| WBGene00006436 | Evidence | CGC_data_submission |
|---|
| SMap | S_parent | Sequence | CHROMOSOME_V |
| Identity | Version | 4 |
| | Name | CGC_name | ttn-1 | Person_evidence | WBPerson56 |
| | | Sequence_name | W06H8.8 |
| | | Molecular_name (43) |
| | | Other_name | tag-7 | Curator_confirmed | WBPerson2970 |
| | | | tag-211 | Curator_confirmed | WBPerson2970 |
| | | | tag-58 | Person_evidence | WBPerson201 |
| | | | Y38B5A.a | Curator_confirmed | WBPerson1983 |
| | | | | Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs |
| | | | Y38B5A.b | Curator_confirmed | WBPerson1983 |
| | | | | Remark | Old cosmid naming mapped via unique overlapping PCR_product on CDSs |
| | | | CELE_W06H8.8 | Accession_evidence | NDB | BX284605 |
| | | Public_name | ttn-1 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:40 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | | | 2 | 28 May 2004 14:21:37 | WBPerson1971 | Event | Acquires_merge | WBGene00021069 |
| | | | 3 | 07 Jul 2005 09:36:06 | WBPerson1983 | Event | Acquires_merge | WBGene00006401 |
| | | | 4 | 13 Dec 2005 14:47:30 | WBPerson2970 | Name_change | CGC_name | ttn-1 |
| | | | | | | | Other_name | tag-58 |
| | | Acquires_merge | WBGene00006401 |
| | | | WBGene00021069 |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | ttn |
| | Allele (927) |
| | Strain | WBStrain00035550 |
| | | WBStrain00035671 |
| | | WBStrain00035980 |
| | RNASeq_FPKM (74) |
| | GO_annotation (25) |
| | Ortholog (28) |
| | Paralog (17) |
| | Structured_description | Concise_description | ttn-1, through multiple splicing, encodes at least six protein isoformsthat are orthologs of titin (OMIM:188840, mutated in cardiomyopathy ortibial muscular dystrophy), with the three largest isoforms being 2.2MDa, 1.2 MDa and 301 kDa; TTN-1 isoforms are expressed in body wall andvulval muscle, localized to the centers of I-bands, with the two largestisoforms expressed in all muscles except pharyngeal; the largest TTN-1isoform contains 56 Ig domains, 11 FnIII domains, a twitchin-likeprotein kinase domain, a domain similar to the elastic PEVK domain ofvertebrate titin, 96 tandem copies of a 16-residue motif predicted tocomprise a coiled-coil domain, and two other short multiply repeatedmotifs; the TTN-1 kinase domain is catalytically active, and itsactivity is quantitatively regulated by alternative splicing of anadjacent autoinhibitory domain; TTN-1 is mislocalized in analpha-actinin mutant (atn-1[ok84]); ttn-1 is transcribed from at leasttwo promoters, and its transcription is stimulated by NFI-1. | Paper_evidence | WBPaper00005546 |
| | | | | | WBPaper00006525 |
| | | | | | WBPaper00026912 |
| | | | | | WBPaper00027070 |
| | | | | Curator_confirmed | WBPerson567 |
| | | | | Date_last_updated | 18 Jan 2007 00:00:00 |
| | | Automated_description | Enables actin filament binding activity and myosin binding activity. Predicted to be involved in phosphorylation. Located in A band and I band. Expressed in muscle cell. | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Molecular_info | Corresponding_CDS (14) |
| | Corresponding_CDS_history | W06H8.8a:wp262 |
| | | W06H8.8b:wp262 |
| | | W06H8.8d:wp262 |
| | | W06H8.8e:wp262 |
| | | W06H8.8f:wp262 |
| | | W06H8.8g:wp262 |
| | Corresponding_transcript (15) |
| | Other_sequence (76) |
| | Associated_feature (48) |
| Experimental_info | RNAi_result (15) |
| | Expr_pattern | Chronogram625 |
| | | Expr2286 |
| | | Expr6846 |
| | | Expr9017 |
| | | Expr1032615 |
| | | Expr1158464 |
| | | Expr2017574 |
| | | Expr2035713 |
| | Drives_construct | WBCnstr00002629 |
| | Antibody | WBAntibody00000570 |
| | | WBAntibody00000571 |
| | | WBAntibody00002134 |
| | | WBAntibody00002135 |
| | | WBAntibody00002136 |
| | Microarray_results (80) |
| | Expression_cluster | WBPaper00029047:atx-3_upregulated |
| | | WBPaper00029359_1217 |
| | | WBPaper00029359_1280 |
| | | WBPaper00029359_1353 |
| | | WBPaper00029359_1444 |
| | | WBPaper00029359_1504 |
| | | WBPaper00029359_1548 |
| | | WBPaper00029359_1604 |
| | | WBPaper00031040:TGF-beta_adult_upregulated |
| | | WBPaper00036375:enriched_in_PVD_OLL |
| | | WBPaper00037055:DAF-16_binding_DNA |
| | | WBPaper00037950:bodywall-muscle_embryo_enriched |
| | | WBPaper00037950:bodywall-muscle_embryo_SelectivelyEnriched |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_adult_enriched |
| | | WBPaper00037950:CEP-sheath-cells_adult_SelectivelyEnriched |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:intestine_L1-larva_expressed |
| | | WBPaper00037950:pharyngeal-muscle_L1-larva_expressed |
| | | WBPaper00038118:stress_upregulated_N2 |
| | | WBPaper00038168:lin-15B(n744)_upregulated |
| | | WBPaper00038289:oocyte_protein |
| | | WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00040285:H2S_24hr_downregulated |
| | | WBPaper00041071:spe-44_upregulated |
| | | WBPaper00042215:wdr-23(tm1817)_upregulated |
| | | WBPaper00042561:smg-2(RNAi)_upregulated |
| | | WBPaper00042561:smgl-1(RNAi)_upregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044746:aging_downregulated_HeatShock |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated |
| | | WBPaper00045257:bar-1(ga80)_upregulated |
| | | WBPaper00045316:prg-1_upregulated_L4 |
| | | WBPaper00045417:128Q-huntingtin_upreglated |
| | | WBPaper00045521:Spermatogenic |
| | | WBPaper00045571:germline-ablation_upregulated |
| | | WBPaper00046121:mesoderm_unique |
| | | WBPaper00046303:P.aeruginosa_downregulated_protein |
| | | WBPaper00046446:rapid-synthesized_AgingAdult |
| | | WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h |
| | | WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background |
| | | WBPaper00047131:daf-2(e1370)_upregulated_N2-background |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049377:MWCNT_upregulated |
| | | WBPaper00049545:cco-1(RNAi)_downregulated |
| | | WBPaper00049626:UNC-75_target |
| | | WBPaper00049942:hsf-1(RNAi)_upregulated |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_downregulated_24-cell-embryo |
| | | WBPaper00050163:chd-3(eh4)_downregulated_24-cell-embryo |
| | | WBPaper00050234:lin-28(RNAi)_downregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00051245:body-wall-muscle_nucleus_expressed |
| | | WBPaper00051245:epidermis_cytoplasm_expressed |
| | | WBPaper00051245:pharyngeal-muscle_cytoplasm_expressed |
| | | WBPaper00051257:Levamisole_upregulated |
| | | WBPaper00051558:aging_regulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(icb38)_upregulated |
| | | WBPaper00053302:alovudine_72h_regulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053318:Aging_downregulated_mRNA_N2 |
| | | WBPaper00053606:N2_vs_elt-7(tm840)_upregulated |
| | | WBPaper00053615:SMO-1_target |
| | | WBPaper00054493:hpl-2(tm1489)_upregulated |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_upregulated |
| | | WBPaper00055354:Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated |
| | | WBPaper00055969:electromagnetic-field_downregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056161:male_enriched_siRNA |
| | | WBPaper00056218:daf-16(mu86)_downregulated_Day7 |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056617:adr-2(gv42)_upregulated_embryo_protein |
| | | WBPaper00056868:P.aeruginosa_downregulated_smallRNA |
| | | WBPaper00056900:ERH-2_interacting |
| | | WBPaper00056900:TOFU-6_interacting |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057140:meg-3(tm4259)_meg-4(ax2026)_upregulated |
| | | WBPaper00057154:HeatShock_upregulated_mRNA |
| | | WBPaper00057288:Cold_upregulated_transcript |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058725:sftb-1(cer6)_upregulated |
| | | WBPaper00058725:sftb-1(cer39)_upregulated |
| | | WBPaper00058958:100mGy-irradiation-72h_upregulated |
| | | WBPaper00059194:KLF-1_interacting |
| | | WBPaper00059231:alh-6(lax105)_D3Adult_upregulated |
| | | WBPaper00059254:WAGO-1_interacting |
| | | WBPaper00059328:mrps-5(RNAi)_upregulated_protein |
| | | WBPaper00059334:SACY-1_interacting |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059605:MUT-16_interacting |
| | | WBPaper00059987:Wounding_upregulated |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060683:hlh-11(ko1)_upregulated |
| | | WBPaper00060811:L1_vs_adult_downregulated_neural |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:BWM_anterior |
| | | WBPaper00061340:BWM_far_posterior |
| | | WBPaper00061340:mu_sph |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061377:MYRF-1_interacting |
| | | WBPaper00061377:PAN-1_interacting |
| | | WBPaper00061390:daf-22(ok693)_ascarosides_upregulated |
| | | WBPaper00061439:unc-30(ok613)_downregulated |
| | | WBPaper00061466:nath-10(icb99)_upregulated |
| | | WBPaper00061466:nath-10(icb102)_upregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061527:172183_at-176110_at |
| | | WBPaper00061527:176662_at-Y53F4B.16 |
| | | WBPaper00061527:hlh-30_18579-unc-43_21739 |
| | | WBPaper00061527:myo-3-Y71G12B.11_22540 |
| | | WBPaper00061527:tnt-4-myo-1_2160 |
| | | WBPaper00061527:tub-2_4713-daf-2_5288 |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062156:jmjd-1.2(zr1010)_upregulated |
| | | WBPaper00062156:jmjd-5(zr1234)_upregulated |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062193:skn-1(RNAi)_downregulated |
| | | WBPaper00062325:etr-1(lq61)_downregulated |
| | | WBPaper00062325:etr-1(lq61)_upregulated |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00062590:Aging_downregulated_neuron |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064055:trl-1(cas1077)_upregulated_non-starved |
| | | WBPaper00064055:trl-1(cas1077)_upregulated_starved |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064156:lbp-3(overexpress)_upregulated |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064315:mes-3(bn199)_upregulated_PGCs |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064721:fasn-1(g14)_downregulated_starved |
| | | WBPaper00064769:him-17(me24)_upregulated |
| | | WBPaper00064933:bcf-1(ylf1)_upregulated_transcript |
| | | WBPaper00064939:vit-5(RNAi)_upregulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065120:body-muscle-transcriptome |
| | | WBPaper00065149:lin-52(n771)_downregulated |
| | | WBPaper00065158:AFD_enriched |
| | | WBPaper00065258:anchor-cell_depleted |
| | | WBPaper00065373:Cisplatin_upregulated_WT |
| | | WBPaper00065373:sek-1(km4)_upregulated_cisplatin |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065623:53 |
| | | WBPaper00065835:Day5_vs_Day1_downregulated |
| | | WBPaper00065835:Day11_vs_Day1_downregulated |
| | | WBPaper00065841:1_1 |
| | | WBPaper00065841:4_0 |
| | | WBPaper00065841:4_1 |
| | | WBPaper00065841:4_2 |
| | | WBPaper00065841:7_0 |
| | | WBPaper00065841:7_1 |
| | | WBPaper00065841:7_2 |
| | | WBPaper00065841:7_3 |
| | | WBPaper00065841:7_4 |
| | | WBPaper00065841:26_0 |
| | | WBPaper00065841:38_0 |
| | | WBPaper00065841:38_1 |
| | | WBPaper00065841:38_2 |
| | | WBPaper00065841:38_3 |
| | | WBPaper00065841:41_0 |
| | | WBPaper00065841:78_0 |
| | | WBPaper00065841:102_0 |
| | | WBPaper00065841:110_0 |
| | | WBPaper00065841:143_0 |
| | | WBPaper00065975:P-body_vs_oocyte_depleted |
| | | WBPaper00065975:P-body_vs_WholeAnimal_depleted |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14 |
| | | cgc4386_cluster_6_4 |
| | | cgc4489_group_8 |
| | | cgc4489_group_19 |
| | | cgc4489_group_20 |
| | | WBPaper00025099:MA_specific |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026629:L2_hermaphrodite_enriched |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00030985:Photorhabdus_luminescens_upregulated |
| | | WBPaper00031003:0hr_muscle_enriched |
| | | WBPaper00031003:24hr_muscle_enriched |
| | | WBPaper00031003:total_muscle_enriched |
| | | WBPaper00031252:AIN-1_IP_enriched |
| | | WBPaper00031252:AIN-2_IP_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Depleted |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00035560:ahr-1_upregulated |
| | | WBPaper00036286:Pattern_G |
| | | WBPaper00037113:CPF_DZN_16C_up-regulated |
| | | WBPaper00037113:Diazinon_16C_regulated |
| | | WBPaper00040210:Diazinon_24C_regulated |
| | | WBPaper00040426:CYD-1_CDK-4_downregulated |
| | | WBPaper00040603:tdp-1(lf)_down_vs_N2_FC_1.2 |
| | | WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2 |
| | | WBPaper00040858:eQTL_age_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_juvenile |
| | | WBPaper00041939:control_vs_EtBr-exposed_48h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_24h |
| | | WBPaper00041939:control_vs_UVC-EtBr-exposed_48h |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_24h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00042236:flcn-1(ok975)_upregulated |
| | | WBPaper00042274:tbx-2(bx59)_downregulated |
| | | WBPaper00042331:a-SWCNTs_downregulated |
| | | WBPaper00045263:0.1mM-paraquat_downregulated |
| | | WBPaper00045263:isp-1(qm150)_downregulated |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00046548:dafachronic-acid_downregulated |
| | | WBPaper00047070:N2_starvation_upregulated |
| | | WBPaper00047070:xpa-1_UV_downregulated |
| | | WBPaper00048563:L1_DD_enriched |
| | | WBPaper00050650:mBmkTX_downregulated |
| | | WBPaper00051387:Triclosan_upregulated |
| | | WBPaper00055899:nitroguanidine_regulated |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_SM |
| | | [cgc6390]:Cluster_C |
| | | [cgc6390]:intrinsic |
| | Interaction (19) |
| Map_info | Map | V | Position | -0.235725 | Error | 0.011128 |
| | Positive | Positive_clone | W06H8 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Pseudo_map_position |
| Reference (13) |
| Remark | Gene name created from parsing 'genotype' field from CGC strain information | CGC_data_submission |
| | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
