| WBGene00004854 | SMap | S_parent | Sequence | CHROMOSOME_X |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | slt-1 | Person_evidence | WBPerson42 |
| | | Sequence_name | F40E10.4 |
| | | Molecular_name | F40E10.4 |
| | | | F40E10.4.1 |
| | | | CE32412 |
| | | Other_name | CELE_F40E10.4 | Accession_evidence | NDB | BX284606 |
| | | Public_name | slt-1 |
| | DB_info | Database | AceView | gene | XP301 |
| | | | WormQTL | gene | WBGene00004854 |
| | | | WormFlux | gene | WBGene00004854 |
| | | | NDB | locus_tag | CELE_F40E10.4 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00004854|UniProtKB=G5EFX6 |
| | | | | family | PTHR45836 |
| | | | NCBI | gene | 181562 |
| | | | RefSeq | protein | NM_078036.8 |
| | | | SwissProt | UniProtAcc | G5EFX6 |
| | | | TREEFAM | TREEFAM_ID | TF332887 |
| | | | UniProt_GCRP | UniProtAcc | G5EFX6 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | slt |
| | Allele (191) |
| | Strain | WBStrain00034914 |
| | | WBStrain00005267 |
| | | WBStrain00005270 |
| | | WBStrain00005271 |
| | | WBStrain00005272 |
| | RNASeq_FPKM (74) |
| | GO_annotation (26) |
| | Ortholog (37) |
| | Paralog | WBGene00007261 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00013542 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00020693 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | | WBGene00022129 | Caenorhabditis elegans | From_analysis | WormBase-Compara |
| | Structured_description | Concise_description | slt-1 encodes the sole C. elegans homolog of Drosophila Split, a secreted extracellular protein containing leucine-rich and EGF-like repeats that functions as a ligand for the Robo receptor; during C. elegans larval development, slt-1 acts via the SAX-3/Robo receptor, and in parallel with UNC-6/Netrin, to direct ventral axon guidance and guidance at the midline; during embryonic development, slt-1 also functions to regulate anterior-posterior migrations of the CAN neurons; slt-1::gfp reporters are initially expressed at high levels in the anterior part of the embryo, with more moderate levels seen in dorsal tail muscles and lower levels seen in cells in the center of the body; in L1 larvae, slt-1::gfp is expressed in both dorsal and ventral muscles, with higher levels seen in dorsal muscle cells; slt-1::gfp is also expressed in a number of additional cells including some neurons, pharyngeal cells, and the anal sphincter muscle. | Paper_evidence | WBPaper00004900 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | Date_last_updated | 19 Jun 2007 00:00:00 |
| | | Automated_description | Enables signaling receptor binding activity. Involved in axon guidance; neuron migration; and regulation of neuron projection development. Predicted to be located in extracellular region. Expressed in anal sphincter muscle; anterior hypodermis; body wall musculature; nerve ring neurons; and socket cell. Human ortholog(s) of this gene implicated in atrial fibrillation; myositis (multiple); and proliferative diabetic retinopathy. Is an ortholog of human SLIT1 (slit guidance ligand 1); SLIT2 (slit guidance ligand 2); and SLIT3 (slit guidance ligand 3). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Potential_model | DOID:13207 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11086) |
| | | DOID:0080745 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11086) |
| | | DOID:10223 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11086) |
| | | DOID:0060224 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11086) |
| Molecular_info | Corresponding_CDS | F40E10.4 |
| | Corresponding_CDS_history | F40E10.4:wp90 |
| | Corresponding_transcript | F40E10.4.1 |
| | Other_sequence (11) |
| | Associated_feature | WBsf648747 |
| | | WBsf648748 |
| | | WBsf663583 |
| | | WBsf663584 |
| | | WBsf663585 |
| | | WBsf717401 |
| | | WBsf236701 |
| | | WBsf236702 |
| | | WBsf236703 |
| Experimental_info | RNAi_result | WBRNAi00011228 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00086123 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00001158 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00046840 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00032019 | Inferred_automatically | RNAi_primary |
| | Expr_pattern | Expr1639 |
| | | Expr8003 |
| | | Expr1016319 |
| | | Expr1032406 |
| | | Expr1150710 |
| | | Expr2015887 |
| | | Expr2034120 |
| | Drives_construct | WBCnstr00000844 |
| | | WBCnstr00008334 |
| | | WBCnstr00013053 |
| | | WBCnstr00035356 |
| | | WBCnstr00038306 |
| | Construct_product | WBCnstr00000848 |
| | | WBCnstr00000849 |
| | | WBCnstr00000851 |
| | | WBCnstr00000852 |
| | | WBCnstr00035356 |
| | Microarray_results (20) |
| | Expression_cluster | WBPaper00037950:bodywall-muscle_larva_enriched |
| | | WBPaper00037950:bodywall-muscle_larva_SelectivelyEnriched |
| | | WBPaper00037950:coelomocytes_embryo_enriched |
| | | WBPaper00037950:coelomocytes_embryo_SelectivelyEnriched |
| | | WBPaper00037950:GABAergic-motor-neurons_embryo_enriched |
| | | WBPaper00037950:GABAergic-motor-neurons_embryo_SelectivelyEnriched |
| | | WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00042215:wdr-23(tm1817)_upregulated |
| | | WBPaper00044426:rotenone_24h_downregulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated |
| | | WBPaper00045774:clk-1_downregulated |
| | | WBPaper00045774:clk-1_downregulated_CoQ10_independent |
| | | WBPaper00046012:tdp-1(ok803)_upregulated |
| | | WBPaper00046121:ecdoderm_unique |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_100-cell-embryo |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00051404:alg-1(gk214)_upregulated |
| | | WBPaper00051404:alg-2(ok304)_upregulated |
| | | WBPaper00052884:emb-4(hc60)_upregulated |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053295:lin-22(icb38)_upregulated |
| | | WBPaper00053295:lin-22(ot269)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:stavudine_72h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster1 |
| | | WBPaper00054758:alg-1(gk204)_upregulated |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:eat-2(ad1116)_upregulated |
| | | WBPaper00055354:Psora_upregulated |
| | | WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rapamycin-Rifampicin_upregulated |
| | | WBPaper00055354:Rifampicin-Psora_upregulated |
| | | WBPaper00055354:Rifampicin_upregulated |
| | | WBPaper00055827:pfd-6(gk493446)_downregulated |
| | | WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056090:E.faecalis_upregulated_N2 |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056809:smn-1(ok355)_upregulated |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057068:ints-4(RNAi)_upregulated |
| | | WBPaper00057068:ints-4(RNAi)_upregulated_Cadmium |
| | | WBPaper00057068:numr-1(RNAi)_downregulated |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058691:cfp-1(tm6369)_upregulated |
| | | WBPaper00058691:set-2(bn129)_upregulated |
| | | WBPaper00058711:wdr-5(ok1417)_upregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated |
| | | WBPaper00059421:daf-3(mgDf90)_downregulated |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060273:isp-1(qm150)_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00061007:HB101_upregulated |
| | | WBPaper00061007:S.aquatilis_upregulated |
| | | WBPaper00061081:E.faecalis_upregulated_N2 |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:ADEsh |
| | | WBPaper00061340:AIM |
| | | WBPaper00061340:AMsh |
| | | WBPaper00061340:AMso |
| | | WBPaper00061340:Anterior_arcade_cell |
| | | WBPaper00061340:CEPso |
| | | WBPaper00061340:Glia |
| | | WBPaper00061340:hyp1V_and_ant_arc_V |
| | | WBPaper00061340:hyp1_hyp2 |
| | | WBPaper00061340:hyp3 |
| | | WBPaper00061340:ILsh_OLLsh_OLQsh |
| | | WBPaper00061340:Parent_of_hyp3_ILsoDx |
| | | WBPaper00061340:Posterior_arcade_cell |
| | | WBPaper00061340:RIH |
| | | WBPaper00061340:XXX |
| | | WBPaper00061341:28C_24h_upregulated |
| | | WBPaper00061341:28C_48h_upregulated |
| | | WBPaper00061439:unc-30(ok613)_downregulated |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061479:mep-1(ne4629)_upregulated |
| | | WBPaper00061479:ubc-9(ne4833)_upregulated |
| | | WBPaper00061527:sol-1-jnk-1_18695 |
| | | WBPaper00061651:NSM_enriched |
| | | WBPaper00061753:csr-1(tor159)_downregulated_20C |
| | | WBPaper00061995:mter-4(syb3662syb3403)_downregulated |
| | | WBPaper00062156:jmjd-5(zr1234)_upregulated |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062440:crh-1(n3315)_downregulated |
| | | WBPaper00062446:nhr-8(hd117)_upregulated |
| | | WBPaper00062497:xpf-1(tm2842)_upregulated |
| | | WBPaper00062590:Aging_downregulated_neuron |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141) |
| | | WBPaper00064156:lbp-3(overexpress)_upregulated |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064939:vit-5(RNAi)_upregulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065560:E.coli-HB101_downregulated_F3 |
| | | WBPaper00065581:hpk-1(pk1393)_upregulated |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065749:Heat-Shock_downregulated_N2 |
| | | WBPaper00065841:5_0 |
| | | WBPaper00065841:21_0 |
| | | WBPaper00065841:21_1 |
| | | WBPaper00065841:56_0 |
| | | WBPaper00065841:58_0 |
| | | WBPaper00065841:95_0 |
| | | WBPaper00065841:96_0 |
| | | WBPaper00065841:109_0 |
| | | WBPaper00065841:128_0 |
| | | WBPaper00065841:142_0 |
| | | WBPaper00066062:xrep-4(lax137)_upregulated |
| | | WBPaper00066110:Cisplatin_upregulated_diploid |
| | | WBPaper00066110:tetraploid_vs_diploid_upregulated |
| | | cgc4489_group_17 |
| | | cgc4489_group_18 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00026929:Resveratrol_regulated_daf-16 |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00030985:Serratia_marcesens_downregulated |
| | | WBPaper00031832:slr-2_regulated |
| | | WBPaper00032948:FedUp |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00036123:Atrazine_regulated |
| | | WBPaper00036286:Pattern_G |
| | | WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated |
| | | WBPaper00040858:eQTL_age_regulated_developing |
| | | WBPaper00040858:eQTL_regulated_developing |
| | | WBPaper00041174:environmental |
| | | WBPaper00041174:genotypic |
| | | WBPaper00041174:genotypic_and_environmental |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h |
| | | WBPaper00045673:colistin_upregulated |
| | | WBPaper00048989:eat-2(ad465)_rapamycin_downregulated |
| | | WBPaper00048989:N2_rapamycin_downregulated |
| | | WBPaper00053236:Starvation_regulated_GR1307 |
| | | WBPaper00053236:Starvation_regulated_N2 |
| | | WBPaper00057098:SiO2-nanoparticles_upregulated |
| | Interaction (102) |
| Map_info | Map | X | Position | 19.7628 | Error | 0.06206 |
| | Positive | Positive_clone | F40E10 | Inferred_automatically | From CDS info |
| | | | | | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 4664 |
| | | | 5528 |
| | Pseudo_map_position |
| Reference (74) |
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission |
| Method | Gene |
