| WBGene00006750 | SMap | S_parent | Sequence | T10A3 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | unc-10 | Person_evidence | WBPerson261 |
| | | Sequence_name | T10A3.1 |
| | | Molecular_name (18) |
| | | Other_name | rim-1 |
| | | | Rim | Paper_evidence | WBPaper00013595 |
| | | | CELE_T10A3.1 | Accession_evidence | NDB | BX284606 |
| | | Public_name | unc-10 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:41 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | unc |
| | Reference_allele | WBVar00142961 |
| | Allele (153) |
| | Legacy_information | e102 : weak coiler tends to back loopy movement in reverse; fairly active slightly small and thin. ES3 ME2. NA2 (e126). |
| | | [C.elegansII] e102 : weak coiler, tends to back, loopy movement in reverse; fairly active; slightly small and thin; Ric. ES3 ME2. OA1: e126. [Brenner 1974; Nguyen et al. 1995] |
| | | [Nonet M] unc-10(e102) was phenotypically rescued by both cosmid C34H12 and a 16 kb BamHI/KpnI subclone of this cosmid that contains effectively only the rim-1 gene. The rim-1 gene (rim for Rab Interacting Molecule) is the combined genefinder products T10A3.1 and K03A1.3 (with several mistakes in the prediction by genefinder). Furthermore, unc-10(md330) and unc-10(md1117) both contain deletions of the vast majority of the rim-1 gene. Specifically, md1117 deleted 8.6 kb that extends from approximately 500 bp 5' of the atg to 200 bp 3' of the TAA of the rim-1 gene product. |
| | | [Nonet M] Encodes Rab-3 interacting protein. |
| | Strain | WBStrain00002752 |
| | | WBStrain00027194 |
| | | WBStrain00029061 |
| | | WBStrain00004100 |
| | | WBStrain00005485 |
| | | WBStrain00005508 |
| | | WBStrain00005509 |
| | | WBStrain00051853 |
| | RNASeq_FPKM (74) |
| | GO_annotation (32) |
| | Ortholog (51) |
| | Structured_description | Concise_description | unc-10 encodes a protein with zinc-finger, Q/N-rich, PDZ, and C2 domains that is homologous to vertebrate Rim1, a presynaptic protein which binds, and effects the activity of, synaptic vesicle-associated GTP-Rab3; UNC-10 is required for normal locomotion and synaptic transmission, and localizes to a subdomain of presynaptic termini, where it probably acts to regulate the priming step of presynaptic vesicle fusion by promoting conformational changes in syntaxin. | Paper_evidence | WBPaper00002487 |
| | | | | | WBPaper00004891 |
| | | | | | WBPaper00005068 |
| | | | | | WBPaper00012788 |
| | | | | | WBPaper00012830 |
| | | | | | WBPaper00012882 |
| | | | | | WBPaper00012897 |
| | | | | | WBPaper00013003 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 17 Jun 2004 00:00:00 |
| | | Automated_description | Enables small GTPase binding activity. Involved in several processes, including chemical synaptic transmission; defecation; and positive regulation of cholinergic synaptic transmission. Located in axon and presynaptic active zone. Expressed in dorsal nerve cord; nerve ring; nervous system; uv1; and ventral nerve cord. Is an ortholog of human RIMS1 (regulating synaptic membrane exocytosis 1). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS | T10A3.1a |
| | | T10A3.1b |
| | | T10A3.1c |
| | | T10A3.1d |
| | | T10A3.1e |
| | | T10A3.1f |
| | Corresponding_transcript | T10A3.1a.1 |
| | | T10A3.1b.1 |
| | | T10A3.1c.1 |
| | | T10A3.1d.1 |
| | | T10A3.1e.1 |
| | | T10A3.1f.1 |
| | Other_sequence (30) |
| | Associated_feature (22) |
| Experimental_info | RNAi_result (19) |
| | Expr_pattern | Chronogram1591 |
| | | Expr2418 |
| | | Expr14780 |
| | | Expr15235 |
| | | Expr15236 |
| | | Expr1017493 |
| | | Expr1032824 |
| | | Expr1156587 |
| | | Expr2017837 |
| | | Expr2035973 |
| | Drives_construct | WBCnstr00003280 |
| | | WBCnstr00034173 |
| | Construct_product (11) |
| | Antibody | WBAntibody00000412 |
| | | WBAntibody00000866 |
| | | WBAntibody00001456 |
| | | WBAntibody00001656 |
| | | WBAntibody00001729 |
| | | WBAntibody00002171 |
| | Microarray_results (30) |
| | Expression_cluster | WBPaper00024970:GABAergic_neuron_specific |
| | | WBPaper00029359_1166 |
| | | WBPaper00029359_1194 |
| | | WBPaper00029359_1197 |
| | | WBPaper00029359_1240 |
| | | WBPaper00029359_1243 |
| | | WBPaper00029359_1291 |
| | | WBPaper00029359_1336 |
| | | WBPaper00029359_1546 |
| | | WBPaper00029359_1549 |
| | | WBPaper00029359_1557 |
| | | WBPaper00029359_1599 |
| | | WBPaper00032976:dosage_compensated_genes |
| | | WBPaper00033065:cyc-1(RNAi)_downregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037682:sma-2_sma-4_upregulated |
| | | WBPaper00037950:A-class-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_larva_enriched |
| | | WBPaper00037950:all-neurons_embryo_enriched |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:coelomocytes_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_embryo_enriched |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_embryo_enriched |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038061:aldicarb_upregulated |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00042194:nhr-114(RNAi)_downregulated |
| | | WBPaper00042215:wdr-23(tm1817)_upregulated |
| | | WBPaper00044656:tatn-1(qd182)_upregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated |
| | | WBPaper00046805:csr-1(RNAi)_downregulated_Set1 |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_100-cell-embryo |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00051404:alg-1(gk214)_upregulated |
| | | WBPaper00051404:alg-2(ok304)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(icb38)_upregulated |
| | | WBPaper00053295:lin-22(ot267)_upregulated |
| | | WBPaper00053295:lin-22(ot269)_upregulated |
| | | WBPaper00053302:alovudine_24h_regulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00054913:AKIR-1_interacting_protein |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00055648:male-tail_expressed |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_upregulated_N2 |
| | | WBPaper00056139:soil-microbiota_upregulated |
| | | WBPaper00056161:hermaphrodite_enriched_siRNA |
| | | WBPaper00056284:ints-1(RNAi)_downregulated |
| | | WBPaper00056284:ints-11(RNAi)_downregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056731:human-amylin_upregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00057140:meg-3(tm4259)_meg-4(ax2026)_downregulated |
| | | WBPaper00057149:prgn-1(tm985)_downregulated |
| | | WBPaper00057161:meg-3(tm4259)_meg-4(ax2026)_downregulated_endo-siRNA_targets |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058691:cfp-1(tm6369)_upregulated |
| | | WBPaper00058691:set-2(bn129)_upregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00058958:100mGy-irradiation-72h_upregulated |
| | | WBPaper00058969:RIS_enriched |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA |
| | | WBPaper00059334:SACY-1_interacting |
| | | WBPaper00059421:daf-3(mgDf90)_downregulated |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059567:olrn-1(ums9)_regulated |
| | | WBPaper00059605:MUT-16_interacting |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060100:SiNP_upregulated_mRNA |
| | | WBPaper00060459:bcat-1(RNAi)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061340:AIB |
| | | WBPaper00061340:AIM |
| | | WBPaper00061340:AIZ |
| | | WBPaper00061340:ALA |
| | | WBPaper00061340:AVD |
| | | WBPaper00061340:AVK |
| | | WBPaper00061340:AVL |
| | | WBPaper00061340:DA_DB |
| | | WBPaper00061340:PVP |
| | | WBPaper00061340:PVT |
| | | WBPaper00061340:Rectal_cell |
| | | WBPaper00061340:RIA |
| | | WBPaper00061340:RIM |
| | | WBPaper00061340:RIV |
| | | WBPaper00061340:RMD |
| | | WBPaper00061340:SIA |
| | | WBPaper00061340:SIB |
| | | WBPaper00061340:SMD |
| | | WBPaper00061466:nath-10(icb102)_downregulated |
| | | WBPaper00061478:SUMO-conjugated_protein |
| | | WBPaper00061527:sol-1-jnk-1_18695 |
| | | WBPaper00061527:syd-1_2945-unc-41_2170 |
| | | WBPaper00061527:tub-2_4713-daf-2_5288 |
| | | WBPaper00061651:SIB_enriched |
| | | WBPaper00061651:SMB_enriched |
| | | WBPaper00061818:ELKS-1_interacting |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062156:jmjd-5(zr1234)_upregulated |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062193:skn-1(RNAi)_downregulated |
| | | WBPaper00062325:muscle_depleted_coding-RNA |
| | | WBPaper00062497:xpf-1(tm2842)_upregulated |
| | | WBPaper00062590:Aging_upregulated_intestine |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064130:Beta-Amyloid_24h_downregulated_mRNA |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064721:fasn-1(g14)_downregulated_starved |
| | | WBPaper00064939:vit-5(RNAi)_upregulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065149:lin-52(n771)_downregulated |
| | | WBPaper00065158:AFD_enriched |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065749:Heat-Shock_downregulated_N2 |
| | | WBPaper00065835:Day5_vs_Day1_downregulated |
| | | WBPaper00065841:22_0 |
| | | WBPaper00065841:29_0 |
| | | WBPaper00065841:58_0 |
| | | WBPaper00065841:76_0 |
| | | WBPaper00065841:83_0 |
| | | WBPaper00065841:97_0 |
| | | WBPaper00065841:108_0 |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | cgc4386_cluster_4_1 |
| | | cgc4489_group_12 |
| | | cgc4489_group_13 |
| | | WBPaper00005475:Aging-regulated |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_upregulated |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Enriched_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00030839:Embryo_A_Class |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00030839:Larval_Pan_Neuronal |
| | | WBPaper00031003:0hr_muscle_depleted |
| | | WBPaper00031003:24hr_muscle_depleted |
| | | WBPaper00031003:total_muscle_depleted |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00036123:Atrazine_regulated |
| | | WBPaper00040185:nhr-23(RNAi)_downregulated |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_prime |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_24h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_24h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00042548:miRISC_enriched |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00047070:N2_starvation_upregulated |
| | | WBPaper00048563:L1_DD_enriched |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00048989:eat-2(ad465)_upregulated_in-DMSO |
| | | WBPaper00048989:N2_allantoin_upregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | Interaction | WBInteraction000035668 |
| | | WBInteraction000038235 |
| | | WBInteraction000049017 |
| | | WBInteraction000112791 |
| | | WBInteraction000113770 |
| | | WBInteraction000114671 |
| | | WBInteraction000126291 |
| | | WBInteraction000126343 |
| | | WBInteraction000126345 |
| | | WBInteraction000126405 |
| | | WBInteraction000126559 |
| | | WBInteraction000126635 |
| | | WBInteraction000134619 |
| | | WBInteraction000160349 |
| | | WBInteraction000166757 |
| | | WBInteraction000166866 |
| | | WBInteraction000166953 |
| | | WBInteraction000167492 |
| | | WBInteraction000173992 |
| | | WBInteraction000175570 |
| | | WBInteraction000178045 |
| | | WBInteraction000178046 |
| | | WBInteraction000178047 |
| | | WBInteraction000188216 |
| | | WBInteraction000203613 |
| | | WBInteraction000204742 |
| | | WBInteraction000204743 |
| | | WBInteraction000204744 |
| | | WBInteraction000229511 |
| | | WBInteraction000229512 |
| | | WBInteraction000229513 |
| | | WBInteraction000229514 |
| | | WBInteraction000229515 |
| | | WBInteraction000229516 |
| | | WBInteraction000232224 |
| | | WBInteraction000250100 |
| | | WBInteraction000277217 |
| | | WBInteraction000294878 |
| | | WBInteraction000299279 |
| | | WBInteraction000306028 |
| | | WBInteraction000322458 |
| | | WBInteraction000341645 |
| | | WBInteraction000341646 |
| | | WBInteraction000354905 |
| | | WBInteraction000359943 |
| | | WBInteraction000359944 |
| | | WBInteraction000361252 |
| | | WBInteraction000380125 |
| | | WBInteraction000399489 |
| | | WBInteraction000399490 |
| | | WBInteraction000410776 |
| | | WBInteraction000434105 |
| | | WBInteraction000447522 |
| | | WBInteraction000469049 |
| | | WBInteraction000471265 |
| | | WBInteraction000471266 |
| | | WBInteraction000501292 |
| | | WBInteraction000501720 |
| | | WBInteraction000502148 |
| | | WBInteraction000502149 |
| | | WBInteraction000502961 |
| | | WBInteraction000502962 |
| | | WBInteraction000520028 |
| | | WBInteraction000540982 |
| | | WBInteraction000543488 |
| | | WBInteraction000544486 |
| | | WBInteraction000544487 |
| | | WBInteraction000544604 |
| | | WBInteraction000544708 |
| | | WBInteraction000544709 |
| | | WBInteraction000555755 |
| | | WBInteraction000556685 |
| | | WBInteraction000556819 |
| | | WBInteraction000558409 |
| | | WBInteraction000560298 |
| | | WBInteraction000560299 |
| | | WBInteraction000566964 |
| | | WBInteraction000570720 |
| | | WBInteraction000574266 |
| | | WBInteraction000578488 |
| | | WBInteraction000583717 |
| | | WBInteraction000584115 |
| Map_info | Map | X | Position | -1.7816 | Error | 0.001118 |
| | Well_ordered |
| | Positive | Positive_clone | C34H12 |
| | | | T10A3 | Person_evidence | WBPerson451 |
| | | | | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 147 |
| | | | 182 |
| | | | 3912 |
| | | | 3913 |
| | | | 6198 |
| | | Multi_point (23) |
| | | Pos_neg_data (13) |
| Reference (108) |
| Remark | Sequence connection from [Koushika SP, Nonet M] |
| | Other name from JA Hodgkin, 09/02/2002 |
| | unc-10 is the same as rim-1 and therefore rim-1 was merged into unc-10 based on advice from JAH |
| Method | Gene |
