ebax-1 encodes a conserved BC-box-containing protein; EBAX-1 functions as part of a protein quality control mechanism that ensures proper axon guidance; specifically, EBAX-1 functions as a substrate-recognition subunit for misfolded SAX-3 in an Elongin BC-containing Cullin-RING ubiquitin ligase (CRL) complex that promotes degradation of misfolded SAX-3/Robo receptor; EBAX-1 function is particularly critical for thermotolerance of axon guidance; in regulating protein quality control, EBAX-1 functions together and physically interacts with DAF-21, a C. elegans Hsp90 homolog; EBAX-1 is expressed during embryonic and larval stages, and acts cell autonomously in neurons, particularly developing neurons, where it localizes to the cytosol.
Enables Hsp90 protein binding activity; misfolded protein binding activity; and signaling receptor binding activity. Involved in positive regulation of miRNA catabolic process; regulation of locomotion; and regulation of reproductive process. Located in axon; cytosol; and neuronal cell body. Part of Cul2-RING ubiquitin ligase complex. Expressed in excretory cell; nervous system; and vulval muscle. Is an ortholog of human ZSWIM8 (zinc finger SWIM-type containing 8).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.