WormBase Tree Display for Gene: WBGene00009165

WBGene00009165 SMap: S_parent: Sequence: F26E4
  Identity: Version: 2
    Name: CGC_name: gpx-1 Person_evidence: WBPerson261
      Sequence_name: F26E4.12
      Molecular_name: F26E4.12
        F26E4.12.1
        CE09696
      Other_name: CELE_F26E4.12 Accession_evidence: NDB BX284601
      Public_name: gpx-1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:49 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 20 Jul 2012 14:20:02 WBPerson2970 Name_change: CGC_name: gpx-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: gpx
    Allele (19)
    Strain: WBStrain00001879
    RNASeq_FPKM (74)
    GO_annotation (19)
    Ortholog (58)
    Paralog: WBGene00007516 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00007517 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00020373 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00011045 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00022377 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00019846 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00018850 Caenorhabditis elegans From_analysis: Panther
    Structured_description: Concise_description: gpx-1 encodes a phospholipid hydroperoxide glutathione peroxidase; GPX-1 is predicted to catalyze the reduction of phospholipid hydroperoxides with glutathione; loss of gpx-1 activity via RNAi results in increased intestinal dipeptide uptake and increased cellular levels of the unsaturated aldehyde 4-hydroxynonenal (4-HNE), a lipid peroxidation product. Paper_evidence: WBPaper00040287
          Curator_confirmed: WBPerson1843
          Date_last_updated: 25 Mar 2014 00:00:00
      Automated_description: Enables phospholipid-hydroperoxide glutathione peroxidase activity. Involved in cellular response to reactive oxygen species and regulation of peptide transport. Located in cytosol and nucleus. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple) and spondylometaphyseal dysplasia Sedaghatian type. Is an ortholog of human GPX4 (glutathione peroxidase 4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:9256 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4556)
      DOID:3717 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4556)
      DOID:1184 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4556)
      DOID:219 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4556)
      DOID:10591 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4556)
      DOID:0112298 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4556)
      DOID:0050861 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:4556)
  Molecular_info: Corresponding_CDS: F26E4.12
    Corresponding_transcript: F26E4.12.1
    Other_sequence (33)
    Associated_feature: WBsf643629
      WBsf643630
      WBsf656796
      WBsf218345
      WBsf218346
      WBsf218347
  Experimental_info: RNAi_result (17)
    Expr_pattern: Expr5875
      Expr1013421
      Expr1033997
      Expr1149552
      Expr2012215
      Expr2030451
    Drives_construct: WBCnstr00002672
      WBCnstr00032407
    Construct_product: WBCnstr00032407
    Microarray_results (17)
    Expression_cluster (152)
    Interaction: WBInteraction000040310
      WBInteraction000043437
      WBInteraction000046251
      WBInteraction000111165
      WBInteraction000111190
      WBInteraction000111782
      WBInteraction000112028
      WBInteraction000112081
      WBInteraction000112470
      WBInteraction000112473
      WBInteraction000112542
      WBInteraction000113336
      WBInteraction000113602
      WBInteraction000116093
      WBInteraction000116217
      WBInteraction000118172
      WBInteraction000118248
      WBInteraction000119124
      WBInteraction000122259
      WBInteraction000124081
      WBInteraction000125690
      WBInteraction000133667
      WBInteraction000133718
      WBInteraction000143915
      WBInteraction000144714
      WBInteraction000156850
      WBInteraction000156896
      WBInteraction000161442
      WBInteraction000170991
      WBInteraction000179011
      WBInteraction000180154
      WBInteraction000187913
      WBInteraction000189487
      WBInteraction000191645
      WBInteraction000199934
      WBInteraction000203296
      WBInteraction000207498
      WBInteraction000210877
      WBInteraction000216886
      WBInteraction000217311
      WBInteraction000219505
      WBInteraction000219507
      WBInteraction000230852
      WBInteraction000231483
      WBInteraction000237509
      WBInteraction000242163
      WBInteraction000248293
      WBInteraction000257941
      WBInteraction000259070
      WBInteraction000259071
      WBInteraction000263731
      WBInteraction000268205
      WBInteraction000272364
      WBInteraction000283788
      WBInteraction000284593
      WBInteraction000285336
      WBInteraction000285813
      WBInteraction000285814
      WBInteraction000301476
      WBInteraction000312737
      WBInteraction000344111
      WBInteraction000348488
      WBInteraction000351051
      WBInteraction000357534
      WBInteraction000366674
      WBInteraction000381191
      WBInteraction000384869
      WBInteraction000384870
      WBInteraction000391785
      WBInteraction000396420
      WBInteraction000397276
      WBInteraction000418564
      WBInteraction000423626
      WBInteraction000444798
      WBInteraction000453006
      WBInteraction000458705
      WBInteraction000461686
      WBInteraction000462767
      WBInteraction000464898
      WBInteraction000465293
      WBInteraction000465552
      WBInteraction000465946
      WBInteraction000466328
      WBInteraction000468233
      WBInteraction000468249
      WBInteraction000468642
      WBInteraction000468954
      WBInteraction000469376
      WBInteraction000470051
      WBInteraction000471343
      WBInteraction000471782
      WBInteraction000472421
      WBInteraction000472616
      WBInteraction000472953
      WBInteraction000472994
      WBInteraction000473224
      WBInteraction000473600
      WBInteraction000474536
      WBInteraction000474926
      WBInteraction000474940
      WBInteraction000475142
      WBInteraction000475393
      WBInteraction000475402
      WBInteraction000519721
      WBInteraction000519725
      WBInteraction000519730
      WBInteraction000524482
      WBInteraction000570710
      WBInteraction000580634
  Map_info: Map: I Position: 3.89832
    Positive: Positive_clone: F26E4 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (11)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene