287
          Curator_confirmed: WBPerson1843
          Date_last_updated: 25 Mar 2014 00:00:00
      Automated_description: Enables phospholipid-hydroperoxide glutathione peroxidase activity. Involved in cellular response to reactive oxygen species and regulation of peptide transport. Located in cytosol and nucleus. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple) and spondylometaphyseal dysplasia Sedaghatian type. Is an ortholog of human GPX4 (glutathione peroxidase 4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:9256 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4556)
      DOID:3717 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4556)
      DOID:1184 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4556)
      DOID:219 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4556)
      DOID:10591 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4556)
      DOID:0112298 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4556)
      DOID:0050861 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4556)
  Molecular_info: Corresponding_CDS: F26E4.12
    Corresponding_transcript: F26E4.12.1
    Other_sequence (33)
    Associated_feature: WBsf643629
      WBsf643630
      WBsf656796
      WBsf218345
      WBsf218346
      WBsf218347
  Experimental_info: RNAi_result (17)
    Expr_pattern: Expr5875
      Expr1013421
      Expr1033997
      Expr1149552
      Expr2012215
      Expr2030451
    Drives_construct: WBCnstr00002672
      WBCnstr00032407
    Construct_product: WBCnstr00032407
    Microarray_results (17)
    Expression_cluster: WBPaper00024505:pharyngeal_enriched
      WBPaper00037950:all-neurons_embryo_enriched
      WBPaper00037950:all-neurons_L1-larva_expressed
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:AVA-neuron_L1-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:excretory-cell_L2-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:intestine_larva_enriched
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038168:lin-15B(n744)_upregulated
      WBPaper00038438:Harposporium_24hr_upregulated_RNAseq
      WBPaper00042215:wdr-23(tm1817)_upregulated
      WBPaper00044260:1-methylnicotinamide_upregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
      WBPaper00045390:tunicamycin_upregulated
      WBPaper00045521:Spermatogenic
      WBPaper00045809:rsd-2(yp10)_downregulated
      WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
      WBPaper00046509:lin-35(n745)_downregulated
      WBPaper00048923:Aging_regulated
      WBPaper00048988:neuron_expressed
      WBPaper00049217:TCER-1_upregulated
      WBPaper00049545:cco-1(RNAi)_downregulated
      WBPaper00049545:jmjd-3.1(+)_downregulated
      WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_downregulated
      WBPaper00050182:lmn-1(L535P)_upregulated
      WBPaper00050344:AFD-neuron_enriched
      WBPaper00050344:ASER-neuron_enriched
      WBPaper00050370:dpy-21(e428)_L3_downregulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050726:OsmoticStress_regulated_Food
      WBPaper00050726:starvation_regulated_HighSalt
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050887:Lactoferrin_upregulated
      WBPaper00050990:intestine_enriched
      WBPaper00050990:intestine_expressed
      WBPaper00051245:body-wall-muscle_cytoplasm_expressed
      WBPaper00051245:epidermis_cytoplasm_expressed
      WBPaper00051245:epidermis_nucleus_expressed
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00053302:zidovudine_24h_regulated
      WBPaper00053388:dauer_regulated_Cluster1
      WBPaper00053599:female_vs_male_downregulated
      WBPaper00053599:mitosis_vs_meiosis_downregulated
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055626:pry-1(mu38)_downregulated
      WBPaper00055648:sperm_expressed
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056161:male_enriched_siRNA
      WBPaper00056275:P.aeruginosa_upregulated
      WBPaper00056275:P.aeruginosa_upregulated_pmk-1(km25)_dependent
      WBPaper00056284:ints-4(RNAi)_downregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
      WBPaper00056809:smn-1(ok355)_downregulated
      WBPaper00057041:spc-1(cas971)_downregulated
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00058711:skn-1(lax188)_upregulated
      WBPaper00058948:PA14_downregulated
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059566:wdr-23(mac32)_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060434:pH4.33_vs_pH6.33_uprgulated
      WBPaper00060661:hypoxia_upregulated
      WBPaper00060661:sensory-neuron_enriched
      WBPaper00060909:atfs-1(cmh15)_downregulated
      WBPaper00061007:HB101_upregulated
      WBPaper00061007:S.aquatilis_upregulated
      WBPaper00061341:28C_48h_downregulated
      WBPaper00061527:T24C12.3-C01G10.9
      WBPaper00061530:nhr-49(e2144)_downregulated
      WBPaper00061651:I3_enriched
      WBPaper00061651:M2_enriched
      WBPaper00061651:M4_enriched
      WBPaper00061651:M5_enriched
      WBPaper00061651:MI_enriched
      WBPaper00062193:skn-1(RNAi)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062345:bortezomib_4h_upregulated_zip-1(jy13)
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00063930:BRD-1_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064871:PA14_upregulated_AWA
      WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
      WBPaper00065029:cadmium_upregulated
      WBPaper00065096:25C_vs_20C_downregulated
      WBPaper00065096:Day10_vs_Day1_downregulated
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065373:sek-1(km4)_downregulated_cisplatin
      WBPaper00065392:Lb.gasseri_upregulated
      WBPaper00065392:Lb.plantarum_upregulated
      WBPaper00065392:Lb.rhamnosus_upregulated
      WBPaper00065835:Day11_vs_Day1_downregulated
      WBPaper00065841:56_0
      WBPaper00065841:58_1
      WBPaper00065841:59_0
      WBPaper00065841:95_0
      WBPaper00065841:96_0
      WBPaper00065841:125_0
      WBPaper00065841:126_0
      WBPaper00065841:135_0
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00066062:xrep-4(lax137)_upregulated
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00025141:unc-4::GFP_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026980:intestine_enriched
      WBPaper00028482:PA14_upregulated
      WBPaper00028789:PA14_vs_OP50_upregulated_4hr
      WBPaper00030839:Embryo_Pan_Neuronal
      WBPaper00031003:hlh_1_enriched
      WBPaper00031184:acrylamide_upregulated
      WBPaper00032165:A_to_C_transit_increased
      WBPaper00032165:differentially_expressed_with_age_medoid_2
      WBPaper00032948:FedUp
      WBPaper00033099:organophosphorus_pesticide_regulated
      WBPaper00034757:up_by_oxidative_stress
      WBPaper00036286:Pattern_G
      WBPaper00038231:Cry5B_1.5-fold_downregulated
      WBPaper00038427:lin-54_embryo_changed
      WBPaper00038427:lin-54_germline_changed
      WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
      WBPaper00040858:eQTL_regulated_developing
      WBPaper00040858:eQTL_regulated_juvenile
      WBPaper00040858:eQTL_regulated_old
      WBPaper00040858:eQTL_regulated_reproductive
      WBPaper00040963:Q50_up
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_prime
      WBPaper00041606:CE_X.nematophila_regulated
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
      WBPaper00045263:0.1mM-paraquat_downregulated
      WBPaper00055899:nitrotriazolone_regulated
      WBPaper00057098:SiO2-nanoparticles_downregulated
      [cgc5767]:cluster_26
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(41_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
    Interaction (109)
  Map_info: Map: I Position: 3.89832
    Positive: Positive_clone: F26E4 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (11)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene