Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.

WormBase Tree Display for Gene: WBGene00004003

expand all nodes | collapse all nodes | view schema

Name Class

WBGene00004003SMapS_parentSequenceCHROMOSOME_V
IdentityVersion1
NameCGC_namepgp-9Person_evidenceWBPerson490
Sequence_nameC47A10.1
Molecular_nameC47A10.1
C47A10.1.1
CE15714
Other_nameCELE_C47A10.1Accession_evidenceNDBBX284605
Public_namepgp-9
DB_infoDatabaseAceViewgene5S243
WormQTLgeneWBGene00004003
WormFluxgeneWBGene00004003
NDBlocus_tagCELE_C47A10.1
PanthergeneCAEEL|WormBase=WBGene00004003|UniProtKB=G5EG58
familyPTHR24221
NCBIgene180165
RefSeqproteinNM_075086.6
TrEMBLUniProtAccG5EG58
UniProt_GCRPUniProtAccG5EG58
OMIMgene171050
171060
603201
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:33WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classpgp
Allele (249)
StrainWBStrain00003585
RNASeq_FPKM (74)
GO_annotation (14)
Ortholog (65)
Paralog (23)
Structured_descriptionConcise_descriptionpgp-9 encodes an ATP-binding protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; PGP-9 is predicted to function as a transmembrane protein that couples energy to transport of various molecules across membranes, and loss of pgp-9 activity via RNAi can result in embryonic lethality; pgp-9 promoter-gfp fusion proteins are expressed in the pharynx (first and second bulbs) and in the intestine.Paper_evidenceWBPaper00004651
WBPaper00006421
WBPaper00006525
WBPaper00024561
Curator_confirmedWBPerson1843
Date_last_updated07 Mar 2006 00:00:00
Automated_descriptionPredicted to enable ATPase-coupled transmembrane transporter activity and efflux transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); and intrahepatic cholestasis (multiple). Is an ortholog of human ABCB1 (ATP binding cassette subfamily B member 1); ABCB4 (ATP binding cassette subfamily B member 4); and ABCB5 (ATP binding cassette subfamily B member 5).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_model (41)
Molecular_infoCorresponding_CDSC47A10.1
Corresponding_transcriptC47A10.1.1
Other_sequenceName_isotig00941
ACC29929_1
GO254812.1
Tcol_isotig19128
DN153428.1
HC04633
FC546014.1
HCC00168_2
JI180170.1
FG972896.1
Oden_isotig10942
ACC17188_1
BUC00542_1
JI222082.1
DN557913.1
HC05918
Oden_isotig24642
LSC00905_1
Oden_isotig27971
EX554453.1
EY461473.1
CJC14002_1
GR14048
Tcol_isotig16918
EB763519.1
HC05917
FR691850.1
JI166507.1
Tcol_isotig23436
HC05914
HC05909
Oden_isotig10944
HCC09740_1
JO467866.1
JI257327.1
EY471572.1
ASC38488_1
HC05916
ACC29144_1
Tcir_isotig26704
Hbac_isotig07027
JI172889.1
GRC03467_1
HBC25899_1
Oden_isotig10943
JI177174.1
HBC18691_1
FR691848.1
Acan_isotig08065
FC544788.1
Associated_featureWBsf982069
WBsf1002739
WBsf1021340
Experimental_infoRNAi_resultWBRNAi00077359Inferred_automaticallyRNAi_primary
WBRNAi00070085Inferred_automaticallyRNAi_primary
WBRNAi00042636Inferred_automaticallyRNAi_primary
WBRNAi00012052Inferred_automaticallyRNAi_primary
WBRNAi00001328Inferred_automaticallyRNAi_primary
WBRNAi00022567Inferred_automaticallyRNAi_primary
Expr_patternChronogram1652
Expr3340
Expr5518
Expr5519
Expr1024605
Expr1031915
Expr1146620
Expr2014876
Expr2033111
Drives_constructWBCnstr00002006
WBCnstr00002007
WBCnstr00004037
WBCnstr00011336
Microarray_results (19)
Expression_clusterWBPaper00005700:transmembrane_protein
WBPaper00029359_1217
WBPaper00029359_1280
WBPaper00029359_1353
WBPaper00029359_1419
WBPaper00029359_1444
WBPaper00029359_1504
WBPaper00029359_1548
WBPaper00029359_1604
WBPaper00031040:TGF-beta_adult_upregulated
WBPaper00036375:enriched_in_PVD_OLL
WBPaper00037950:coelomocytes_embryo_enriched
WBPaper00037950:coelomocytes_embryo_SelectivelyEnriched
WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
WBPaper00038438:S.marcescens_24hr_upregulated_TilingArray
WBPaper00040134:nhr-49(RNAi)_regulated_protein
WBPaper00040560:hpl-2_L3_upregulated
WBPaper00041370:spg-7(RNAi)_upregulated_atfs-1_dependent
WBPaper00042561:smgl-1(RNAi)_upregulated
WBPaper00044316:CH3HgCl_7.5uM_upregulated
WBPaper00044501:gld-1_let-7_regulated
WBPaper00044578:reduced-humidity_downregulated_microarray
WBPaper00044736:oscillating_dev_expression
WBPaper00045017:blmp-1(tm548)_upregulated
WBPaper00045257:bar-1(ga80)_upregulated
WBPaper00045316:prg-1_upregulated_L1
WBPaper00045420:fertilization_downregulated_transcript
WBPaper00045571:germline-ablation_upregulated
WBPaper00045774:clk-1_upregulated
WBPaper00046496:Rifampicin_upregulated
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_6h
WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_6h
WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
WBPaper00046509:lin-35(n745)_downregulated
WBPaper00047132:glp-1(ts)-25C_upregulated
WBPaper00048923:Aging_regulated
WBPaper00048952:glucose_repressed
WBPaper00048971:daf-16(mgDf50)_upregulated_L1
WBPaper00048988:neuron_expressed
WBPaper00049217:TCER-1_upregulated
WBPaper00049498:npr-1(ur89)_regulated_3
WBPaper00049545:cco-1(RNAi)_upregulated
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr)
WBPaper00049905:Age_variant_expression
WBPaper00049920:Glucose-Diet_upregulated_hyl-2(tm2031)
WBPaper00049920:Glucose-Diet_upregulated_N2
WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
WBPaper00049942:hsf-1(RNAi)_upregulated
WBPaper00050015:ifg-1(RNAi)_upregulated
WBPaper00050121:mir-60(n4947)_upregulated
WBPaper00050412:cco-1(RNAi)_upregulated_met-2(ok2307)
WBPaper00050412:cco-1(RNAi)_upregulated_N2
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C
WBPaper00050488:N2_vs_mir-34(gk437)_regulated_dauer_20C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day1-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
WBPaper00050990:arcade_intestinal-valve_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:intestine_expressed
WBPaper00051039:intestine_enriched
WBPaper00051245:intestine_cytoplasm_expressed
WBPaper00051404:alg-1(gk214)_upregulated
WBPaper00051404:alg-2(ok304)_upregulated
WBPaper00051558:aging_regulated
WBPaper00053020:OrsayVirus-infection_downregulated
WBPaper00053184:sma-2(rax5)_downregulated
WBPaper00053302:stavudine_24h_regulated
WBPaper00053402:cco-1(RNAi)_upregulated
WBPaper00053810:isp-1(qm150)_upregulated
WBPaper00053810:nuo-6(qm200)_upregulated
WBPaper00054192:cold-shock_downregulated
WBPaper00054410:set-26(tm2467)_upregulated
WBPaper00055060:flr-1(RNAi)_upregulated
WBPaper00055334:DLC-1_interacting
WBPaper00055354:eat-2(ad1116)_downregulated
WBPaper00055354:Rapamycin-Allantoin_upregulated
WBPaper00055354:Rapamycin-Psora_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
WBPaper00055354:Rifampicin-Allantoin_downregulated
WBPaper00055354:Rifampicin-Psora_upregulated
WBPaper00055482:Tunicamycin_downregulated
WBPaper00055626:pry-1(mu38)_downregulated
WBPaper00055862:antimycin_damt-1(gk961032)_regulated
WBPaper00055941:atfs-1(et15)_upregulated
WBPaper00055941:nuo-6(qm200)_upregulated
WBPaper00056034:pals-22(jy3)_upregulated
WBPaper00056039:efa-6(tm3124)_upregulated
WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
WBPaper00056090:E.faecalis_upregulated_N2
WBPaper00056167:ifo-1(kc2)_upregulated
WBPaper00056169:rrf-3(pk1426)_upregulated_L4
WBPaper00056443:DietaryRestriction_downregulated
WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
WBPaper00056471:S.aureus-4h_downregulated_N2
WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay1
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00057068:Cadmium_upregulated
WBPaper00057140:pptr-1(tm3103)_upregulated
WBPaper00057154:HeatShock_downregulated_mRNA
WBPaper00057265:metaformin_downregulated_OP50
WBPaper00057265:metaformin_downregulated_OP50-MR
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058598:spn-4(tm291)_upregulated
WBPaper00058948:npr-8(ok1439)_downregulated_OP50
WBPaper00058948:PA14_downregulated
WBPaper00059117:B.subtilis_upregulated
WBPaper00059253:sucrose_stearic-acid_downregulated
WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
WBPaper00059824:rnp-6(dh1127)_regulated_OP50
WBPaper00060014:set-2(zr2012)_downregulated
WBPaper00060084:cco-1(RNAi)_upregulated_lin-40(yth27)
WBPaper00060084:cco-1(RNAi)_upregulated_N2
WBPaper00060273:isp-1(qm150)_upregulated
WBPaper00060278:atp-2(RNAi)_upregulated
WBPaper00060358:B.thuringiensis_non-pathogen_regulated_elt-2(RNAi)
WBPaper00060358:B.thuringiensis_pathogen_regulated_elt-2(RNAi)
WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
WBPaper00060459:bcat-1(RNAi)_upregulated
WBPaper00060661:sensory-neuron_enriched
WBPaper00060683:hlh-11(ko1)_upregulated
WBPaper00060683:hlh-11(overexpression)_upregulated
WBPaper00060703:nas-38(ok3407)_downregulated
WBPaper00060909:atfs-1(cmh15)_downregulated
WBPaper00060909:atfs-1(et18)_upregulated
WBPaper00060911:prx-5(RNAi)_upregulated_mRNA
WBPaper00060911:prx-5(RNAi)_upregulated_protein
WBPaper00061007:HB101_upregulated
WBPaper00061007:HB115_upregulated
WBPaper00061007:M.braciatum_upregulated
WBPaper00061007:S.aquatilis_upregulated
WBPaper00061007:X.citri_upregulated
WBPaper00061106:endu-2(tm4977)_upregulated
WBPaper00061340:Coelomocyte
WBPaper00061340:OLL
WBPaper00061341:28C_48h_downregulated
WBPaper00061405:S.aureus_downregulated_starvation
WBPaper00061466:nath-10(icb102)_downregulated
WBPaper00061479:hda-1(ne4752)_upregulated
WBPaper00061479:mep-1(ne4629)_upregulated
WBPaper00061479:ubc-9(ne4833)_upregulated
WBPaper00061527:ugt-2-nhr-115
WBPaper00061692:acivicin_upregulated
WBPaper00061853:osm-3(dh441)_downregulated
WBPaper00061853:osm-3(dh441)_downregulated_tunicamycin
WBPaper00061902:camt-1(ok515)_regulated_RMG
WBPaper00062078:NMR-HspB1_regulated
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062193:hsf-1(RNAi)_downregulated
WBPaper00062237:dnj-21(RNAi)_upregulated_protein
WBPaper00062293:isp-1(qm150)_upregulated
WBPaper00062305:P.brevicompactum_upregulated
WBPaper00062325:etr-1(lq61)_upregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062347:blmp-1(tm548)_upregulated
WBPaper00062354:H.zoospora_6h_regulated
WBPaper00062440:crh-1(n3315)_upregulated
WBPaper00062456:doxycycline_upregulated_CB4856_protein
WBPaper00062669:extracellular-vesicle_protein
WBPaper00064005:starvation_upregulated_aptf-1(gk794)_mRNA
WBPaper00064005:starvation_upregulated_N2_mRNA
WBPaper00064071:NHR-49_interacting
WBPaper00064088:Day-3-adult_vs_L4_upregulated_glp-1(e2141)
WBPaper00064130:Beta-Amyloid_downregulated_protein
WBPaper00064156:lbp-3(overexpress)_upregulated
WBPaper00064291:antimycin_upregulated
WBPaper00064539:nhr-114(gk849)_upregulated
WBPaper00064637:cox-5B(RNAi)_upregulated
WBPaper00064716:paraquat_downregulated
WBPaper00064728:cpl-1(W32AY35A)_upregulated
WBPaper00064769:him-17(me24)_upregulated
WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
WBPaper00065029:cadmium_upregulated
WBPaper00065096:25C_vs_20C_downregulated
WBPaper00065096:Day10_vs_Day1_downregulated
WBPaper00065258:anchor-cell_depleted
WBPaper00065331:100nM-ivermectin_upregulated
WBPaper00065392:Lb.delbrueckii_upregulated
WBPaper00065392:P.pentosaceus_upregulated
WBPaper00065578:gcn-1(nc40)_downregulated
WBPaper00065734:unc-25(e156)_upregulated
WBPaper00065749:endu-2(tm4977)_upregulated
WBPaper00065749:Heat-Shock-With-Recovery_upregulated_N2
WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977)
WBPaper00065835:Day11_vs_Day1_downregulated
WBPaper00065841:12_0
WBPaper00065841:26_2
WBPaper00065841:30_0
WBPaper00065841:39_0
WBPaper00065841:39_1
WBPaper00065841:39_2
WBPaper00065841:39_3
WBPaper00065926:pgph-2(overepxreesion)_upregulated_glucose
WBPaper00065945:epidermis-rpoa-2(-)_upregulated_protein
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00065993:glp-1(e2141)_upregulated
WBPaper00066118:cyclobutrifluram_upregulated
WBPaper00066146:germline-inx-14(RNAi)_upregulated_PA14
WBPaper00066204:CdCl2_upregulated_mRNA
cgc4489_group_24
WBPaper00025141:N2_Expressed_Genes
WBPaper00029437:dcr-1_upregulated
WBPaper00031252:AIN-1_IP_enriched
WBPaper00035873:dpy-9_regulated
WBPaper00035873:osmotically_regulated
WBPaper00036123:Fluoranthene_regulated
WBPaper00036286:Pattern_I
WBPaper00037695:WC_5-day
WBPaper00038231:Cry5B_1.5-fold_downregulated
WBPaper00038231:Cry5B_2-fold_downregulated
WBPaper00039792:TempShiftIncrease
WBPaper00039851:HK_C_albicans_vs_HK_OP50
WBPaper00039851:Live_C_albicans_vs_HK_OP50
WBPaper00040821:Au-NP_regulated
WBPaper00040823:alg-1(gk214)_upregulated
WBPaper00040985:AIN-2_asynchronous_intestine
WBPaper00040985:AIN-2_L4_intestine
WBPaper00040998:nhr-66_regulated
WBPaper00041002:HF_3d_2.0mM_Up
WBPaper00041002:HF_11d_0.2mM_Up
WBPaper00041267:SpaceFlight_Downregulated
WBPaper00041370:spg-7(RNAi)_upregulated
WBPaper00041606:CE_X.nematophila_regulated
WBPaper00041939:control_vs_EtBr-exposed_51h
WBPaper00041939:control_vs_UVC-EtBr-exposed_51h
WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_3h
WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h
WBPaper00045263:0.1mM-paraquat_downregulated
WBPaper00045263:isp-1(qm150)_upregulated
WBPaper00045263:nuo-6(qm200)_upregulated
WBPaper00045960:L4-lethargus_upregulated
WBPaper00046548:dafachronic-acid_downregulated
WBPaper00046853:AOBr_M.aeruginosa-batch-culture_downregulated
WBPaper00047070:N2_UV_upregulated
WBPaper00047070:xpa-1_UV_upregulated
WBPaper00048637:lin-35(n745)_starvation_upregulated
WBPaper00049311:AgNO3_regulated
WBPaper00050515:nipi-3(fr4)_upregulated
WBPaper00053236:daf-16(mgDF50)_regulated_Starved
WBPaper00053236:Starvation_regulated_N2
WBPaper00056330:mrps-5(RNAi)_upregulated
Interaction (24)
Map_infoMapVPosition13.1928Error0.00649
PositivePositive_cloneC47A10Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point5600
4301
Pseudo_map_position
ReferenceWBPaper00006402
WBPaper00006421
WBPaper00028970
WBPaper00031484
WBPaper00038491
WBPaper00046184
WBPaper00055090
WBPaper00061262
WBPaper00062515
WBPaper00065331
RemarkSequence connection from [Sheps JA, Baillie DL] [040902 ck1]
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene