WormBase Tree Display for Gene: WBGene00003003

WBGene00003003 SMap: S_parent: Sequence: T25C12
  Identity: Version: 1
    Name: CGC_name: lin-14 Person_evidence: WBPerson261
      Sequence_name: T25C12.1
      Molecular_name: T25C12.1a
        T25C12.1a.1
        CE43285
        T25C12.1b
        CE03734
        T25C12.1b.1
      Other_name: CELE_T25C12.1 Accession_evidence: NDB BX284606
      Public_name: lin-14
    DB_info: Database: AceView gene XM103
        WormQTL gene WBGene00003003
        WormFlux gene WBGene00003003
        NDB locus_tag CELE_T25C12.1
        NCBI gene 181337
        RefSeq protein NM_077515.5
            NM_077516.7
        SwissProt UniProtAcc Q21446
        TREEFAM TREEFAM_ID TF316913
        UniProt_GCRP UniProtAcc Q21446
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:30 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: lin
    Reference_allele: WBVar00089301
      WBVar00089587
    Allele (337)
    Legacy_information: Class 1 alleles (loss-of-function) n526n540ird : precocious heterochronic lineage alterations in ectoderm; abnormal development of vulva endoderm and mesoderm; abnormal cuticle formation; ES2; male more severely affected only three molts gonadal development abnormal. Similar phenotype in n536n540/Df. NA > 10 (n179ts etc.; also Class 1a n355n679ird ts (only early events precocious); Class 1b n360ts (only late events precocious). Class 2 alleles (gain-of-function) n536sd : retarded heterochronic alterations in many lineages abnormal vulval development cuticle formation supernumerary molts extra divisions in sex mesoblasts intestine etc.; gonadal lineages normal. ES3. ME0? NA2 (n355sd). For both Class 1 and Class 2 mutations late lineages are less affected if animal develops via dauer stage.
      See also n179, n355, n360, n407, n530, n531, n532, n534, n535, n536, n539, n540, n679, n726, n727, n837, n838, n839, n840, n841, n842
      [C.elegansII] n526n540ird : lf allele (Class II, a-b-), precocious heterochronic lineage alterations in ectoderm; abnormal development of vulva,endoderm and mesoderm; abnormal cuticle formation; precocious dauer entry at L1 molt; ES2; male more severely affected, only three molts, gonadal development abnormal. Similar phenotype in n536n540/Df. OA>10: n179ts, etc.; also n355n679ird,ts (Class V, a-b+, only early events precocious); n360ts(Class III, a+b-, only late events precocious). Also gain-of-function alleles: n536sd (Class I, retarded heterochronic alterations in many lineages; abnormal vulval development, cuticle formation, supernumerary molts, extra divisions in sex mesoblasts, intestine etc.; gonadal lineages normal. ES3), n355sd(similar). Numerous intragenic revertants. For both lf and gf mutations, late lineages are less affected if animal develops via dauer stage. Cloned: two 3.5 kb transcripts, differing 5',encoding 70 kD novel proteins; antibodies stain nuclei; protein levels high in L1, reduced or absent later. Gain-of-function mutations affect3' UTR. [Ruvkun and Giusto 1989; Wightman et al. 1993; GR; VT]
    Strain (20)
    RNASeq_FPKM (74)
    GO_annotation (16)
    Ortholog (28)
    Structured_description: Concise_description: lin-14 encodes a novel protein whose activity is required for specifying the division timings of a specific group of cells during postembryonic development; lin-14 loss-of-function mutations result in the premature appearance of later larval lineages, while gain-of-function mutations result in reiteration of L1 larval stages lineages; in addition, lin-14 acts as a positive regulator of AVM, PVM, and FLP touch cell development; in regulating developmental timing, lin-14 acts, in part, by positively regulating the activity of lin-28, which encodes a cytoplasmic protein also required for proper developmental timing; at hatching, LIN-14 is detected in the nuclei of blast cells and neurons; later, from the late L1 to adult stages, LIN-14 levels are negatively regulated by translational repression mediated by lin-4, a 22-nt small temporal RNA (stRNA) that is complementary to sequences in the lin-14 3' UTR. Paper_evidence: WBPaper00000620
            WBPaper00001137
            WBPaper00001468
            WBPaper00001829
            WBPaper00001848
            WBPaper00003931
            WBPaper00005159
          Curator_confirmed: WBPerson1843
          Date_last_updated: 02 Sep 2005 00:00:00
      Automated_description: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and single-stranded DNA binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; regulation of cell fate specification; and regulation of nematode larval development, heterochronic. Located in condensed nuclear chromosome. Expressed in several structures, including QL; QR; neurons; oocyte; and somatic nervous system. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: T25C12.1a
      T25C12.1b
    Corresponding_CDS_history: T25C12.1a:wp196
    Corresponding_transcript: T25C12.1a.1
      T25C12.1b.1
    Other_sequence (11)
    Associated_feature (55)
    Transcription_factor: WBTranscriptionFactor000395
  Experimental_info: RNAi_result (17)
    Expr_pattern (13)
    Drives_construct: WBCnstr00000926
      WBCnstr00007336
      WBCnstr00007627
      WBCnstr00015030
      WBCnstr00015050
      WBCnstr00015780
      WBCnstr00015781
      WBCnstr00036292
    Construct_product: WBCnstr00000967
      WBCnstr00007627
      WBCnstr00019563
      WBCnstr00019564
      WBCnstr00021119
      WBCnstr00021910
      WBCnstr00036292
    Regulate_expr_cluster: WBPaper00026952:class_A
      WBPaper00026952:class_B
      WBPaper00026952:class_C
      WBPaper00026952:class_D
      WBPaper00026952:class_E
      WBPaper00026952:class_F
      WBPaper00026952:class_G
      WBPaper00026952:class_H
    Antibody: WBAntibody00000046
      WBAntibody00000337
      WBAntibody00000338
      WBAntibody00001031
      WBAntibody00001569
      WBAntibody00001873
    Microarray_results (33)
    Expression_cluster (173)
    Interaction (256)
    WBProcess: WBbiopr:00000031
      WBbiopr:00000057
      WBbiopr:00000083
  Map_info: Map: X Position: 3.78431 Error: 0.060767
    Well_ordered
    Positive: Inside_rearr: nDf19
        yDp8
        yDp10
      Positive_clone: PPE4
        T25C12 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 251
        492
        636
        637
        688
        3648
        3652
      Multi_point (22)
      Pos_neg_data: 3918
        3920
        654
        668
        3155
        294
        1831
        8427
  Reference: WBPaper00000523
    WBPaper00000544
    WBPaper00000620
    WBPaper00000672
    WBPaper00000731
    WBPaper00000737
    WBPaper00000749
    WBPaper00000787
    WBPaper00000850
    WBPaper00000944
    WBPaper00000966
    WBPaper00000993
    WBPaper00001011
    WBPaper00001047
    WBPaper00001057
    WBPaper00001066
    WBPaper00001128
    WBPaper00001137
    WBPaper00001144
    WBPaper00001206
    WBPaper00001224
    WBPaper00001244
    WBPaper00001292
    WBPaper00001325
    WBPaper00001364
    WBPaper00001397
    WBPaper00001435
    WBPaper00001439
    WBPaper00001446
    WBPaper00001467
    WBPaper00001468
    WBPaper00001473
    WBPaper00001570
    WBPaper00001578
    WBPaper00001655
    WBPaper00001717
    WBPaper00001727
    WBPaper00001728
    WBPaper00001772
    WBPaper00001824
    WBPaper00001829
    WBPaper00001842
    WBPaper00001848
    WBPaper00001849
    WBPaper00001853
    WBPaper00001867
    WBPaper00001898
    WBPaper00001906
    WBPaper00001953
    WBPaper00001991
    WBPaper00002006
    WBPaper00002123
    WBPaper00002205
    WBPaper00002222
    WBPaper00002223
    WBPaper00002322
    WBPaper00002362
    WBPaper00002412
    WBPaper00002473
    WBPaper00002520
    WBPaper00002521
    WBPaper00002609
    WBPaper00002634
    WBPaper00002728
    WBPaper00002938
    WBPaper00002970
    WBPaper00003064
    WBPaper00003119
    WBPaper00003191
    WBPaper00003201
    WBPaper00003377
    WBPaper00003403
    WBPaper00003583
    WBPaper00003729
    WBPaper00003838
    WBPaper00003929
    WBPaper00003931
    WBPaper00003937
    WBPaper00004231
    WBPaper00004399
    WBPaper00004408
    WBPaper00004463
    WBPaper00004497
    WBPaper00005046
    WBPaper00005159
    WBPaper00005192
    WBPaper00005201
    WBPaper00005543
    WBPaper00005601
    WBPaper00005633
    WBPaper00005947
    WBPaper00005971
    WBPaper00005974
    WBPaper00006019
    WBPaper00006081
    WBPaper00006094
    WBPaper00006259
    WBPaper00006293
    WBPaper00006345
    WBPaper00006373
    WBPaper00006384
    WBPaper00010110
    WBPaper00010165
    WBPaper00010410
    WBPaper00010456
    WBPaper00010489
    WBPaper00010549
    WBPaper00010866
    WBPaper00010877
    WBPaper00010918
    WBPaper00010936
    WBPaper00010973
    WBPaper00011001
    WBPaper00011012
    WBPaper00011013
    WBPaper00011058
    WBPaper00011068
    WBPaper00011096
    WBPaper00011121
    WBPaper00011140
    WBPaper00011239
    WBPaper00011254
    WBPaper00011256
    WBPaper00012408
    WBPaper00012566
    WBPaper00012605
    WBPaper00012643
    WBPaper00012655
    WBPaper00012664
    WBPaper00012681
    WBPaper00013416
    WBPaper00013702
    WBPaper00013708
    WBPaper00013716
    WBPaper00013717
    WBPaper00013842
    WBPaper00013844
    WBPaper00013845
    WBPaper00013917
    WBPaper00013918
    WBPaper00014003
    WBPaper00014058
    WBPaper00014070
    WBPaper00014071
    WBPaper00014084
    WBPaper00014086
    WBPaper00014165
    WBPaper00014192
    WBPaper00014199
    WBPaper00014200
    WBPaper00014201
    WBPaper00014226
    WBPaper00014232
    WBPaper00014384
    WBPaper00014416
    WBPaper00014480
    WBPaper00014490
    WBPaper00014557
    WBPaper00014638
    WBPaper00014791
    WBPaper00014966
    WBPaper00015098
    WBPaper00015099
    WBPaper00015101
    WBPaper00015188
    WBPaper00015201
    WBPaper00015363
    WBPaper00015364
    WBPaper00015365
    WBPaper00015369
    WBPaper00015404
    WBPaper00015416
    WBPaper00015417
    WBPaper00015418
    WBPaper00015440
    WBPaper00015492
    WBPaper00015513
    WBPaper00015526
    WBPaper00015682
    WBPaper00016093
    WBPaper00016094
    WBPaper00016098
    WBPaper00016175
    WBPaper00016194
    WBPaper00016228
    WBPaper00016257
    WBPaper00016349
    WBPaper00016419
    WBPaper00016421
    WBPaper00016468
    WBPaper00016503
    WBPaper00016555
    WBPaper00016762
    WBPaper00016949
    WBPaper00017124
    WBPaper00017286
    WBPaper00017778
    WBPaper00017895
    WBPaper00018068
    WBPaper00018442
    WBPaper00018443
    WBPaper00018445
    WBPaper00018999
    WBPaper00019291
    WBPaper00019334
    WBPaper00019531
    WBPaper00019532
    WBPaper00019535
    WBPaper00020760
    WBPaper00020777
    WBPaper00020865
    WBPaper00020920
    WBPaper00020926
    WBPaper00020927
    WBPaper00020933
    WBPaper00020995
    WBPaper00021120
    WBPaper00021764
    WBPaper00021804
    WBPaper00021831
    WBPaper00021976
    WBPaper00022013
    WBPaper00022059
    WBPaper00022161
    WBPaper00022162
    WBPaper00022194
    WBPaper00022203
    WBPaper00022206
    WBPaper00022319
    WBPaper00022320
    WBPaper00022329
    WBPaper00022337
    WBPaper00022374
    WBPaper00022402
    WBPaper00022569
    WBPaper00022577
    WBPaper00022607
    WBPaper00022656
    WBPaper00022711
    WBPaper00022939
    WBPaper00022955
    WBPaper00023027
    WBPaper00023149
    WBPaper00023185
    WBPaper00023245
    WBPaper00023460
    WBPaper00023502
    WBPaper00023625
    WBPaper00023818
    WBPaper00024225
    WBPaper00024232
    WBPaper00024433
    WBPaper00024529
    WBPaper00025091
    WBPaper00025125
    WBPaper00026151
    WBPaper00026198
    WBPaper00026381
    WBPaper00026508
    WBPaper00026707
    WBPaper00026716
    WBPaper00026761
    WBPaper00026780
    WBPaper00026891
    WBPaper00026952
    WBPaper00026999
    WBPaper00027236
    WBPaper00027281
    WBPaper00027282
    WBPaper00027299
    WBPaper00027309
    WBPaper00027316
    WBPaper00027806
    WBPaper00027913
    WBPaper00028747
    WBPaper00028857
    WBPaper00029018
    WBPaper00029328
    WBPaper00029397
    WBPaper00030505
    WBPaper00030579
    WBPaper00030954
    WBPaper00031224
    WBPaper00031252
    WBPaper00031556
    WBPaper00031777
    WBPaper00032230
    WBPaper00032489
    WBPaper00033679
    WBPaper00033829
    WBPaper00034027
    WBPaper00034318
    WBPaper00034710
    WBPaper00034854
    WBPaper00035157
    WBPaper00035431
    WBPaper00036027
    WBPaper00036334
    WBPaper00036657
    WBPaper00036764
    WBPaper00037676
    WBPaper00037702
    WBPaper00038300
    WBPaper00038902
    WBPaper00039548
    WBPaper00039549
    WBPaper00039557
    WBPaper00039767
    WBPaper00039813
    WBPaper00040098
    WBPaper00040280
    WBPaper00040293
    WBPaper00040322
    WBPaper00040932
    WBPaper00041116
    WBPaper00041184
    WBPaper00041361
    WBPaper00041805
    WBPaper00042343
    WBPaper00042598
    WBPaper00042846
    WBPaper00042942
    WBPaper00043623
    WBPaper00043701
    WBPaper00043706
    WBPaper00043989
    WBPaper00044188
    WBPaper00044218
    WBPaper00044404
    WBPaper00044681
    WBPaper00045411
    WBPaper00046050
    WBPaper00046160
    WBPaper00046295
    WBPaper00046593
    WBPaper00046950
    WBPaper00047168
    WBPaper00047696
    WBPaper00047987
    WBPaper00048181
    WBPaper00049286
    WBPaper00050052
    WBPaper00050278
    WBPaper00050411
    WBPaper00050864
    WBPaper00051263
    WBPaper00051994
    WBPaper00052242
    WBPaper00053088
    WBPaper00053207
    WBPaper00053544
    WBPaper00053555
    WBPaper00054944
    WBPaper00056201
    WBPaper00056761
    WBPaper00057033
    WBPaper00057862
    WBPaper00058034
    WBPaper00062103
    WBPaper00062884
    WBPaper00063193
    WBPaper00063723
    WBPaper00064658
    WBPaper00065168
    WBPaper00065849
  Method: Gene