WormBase Tree Display for Gene: WBGene00006987
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WBGene00006987 | SMap | S_parent | Sequence | CHROMOSOME_III | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | zmp | ||||||
Allele (105) | |||||||
Legacy_information | [Kramer JM] zmp for Zinc MetalloProtease. cg115 is deletion derivative of pk205tci, no apparent phenotype. Overexpression of zmp-1 leads to abnormality, degradation of extracellular matrix components. cDNAs map to C28H8/EGAP1. Encodes predicted protein related to matrix metalloproteases. | ||||||
Strain | WBStrain00030910 | ||||||
WBStrain00030915 | |||||||
WBStrain00030928 | |||||||
WBStrain00002340 | |||||||
WBStrain00005036 | |||||||
WBStrain00053461 | |||||||
WBStrain00053459 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (22) | |||||||
Ortholog (44) | |||||||
Paralog | WBGene00016283 | Caenorhabditis elegans | From_analysis | TreeFam | |||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00020646 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00019212 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00012364 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00010423 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
Panther | |||||||
WormBase-Compara | |||||||
WBGene00012185 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00010524 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00194737 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
Structured_description | Concise_description | zmp-1 encodes a zinc matrix metalloproteinase that enables anchor cell (AC) invasion during postembryonic vulval development; ZMP-1's proteinase activity has been confirmed in vitro; N-terminus to C-terminus, ZMP-1 is predicted to have a signal sequence, peptidoglycan-binding domain, a central matrix protease domain, a coiled-coil domain, and four hemopexin domains; ZMP-1 is expressed in AC during larval development, vulD and vulE in larvae and adults, and vulA in young adults onward; ZMP-1 is expressed in AC at the time it invades the basement membrane (L3 larval stage), and is localized to puncta often concentrated at the invasive basolateral membrane; ZMP-1::GFP diffuses from AC to utse cytoplasm upon fusion of these cells; ZMP-1 expression in AC requires EGL-43 (perhaps directly), and FOS-1A (indirectly); transcription of zmp-1 in AC, vulA, and vulE is driven by physically distinct sites in the zmp-1 5' flanking sequence; other regulators of ZMP-1 expression in other cell types include COG-1, EGL-38, LIN-11, LIN-29, and NHR-67; zmp-1(cg115) and zmp-1(RNAi) animals have no grossly obvious phenotypes, but null zmp-1(cg115) mutations enhance a subtle defect of AC invasion seen with null cdh-3(pk87) or him-4(rh319) mutations. | Paper_evidence (15) | ||||
Curator_confirmed | WBPerson567 | ||||||
Date_last_updated | 25 Oct 2007 00:00:00 | ||||||
Automated_description | Enables metallopeptidase activity. Involved in basement membrane disassembly. Located in cell surface. Expressed in several structures, including P6.paal; P6.paar; P6.papl; gonad; and vulval cell. Human ortholog(s) of this gene implicated in prostate cancer and transitional cell carcinoma. Is an ortholog of human MMP15 (matrix metallopeptidase 15) and MMP24 (matrix metallopeptidase 24). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed (2) | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:10283 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7161) | ||
DOID:2671 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7161) | ||||
Molecular_info | Corresponding_CDS | EGAP1.3 | |||||
Corresponding_transcript | EGAP1.3.1 | ||||||
Associated_feature (14) | |||||||
Experimental_info | RNAi_result | WBRNAi00028231 | Inferred_automatically | RNAi_primary | |||
WBRNAi00114621 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00011309 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00005962 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00076175 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00107794 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00089025 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00041425 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00061775 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern (13) | |||||||
Drives_construct (17) | |||||||
Construct_product | WBCnstr00004675 | ||||||
WBCnstr00034050 | |||||||
Microarray_results (17) | |||||||
Expression_cluster (174) | |||||||
Interaction (37) | |||||||
Map_info | Map | III | Position | -1.43269 | Error | 0.000555 | |
Positive | Positive_clone | C28H8 | |||||
EGAP1 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | Multi_point | 4769 | |||||
Pseudo_map_position | |||||||
Reference (38) | |||||||
Remark | C28H8 and EGAP borders : found metalloprotease blastX matches and made gene corresponding to zmp-1,[sdm 000904] | ||||||
Sequence correction updated to EGAP1.3 from EGAP1.2 (this may have been an error) [krb 020717] | |||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |