WormBase Tree Display for Gene: WBGene00006987
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| WBGene00006987 | SMap | S_parent | Sequence | CHROMOSOME_III | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | zmp-1 | Person_evidence | WBPerson345 | |||||
| Sequence_name | EGAP1.3 | ||||||||
| Molecular_name | EGAP1.3 | ||||||||
| EGAP1.3.1 | |||||||||
| CE30930 | |||||||||
| Other_name | CELE_EGAP1.3 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | zmp-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:44 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | zmp | ||||||||
| Allele (105) | |||||||||
| Legacy_information | [Kramer JM] zmp for Zinc MetalloProtease. cg115 is deletion derivative of pk205tci, no apparent phenotype. Overexpression of zmp-1 leads to abnormality, degradation of extracellular matrix components. cDNAs map to C28H8/EGAP1. Encodes predicted protein related to matrix metalloproteases. | ||||||||
| Strain | WBStrain00030910 | ||||||||
| WBStrain00030915 | |||||||||
| WBStrain00030928 | |||||||||
| WBStrain00002340 | |||||||||
| WBStrain00005036 | |||||||||
| WBStrain00053461 | |||||||||
| WBStrain00053459 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (22) | |||||||||
| Ortholog (44) | |||||||||
| Paralog | WBGene00016283 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00020646 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00019212 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00012364 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00010423 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Panther | |||||||||
| WormBase-Compara | |||||||||
| WBGene00012185 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00010524 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| WBGene00194737 | Caenorhabditis elegans | From_analysis | Panther | ||||||
| WormBase-Compara | |||||||||
| Structured_description | Concise_description | zmp-1 encodes a zinc matrix metalloproteinase that enables anchor cell (AC) invasion during postembryonic vulval development; ZMP-1's proteinase activity has been confirmed in vitro; N-terminus to C-terminus, ZMP-1 is predicted to have a signal sequence, peptidoglycan-binding domain, a central matrix protease domain, a coiled-coil domain, and four hemopexin domains; ZMP-1 is expressed in AC during larval development, vulD and vulE in larvae and adults, and vulA in young adults onward; ZMP-1 is expressed in AC at the time it invades the basement membrane (L3 larval stage), and is localized to puncta often concentrated at the invasive basolateral membrane; ZMP-1::GFP diffuses from AC to utse cytoplasm upon fusion of these cells; ZMP-1 expression in AC requires EGL-43 (perhaps directly), and FOS-1A (indirectly); transcription of zmp-1 in AC, vulA, and vulE is driven by physically distinct sites in the zmp-1 5' flanking sequence; other regulators of ZMP-1 expression in other cell types include COG-1, EGL-38, LIN-11, LIN-29, and NHR-67; zmp-1(cg115) and zmp-1(RNAi) animals have no grossly obvious phenotypes, but null zmp-1(cg115) mutations enhance a subtle defect of AC invasion seen with null cdh-3(pk87) or him-4(rh319) mutations. | Paper_evidence (15) | ||||||
| Curator_confirmed | WBPerson567 | ||||||||
| Date_last_updated | 25 Oct 2007 00:00:00 | ||||||||
| Automated_description | Enables metallopeptidase activity. Involved in basement membrane disassembly. Located in cell surface. Expressed in several structures, including P6.paal; P6.paar; P6.papl; gonad; and vulval cell. Human ortholog(s) of this gene implicated in prostate cancer and transitional cell carcinoma. Is an ortholog of human MMP15 (matrix metallopeptidase 15) and MMP24 (matrix metallopeptidase 24). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:10283 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7161) | ||||
| DOID:2671 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7161) | ||||||
| Molecular_info | Corresponding_CDS | EGAP1.3 | |||||||
| Corresponding_transcript | EGAP1.3.1 | ||||||||
| Associated_feature (14) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00028231 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00114621 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00011309 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00005962 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00076175 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00107794 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00089025 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00041425 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00061775 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (13) | |||||||||
| Drives_construct (17) | |||||||||
| Construct_product | WBCnstr00004675 | ||||||||
| WBCnstr00034050 | |||||||||
| Microarray_results (17) | |||||||||
| Expression_cluster (174) | |||||||||
| Interaction (37) | |||||||||
| Map_info | Map | III | Position | -1.43269 | Error | 0.000555 | |||
| Positive | Positive_clone | C28H8 | |||||||
| EGAP1 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | Multi_point | 4769 | |||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00004463 | ||||||||
| WBPaper00004481 | |||||||||
| WBPaper00005792 | |||||||||
| WBPaper00005842 | |||||||||
| WBPaper00005989 | |||||||||
| WBPaper00013312 | |||||||||
| WBPaper00016781 | |||||||||
| WBPaper00017586 | |||||||||
| WBPaper00025135 | |||||||||
| WBPaper00025717 | |||||||||
| WBPaper00025842 | |||||||||
| WBPaper00025864 | |||||||||
| WBPaper00026611 | |||||||||
| WBPaper00026742 | |||||||||
| WBPaper00027316 | |||||||||
| WBPaper00027877 | |||||||||
| WBPaper00027992 | |||||||||
| WBPaper00028559 | |||||||||
| WBPaper00028986 | |||||||||
| WBPaper00029327 | |||||||||
| WBPaper00030702 | |||||||||
| WBPaper00032452 | |||||||||
| WBPaper00033507 | |||||||||
| WBPaper00035117 | |||||||||
| WBPaper00035457 | |||||||||
| WBPaper00036427 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00038871 | |||||||||
| WBPaper00039483 | |||||||||
| WBPaper00045833 | |||||||||
| WBPaper00051048 | |||||||||
| WBPaper00052102 | |||||||||
| WBPaper00053373 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00056095 | |||||||||
| WBPaper00061665 | |||||||||
| WBPaper00062469 | |||||||||
| WBPaper00064788 | |||||||||
| Remark | C28H8 and EGAP borders : found metalloprotease blastX matches and made gene corresponding to zmp-1,[sdm 000904] | ||||||||
| Sequence correction updated to EGAP1.3 from EGAP1.2 (this may have been an error) [krb 020717] | |||||||||
| Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||||
| Method | Gene |
