WormBase Tree Display for Gene: WBGene00006541

WBGene00006541 SMap: S_parent: Sequence: H13N06
  Identity: Version: 1
    Name: CGC_name: tbh-1 Person_evidence: WBPerson268
      Sequence_name: H13N06.6
      Molecular_name: H13N06.6a
        H13N06.6a.1
        CE31553
        H13N06.6b
        CE43881
        H13N06.6c
        CE50388
        H13N06.6b.1
        H13N06.6c.1
      Other_name: CELE_H13N06.6 Accession_evidence: NDB BX284606
      Public_name: tbh-1
    DB_info: Database (14)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:40 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: tbh
    Allele (99)
    Strain: WBStrain00027363
      WBStrain00031863
    RNASeq_FPKM (74)
    GO_annotation (20)
    Ortholog (32)
    Paralog: WBGene00017671
      WBGene00020556 Caenorhabditis elegans From_analysis: TreeFam
    Structured_description: Concise_description: tbh-1 encodes a tyramine beta-hydroxylase orthologous to human DBH (OMIM:609312, mutated in dopamine beta-hydroxylase deficiency); TBH-1 activity is required for biosynthesis of the octopamine neurotransmitter. Paper_evidence: WBPaper00025096
            WBPaper00031241
            WBPaper00031303
          Curator_confirmed: WBPerson1843
            WBPerson1823
            WBPerson567
          Date_last_updated: 06 Mar 2014 00:00:00
      Automated_description: Enables tyramine-beta hydroxylase activity. Involved in octopamine biosynthetic process. Located in synapse. Expressed in RICL; RICR; and gonad. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; and dopamine beta-hydroxylase deficiency. Is an ortholog of human DBH (dopamine beta-hydroxylase). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:10024 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2689)
      DOID:1094 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2689)
      DOID:14330 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2689)
      DOID:1574 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2689)
      DOID:0090145 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2689)
      DOID:10763 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2689)
  Molecular_info: Corresponding_CDS: H13N06.6a
      H13N06.6b
      H13N06.6c
    Corresponding_CDS_history: H13N06.6:wp83
      H13N06.6b:wp246
    Corresponding_transcript: H13N06.6a.1
      H13N06.6b.1
      H13N06.6c.1
    Other_sequence (26)
    Associated_feature: WBsf238328
      WBsf238329
      WBsf238330
  Experimental_info: RNAi_result: WBRNAi00016264 Inferred_automatically: RNAi_primary
      WBRNAi00049396 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr3721
      Expr4165
      Expr6276
      Expr8276
      Expr16043
      Expr1023515
      Expr1153129
      Expr2017344
      Expr2035480
    Drives_construct: WBCnstr00001277
      WBCnstr00002828
      WBCnstr00005005
      WBCnstr00013232
      WBCnstr00034312
    Construct_product: WBCnstr00034312
    Regulate_expr_cluster: WBPaper00060921:tbh-1(ok1196)_downregulated
      WBPaper00060921:tbh-1(ok1196)_upregulated
    Antibody: WBAntibody00000844
    Microarray_results (19)
    Expression_cluster (251)
    Interaction: WBInteraction000103914
      WBInteraction000109652
      WBInteraction000110363
      WBInteraction000110614
      WBInteraction000111010
      WBInteraction000116135
      WBInteraction000117462
      WBInteraction000121176
      WBInteraction000124112
      WBInteraction000127190
      WBInteraction000134327
      WBInteraction000136597
      WBInteraction000137135
      WBInteraction000141478
      WBInteraction000143590
      WBInteraction000145151
      WBInteraction000145629
      WBInteraction000149328
      WBInteraction000149809
      WBInteraction000149828
      WBInteraction000149889
      WBInteraction000150073
      WBInteraction000152303
      WBInteraction000157719
      WBInteraction000168009
      WBInteraction000170567
      WBInteraction000170736
      WBInteraction000170954
      WBInteraction000171261
      WBInteraction000177380
      WBInteraction000180332
      WBInteraction000181023
      WBInteraction000182560
      WBInteraction000183868
      WBInteraction000185451
      WBInteraction000190414
      WBInteraction000191585
      WBInteraction000192067
      WBInteraction000193172
      WBInteraction000194336
      WBInteraction000198804
      WBInteraction000201302
      WBInteraction000201505
      WBInteraction000201671
      WBInteraction000202643
      WBInteraction000206141
      WBInteraction000209715
      WBInteraction000212289
      WBInteraction000213010
      WBInteraction000213584
      WBInteraction000214090
      WBInteraction000218650
      WBInteraction000218673
      WBInteraction000222322
      WBInteraction000222805
      WBInteraction000223313
      WBInteraction000224287
      WBInteraction000228182
      WBInteraction000228982
      WBInteraction000233324
      WBInteraction000234025
      WBInteraction000234982
      WBInteraction000237204
      WBInteraction000237378
      WBInteraction000237971
      WBInteraction000239330
      WBInteraction000241591
      WBInteraction000243103
      WBInteraction000244213
      WBInteraction000246402
      WBInteraction000251452
      WBInteraction000252850
      WBInteraction000259304
      WBInteraction000260151
      WBInteraction000260394
      WBInteraction000261288
      WBInteraction000263534
      WBInteraction000265183
      WBInteraction000266752
      WBInteraction000267427
      WBInteraction000268494
      WBInteraction000269584
      WBInteraction000270002
      WBInteraction000270388
      WBInteraction000271380
      WBInteraction000273337
      WBInteraction000274233
      WBInteraction000277373
      WBInteraction000278644
      WBInteraction000278963
      WBInteraction000282067
      WBInteraction000283690
      WBInteraction000286921
      WBInteraction000287690
      WBInteraction000289684
      WBInteraction000290384
      WBInteraction000290983
      WBInteraction000292251
      WBInteraction000303916
      WBInteraction000314516
      WBInteraction000315443
      WBInteraction000319553
      WBInteraction000320192
      WBInteraction000322016
      WBInteraction000332748
      WBInteraction000333494
      WBInteraction000335411
      WBInteraction000339525
      WBInteraction000341951
      WBInteraction000346041
      WBInteraction000348477
      WBInteraction000348600
      WBInteraction000350278
      WBInteraction000355901
      WBInteraction000357533
      WBInteraction000361054
      WBInteraction000362668
      WBInteraction000364829
      WBInteraction000366085
      WBInteraction000366979
      WBInteraction000369351
      WBInteraction000370200
      WBInteraction000379238
      WBInteraction000379486
      WBInteraction000383651
      WBInteraction000393705
      WBInteraction000394324
      WBInteraction000394339
      WBInteraction000395668
      WBInteraction000400190
      WBInteraction000401617
      WBInteraction000406941
      WBInteraction000411480
      WBInteraction000412552
      WBInteraction000416903
      WBInteraction000419000
      WBInteraction000419489
      WBInteraction000419619
      WBInteraction000424176
      WBInteraction000427361
      WBInteraction000430211
      WBInteraction000430853
      WBInteraction000431260
      WBInteraction000431671
      WBInteraction000432794
      WBInteraction000434617
      WBInteraction000436449
      WBInteraction000438817
      WBInteraction000439855
      WBInteraction000441547
      WBInteraction000443061
      WBInteraction000445946
      WBInteraction000446950
      WBInteraction000447462
      WBInteraction000452871
      WBInteraction000454939
      WBInteraction000455490
      WBInteraction000455987
      WBInteraction000459027
      WBInteraction000459636
      WBInteraction000461663
      WBInteraction000551804
      WBInteraction000557820
      WBInteraction000560705
      WBInteraction000567566
      WBInteraction000567816
      WBInteraction000569451
      WBInteraction000574048
      WBInteraction000578955
      WBInteraction000584915
      WBInteraction000586204
    WBProcess: WBbiopr:00000001
  Map_info: Map: X Position: 22.7341 Error: 0.010816
    Positive: Positive_clone: H13N06 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4927
        4273
        5530
    Pseudo_map_position
  Reference (49)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene