WormBase Tree Display for Gene: WBGene00006541
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| WBGene00006541 | SMap | S_parent | Sequence | H13N06 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | tbh-1 | Person_evidence | WBPerson268 | |||||
| Sequence_name | H13N06.6 | ||||||||
| Molecular_name | H13N06.6a | ||||||||
| H13N06.6a.1 | |||||||||
| CE31553 | |||||||||
| H13N06.6b | |||||||||
| CE43881 | |||||||||
| H13N06.6c | |||||||||
| CE50388 | |||||||||
| H13N06.6b.1 | |||||||||
| H13N06.6c.1 | |||||||||
| Other_name | CELE_H13N06.6 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | tbh-1 | ||||||||
| DB_info | Database (14) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:40 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | tbh | ||||||||
| Allele (99) | |||||||||
| Strain | WBStrain00027363 | ||||||||
| WBStrain00031863 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (20) | |||||||||
| Ortholog (32) | |||||||||
| Paralog | WBGene00017671 | ||||||||
| WBGene00020556 | Caenorhabditis elegans | From_analysis | TreeFam | ||||||
| Structured_description | Concise_description | tbh-1 encodes a tyramine beta-hydroxylase orthologous to human DBH (OMIM:609312, mutated in dopamine beta-hydroxylase deficiency); TBH-1 activity is required for biosynthesis of the octopamine neurotransmitter. | Paper_evidence | WBPaper00025096 | |||||
| WBPaper00031241 | |||||||||
| WBPaper00031303 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson1823 | |||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 06 Mar 2014 00:00:00 | ||||||||
| Automated_description | Enables tyramine-beta hydroxylase activity. Involved in octopamine biosynthetic process. Located in synapse. Expressed in RICL; RICR; and gonad. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; and dopamine beta-hydroxylase deficiency. Is an ortholog of human DBH (dopamine beta-hydroxylase). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:10024 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2689) | ||||
| DOID:1094 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2689) | ||||||
| DOID:14330 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2689) | ||||||
| DOID:1574 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2689) | ||||||
| DOID:0090145 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2689) | ||||||
| DOID:10763 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:2689) | ||||||
| Molecular_info | Corresponding_CDS | H13N06.6a | |||||||
| H13N06.6b | |||||||||
| H13N06.6c | |||||||||
| Corresponding_CDS_history | H13N06.6:wp83 | ||||||||
| H13N06.6b:wp246 | |||||||||
| Corresponding_transcript | H13N06.6a.1 | ||||||||
| H13N06.6b.1 | |||||||||
| H13N06.6c.1 | |||||||||
| Other_sequence (26) | |||||||||
| Associated_feature | WBsf238328 | ||||||||
| WBsf238329 | |||||||||
| WBsf238330 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00016264 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00049396 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr3721 | ||||||||
| Expr4165 | |||||||||
| Expr6276 | |||||||||
| Expr8276 | |||||||||
| Expr16043 | |||||||||
| Expr1023515 | |||||||||
| Expr1153129 | |||||||||
| Expr2017344 | |||||||||
| Expr2035480 | |||||||||
| Drives_construct | WBCnstr00001277 | ||||||||
| WBCnstr00002828 | |||||||||
| WBCnstr00005005 | |||||||||
| WBCnstr00013232 | |||||||||
| WBCnstr00034312 | |||||||||
| Construct_product | WBCnstr00034312 | ||||||||
| Regulate_expr_cluster | WBPaper00060921:tbh-1(ok1196)_downregulated | ||||||||
| WBPaper00060921:tbh-1(ok1196)_upregulated | |||||||||
| Antibody | WBAntibody00000844 | ||||||||
| Microarray_results (19) | |||||||||
| Expression_cluster (251) | |||||||||
| Interaction (171) | |||||||||
| WBProcess | WBbiopr:00000001 | ||||||||
| Map_info | Map | X | Position | 22.7341 | Error | 0.010816 | |||
| Positive | Positive_clone | H13N06 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Mapping_data | Multi_point | 4927 | |||||||
| 4273 | |||||||||
| 5530 | |||||||||
| Pseudo_map_position | |||||||||
| Reference (49) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
