Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Gene: WBGene00006541

expand all nodes | collapse all nodes | view schema

Name Class

WBGene00006541SMapS_parentSequenceH13N06
IdentityVersion1
NameCGC_nametbh-1Person_evidenceWBPerson268
Sequence_nameH13N06.6
Molecular_nameH13N06.6a
H13N06.6a.1
CE31553
H13N06.6b
CE43881
H13N06.6c
CE50388
H13N06.6b.1
H13N06.6c.1
Other_nameCELE_H13N06.6Accession_evidenceNDBBX284606
Public_nametbh-1
DB_infoDatabase (14)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:40WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classtbh
Allele (99)
StrainWBStrain00027363
WBStrain00031863
RNASeq_FPKM (74)
GO_annotation (20)
Ortholog (32)
ParalogWBGene00017671
WBGene00020556Caenorhabditis elegansFrom_analysisTreeFam
Structured_descriptionConcise_descriptiontbh-1 encodes a tyramine beta-hydroxylase orthologous to human DBH (OMIM:609312, mutated in dopamine beta-hydroxylase deficiency); TBH-1 activity is required for biosynthesis of the octopamine neurotransmitter.Paper_evidenceWBPaper00025096
WBPaper00031241
WBPaper00031303
Curator_confirmedWBPerson1843
WBPerson1823
WBPerson567
Date_last_updated06 Mar 2014 00:00:00
Automated_descriptionEnables tyramine-beta hydroxylase activity. Involved in octopamine biosynthetic process. Located in synapse. Expressed in RICL; RICR; and gonad. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; and dopamine beta-hydroxylase deficiency. Is an ortholog of human DBH (dopamine beta-hydroxylase).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:10024Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2689)
DOID:1094Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2689)
DOID:14330Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2689)
DOID:1574Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2689)
DOID:0090145Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2689)
DOID:10763Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:2689)
Molecular_infoCorresponding_CDSH13N06.6a
H13N06.6b
H13N06.6c
Corresponding_CDS_historyH13N06.6:wp83
H13N06.6b:wp246
Corresponding_transcriptH13N06.6a.1
H13N06.6b.1
H13N06.6c.1
Other_sequence (26)
Associated_featureWBsf238328
WBsf238329
WBsf238330
Experimental_infoRNAi_resultWBRNAi00016264Inferred_automaticallyRNAi_primary
WBRNAi00049396Inferred_automaticallyRNAi_primary
Expr_patternExpr3721
Expr4165
Expr6276
Expr8276
Expr16043
Expr1023515
Expr1153129
Expr2017344
Expr2035480
Drives_constructWBCnstr00001277
WBCnstr00002828
WBCnstr00005005
WBCnstr00013232
WBCnstr00034312
Construct_productWBCnstr00034312
Regulate_expr_clusterWBPaper00060921:tbh-1(ok1196)_downregulated
WBPaper00060921:tbh-1(ok1196)_upregulated
AntibodyWBAntibody00000844
Microarray_results (19)
Expression_clusterWBPaper00028451:Oogenic_protein
WBPaper00030922:glycosylated_protein
WBPaper00031040:TGF-beta_adult_downregulated
WBPaper00033065:cyc-1(RNAi)_downregulated
WBPaper00035073:mitochondria_protein
WBPaper00037682:sma-2_downregulated
WBPaper00037682:sma-2_sma-4_downregulated
WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
WBPaper00037950:all-neurons_L2-larva_expressed
WBPaper00037950:all-neurons_larva_enriched
WBPaper00037950:all-neurons_larva_SelectivelyEnriched
WBPaper00037950:CEP-sheath-cells_adult_enriched
WBPaper00037950:CEP-sheath-cells_adult_SelectivelyEnriched
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:coelomocytes_L2-larva_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:excretory-cell_L2-larva_expressed
WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00038289:oocyte_protein
WBPaper00041072:UTX-1_interacting_protein
WBPaper00041954:ethanol_upregulated
WBPaper00043951:insoluble_protein_day16_N2
WBPaper00044037:eat-2_downregulated
WBPaper00044316:CH3HgCl_7.5uM_downregulated
WBPaper00044501:gld-1_let-7_regulated
WBPaper00044656:tatn-1(qd182)_downregulated
WBPaper00044736:rising_dev_expression
WBPaper00044746:aging_upregulated_HeatShock
WBPaper00045017:blmp-1(tm548)_downregulated
WBPaper00045420:fertilization_downregulated_transcript
WBPaper00045521:Spermatogenic
WBPaper00045571:germline-ablation_upregulated
WBPaper00045861:ash-2(tm1095)_downregulated
WBPaper00045861:set-2(ok952)_downregulated
WBPaper00045861:wdr-5(ok1417)_downregulated
WBPaper00045971:tunicamycin_upregulated_RtcB(null)
WBPaper00046012:tdp-1(ok803)_downregulated
WBPaper00046337:monosomal_N2_vs_daf-2_upregulated
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00049018:ham-3(RNAi)_downregulated
WBPaper00049134:hpk-1(pk1393)_downregulated
WBPaper00049498:npr-1(ur89)_regulated_6
WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
WBPaper00049942:hsf-1(RNAi)_downregulated
WBPaper00050412:cco-1(RNAi)_downregulated_met-2(ok2307)
WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
WBPaper00050522:mafr-1(tm6082)_downregulated
WBPaper00050743:elli-1(sam-3)_upregulated
WBPaper00050859:upregulated_glh-1(gk100)_vs_control_day1-adult
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
WBPaper00051039:germline_enriched
WBPaper00051265:F4_hrde-1(tm1200)_upregulated
WBPaper00051265:F4_morc-1(tm6048)_upregulated
WBPaper00051352:Long-Term-Association-Memory_downregulated
WBPaper00052884:emb-4(hc60)_downregulated
WBPaper00053184:sma-2(rax5)_downregulated
WBPaper00053184:sma-4(rax3)_downregulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053402:cco-1(RNAi)_downregulated
WBPaper00053599:female_vs_male_upregulated
WBPaper00053599:mitosis_vs_meiosis_downregulated
WBPaper00053599:oocyte_vs_mitosis_downregulated
WBPaper00053606:elt-2(ca15)_vs_elt-2(ca15);elt-7(tm840)_upregulated
WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_upregulated
WBPaper00053615:SMO-1_target
WBPaper00053810:nuo-6(qm200)_upregulated
WBPaper00053814:25C_downregulated_OP50
WBPaper00053814:25C_downregulated_PY79
WBPaper00054410:set-26(tm2467)_downregulated
WBPaper00054493:hpl-2(tm1489)_downregulated
WBPaper00055013:hmg-3(bar24)_upregulated
WBPaper00055049:S.gordonii_downregulated
WBPaper00055354:Metformin_downregulated
WBPaper00055354:Psora-Allantoin_downregulated
WBPaper00055354:Rapamycin-Metformin_downregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
WBPaper00055354:Rapamycin-Rifampicin-Psora_downregulated
WBPaper00055354:Rapamycin-Rifampicin_downregulated
WBPaper00055354:Rifampicin-Allantoin_downregulated
WBPaper00055354:Rifampicin_downregulated
WBPaper00055827:pfd-6(gk493446)_upregulated
WBPaper00055941:atfs-1(et15)_downregulated
WBPaper00055941:nuo-6(qm200)_upregulated
WBPaper00055971:nhl-2(ok818)_25C_upregulated
WBPaper00056034:pals-22(jy3)_downregulated
WBPaper00056039:efa-6(tm3124)_upregulated
WBPaper00056039:ptl-1(ok621)_upregulated
WBPaper00056090:E.faecalis_downregulated_hpx-2(dg047)
WBPaper00056090:E.faecalis_downregulated_N2
WBPaper00056139:soil-microbiota_downregulated
WBPaper00056167:Cry5B_upregulated
WBPaper00056169:rrf-3(pk1426)_upregulated_L4
WBPaper00056218:daf-16(mu86)_upregulated_Day7
WBPaper00056275:P.aeruginosa_upregulated
WBPaper00056275:P.aeruginosa_upregulated_atf-7(qd22qd130)_dependent
WBPaper00056275:P.aeruginosa_upregulated_pmk-1(km25)_dependent
WBPaper00056290:hsp-6(mg585)_downregulated
WBPaper00056290:mdt-15(mg584)_downregulated
WBPaper00056330:glycine_upregulated
WBPaper00056443:DietaryRestriction_downregulated
WBPaper00056443:sek-1(km4)_downregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_downregulated
WBPaper00057154:HeatShock_downregulated_mRNA
WBPaper00057288:iff-1(RNAi)_upregulated_protein
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058598:spn-4(tm291)_upregulated
WBPaper00058945:mir-1(gk276)_downregulated
WBPaper00059027:neuron-synapses_enriched
WBPaper00059117:B.subtilis_downregulated
WBPaper00059224:tph-1(mg280)_downregulated
WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
WBPaper00059537:ngn-1(ok2200)_downregulated
WBPaper00059567:olrn-1(ums9)_regulated
WBPaper00059598:HeatShock_upregulated
WBPaper00059664:srbc-48(ac23)_downregulated
WBPaper00059728:5ug_cholesterol_downregulated
WBPaper00059728:20ug_cholesterol_downregulated
WBPaper00059739:hira-1(gk835598)_downregulated_adult
WBPaper00059763:neuron_expressed
WBPaper00060084:cco-1(RNAi)_downregulated_lin-40(yth27)
WBPaper00060317:anc-1(RNAi)_downregulated
WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
WBPaper00060445:ikb-1(nr2027)_upregulated_L4
WBPaper00060445:nfki-1(cer1)_ikb-1(nr2027)_upregulated_L4
WBPaper00060445:nfki-1(cer1)_upregulated_L4
WBPaper00060458:rnf-5(tm794)_regulated
WBPaper00060661:sensory-neuron_depleted
WBPaper00060683:hlh-11(ko1)_downregulated
WBPaper00060811:L1_vs_adult_upregulated_neural
WBPaper00060909:atfs-1(cmh15)_upregulated
WBPaper00060909:atfs-1(et18)_upregulated
WBPaper00060921:tbh-1(ok1196)_downregulated
WBPaper00061007:HB101_downregulated
WBPaper00061007:S.aquatilis_downregulated
WBPaper00061045:Y56A3A.22(cck200)_downregulated
WBPaper00061340:RIC
WBPaper00061341:28C_48h_downregulated
WBPaper00061439:unc-30(ok613)_downregulated_P.aeruginosa-infection
WBPaper00061478:SUMO-conjugated_protein
WBPaper00061527:ZC373.2-Y62H9A.6_1596
WBPaper00061651:Gonadal_sheath_cell_enriched
WBPaper00061651:RIC_enriched
WBPaper00061902:camt-1(ok515)_regulated_RMG
WBPaper00062103:neuron_enriched
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062446:nhr-8(hd117)_downregulated
WBPaper00062456:doxycycline_downregulated_N2_protein
WBPaper00062554:MAGU-2_interacting
WBPaper00062585:hlh-26(ok1453)_downregulated_E.faecium
WBPaper00062669:extracellular-vesicle_protein
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
WBPaper00064201:SNA-1_interacting
WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated
WBPaper00064494:postdauer_downregulated_WholeAnimal
WBPaper00064505:tamoxifen_upregulated
WBPaper00064716:paraquat_downregulated
WBPaper00064871:hypoxia_upregulated_F2
WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
WBPaper00064952:Day5_vs_L4_upregulated_25C
WBPaper00064952:Day10_vs_L4_upregulated_20C
WBPaper00064952:Day10_vs_L4_upregulated_25C
WBPaper00065074:glna(-)_upregulated
WBPaper00065086:JU1400_N.ferruginous_regulated
WBPaper00065096:25C_vs_20C_upregulated
WBPaper00065096:Day10_vs_Day1_upregulated
WBPaper00065120:body-muscle-transcriptome
WBPaper00065288:mdt-15(tm2182)_upregulated
WBPaper00065373:Cisplatin_upregulated_WT
WBPaper00065373:sek-1(km4)_upregulated_cisplatin
WBPaper00065373:sek-1(km4)_upregulated_Ref
WBPaper00065623:19
WBPaper00065841:18_0
WBPaper00065841:48_0
WBPaper00065975:P-body_vs_oocyte_depleted
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00065984:pals-17(syb3980)_upregulated
WBPaper00065993:glp-1(e2141)_upregulated
WBPaper00066085:hda-3(ok1991)_downregulated
WBPaper00066085:sin-3(syb2172)_upregulated
WBPaper00066110:Doxorubicin_downregulated_diploid
WBPaper00066110:tetraploid_vs_diploid_downregulated
WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
WBPaper00066204:CdCl2_downregulated_mRNA
WBPaper00066232:hsf-1(RNAi)_downregulated_ash-2
WBPaper00066232:hsf-1(RNAi)_downregulated_WT
cgc4386_cluster_2_1
cgc4489_group_9
WBPaper00025141:N2_Expressed_Genes
WBPaper00026929:sir-2.1_overexpression_regulated
WBPaper00027758:Group_II
WBPaper00029437:dcr-1_downregulated
WBPaper00030839:Embryo_Pan_Neuronal
WBPaper00032062:age_regulated_genes
WBPaper00035873:dpy-9_regulated
WBPaper00035873:dpy-10_regulated
WBPaper00035873:osm-8_regulated
WBPaper00036130:mir-243_down_regulated
WBPaper00036286:Pattern_D
WBPaper00036383:ash-2_L3_regulated
WBPaper00038172:tax-6null_up_regulated
WBPaper00038427:lin-54_germline_changed
WBPaper00040184:hcf-1up_sir-2.1up_daf-2up
WBPaper00040210:Diazinon_24C_regulated
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2
WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.5
WBPaper00040858:eQTL_age_regulated_aging
WBPaper00040963:Q100_down
WBPaper00040963:Q200_down
WBPaper00041606:CE_S.marcescens_regulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_UVC-exposed_3h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_3h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_24h
WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h
WBPaper00042258:DA1877_upregulated_YoungAdult
WBPaper00045263:0.1mM-paraquat_upregulated
WBPaper00045263:isp-1(qm150)_upregulated
WBPaper00045263:nuo-6(qm200)_upregulated
WBPaper00045263:ProLongevity-mtROS_upregulated
WBPaper00046083:oga-1(ok1207)_OP50_upregulated
WBPaper00046083:ogt-1(ok1474)_OP50_upregulated
WBPaper00046083:pmk-1(km25)_OP50_upregulated
WBPaper00048989:N2_allantoin_upregulated
WBPaper00048989:N2_rapamycin_downregulated
WBPaper00050515:nipi-3(fr4)_downregulated
WBPaper00051387:Triclosan_downregulated
WBPaper00056330:mrps-5(RNAi)_downregulated
[cgc5767]:expression_class_M
[cgc5767]:expression_class_SM
[cgc6390]:herm_soma-enriched
Interaction (171)
WBProcessWBbiopr:00000001
Map_infoMapXPosition22.7341Error0.010816
PositivePositive_cloneH13N06Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point4927
4273
5530
Pseudo_map_position
Reference (49)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene