WormBase Tree Display for Gene: WBGene00006661

WBGene00006661 Evidence: Person_evidence: WBPerson655
  SMap: S_parent: Sequence: F17C8
  Identity: Version: 1
    Name: CGC_name: twk-6 Person_evidence: WBPerson655
      Sequence_name: F17C8.5
      Molecular_name: F17C8.5
        F17C8.5.1
        CE00959
      Other_name: twk-5 Person_evidence: WBPerson655
        CELE_F17C8.5 Accession_evidence: NDB BX284603
      Public_name: twk-6
    DB_info: Database: AceView gene 3F833
        WormQTL gene WBGene00006661
        WormFlux gene WBGene00006661
        NDB locus_tag CELE_F17C8.5
        Panther gene CAEEL|WormBase=WBGene00006661|UniProtKB=Q19525
          family PTHR11003
        NCBI gene 192070
        RefSeq protein NM_065572.2
        TREEFAM TREEFAM_ID TF352531
        TrEMBL UniProtAcc Q19525
        UniProt_GCRP UniProtAcc Q19525
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:41 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: twk
    Allele (18)
    Legacy_information: [Thomas JH] twk for potassium channel family, type Twik (double P domain)
    Strain: WBStrain00002198
      WBStrain00002544
    RNASeq_FPKM (74)
    GO_annotation (11)
    Ortholog (34)
    Paralog (48)
    Structured_description: Concise_description: twk-6 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains; as loss of TWK-6 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of TWK-6 in C. elegans development and/or behavior is not yet known; TWK-6 may, however, function redundantly with other TWK channels; TWK-6 is expressed in the hypodermis. Paper_evidence: WBPaper00004403
            WBPaper00004644
            WBPaper00005654
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport and stabilization of membrane potential. Predicted to be located in membrane. Expressed in hypodermis and tail. Is an ortholog of several human genes including KCNK2 (potassium two pore domain channel subfamily K member 2); KCNK4 (potassium two pore domain channel subfamily K member 4); and KCNK5 (potassium two pore domain channel subfamily K member 5). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F17C8.5
    Corresponding_transcript: F17C8.5.1
  Experimental_info: RNAi_result: WBRNAi00041365 Inferred_automatically: RNAi_primary
      WBRNAi00044886 Inferred_automatically: RNAi_primary
      WBRNAi00031073 Inferred_automatically: RNAi_primary
      WBRNAi00041364 Inferred_automatically: RNAi_primary
      WBRNAi00005129 Inferred_automatically: RNAi_primary
      WBRNAi00005809 Inferred_automatically: RNAi_primary
      WBRNAi00013466 Inferred_automatically: RNAi_primary
      WBRNAi00006783 Inferred_automatically: RNAi_primary
      WBRNAi00011270 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram1721
      Expr1367
      Expr5784
      Expr5785
      Expr1013050
      Expr1148852
      Expr2017678
      Expr2035816
    Drives_construct: WBCnstr00002941
      WBCnstr00004465
      WBCnstr00010240
      WBCnstr00034233
    Construct_product: WBCnstr00010240
      WBCnstr00034233
    Microarray_results (18)
    Expression_cluster (122)
    Interaction: WBInteraction000345318
      WBInteraction000503139
  Map_info: Map: III Position: -2.61078 Error: 0.003023
    Positive: Positive_clone: F17C8 Person_evidence: WBPerson654
            WBPerson655
          Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00026748
  Remark: twk-6 was connected to F19D8.1 Person_evidence: WBPerson655
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene