WormBase Tree Display for Gene: WBGene00003003
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| WBGene00003003 | SMap | S_parent | Sequence | T25C12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | lin-14 | Person_evidence | WBPerson261 | |||||
| Sequence_name | T25C12.1 | ||||||||
| Molecular_name | T25C12.1a | ||||||||
| T25C12.1a.1 | |||||||||
| CE43285 | |||||||||
| T25C12.1b | |||||||||
| CE03734 | |||||||||
| T25C12.1b.1 | |||||||||
| Other_name | CELE_T25C12.1 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | lin-14 | ||||||||
| DB_info | Database | AceView | gene | XM103 | |||||
| WormQTL | gene | WBGene00003003 | |||||||
| WormFlux | gene | WBGene00003003 | |||||||
| NDB | locus_tag | CELE_T25C12.1 | |||||||
| NCBI | gene | 181337 | |||||||
| RefSeq | protein | NM_077515.5 | |||||||
| NM_077516.7 | |||||||||
| SwissProt | UniProtAcc | Q21446 | |||||||
| TREEFAM | TREEFAM_ID | TF316913 | |||||||
| UniProt_GCRP | UniProtAcc | Q21446 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lin | ||||||||
| Reference_allele | WBVar00089301 | ||||||||
| WBVar00089587 | |||||||||
| Allele (337) | |||||||||
| Legacy_information (3) | |||||||||
| Strain (20) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (16) | |||||||||
| Ortholog (28) | |||||||||
| Structured_description | Concise_description | lin-14 encodes a novel protein whose activity is required for specifying the division timings of a specific group of cells during postembryonic development; lin-14 loss-of-function mutations result in the premature appearance of later larval lineages, while gain-of-function mutations result in reiteration of L1 larval stages lineages; in addition, lin-14 acts as a positive regulator of AVM, PVM, and FLP touch cell development; in regulating developmental timing, lin-14 acts, in part, by positively regulating the activity of lin-28, which encodes a cytoplasmic protein also required for proper developmental timing; at hatching, LIN-14 is detected in the nuclei of blast cells and neurons; later, from the late L1 to adult stages, LIN-14 levels are negatively regulated by translational repression mediated by lin-4, a 22-nt small temporal RNA (stRNA) that is complementary to sequences in the lin-14 3' UTR. | Paper_evidence | WBPaper00000620 | |||||
| WBPaper00001137 | |||||||||
| WBPaper00001468 | |||||||||
| WBPaper00001829 | |||||||||
| WBPaper00001848 | |||||||||
| WBPaper00003931 | |||||||||
| WBPaper00005159 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 02 Sep 2005 00:00:00 | ||||||||
| Automated_description | Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and single-stranded DNA binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; regulation of cell fate specification; and regulation of nematode larval development, heterochronic. Located in condensed nuclear chromosome. Expressed in several structures, including QL; QR; neurons; oocyte; and somatic nervous system. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | T25C12.1a | |||||||
| T25C12.1b | |||||||||
| Corresponding_CDS_history | T25C12.1a:wp196 | ||||||||
| Corresponding_transcript | T25C12.1a.1 | ||||||||
| T25C12.1b.1 | |||||||||
| Other_sequence (11) | |||||||||
| Associated_feature (55) | |||||||||
| Transcription_factor | WBTranscriptionFactor000395 | ||||||||
| Experimental_info | RNAi_result (17) | ||||||||
| Expr_pattern (13) | |||||||||
| Drives_construct | WBCnstr00000926 | ||||||||
| WBCnstr00007336 | |||||||||
| WBCnstr00007627 | |||||||||
| WBCnstr00015030 | |||||||||
| WBCnstr00015050 | |||||||||
| WBCnstr00015780 | |||||||||
| WBCnstr00015781 | |||||||||
| WBCnstr00036292 | |||||||||
| Construct_product | WBCnstr00000967 | ||||||||
| WBCnstr00007627 | |||||||||
| WBCnstr00019563 | |||||||||
| WBCnstr00019564 | |||||||||
| WBCnstr00021119 | |||||||||
| WBCnstr00021910 | |||||||||
| WBCnstr00036292 | |||||||||
| Regulate_expr_cluster | WBPaper00026952:class_A | ||||||||
| WBPaper00026952:class_B | |||||||||
| WBPaper00026952:class_C | |||||||||
| WBPaper00026952:class_D | |||||||||
| WBPaper00026952:class_E | |||||||||
| WBPaper00026952:class_F | |||||||||
| WBPaper00026952:class_G | |||||||||
| WBPaper00026952:class_H | |||||||||
| Antibody | WBAntibody00000046 | ||||||||
| WBAntibody00000337 | |||||||||
| WBAntibody00000338 | |||||||||
| WBAntibody00001031 | |||||||||
| WBAntibody00001569 | |||||||||
| WBAntibody00001873 | |||||||||
| Microarray_results (33) | |||||||||
| Expression_cluster (173) | |||||||||
| Interaction (256) | |||||||||
| WBProcess | WBbiopr:00000031 | ||||||||
| WBbiopr:00000057 | |||||||||
| WBbiopr:00000083 | |||||||||
| Map_info | Map | X | Position | 3.78431 | Error | 0.060767 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | nDf19 | |||||||
| yDp8 | |||||||||
| yDp10 | |||||||||
| Positive_clone | PPE4 | ||||||||
| T25C12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | 2_point | 251 | |||||||
| 492 | |||||||||
| 636 | |||||||||
| 637 | |||||||||
| 688 | |||||||||
| 3648 | |||||||||
| 3652 | |||||||||
| Multi_point (22) | |||||||||
| Pos_neg_data | 3918 | ||||||||
| 3920 | |||||||||
| 654 | |||||||||
| 668 | |||||||||
| 3155 | |||||||||
| 294 | |||||||||
| 1831 | |||||||||
| 8427 | |||||||||
| Reference (365) | |||||||||
| Method | Gene |
