WormBase Tree Display for Gene: WBGene00004811

WBGene00004811 Evidence: CGC_data_submission
  SMap: S_parent: Sequence: F47H4
  Identity: Version: 1
    Name: CGC_name: skr-5 Person_evidence: WBPerson322
      Sequence_name: F47H4.10
      Molecular_name: F47H4.10
        F47H4.10.1
        CE20827
      Other_name: CELE_F47H4.10 Accession_evidence: NDB BX284605
      Public_name: skr-5
    DB_info: Database: AceView gene 5R829
        WormQTL gene WBGene00004811
        WormFlux gene WBGene00004811
        NDB locus_tag CELE_F47H4.10
        Panther gene CAEEL|WormBase=WBGene00004811|UniProtKB=Q9XU27
          family PTHR11165
        NCBI gene 180148
        RefSeq protein NM_074992.8
        TREEFAM TREEFAM_ID TF354233
        TrEMBL UniProtAcc Q9XU27
        UniProt_GCRP UniProtAcc Q9XU27
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:36 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: skr
    Allele (81)
    Strain (2)
    RNASeq_FPKM (74)
    GO_annotation: 00101456
      00101457
      00101458
      00101459
      00101460
      00101461
      00113218
    Ortholog (60)
    Paralog (19)
    Structured_description: Concise_description: The skr-5 gene encodes a homolog of Skp1 in S. cerevisiae that has no known function in vivo, since skr-5(RNAi) animals are at least superficially normal. Paper_evidence: WBPaper00005128
            WBPaper00005129
          Curator_confirmed: WBPerson567
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable cullin family protein binding activity. Involved in determination of adult lifespan. Predicted to be located in cytoplasm and nucleus. Expressed in hypodermis; intestinal cell; and vulval muscle. Is an ortholog of human SKP1 (S-phase kinase associated protein 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F47H4.10
    Corresponding_transcript: F47H4.10.1
    Other_sequence: DI02100
  Experimental_info: RNAi_result (14)
    Expr_pattern: Expr9354
      Expr12090
      Expr14989
      Expr1015927
      Expr1151537
      Expr2015853
      Expr2034086
    Drives_construct: WBCnstr00008990
      WBCnstr00013919
      WBCnstr00020216
      WBCnstr00035372
      WBCnstr00041836
    Construct_product: WBCnstr00020216
      WBCnstr00035372
    Microarray_results (17)
    Expression_cluster: WBPaper00027339:daf-12(rh273)_upregulated
      WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00033065:cyc-1(RNAi)_upregulated
      WBPaper00036291:ung-1_regulated
      WBPaper00037950:dopaminergic-neurons_larva_enriched
      WBPaper00037950:GABAergic-motor-neurons_larva_enriched
      WBPaper00037950:intestine_CoreEnriched
      WBPaper00037950:intestine_embryo_enriched
      WBPaper00037950:intestine_larva_enriched
      WBPaper00037950:PVD-OLL-neurons_larva_enriched
      WBPaper00038168:lin-15B(n744)_upregulated
      WBPaper00038168:lin-35_upregulated
      WBPaper00038237:age-1_upregulated_intestine_rescue
      WBPaper00038237:age-1_upregulated_neuron_rescue
      WBPaper00038237:age-1_upregulated_nontransgenic
      WBPaper00038438:Harposporium_24hr_upregulated_RNAseq
      WBPaper00040560:hpl-2_L3_upregulated
      WBPaper00042477:rsr-2(RNAi)_downregulated_RNAseq
      WBPaper00042561:smg-2(RNAi)_upregulated
      WBPaper00042561:smgl-1(RNAi)_upregulated
      WBPaper00042561:smgl-2(RNAi)_upregulated
      WBPaper00044030:nhr-8(hd117)_upregulated
      WBPaper00044316:CH3HgCl_7.5uM_upregulated
      WBPaper00044426:rotenone_5day_downregulated
      WBPaper00044736:flat_dev_expression
      WBPaper00044760:germline_specific
      WBPaper00045314:S.aureus-induced_hlh-30(tm1978)
      WBPaper00045390:tunicamycin_downregulated
      WBPaper00045390:ubc-9(RNAi)_downregulated
      WBPaper00045401:N.parisii_30h_upregulated
      WBPaper00045420:fertilization_downregulated_transcript
      WBPaper00045774:clk-1_upregulated
      WBPaper00045934:wrn-1(gk99)_downregulated
      WBPaper00046795:starvation_upregulated
      WBPaper00047132:glp-1(ts)-25C_upregulated
      WBPaper00049018:swsn-2.2(RNAi)_upregulated
      WBPaper00049377:MWCNT_downregulated
      WBPaper00049545:jmjd-3.1(+)_upregulated
      WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00050121:mir-60(n4947)_upregulated
      WBPaper00050332:daf-16(RNAi)_downregulated
      WBPaper00050468:hlh-30-dependent_Cry5B_regulated
      WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult
      WBPaper00050488:20C_vs_25C_regulated_mir-34(OverExpression)_adult
      WBPaper00050488:20C_vs_25C_regulated_N2_adult
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_20C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_adult_25C
      WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
      WBPaper00050488:mir-34(OverExpression)_vs_N2_regulated_adult_20C
      WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
      WBPaper00050488:N2_vs_mir-34(OverExpression)_regulated_adult_25C
      WBPaper00050504:hrp-2(RNAi)_upregulated
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050903:mir-35-41(nDf50)_25C_upregulated
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00051137:Orsay-virus_upregulated_rde-1(ne219)
      WBPaper00051245:intestine_cytoplasm_expressed
      WBPaper00051245:intestine_specific
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00053302:stavudine_24h_regulated
      WBPaper00053388:dauer_regulated_Cluster4
      WBPaper00053402:cco-1(RNAi)_upregulated
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_downregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053771:up_at_24h-NaCl
      WBPaper00053771:up_at_dpy-7(e88)
      WBPaper00053798:nhr-49(nr2041)_tBOOH_upregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:isp-1(qm150)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00053810:sod-2(ok1030)_upregulated
      WBPaper00053909:N2_vs_CB4856_upregulated
      WBPaper00054493:hpl-2(tm1489)_downregulated
      WBPaper00054872:egl-9(sa307)_upregulated
      WBPaper00055013:hmg-3(bar24)_upregulated
      WBPaper00055013:spt-16(RNAi)_upregulated
      WBPaper00055354:Psora-Allantoin_upregulated
      WBPaper00055354:Psora_upregulated
      WBPaper00055354:Rapamycin-Metformin_upregulated
      WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
      WBPaper00055354:Rapamycin-Rifampicin_upregulated
      WBPaper00055354:Rifampicin-Allantoin_upregulated
      WBPaper00055354:Rifampicin-Psora_upregulated
      WBPaper00055354:Rifampicin_upregulated
      WBPaper00055386:daf-2(e1370)_upregulated
      WBPaper00055827:daf-2(e1370)_upregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055941:atfs-1(et15)_upregulated
      WBPaper00055941:nuo-6(qm200);atfs-1(gk3094)_upregulated
      WBPaper00055941:nuo-6(qm200)_upregulated
      WBPaper00055971:nhl-2(ok818)_20C_downregulated
      WBPaper00055971:nhl-2(ok818)_25C_downregulated
      WBPaper00056034:pals-22(jy3)_upregulated
      WBPaper00056034:pals-25(jy9)_upregulated
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056167:Cry5B_downregulated
      WBPaper00056167:ifo-1(kc2)_downregulated
      WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
      WBPaper00056290:hsp-6(mg585)_upregulated
      WBPaper00056443:DietaryRestriction_upregulated
      WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay1
      WBPaper00056809:smn-1(ok355)_upregulated
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057041:spc-1(cas971)_downregulated
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00057068:Cadmium_upregulated
      WBPaper00057068:ints-4(RNAi)_upregulated
      WBPaper00057265:metaformin_downregulated_OP50
      WBPaper00057265:metaformin_downregulated_OP50-MR
      WBPaper00057347:nhr-14(tm1473)_upreglated
      WBPaper00058598:mex-3(eu149)_downregulated
      WBPaper00058948:npr-8(ok1439)_upregulated_PA14
      WBPaper00058948:PA14_downregulated
      WBPaper00059027:neuron-synapses_depleted
      WBPaper00059334:sacy-1(depletion)_regulated
      WBPaper00059537:ngn-1(ok2200)_upregulated
      WBPaper00059664:srbc-48(ac23)_upregulated
      WBPaper00059739:hira-1(gk835598)_upregulated_adult
      WBPaper00059739:hira-1(gk835598)_upregulated_L4
      WBPaper00059895:wounding_upregulated
      WBPaper00059987:Wounding_upregulated
      WBPaper00060100:SiNP_downregulated_mRNA
      WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060399:CoCl2_6hr_upregulated_N2
      WBPaper00060661:sensory-neuron_depleted
      WBPaper00060703:nas-38(ok3407)_upregulated
      WBPaper00060764:swsn-1(os22ts)_upregulated
      WBPaper00060886:spr-5(by101);met-2(n4256)_upregulated
      WBPaper00061081:E.faecalis_upregulated_N2
      WBPaper00061081:E.faecalis_upregulated_skpo-1(ok1640)
      WBPaper00061274:microgravity_downregulated
      WBPaper00061319:pnp-1(jy90)_upregulated
      WBPaper00061422:let-607(RNAi)_regulated
      WBPaper00061424:Diet_MYb120_upregulated
      WBPaper00061424:Diet_MYb131_upregulated
      WBPaper00061527:C32F10.4-D1086.2
      WBPaper00061530:nhr-49(e2144)_upregulated
      WBPaper00061699:daf-18(ok480)_downregulated
      WBPaper00061753:csr-1(tor159)_upregulated_25C
      WBPaper00061952:daf-18(nr2037)_downregulated
      WBPaper00061952:daf-18(yh1)_downregulated
      WBPaper00062118:neural-HSF-1_upregulated
      WBPaper00062146:MOG-7-degron_2h_regulated
      WBPaper00062159:hda-2(ok1479)_upregulated
      WBPaper00062184:PA14_upregulated
      WBPaper00062193:daf-16(RNAi)_downregulated
      WBPaper00062193:skn-1(RNAi)_upregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062345:bortezomib_4h_upregulated_N2
      WBPaper00062440:crh-1(n3315)_downregulated
      WBPaper00062446:nhr-8(hd117)_upregulated
      WBPaper00062585:hlh-26(ok1453)_downregulated_E.faecium
      WBPaper00062587:lsl-1(ljm1)_downregulated
      WBPaper00062587:lsl-1(tm4769)_downregulated
      WBPaper00062590:Aging_upregulated_intestine
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064107:lin-35(n745)_upregulated
      WBPaper00064156:lbp-3(overexpress)_upregulated
      WBPaper00064532:pals-22(jy3)_upregulated
      WBPaper00064532:pals-25(icb98)_upregulated
      WBPaper00064532:pals-25(jy111)_upregulated
      WBPaper00064539:nhr-114(gk849)_upregulated
      WBPaper00064602:egl-9(sa307)_upregulated
      WBPaper00064637:cox-5B(RNAi)_upregulated
      WBPaper00064661:lpd-3(ok2138)_upregulated
      WBPaper00064871:PA14_upregulated_AWA
      WBPaper00064933:bcf-1(ylf1)_upregulated_transcript
      WBPaper00065029:cadmium_upregulated
      WBPaper00065086:N2_N.ausubeli_regulated
      WBPaper00065086:N2_N.ferruginous_regulated
      WBPaper00065086:N2_N.ironsii_regulated
      WBPaper00065086:N2_N.parisii_regulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065158:25C_vs_15C_downregulated_WholeAnimal
      WBPaper00065158:AFD_depleted
      WBPaper00065225:nhr-42(tm1375)_upregulated_S.aureus-infected
      WBPaper00065288:mdt-15(tm2182)_upregulated
      WBPaper00065734:unc-25(e156)_upregulated
      WBPaper00065749:endu-2(tm4977)_upregulated
      WBPaper00065926:pgph-2(overepxreesion)_upregulated
      WBPaper00065926:pgph-2(overepxreesion)_upregulated_glucose
      WBPaper00065984:pals-17(syb3980)_upregulated
      WBPaper00065993:glp-1(e2141)_upregulated
      WBPaper00065995:M.humicola-extract_downregulated_N2
      WBPaper00066110:tetraploid_vs_diploid_upregulated
      WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
      WBPaper00066204:CdCl2_upregulated_mRNA
      WBPaper00066232:ash-2(RNAi)_downregulated_WT
      WBPaper00066232:hsf-1(RNAi)_upregulated_ash-2
      WBPaper00066232:hsf-1(RNAi)_upregulated_WT
      cgc4386_cluster_3_3
      cgc4489_group_9
      WBPaper00024671:AFD_AWB_vs_unsorted_downregulated
      WBPaper00026929:Resveratrol_regulated_daf-16
      WBPaper00026980:intestine_enriched
      WBPaper00028789:PA14_vs_OP50_upregulated_8hr
      WBPaper00029437:dcr-1_upregulated
      WBPaper00031850:mdt-15(RNAi)_upregulated
      WBPaper00034757:up_by_oxidative_stress
      WBPaper00035227:heat_shock_regulated
      WBPaper00035588:alg-1(-)_upregulated
      WBPaper00037695:WC_5-day
      WBPaper00038231:Cry5B_1.5-fold_upregulated
      WBPaper00038231:Cry5B_2-fold_upregulated
      WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
      WBPaper00040821:Au-NP_regulated
      WBPaper00040858:eQTL_regulated_old
      WBPaper00040963:Q200_up
      WBPaper00040963:TA100_up
      WBPaper00040963:TA200_up
      WBPaper00040963:TA300_up
      WBPaper00041002:HF_3d_0.2mM_Up
      WBPaper00041002:HF_3d_2.0mM_Down
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00041370:spg-7(RNAi)_upregulated
      WBPaper00041609:hpl-1_hpl-2_upregulated
      WBPaper00041939:control_vs_EtBr-exposed_48h
      WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_3h
      WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_3h
      WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_48h
      WBPaper00041960:daf-16_fasting_upregulated
      WBPaper00041960:kgb-1_fasting_upregulated
      WBPaper00041960:N2_fasting_upregulated
      WBPaper00041960:N2_fasting_upregulated_9hto12h
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00042331:a-SWCNTs_downregulated
      WBPaper00045263:0.1mM-paraquat_upregulated
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00045263:ProLongevity-mtROS_upregulated
      WBPaper00045865:biofilm_upregulated_A
      WBPaper00047021:MWCNT_downregulated
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00047070:xpa-1_UV_upregulated
      WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
      WBPaper00050515:nipi-3(fr4)_upregulated
      WBPaper00051448:P.aeruginosa_Slow-Killing_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00056330:mrps-5(RNAi)_upregulated
      [cgc5376]:let-60(G12V)-regulated_genes
      [cgc5976]:class_1
    Interaction (25)
  Map_info: Map: V Position: 12.8833 Error: 0.001418
    Positive: Positive_clone: F47H4 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (15)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene