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WormBase Tree Display for Gene: WBGene00006971

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Name Class

WBGene00006971SMapS_parentSequenceR13F6
IdentityVersion1
NameCGC_namezak-1Person_evidenceWBPerson1315
Sequence_nameR13F6.6
Molecular_nameR13F6.6a
R13F6.6a.1
CE39026
R13F6.6b
CE32708
R13F6.6c
CE45943
R13F6.6a.2
R13F6.6b.1
R13F6.6b.2
R13F6.6c.1
Other_nameCELE_R13F6.6Accession_evidenceNDBBX284603
Public_namezak-1
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:44WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classzak
Allele (57)
StrainWBStrain00051212
RNASeq_FPKM (74)
GO_annotation (22)
Ortholog (29)
Paralog (11)
Structured_descriptionConcise_descriptionzak-1 encodes a mitogen-activated protein kinase kinase kinase (MAPKKK) that is orthologous to mammalian zipper sterile-motif kinases (ZAKs); ZAK-1 is predicted to play a role in regulation of MAPK signaling cascades and large-scale RNAi experiments indicate that its activity is required for proper embryonic and larval development.Paper_evidenceWBPaper00004403
WBPaper00005654
WBPaper00013126
WBPaper00024295
Curator_confirmedWBPerson1843
Date_last_updated14 Aug 2006 00:00:00
Automated_descriptionEnables MAP kinase kinase kinase activity. Involved in stress-activated MAPK cascade. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in centronuclear myopathy 6 with fiber-type disproportion. Is an ortholog of human MAP3K20 (mitogen-activated protein kinase kinase kinase 20).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0111221Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:17797)
Molecular_infoCorresponding_CDSR13F6.6a
R13F6.6b
R13F6.6c
Corresponding_CDS_historyR13F6.6:wp82
R13F6.6a:wp147
R13F6.6a:wp225
Corresponding_transcriptR13F6.6a.1
R13F6.6a.2
R13F6.6b.1
R13F6.6b.2
R13F6.6c.1
Other_sequenceAS11924
JI165508.1
CJC06263_1
MC05171
CR05032
HGC05974
HG09306
ASC04037_1
CRC02818_1
MCC05841_1
Experimental_infoRNAi_result (13)
Expr_patternExpr1010577
Expr1032978
Expr1155575
Expr2018122
Expr2036259
Drives_constructWBCnstr00034062
Construct_productWBCnstr00034062
Microarray_results (28)
Expression_clusterWBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00036375:enriched_in_PVD_OLL
WBPaper00037682:sma-2_upregulated
WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
WBPaper00040221:DAF-12_target_ALF4
WBPaper00042561:smg-2(RNAi)_upregulated
WBPaper00042561:smgl-1(RNAi)_upregulated
WBPaper00044736:flat_dev_expression
WBPaper00045521:Gender_Neutral
WBPaper00046121:ecdoderm_unique
WBPaper00050344:PLM-neuron_enriched
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
WBPaper00050990:intestine_enriched
WBPaper00050990:intestine_expressed
WBPaper00051305:vit-2(ac3)_upregulated
WBPaper00051558:aging_regulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053295:lin-22(ot269)_upregulated
WBPaper00053302:alovudine_24h_regulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053308:SMG-2_associated_NMD(-)_upregulated_ClassI
WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq
WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq
WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
WBPaper00054758:alg-1(gk204)_upregulated
WBPaper00055354:eat-2(ad1116)_downregulated
WBPaper00055354:Rapamycin-Metformin_upregulated
WBPaper00055354:Rapamycin_downregulated
WBPaper00055354:Rifampicin_upregulated
WBPaper00055827:daf-2(e1370)_upregulated
WBPaper00055862:antimycin_damt-1(gk961032)_regulated
WBPaper00055971:nhl-2(ok818)_25C_downregulated
WBPaper00056034:pals-22(jy3)_upregulated
WBPaper00056034:pals-25(jy9)_upregulated
WBPaper00056284:ints-5(RNAi)_upregulated
WBPaper00056443:DietaryRestriction_upregulated
WBPaper00056443:sek-1(km4)_upregulated
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00057068:ints-4(RNAi)_upregulated
WBPaper00057288:Cold_downregulated_transcript
WBPaper00058691:cfp-1(tm6369)_downregulated
WBPaper00058691:sin-3(tm1276)_downregulated
WBPaper00058948:PA14_downregulated
WBPaper00059027:neuron-synapses_depleted
WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
WBPaper00059356:BAZ-2_SET-6_interacting
WBPaper00059754:C.neoformans_H99_upregulated
WBPaper00060661:sensory-neuron_enriched
WBPaper00060909:atfs-1(cmh15)_downregulated
WBPaper00061007:S.aquatilis_upregulated
WBPaper00061340:AMso
WBPaper00061340:PVR
WBPaper00061439:unc-30(ok613)_downregulated
WBPaper00061466:nath-10(icb102)_downregulated
WBPaper00061479:hda-1(ne4752)_upregulated
WBPaper00061479:mep-1(ne4629)_upregulated
WBPaper00061527:acy-2-F35C5.11
WBPaper00061527:R07G3.8_9125-ric-4_17408
WBPaper00062056:lin-35(n745)_upregulated
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062193:hsf-1(RNAi)_downregulated
WBPaper00062193:skn-1(RNAi)_downregulated
WBPaper00062325:muscle_enriched_coding-RNA
WBPaper00062590:Aging_upregulated_coelomocyte
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064315:mes-3(bn199)_upregulated_PGCs
WBPaper00064494:postdauer_upregulated_AWA
WBPaper00064637:cox-5B(RNAi)_upregulated
WBPaper00065749:Heat-Shock-With-Recovery_upregulated_N2
WBPaper00065835:Day11_vs_Day1_upregulated
WBPaper00065841:13_0
WBPaper00065841:34_0
WBPaper00065841:34_1
WBPaper00065841:105_0
WBPaper00065975:P-body_vs_oocyte_enriched
WBPaper00065975:P-body_vs_WholeAnimal_enriched
WBPaper00065993:glp-1(e2141)_upregulated
WBPaper00065995:M.humicola-extract_downregulated_old-1(ok1273)
WBPaper00066232:ash-2(RNAi)_downregulated_WT
WBPaper00066232:hsf-1(RNAi)_upregulated_ash-2
cgc4386_cluster_6_5
cgc4489_group_7
WBPaper00025141:N2_Expressed_Genes
WBPaper00026929:Resveratrol_regulated_daf-16
WBPaper00031252:AIN-2_IP_enriched
WBPaper00032948:StarveUp2
WBPaper00035227:heat_shock_regulated
WBPaper00038231:Cry5B_1.5-fold_upregulated
WBPaper00039866:ClassComp_daf-19_downregulated
WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up
WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
WBPaper00040858:eQTL_age_regulated_aging
WBPaper00040963:TA100_up
WBPaper00040963:TA200_up
WBPaper00040963:TA300_up
WBPaper00041174:environmental
WBPaper00041174:genotypic
WBPaper00041174:genotypic_and_environmental
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_24h
WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00041939:control_vs_UVC-exposed_51h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
WBPaper00042574:JU1580_OrsayVirus_upregulated
WBPaper00047070:N2_starvation_upregulated
WBPaper00047070:xpa-1_UV_upregulated
WBPaper00048563:L1_DD_enriched
WBPaper00048637:lin-35(n745)_starvation_upregulated
WBPaper00053236:Starvation_regulated_GR1307
WBPaper00053236:Starvation_regulated_N2
WBPaper00053550:daf-19(m86)_downregulated_3-fold-embryo
Map_infoMapIIIPosition-0.926358Error0.00147
PositivePositive_cloneR13F6Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point4762
Pseudo_map_position
ReferenceWBPaper00018823
WBPaper00019662
WBPaper00024295
WBPaper00038491
WBPaper00055090
WBPaper00059543
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene