| WBGene00003239 | SMap | S_parent | Sequence | C35C5 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | mig-2 | Person_evidence | WBPerson261 |
| | | Sequence_name | C35C5.4 |
| | | Molecular_name | C35C5.4a |
| | | | C35C5.4a.1 |
| | | | CE18544 |
| | | | C35C5.4b |
| | | | CE50721 |
| | | | C35C5.4b.1 |
| | | Other_name | CELE_C35C5.4 | Accession_evidence | NDB | BX284606 |
| | | Public_name | mig-2 |
| | DB_info | Database | AceView | gene | XM167 |
| | | | WormQTL | gene | WBGene00003239 |
| | | | WormFlux | gene | WBGene00003239 |
| | | | NDB | locus_tag | CELE_C35C5.4 |
| | | | Panther | gene | CAEEL|WormBase=WBGene00003239|UniProtKB=G5EBV3 |
| | | | | family | PTHR24072 |
| | | | NCBI | gene | 181344 |
| | | | RefSeq | protein | NM_077530.5 |
| | | | | | NM_001313405.4 |
| | | | TrEMBL | UniProtAcc | A0A0K3AYI6 |
| | | | | | G5EBV3 |
| | | | UniProt_GCRP | UniProtAcc | G5EBV3 |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:31 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | mig |
| | Allele (39) |
| | Legacy_information | rh17 : variable abnormal migration of Q neuroblasts HSN cells CAN cells. |
| | | [C.elegansII] rh17 : variable abnormal migration of Q neuroblasts, HSN cells, CAN cells etc.; Egl; uncoordinated; axon defects. OA1. [Hedgecock et al. 1987; Desai et al. 1988; NJ] |
| | | [Zipkin ID, Kindt RM, Kenyon CJ] mu28 homozygotes exhibit abnormal migration of Q daughters. Predicted gene C35C5.4, encodes Rho-related protein. |
| | Strain | WBStrain00024138 |
| | | WBStrain00024141 |
| | | WBStrain00024146 |
| | | WBStrain00024159 |
| | | WBStrain00024170 |
| | | WBStrain00024172 |
| | | WBStrain00028737 |
| | | WBStrain00028748 |
| | | WBStrain00032460 |
| | | WBStrain00004808 |
| | RNASeq_FPKM (74) |
| | GO_annotation | 00001666 |
| | | 00001667 |
| | | 00001668 |
| | | 00001669 |
| | | 00001670 |
| | | 00001671 |
| | | 00001672 |
| | | 00001673 |
| | | 00001674 |
| | | 00001675 |
| | | 00001676 |
| | | 00001677 |
| | | 00010275 |
| | | 00010276 |
| | | 00010277 |
| | | 00010278 |
| | | 00010279 |
| | | 00010280 |
| | | 00010281 |
| | | 00010282 |
| | | 00010283 |
| | | 00010284 |
| | | 00010285 |
| | | 00010286 |
| | | 00010287 |
| | | 00010288 |
| | | 00010289 |
| | | 00010290 |
| | | 00010291 |
| | | 00010292 |
| | | 00010293 |
| | | 00010294 |
| | | 00010295 |
| | | 00010296 |
| | | 00010297 |
| | | 00010298 |
| | | 00010299 |
| | | 00010300 |
| | | 00010301 |
| | | 00010302 |
| | | 00010303 |
| | | 00010304 |
| | | 00010305 |
| | | 00010306 |
| | | 00010307 |
| | | 00010308 |
| | | 00010309 |
| | | 00010310 |
| | | 00010311 |
| | | 00010312 |
| | | 00010313 |
| | | 00010314 |
| | | 00010315 |
| | | 00110768 |
| | | 00110769 |
| | | 00110770 |
| | Ortholog (39) |
| | Paralog | WBGene00000390 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00000424 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00004357 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00004287 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00022177 | Caenorhabditis elegans | From_analysis | Panther |
| | | WBGene00009059 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00012532 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00019544 | Caenorhabditis elegans | From_analysis | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | mig-2 encodes a member of the RhoG family of GTP-binding proteins; MIG-2 activity is required for migration of Q neuroblasts, HSN neurons, and CAN cells as well as neurite outgrowth and guidance; in regulating Q neuroblast migration and dendrite outgrowth, MIG-2 functions upstream of the ANI-1 anillin to asymmetrically regulate ANI-1 localization, and thus stabilize F-actin, at the leading edge and growth cone; MIG-2 is expressed in early embryos and in adults in the vulva, gonadal distal tip cells, and the sex myoblasts and their descendants. | Paper_evidence | WBPaper00046615 |
| | | | | | WBPaper00002878 |
| | | | | Curator_confirmed | WBPerson48 |
| | | | | | WBPerson1843 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 28 May 2015 00:00:00 |
| | | Automated_description | Enables GTPase activity and protein kinase binding activity. Involved in several processes, including actin cytoskeleton organization; axon guidance; and cell migration. Located in cytoplasm; cytoplasmic side of plasma membrane; and neuron projection. Expressed in several structures, including CAN; HSN; distal tip cell; touch receptor neurons; and vulval cell. Used to study epilepsy. Is an ortholog of human RHOG (ras homolog family member G). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:1826 | Homo sapiens | Paper_evidence | WBPaper00035198 |
| | | | | Curator_confirmed | WBPerson38202 |
| | | | | Date_last_updated | 04 Jun 2018 00:00:00 |
| Models_disease_asserted | WBDOannot00000557 |
| Molecular_info | Corresponding_CDS | C35C5.4a |
| | | C35C5.4b |
| | Corresponding_transcript | C35C5.4a.1 |
| | | C35C5.4b.1 |
| | Other_sequence (25) |
| | Associated_feature | WBsf663364 |
| | | WBsf1007033 |
| | | WBsf1007034 |
| | | WBsf1007035 |
| | | WBsf236390 |
| | | WBsf236391 |
| | | WBsf236392 |
| | | WBsf236393 |
| | | WBsf236394 |
| Experimental_info | RNAi_result (20) |
| | Expr_pattern | Expr1463 |
| | | Expr8941 |
| | | Expr12554 |
| | | Expr16070 |
| | | Expr1019676 |
| | | Expr1031535 |
| | | Expr1145980 |
| | | Expr2013570 |
| | | Expr2031803 |
| | Drives_construct | WBCnstr00000269 |
| | | WBCnstr00001031 |
| | | WBCnstr00001032 |
| | | WBCnstr00036166 |
| | Construct_product | WBCnstr00001031 |
| | | WBCnstr00007681 |
| | | WBCnstr00007697 |
| | | WBCnstr00009004 |
| | | WBCnstr00017999 |
| | | WBCnstr00036166 |
| | Microarray_results (25) |
| | Expression_cluster | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:CEP-sheath-cells_adult_enriched |
| | | WBPaper00037950:CEP-sheath-cells_adult_SelectivelyEnriched |
| | | WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_larva_enriched |
| | | WBPaper00037950:dopaminergic-neurons_larva_SelectivelyEnriched |
| | | WBPaper00037950:hypodermis_L3-L4-larva_expressed |
| | | WBPaper00037950:hypodermis_larva_enriched |
| | | WBPaper00037950:hypodermis_larva_SelectivelyEnriched |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00044501:gld-1_let-7_regulated |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00046012:tdp-1(ok803)_upregulated |
| | | WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_upregulated_6h |
| | | WBPaper00046497:B.thuringiensis_0.5mix_upregulated_12h |
| | | WBPaper00046497:B.thuringiensis_upregulated_protein |
| | | WBPaper00046509:htz-1(ok3099)_downregulated |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00050094:mes-2(bn11)_upregulated |
| | | WBPaper00050182:lmn-1(L535P)_upregulated |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050370:dpy-21(e428)_L3_upregulated |
| | | WBPaper00050488:20C_vs_25C_regulated_mir-34(gk437)_adult |
| | | WBPaper00050488:20C_vs_25C_regulated_N2_adult |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050488:mir-34(gk437)_vs_mir-34(OverExpression)_regulated_dauer_20C |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050903:mir-35-41(nDf50)_25C_downregulated |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00050990:seam_expressed |
| | | WBPaper00053184:sma-2(rax5)_upregulated |
| | | WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq |
| | | WBPaper00053321:PGCs_depleted_NuGen |
| | | WBPaper00053388:dauer_regulated_Cluster3 |
| | | WBPaper00053599:female_vs_male_upregulated |
| | | WBPaper00053599:mitosis_vs_meiosis_downregulated |
| | | WBPaper00053599:oocyte_vs_mitosis_downregulated |
| | | WBPaper00055804:FBF-1-FBF-2-associated_oogenic-enriched |
| | | WBPaper00056161:hermaphrodite_enriched_siRNA |
| | | WBPaper00056275:P.aeruginosa_upregulated |
| | | WBPaper00056275:P.aeruginosa_upregulated_atf-7(qd22qd130)_dependent |
| | | WBPaper00056275:P.aeruginosa_upregulated_pmk-1(km25)_dependent |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056826:SGP_biased |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00057288:iff-1(RNAi)_downregulated_transcript |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058725:sftb-1(cer39)_downregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00059471:EGL-43_interacting |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00059987:Wounding_upregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:F_U |
| | | WBPaper00061340:Intestinal_and_rectal_muscle |
| | | WBPaper00061340:K_Kprime |
| | | WBPaper00061340:mu_int_mu_anal |
| | | WBPaper00061340:mu_sph |
| | | WBPaper00061340:Parents_of_PHsh_hyp8_hyp9 |
| | | WBPaper00061340:Parent_of_PVP_and_rect_V |
| | | WBPaper00061527:cfz-2_18944-cfz-2_2268 |
| | | WBPaper00061527:utx-1_2886-swan-1_2192 |
| | | WBPaper00062193:skn-1(RNAi)_downregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062669:extracellular-vesicle_protein |
| | | WBPaper00064005:starvation_upregulated_N2_protein |
| | | WBPaper00064071:NHR-49_interacting |
| | | WBPaper00064315:mes-3(bn199)_upregulated_EGCs |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064716:paraquat_upregulated |
| | | WBPaper00065258:anchor-cell_enriched |
| | | cgc4386_cluster_6_2 |
| | | cgc4489_group_6 |
| | | WBPaper00025032:cluster_74 |
| | | WBPaper00025141:N2_Expressed_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00028482:PA14_upregulated |
| | | WBPaper00030985:Erwinia_carotovora_downregulated |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00032165:A_to_C_transit_increased |
| | | WBPaper00035227:heat_shock_regulated |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00035905:FBF-1_Associated |
| | | WBPaper00036286:Pattern_I |
| | | WBPaper00038231:Cry5B_1.5-fold_upregulated |
| | | WBPaper00038231:Cry5B_2-fold_upregulated |
| | | WBPaper00040210:Diazinon_24C_regulated |
| | | WBPaper00040603:tdp-1(lf)_up_vs_N2_FC_1.2 |
| | | WBPaper00040823:alg-1(gk214)_upregulated |
| | | WBPaper00040858:eQTL_age_regulated_aging |
| | | WBPaper00040858:eQTL_regulated_old |
| | | WBPaper00040963:Q100_down |
| | | WBPaper00040963:Q200_down |
| | | WBPaper00041002:HF_3d_2.0mM_Up |
| | | WBPaper00041002:HF_11d_2.0mM_Down |
| | | WBPaper00041002:HQ_3d_0.2mM_Up |
| | | WBPaper00041606:CE_X.nematophila_regulated |
| | | WBPaper00041939:EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_UVC-exposed_51h |
| | | WBPaper00041960:N2_fasting_upregulated_anytime |
| | | WBPaper00045263:0.1mM-paraquat_upregulated |
| | | [cgc5767]:cluster_5 |
| | | [cgc5767]:expression_class_E |
| | | [cgc5767]:expression_class_E_pi(122_min) |
| | | [cgc5767]:expression_class_M |
| | | [cgc5767]:expression_class_ME |
| | Interaction (285) |
| | WBProcess | WBbiopr:00000006 |
| | | WBbiopr:00000015 |
| | | WBbiopr:00000107 |
| | | WBbiopr:00000111 |
| Map_info | Map | X | Position | 4.35742 | Error | 0.06415 |
| | Well_ordered |
| | Positive | Positive_clone | C35C5 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | Multi_point | 3673 |
| Reference (178) |
| Remark | Data extracted from Zipkin et al. (1997) |
| Method | Gene |
