WormBase Tree Display for Gene: WBGene00003003
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WBGene00003003 | SMap | S_parent | Sequence | T25C12 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | lin | ||||||
Reference_allele | WBVar00089301 | ||||||
WBVar00089587 | |||||||
Allele (337) | |||||||
Legacy_information | Class 1 alleles (loss-of-function) n526n540ird : precocious heterochronic lineage alterations in ectoderm; abnormal development of vulva endoderm and mesoderm; abnormal cuticle formation; ES2; male more severely affected only three molts gonadal development abnormal. Similar phenotype in n536n540/Df. NA > 10 (n179ts etc.; also Class 1a n355n679ird ts (only early events precocious); Class 1b n360ts (only late events precocious). Class 2 alleles (gain-of-function) n536sd : retarded heterochronic alterations in many lineages abnormal vulval development cuticle formation supernumerary molts extra divisions in sex mesoblasts intestine etc.; gonadal lineages normal. ES3. ME0? NA2 (n355sd). For both Class 1 and Class 2 mutations late lineages are less affected if animal develops via dauer stage. | ||||||
See also n179, n355, n360, n407, n530, n531, n532, n534, n535, n536, n539, n540, n679, n726, n727, n837, n838, n839, n840, n841, n842 | |||||||
[C.elegansII] n526n540ird : lf allele (Class II, a-b-), precocious heterochronic lineage alterations in ectoderm; abnormal development of vulva,endoderm and mesoderm; abnormal cuticle formation; precocious dauer entry at L1 molt; ES2; male more severely affected, only three molts, gonadal development abnormal. Similar phenotype in n536n540/Df. OA>10: n179ts, etc.; also n355n679ird,ts (Class V, a-b+, only early events precocious); n360ts(Class III, a+b-, only late events precocious). Also gain-of-function alleles: n536sd (Class I, retarded heterochronic alterations in many lineages; abnormal vulval development, cuticle formation, supernumerary molts, extra divisions in sex mesoblasts, intestine etc.; gonadal lineages normal. ES3), n355sd(similar). Numerous intragenic revertants. For both lf and gf mutations, late lineages are less affected if animal develops via dauer stage. Cloned: two 3.5 kb transcripts, differing 5',encoding 70 kD novel proteins; antibodies stain nuclei; protein levels high in L1, reduced or absent later. Gain-of-function mutations affect3' UTR. [Ruvkun and Giusto 1989; Wightman et al. 1993; GR; VT] | |||||||
Strain (20) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (16) | |||||||
Ortholog (28) | |||||||
Structured_description | Concise_description | lin-14 encodes a novel protein whose activity is required for specifying the division timings of a specific group of cells during postembryonic development; lin-14 loss-of-function mutations result in the premature appearance of later larval lineages, while gain-of-function mutations result in reiteration of L1 larval stages lineages; in addition, lin-14 acts as a positive regulator of AVM, PVM, and FLP touch cell development; in regulating developmental timing, lin-14 acts, in part, by positively regulating the activity of lin-28, which encodes a cytoplasmic protein also required for proper developmental timing; at hatching, LIN-14 is detected in the nuclei of blast cells and neurons; later, from the late L1 to adult stages, LIN-14 levels are negatively regulated by translational repression mediated by lin-4, a 22-nt small temporal RNA (stRNA) that is complementary to sequences in the lin-14 3' UTR. | Paper_evidence | WBPaper00000620 | |||
WBPaper00001137 | |||||||
WBPaper00001468 | |||||||
WBPaper00001829 | |||||||
WBPaper00001848 | |||||||
WBPaper00003931 | |||||||
WBPaper00005159 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 02 Sep 2005 00:00:00 | ||||||
Automated_description | Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and single-stranded DNA binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; regulation of cell fate specification; and regulation of nematode larval development, heterochronic. Located in condensed nuclear chromosome. Expressed in several structures, including QL; QR; neurons; oocyte; and somatic nervous system. | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | T25C12.1a | |||||
T25C12.1b | |||||||
Corresponding_CDS_history | T25C12.1a:wp196 | ||||||
Corresponding_transcript | T25C12.1a.1 | ||||||
T25C12.1b.1 | |||||||
Other_sequence (11) | |||||||
Associated_feature (55) | |||||||
Transcription_factor | WBTranscriptionFactor000395 | ||||||
Experimental_info | RNAi_result (17) | ||||||
Expr_pattern (13) | |||||||
Drives_construct | WBCnstr00000926 | ||||||
WBCnstr00007336 | |||||||
WBCnstr00007627 | |||||||
WBCnstr00015030 | |||||||
WBCnstr00015050 | |||||||
WBCnstr00015780 | |||||||
WBCnstr00015781 | |||||||
WBCnstr00036292 | |||||||
Construct_product | WBCnstr00000967 | ||||||
WBCnstr00007627 | |||||||
WBCnstr00019563 | |||||||
WBCnstr00019564 | |||||||
WBCnstr00021119 | |||||||
WBCnstr00021910 | |||||||
WBCnstr00036292 | |||||||
Regulate_expr_cluster | WBPaper00026952:class_A | ||||||
WBPaper00026952:class_B | |||||||
WBPaper00026952:class_C | |||||||
WBPaper00026952:class_D | |||||||
WBPaper00026952:class_E | |||||||
WBPaper00026952:class_F | |||||||
WBPaper00026952:class_G | |||||||
WBPaper00026952:class_H | |||||||
Antibody | WBAntibody00000046 | ||||||
WBAntibody00000337 | |||||||
WBAntibody00000338 | |||||||
WBAntibody00001031 | |||||||
WBAntibody00001569 | |||||||
WBAntibody00001873 | |||||||
Microarray_results (33) | |||||||
Expression_cluster (173) | |||||||
Interaction (256) | |||||||
WBProcess | WBbiopr:00000031 | ||||||
WBbiopr:00000057 | |||||||
WBbiopr:00000083 | |||||||
Map_info | Map | X | Position | 3.78431 | Error | 0.060767 | |
Well_ordered | |||||||
Positive | Inside_rearr | nDf19 | |||||
yDp8 | |||||||
yDp10 | |||||||
Positive_clone | PPE4 | ||||||
T25C12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Mapping_data | 2_point | 251 | |||||
492 | |||||||
636 | |||||||
637 | |||||||
688 | |||||||
3648 | |||||||
3652 | |||||||
Multi_point (22) | |||||||
Pos_neg_data | 3918 | ||||||
3920 | |||||||
654 | |||||||
668 | |||||||
3155 | |||||||
294 | |||||||
1831 | |||||||
8427 | |||||||
Reference (365) | |||||||
Method | Gene |