WormBase Tree Display for Gene: WBGene00006820
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| WBGene00006820 | SMap | S_parent | Sequence | CHROMOSOME_I | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | unc-89 | Person_evidence | WBPerson261 | |||||
| Sequence_name | C09D1.1 | ||||||||
| Molecular_name (48) | |||||||||
| Other_name | phm-1 | ||||||||
| CELE_C09D1.1 | Accession_evidence | NDB | BX284601 | ||||||
| Public_name | unc-89 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:43 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| 2 | 21 Dec 2004 16:19:44 | WBPerson2970 | Event | Acquires_merge | WBGene00043148 | ||||
| Acquires_merge | WBGene00043148 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | unc | ||||||||
| Reference_allele | WBVar00144017 | ||||||||
| Allele (812) | |||||||||
| Legacy_information | e1460 : good movement slightly small thin and transparent; abnormal reduced birefringence in body wall and pharyngeal muscle; thick filaments disarranged no M-line. ES1 ME3. NA > 10 (st85amber r291 etc.). | ||||||||
| [Leon Avery] Pharyngeal contractions are feeble. Worms are small and starved. | |||||||||
| See also ad539, e1460, e2338 | |||||||||
| [C.elegansII] e1460 : good movement, slightly small, thin and transparent; abnormal reduced birefringence in body wall and pharyngeal muscle; thick filaments disarranged, no M-line. ES1 ME3. OA>10: st85amb, r291,ad539 (pka phm-1, worms small and starved, feeble pharyngeal contractions), e2338amb,st515::Tc1 etc. Cloned: encodes 750 kD protein related to UNC-22 (twitchin). Antibodies stain middle of A bands. [Waterston et al. 1980; GB] | |||||||||
| Strain | WBStrain00002024 | ||||||||
| WBStrain00002131 | |||||||||
| WBStrain00031887 | |||||||||
| WBStrain00033489 | |||||||||
| WBStrain00036403 | |||||||||
| WBStrain00036411 | |||||||||
| WBStrain00004337 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (49) | |||||||||
| Ortholog (56) | |||||||||
| Paralog | WBGene00001000 | Caenorhabditis elegans | From_analysis | WormBase-Compara | |||||
| WBGene00001863 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00004130 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00006436 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00006759 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00011880 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00017657 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| WBGene00019727 | Caenorhabditis elegans | From_analysis | WormBase-Compara | ||||||
| Structured_description | Concise_description | unc-89 encodes several protein isoforms variably characterized by the presence or absence of SH3, DH, PH, immunoglobulin and myosin light chain kinase (MLCK)-like protein kinase domains; during development, unc-89 is required for proper organization of A bands in striated muscle and thus for fully normal locomotion, pharyngeal muscle contractions, and body size; unc-89 is expressed in body wall muscle, pharyngeal muscle and some cells in the tail; UNC-89 protein isoforms localize to the middle of A-bands, consistent with UNC-89 being an M line component; UNC-89 interacts with the SCPL-1 phosphatase both in vitro and in vivo. | Paper_evidence | WBPaper00002411 | |||||
| WBPaper00024436 | |||||||||
| WBPaper00031595 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 16 Dec 2011 00:00:00 | ||||||||
| Automated_description | Enables MATH domain binding activity; enzyme binding activity; and guanyl-nucleotide exchange factor activity. Involved in several processes, including myofibril assembly; pharyngeal gland morphogenesis; and regulation of striated muscle contraction. Located in M band. Expressed in alimentary muscle; gonad; tail; and vulval muscle. Human ortholog(s) of this gene implicated in centronuclear myopathy 5. Is an ortholog of human SPEG (striated muscle enriched protein kinase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0111222 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:16901) | ||||
| Molecular_info | Corresponding_CDS (16) | ||||||||
| Corresponding_CDS_history | C09D1.1g:wp261 | ||||||||
| Corresponding_transcript (16) | |||||||||
| Other_sequence (139) | |||||||||
| Associated_feature (48) | |||||||||
| Experimental_info | RNAi_result (25) | ||||||||
| Expr_pattern (15) | |||||||||
| Drives_construct | WBCnstr00002806 | ||||||||
| WBCnstr00002896 | |||||||||
| WBCnstr00011122 | |||||||||
| Construct_product | WBCnstr00011122 | ||||||||
| WBCnstr00022809 | |||||||||
| WBCnstr00022810 | |||||||||
| Antibody | WBAntibody00000105 | ||||||||
| WBAntibody00000106 | |||||||||
| WBAntibody00000758 | |||||||||
| WBAntibody00000759 | |||||||||
| Microarray_results (68) | |||||||||
| Expression_cluster (231) | |||||||||
| Interaction (87) | |||||||||
| WBProcess | WBbiopr:00000006 | ||||||||
| Map_info | Map | I | Position | -1.73264 | Error | 0.009136 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | sDf4 | |||||||
| Positive_clone | C09D1 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
| Mapping_data | Multi_point (15) | ||||||||
| Pos_neg_data | 506 | ||||||||
| 6165 | |||||||||
| 6270 | |||||||||
| 6339 | |||||||||
| 4746 | |||||||||
| 3932 | |||||||||
| 3933 | |||||||||
| 4559 | |||||||||
| 5704 | |||||||||
| Reference (90) | |||||||||
| Method | Gene |
