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WormBase Tree Display for Gene: WBGene00004140

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Name Class

WBGene00004140SMapS_parentSequenceR09E10
IdentityVersion2
NameCGC_nameebax-1Person_evidenceWBPerson293
Sequence_nameR09E10.7
Molecular_nameR09E10.7
R09E10.7.1
CE37845
Other_namepqn-55Person_evidenceWBPerson625
CELE_R09E10.7Accession_evidenceNDBBX284604
Public_nameebax-1
DB_infoDatabaseAceViewgene4L57
WormQTLgeneWBGene00004140
WormFluxgeneWBGene00004140
NDBlocus_tagCELE_R09E10.7
PanthergeneCAEEL|WormBase=WBGene00004140|UniProtKB=Q21875
familyPTHR22619
NCBIgene177915
RefSeqproteinNM_069487.7
TREEFAMTREEFAM_IDTF324881
TrEMBLUniProtAccQ21875
UniProt_GCRPUniProtAccQ21875
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:34WBPerson1971EventImportedInitial conversion from geneace
210 Jul 2013 13:59:51WBPerson2970Name_changeCGC_nameebax-1
Other_namepqn-55
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classebax
Allele (84)
StrainWBStrain00050654
WBStrain00050655
WBStrain00052085
RNASeq_FPKM (74)
GO_annotation (20)
Ortholog (45)
Structured_descriptionConcise_descriptionebax-1 encodes a conserved BC-box-containing protein; EBAX-1 functions as part of a protein quality control mechanism that ensures proper axon guidance; specifically, EBAX-1 functions as a substrate-recognition subunit for misfolded SAX-3 in an Elongin BC-containing Cullin-RING ubiquitin ligase (CRL) complex that promotes degradation of misfolded SAX-3/Robo receptor; EBAX-1 function is particularly critical for thermotolerance of axon guidance; in regulating protein quality control, EBAX-1 functions together and physically interacts with DAF-21, a C. elegans Hsp90 homolog; EBAX-1 is expressed during embryonic and larval stages, and acts cell autonomously in neurons, particularly developing neurons, where it localizes to the cytosol.Paper_evidenceWBPaper00044158
Curator_confirmedWBPerson1843
Date_last_updated30 Sep 2014 00:00:00
Automated_descriptionEnables Hsp90 protein binding activity; misfolded protein binding activity; and signaling receptor binding activity. Involved in positive regulation of miRNA catabolic process; regulation of locomotion; and regulation of reproductive process. Located in axon; cytosol; and neuronal cell body. Part of Cul2-RING ubiquitin ligase complex. Expressed in excretory cell; nervous system; and vulval muscle. Is an ortholog of human ZSWIM8 (zinc finger SWIM-type containing 8).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Molecular_infoCorresponding_CDSR09E10.7
Corresponding_CDS_historyR09E10.7:wp136
Corresponding_transcriptR09E10.7.1
Other_sequenceTcir_isotig20209
CRC00576_1
GE625664.1
CR03532
JI163992.1
Dviv_isotig23842
Associated_featureWBsf660575
WBsf660576
WBsf660577
WBsf228977
WBsf228978
Experimental_infoRNAi_resultWBRNAi00072280Inferred_automaticallyRNAi_primary
WBRNAi00051626Inferred_automaticallyRNAi_primary
WBRNAi00017651Inferred_automaticallyRNAi_primary
WBRNAi00034784Inferred_automaticallyRNAi_primary
WBRNAi00081120Inferred_automaticallyRNAi_primary
WBRNAi00051625Inferred_automaticallyRNAi_primary
Expr_patternExpr11256
Expr12595
Expr1028257
Expr1032014
Expr1155298
Expr2011161
Expr2029397
Drives_constructWBCnstr00019380
WBCnstr00022366
WBCnstr00037933
Construct_productWBCnstr00019380
WBCnstr00037933
Microarray_results (19)
Expression_clusterWBPaper00032528:L3_enriched
WBPaper00033065:isp-1-1(qm150)_upregulated
WBPaper00037950:A-class-motor-neurons_L1-larva_expressed
WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
WBPaper00037950:all-neurons_L1-larva_expressed
WBPaper00037950:AVA-neuron_L1-larva_expressed
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:coelomocytes_L1-larva_expressed
WBPaper00037950:dopaminergic-neurons_L1-larva_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
WBPaper00037950:hypodermis_L1-larva_expressed
WBPaper00037950:hypodermis_L3-L4-larva_expressed
WBPaper00037950:intestine_L1-larva_expressed
WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00040221:DAF-12_target_ALF4
WBPaper00042477:rsr-2(RNAi)_downregulated_RNAseq
WBPaper00044037:eat-2_downregulated
WBPaper00044260:nicotic-acid_downregulated
WBPaper00044426:rotenone_24h_downregulated
WBPaper00044736:oscillating_dev_expression
WBPaper00045521:Oogenic
WBPaper00046024:sleep_downregulated_oscillating
WBPaper00046805:csr-1(RNAi)_downregulated_Set1
WBPaper00048923:Aging_regulated
WBPaper00048988:neuron_expressed
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
WBPaper00049626:UNC-75_target
WBPaper00049920:Glucose-Diet_downregulated_hyl-2(tm2031)
WBPaper00050015:ifg-1(RNAi)_upregulated
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050990:body-muscle_expressed
WBPaper00050990:intestine_expressed
WBPaper00051039:germline_enriched
WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq
WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq
WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_L1_SMARTseq
WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
WBPaper00053388:dauer_regulated_Cluster5
WBPaper00053599:mitosis_vs_meiosis_downregulated
WBPaper00053599:oocyte_vs_mitosis_downregulated
WBPaper00054410:set-26(tm2467)_downregulated
WBPaper00055060:flr-1(RNAi)_upregulated
WBPaper00055334:DLC-1_interacting
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin_upregulated
WBPaper00055354:Rifampicin_upregulated
WBPaper00055386:daf-2(e1370)_downregulated
WBPaper00055862:antimycin_damt-1(gk961032)_regulated
WBPaper00055971:nhl-2(ok818)_20C_upregulated
WBPaper00055971:nhl-2(ok818)_25C_upregulated
WBPaper00056169:rrf-3(pk1426)_downregulated_L4
WBPaper00056284:ints-11(RNAi)_downregulated
WBPaper00056290:hsp-6(mg585)_upregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00056471:S.aureus-4h_downregulated_N2
WBPaper00056809:smn-1(ok355)_downregulated
WBPaper00057068:numr-1(RNAi)_downregulated
WBPaper00057288:iff-1(RNAi)_downregulated_transcript
WBPaper00059328:mrps-5(RNAi)_downregulated_mRNA
WBPaper00059440:GLP-1_represseded
WBPaper00059440:LAG-1_repressed_48hr-auxin
WBPaper00059471:EGL-43_interacting
WBPaper00060459:bcat-1(RNAi)_downregulated
WBPaper00060661:sensory-neuron_enriched
WBPaper00060811:L1_vs_adult_downregulated_neural
WBPaper00060909:atfs-1(cmh15)_downregulated
WBPaper00061340:Parents_of_Y_DA6_DA7_DA9
WBPaper00061479:HDA-1_interacting_protein
WBPaper00061527:pkn-1_20439-tbc-12_11015
WBPaper00062193:hsf-1(RNAi)_downregulated
WBPaper00062193:skn-1(RNAi)_downregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062446:nhr-8(hd117)_upregulated
WBPaper00062590:Aging_upregulated_intestine
WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064291:antimycin_downregulated
WBPaper00064315:mes-4(bn73)_upregulated_EGCs
WBPaper00064532:pals-25(icb98)_downregulated
WBPaper00064716:paraquat_upregulated
WBPaper00064735:bet-1B(OE)_vs_N2_downregulated
WBPaper00064871:hypoxia_downregulated_F1
WBPaper00064933:bcf-1(ylf1)_upregulated_transcript
WBPaper00065096:Day10_vs_Day1_upregulated
WBPaper00065841:31_0
WBPaper00066062:xrep-4(lax137)_upregulated
WBPaper00066093:E.coli-purE_downregulated
WBPaper00066110:Doxorubicin_downregulated_diploid
cgc4386_cluster_6_3
cgc4489_group_6
WBPaper00025032:cluster_2
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00027342:alpha-Synuclein(A53T)_downregulated
WBPaper00031003:hlh_1_enriched
WBPaper00031252:AIN-2_IP_enriched
WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
WBPaper00040823:alg-1(gk214)_downregulated
WBPaper00040858:eQTL_age_regulated_aging
WBPaper00040858:eQTL_age_regulated_developing
WBPaper00040858:eQTL_regulated_developing
WBPaper00040858:eQTL_regulated_juvenile
WBPaper00040858:eQTL_regulated_old
WBPaper00040963:Q100_down
WBPaper00040963:Q200_down
WBPaper00040963:TA300_down
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041906:I-3690_vs_OP50_3d
WBPaper00041939:control_vs_EtBr-exposed_48h
WBPaper00041939:control_vs_EtBr-exposed_51h
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00042331:a-SWCNTs_downregulated
WBPaper00045263:0.1mM-paraquat_upregulated
WBPaper00045263:isp-1(qm150)_upregulated
WBPaper00047070:N2_starvation_downregulated
WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
WBPaper00055899:nitroguanidine_regulated
WBPaper00057098:SiO2-nanoparticles_upregulated
[cgc5767]:cluster_2
[cgc5767]:expression_class_E
[cgc5767]:expression_class_E_pi(41_min)
[cgc5767]:expression_class_E_pi(53_min)
[cgc5767]:expression_class_M
[cgc5767]:expression_class_ME
[cgc6390]:mixed_oogenesis-somatic
InteractionWBInteraction000456278
WBInteraction000523851
WBInteraction000523852
WBInteraction000523853
WBInteraction000549241
WBInteraction000575353
Anatomy_functionWBbtf0601
WBbtf0602
Map_infoMapIVPosition4.57168Error0.00135
PositivePositive_cloneR09E10Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point4603
4622
Pseudo_map_position
Reference (12)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene