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WormBase Tree Display for Gene: WBGene00006318

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Name Class

WBGene00006318EvidencePerson_evidenceWBPerson655
SMapS_parentSequenceF34D6
IdentityVersion1
NameCGC_namesup-9Person_evidenceWBPerson261
Sequence_nameF34D6.3
Molecular_nameF34D6.3
F34D6.3.1
CE28297
Other_nametwk-23Person_evidenceWBPerson655
twk-38Person_evidenceWBPerson655
CELE_F34D6.3Accession_evidenceNDBBX284602
Public_namesup-9
DB_infoDatabaseAceViewgene2C976
WormQTLgeneWBGene00006318
WormFluxgeneWBGene00006318
NDBlocus_tagCELE_F34D6.3
PanthergeneCAEEL|WormBase=WBGene00006318|UniProtKB=O17185
familyPTHR11003
NCBIgene173613
RefSeqproteinNM_061932.6
SwissProtUniProtAccO17185
UniProt_GCRPUniProtAccO17185
OMIMgene603220
605874
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:40WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classsup
Allele (210)
Legacy_informationn180 : recessive suppressor of unc-93(e1500) no phenotype alone; probably null allele. ES3 in presence of e1500 ME3. NA > 20 (n180spo n192uvi etc.; all resemble n180).
See also n180, n186, n188, n189, n190, n191, n222, n223, n229, n233, n238, n241, n260, n261, n264, n266, n271, n345, n350, n353, n508, n514, n518, n519, n625, n634, n636, n659, n668, n1009, n1012, n1016, n1020, n1023, n1025, n1026, n1028, n1037, n1330
[Reiner D]] Mac-d (Muscle ACtivation-Defective)
[C.elegansII] n180 : recessive suppressor of unc-93(e1500) no phenotype alone; probably null allele. ES3 in presence of e1500 ME3. OA>20(lf):n180spo, n192uvi, n186, n350 (all resemble n180). Also neomorphic dominant allele n1550sd(severe rubber-band, almost sterile, inviable;n1550/+ strong "rubber-band" Unc-93 phenotype. Muscle activation defective (flaccid, long)). Also dominant negative suppressor alleles n1435, n242 (semidominant suppressors of sup-10(n983). [Greenwald and Horvitz 1980, Levin & Horvitz 1993]
Strain (11)
RNASeq_FPKM (74)
GO_annotation (21)
Ortholog (38)
ParalogWBGene00001190Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006673Caenorhabditis elegansFrom_analysisTreeFam
Inparanoid_8
Panther
WormBase-Compara
WBGene00006696Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00006660Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00006669Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00019904Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006671Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006681Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006670Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00018002Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006792Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006664Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006656Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006693Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006690Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00010784Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006659Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006665Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006658Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006676Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006682Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006691Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006680Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006662Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006657Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006668Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006667Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00015137Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006692Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006666Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006672Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006688Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006678Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006686Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006685Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006695Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006679Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006687Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006677Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006694Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006683Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006663Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006689Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006674Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006675Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006684Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006661Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionsup-9 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains; sup-9 was originally defined by gain-of-function mutations that result in defects in pharyngeal, body-wall, egg-laying, and enteric muscle activation; loss of sup-9 function via reversion or RNA-mediated interference (RNAi) does not result in any abnormalities suggesting that SUP-9 may function redundantly with other TWK channels; SUP-9 is expressed in neurons and muscle.Paper_evidenceWBPaper00002305
WBPaper00004644
Curator_confirmedWBPerson1843
Date_last_updated17 Jun 2004 00:00:00
Automated_descriptionPredicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Involved in regulation of muscle contraction. Located in muscle cell projection membrane and striated muscle dense body. Expressed in body wall musculature; muscle cell; and neurons. Human ortholog(s) of this gene implicated in Birk-Barel syndrome and primary pulmonary hypertension. Is an ortholog of human KCNK3 (potassium two pore domain channel subfamily K member 3) and KCNK9 (potassium two pore domain channel subfamily K member 9).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:14557Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6278)
DOID:0050675Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:6283)
Molecular_infoCorresponding_CDSF34D6.3
Corresponding_transcriptF34D6.3.1
Other_sequence (14)
Associated_featureWBsf649937
WBsf987013
WBsf1011749
WBsf222784
Experimental_infoRNAi_resultWBRNAi00027786Inferred_automaticallyRNAi_primary
WBRNAi00046256Inferred_automaticallyRNAi_primary
WBRNAi00014271Inferred_automaticallyRNAi_primary
WBRNAi00070646Inferred_automaticallyRNAi_primary
WBRNAi00103324Inferred_automaticallyRNAi_primary
WBRNAi00070647Inferred_automaticallyRNAi_primary
Expr_patternExpr1378
Expr2772
Expr2775
Expr2776
Expr2777
Expr1010241
Expr1032552
Expr1150142
Expr2017133
Expr2035269
Drives_constructWBCnstr00000319
WBCnstr00034398
Construct_productWBCnstr00034398
AntibodyWBAntibody00000681
Microarray_results (18)
Expression_cluster (114)
Interaction (50)
Map_infoMapIIPosition-12.1433Error0.015949
Well_ordered
PositiveInside_rearrnDf2
nDf3
nDf4
nDf5
Positive_cloneF34D6Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_data2_point404
784
6131
7115
Multi_point (12)
Pos_neg_data454
458
460
462
Landmark_gene
Reference (57)
MethodGene