WormBase Tree Display for Gene: WBGene00003003

WBGene00003003 SMap: S_parent: Sequence: T25C12
  Identity: Version: 1
    Name: CGC_name: lin-14 Person_evidence: WBPerson261
      Sequence_name: T25C12.1
      Molecular_name: T25C12.1a
        T25C12.1a.1
        CE43285
        T25C12.1b
        CE03734
        T25C12.1b.1
      Other_name: CELE_T25C12.1 Accession_evidence: NDB BX284606
      Public_name: lin-14
    DB_info: Database: AceView gene XM103
        WormQTL gene WBGene00003003
        WormFlux gene WBGene00003003
        NDB locus_tag CELE_T25C12.1
        NCBI gene 181337
        RefSeq protein NM_077515.5
            NM_077516.7
        SwissProt UniProtAcc Q21446
        TREEFAM TREEFAM_ID TF316913
        UniProt_GCRP UniProtAcc Q21446
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:30 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: lin
    Reference_allele: WBVar00089301
      WBVar00089587
    Allele (337)
    Legacy_information: Class 1 alleles (loss-of-function) n526n540ird : precocious heterochronic lineage alterations in ectoderm; abnormal development of vulva endoderm and mesoderm; abnormal cuticle formation; ES2; male more severely affected only three molts gonadal development abnormal. Similar phenotype in n536n540/Df. NA > 10 (n179ts etc.; also Class 1a n355n679ird ts (only early events precocious); Class 1b n360ts (only late events precocious). Class 2 alleles (gain-of-function) n536sd : retarded heterochronic alterations in many lineages abnormal vulval development cuticle formation supernumerary molts extra divisions in sex mesoblasts intestine etc.; gonadal lineages normal. ES3. ME0? NA2 (n355sd). For both Class 1 and Class 2 mutations late lineages are less affected if animal develops via dauer stage.
      See also n179, n355, n360, n407, n530, n531, n532, n534, n535, n536, n539, n540, n679, n726, n727, n837, n838, n839, n840, n841, n842
      [C.elegansII] n526n540ird : lf allele (Class II, a-b-), precocious heterochronic lineage alterations in ectoderm; abnormal development of vulva,endoderm and mesoderm; abnormal cuticle formation; precocious dauer entry at L1 molt; ES2; male more severely affected, only three molts, gonadal development abnormal. Similar phenotype in n536n540/Df. OA>10: n179ts, etc.; also n355n679ird,ts (Class V, a-b+, only early events precocious); n360ts(Class III, a+b-, only late events precocious). Also gain-of-function alleles: n536sd (Class I, retarded heterochronic alterations in many lineages; abnormal vulval development, cuticle formation, supernumerary molts, extra divisions in sex mesoblasts, intestine etc.; gonadal lineages normal. ES3), n355sd(similar). Numerous intragenic revertants. For both lf and gf mutations, late lineages are less affected if animal develops via dauer stage. Cloned: two 3.5 kb transcripts, differing 5',encoding 70 kD novel proteins; antibodies stain nuclei; protein levels high in L1, reduced or absent later. Gain-of-function mutations affect3' UTR. [Ruvkun and Giusto 1989; Wightman et al. 1993; GR; VT]
    Strain (20)
    RNASeq_FPKM (74)
    GO_annotation (16)
    Ortholog (28)
    Structured_description: Concise_description: lin-14 encodes a novel protein whose activity is required for specifying the division timings of a specific group of cells during postembryonic development; lin-14 loss-of-function mutations result in the premature appearance of later larval lineages, while gain-of-function mutations result in reiteration of L1 larval stages lineages; in addition, lin-14 acts as a positive regulator of AVM, PVM, and FLP touch cell development; in regulating developmental timing, lin-14 acts, in part, by positively regulating the activity of lin-28, which encodes a cytoplasmic protein also required for proper developmental timing; at hatching, LIN-14 is detected in the nuclei of blast cells and neurons; later, from the late L1 to adult stages, LIN-14 levels are negatively regulated by translational repression mediated by lin-4, a 22-nt small temporal RNA (stRNA) that is complementary to sequences in the lin-14 3' UTR. Paper_evidence: WBPaper00000620
            WBPaper00001137
            WBPaper00001468
            WBPaper00001829
            WBPaper00001848
            WBPaper00003931
            WBPaper00005159
          Curator_confirmed: WBPerson1843
          Date_last_updated: 02 Sep 2005 00:00:00
      Automated_description: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and single-stranded DNA binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; regulation of cell fate specification; and regulation of nematode larval development, heterochronic. Located in condensed nuclear chromosome. Expressed in several structures, including QL; QR; neurons; oocyte; and somatic nervous system. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: T25C12.1a
      T25C12.1b
    Corresponding_CDS_history: T25C12.1a:wp196
    Corresponding_transcript: T25C12.1a.1
      T25C12.1b.1
    Other_sequence (11)
    Associated_feature (55)
    Transcription_factor: WBTranscriptionFactor000395
  Experimental_info: RNAi_result (17)
    Expr_pattern (13)
    Drives_construct: WBCnstr00000926
      WBCnstr00007336
      WBCnstr00007627
      WBCnstr00015030
      WBCnstr00015050
      WBCnstr00015780
      WBCnstr00015781
      WBCnstr00036292
    Construct_product: WBCnstr00000967
      WBCnstr00007627
      WBCnstr00019563
      WBCnstr00019564
      WBCnstr00021119
      WBCnstr00021910
      WBCnstr00036292
    Regulate_expr_cluster: WBPaper00026952:class_A
      WBPaper00026952:class_B
      WBPaper00026952:class_C
      WBPaper00026952:class_D
      WBPaper00026952:class_E
      WBPaper00026952:class_F
      WBPaper00026952:class_G
      WBPaper00026952:class_H
    Antibody: WBAntibody00000046
      WBAntibody00000337
      WBAntibody00000338
      WBAntibody00001031
      WBAntibody00001569
      WBAntibody00001873
    Microarray_results (33)
    Expression_cluster (173)
    Interaction: WBInteraction000000001
      WBInteraction000000004
      WBInteraction000000005
      WBInteraction000000006
      WBInteraction000000007
      WBInteraction000000029
      WBInteraction000000338
      WBInteraction000000426
      WBInteraction000000560
      WBInteraction000000562
      WBInteraction000000563
      WBInteraction000000566
      WBInteraction000000625
      WBInteraction000000655
      WBInteraction000000656
      WBInteraction000000659
      WBInteraction000000662
      WBInteraction000000953
      WBInteraction000001054
      WBInteraction000001078
      WBInteraction000001105
      WBInteraction000001130
      WBInteraction000001391
      WBInteraction000001407
      WBInteraction000001409
      WBInteraction000001446
      WBInteraction000001577
      WBInteraction000002110
      WBInteraction000002472
      WBInteraction000002633
      WBInteraction000002999
      WBInteraction000003001
      WBInteraction000003067
      WBInteraction000003068
      WBInteraction000003069
      WBInteraction000003070
      WBInteraction000003081
      WBInteraction000003082
      WBInteraction000003096
      WBInteraction000003113
      WBInteraction000003121
      WBInteraction000003133
      WBInteraction000003160
      WBInteraction000003161
      WBInteraction000003171
      WBInteraction000003176
      WBInteraction000003194
      WBInteraction000003217
      WBInteraction000003241
      WBInteraction000003273
      WBInteraction000003285
      WBInteraction000003297
      WBInteraction000003312
      WBInteraction000003316
      WBInteraction000003329
      WBInteraction000003338
      WBInteraction000003381
      WBInteraction000003428
      WBInteraction000003430
      WBInteraction000003433
      WBInteraction000003442
      WBInteraction000003449
      WBInteraction000003450
      WBInteraction000003452
      WBInteraction000003492
      WBInteraction000003523
      WBInteraction000003524
      WBInteraction000003546
      WBInteraction000003647
      WBInteraction000003648
      WBInteraction000003703
      WBInteraction000003732
      WBInteraction000003739
      WBInteraction000003763
      WBInteraction000003782
      WBInteraction000003827
      WBInteraction000003853
      WBInteraction000003924
      WBInteraction000003964
      WBInteraction000003974
      WBInteraction000003975
      WBInteraction000003995
      WBInteraction000004002
      WBInteraction000004034
      WBInteraction000004067
      WBInteraction000004077
      WBInteraction000004094
      WBInteraction000004098
      WBInteraction000004101
      WBInteraction000004110
      WBInteraction000005058
      WBInteraction000005059
      WBInteraction000005060
      WBInteraction000005061
      WBInteraction000005486
      WBInteraction000005710
      WBInteraction000005711
      WBInteraction000005712
      WBInteraction000005713
      WBInteraction000005714
      WBInteraction000005715
      WBInteraction000005716
      WBInteraction000005719
      WBInteraction000005730
      WBInteraction000005731
      WBInteraction000005732
      WBInteraction000005733
      WBInteraction000005734
      WBInteraction000005735
      WBInteraction000005736
      WBInteraction000008490
      WBInteraction000009687
      WBInteraction000009689
      WBInteraction000009719
      WBInteraction000009994
      WBInteraction000028499
      WBInteraction000028581
      WBInteraction000028750
      WBInteraction000028855
      WBInteraction000029342
      WBInteraction000029779
      WBInteraction000029781
      WBInteraction000030142
      WBInteraction000030359
      WBInteraction000030377
      WBInteraction000031072
      WBInteraction000031073
      WBInteraction000031074
      WBInteraction000051439
      WBInteraction000051440
      WBInteraction000051725
      WBInteraction000051727
      WBInteraction000052060
      WBInteraction000052067
      WBInteraction000052068
      WBInteraction000052069
      WBInteraction000052180
      WBInteraction000052181
      WBInteraction000052284
      WBInteraction000052289
      WBInteraction000052336
      WBInteraction000052338
      WBInteraction000052353
      WBInteraction000052432
      WBInteraction000052433
      WBInteraction000052434
      WBInteraction000052435
      WBInteraction000052592
      WBInteraction000052623
      WBInteraction000052731
      WBInteraction000052862
      WBInteraction000126193
      WBInteraction000126204
      WBInteraction000126221
      WBInteraction000126223
      WBInteraction000126823
      WBInteraction000134336
      WBInteraction000148731
      WBInteraction000165558
      WBInteraction000165572
      WBInteraction000165671
      WBInteraction000165690
      WBInteraction000165695
      WBInteraction000165698
      WBInteraction000165969
      WBInteraction000165970
      WBInteraction000165971
      WBInteraction000166018
      WBInteraction000166476
      WBInteraction000218301
      WBInteraction000233907
      WBInteraction000233908
      WBInteraction000233911
      WBInteraction000233912
      WBInteraction000233913
      WBInteraction000259772
      WBInteraction000259773
      WBInteraction000278366
      WBInteraction000283944
      WBInteraction000306855
      WBInteraction000328895
      WBInteraction000328896
      WBInteraction000351279
      WBInteraction000351280
      WBInteraction000355871
      WBInteraction000392378
      WBInteraction000447247
      WBInteraction000462936
      WBInteraction000467040
      WBInteraction000471483
      WBInteraction000500329
      WBInteraction000500972
      WBInteraction000500978
      WBInteraction000501659
      WBInteraction000501674
      WBInteraction000501826
      WBInteraction000502199
      WBInteraction000502262
      WBInteraction000502908
      WBInteraction000504444
      WBInteraction000504446
      WBInteraction000517598
      WBInteraction000517600
      WBInteraction000517602
      WBInteraction000517604
      WBInteraction000517606
      WBInteraction000517608
      WBInteraction000517610
      WBInteraction000517613
      WBInteraction000517615
      WBInteraction000517617
      WBInteraction000517619
      WBInteraction000517621
      WBInteraction000517623
      WBInteraction000517625
      WBInteraction000517654
      WBInteraction000517655
      WBInteraction000517656
      WBInteraction000517657
      WBInteraction000517658
      WBInteraction000517659
      WBInteraction000517660
      WBInteraction000517661
      WBInteraction000517662
      WBInteraction000517663
      WBInteraction000517664
      WBInteraction000517665
      WBInteraction000517666
      WBInteraction000517667
      WBInteraction000517668
      WBInteraction000517669
      WBInteraction000517670
      WBInteraction000517671
      WBInteraction000517672
      WBInteraction000517673
      WBInteraction000517674
      WBInteraction000517675
      WBInteraction000517888
      WBInteraction000518629
      WBInteraction000519339
      WBInteraction000519340
      WBInteraction000520755
      WBInteraction000520773
      WBInteraction000520860
      WBInteraction000520861
      WBInteraction000521365
      WBInteraction000521366
      WBInteraction000521368
      WBInteraction000521369
      WBInteraction000525408
      WBInteraction000551276
      WBInteraction000554895
      WBInteraction000554896
      WBInteraction000561330
      WBInteraction000564867
      WBInteraction000575091
    WBProcess: WBbiopr:00000031
      WBbiopr:00000057
      WBbiopr:00000083
  Map_info: Map: X Position: 3.78431 Error: 0.060767
    Well_ordered
    Positive: Inside_rearr: nDf19
        yDp8
        yDp10
      Positive_clone: PPE4
        T25C12 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: 2_point: 251
        492
        636
        637
        688
        3648
        3652
      Multi_point (22)
      Pos_neg_data: 3918
        3920
        654
        668
        3155
        294
        1831
        8427
  Reference (365)
  Method: Gene