WormBase Tree Display for Gene: WBGene00003003
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| WBGene00003003 | SMap | S_parent | Sequence | T25C12 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 1 | |||||||
| Name | CGC_name | lin-14 | Person_evidence | WBPerson261 | |||||
| Sequence_name | T25C12.1 | ||||||||
| Molecular_name | T25C12.1a | ||||||||
| T25C12.1a.1 | |||||||||
| CE43285 | |||||||||
| T25C12.1b | |||||||||
| CE03734 | |||||||||
| T25C12.1b.1 | |||||||||
| Other_name | CELE_T25C12.1 | Accession_evidence | NDB | BX284606 | |||||
| Public_name | lin-14 | ||||||||
| DB_info | Database | AceView | gene | XM103 | |||||
| WormQTL | gene | WBGene00003003 | |||||||
| WormFlux | gene | WBGene00003003 | |||||||
| NDB | locus_tag | CELE_T25C12.1 | |||||||
| NCBI | gene | 181337 | |||||||
| RefSeq | protein | NM_077515.5 | |||||||
| NM_077516.7 | |||||||||
| SwissProt | UniProtAcc | Q21446 | |||||||
| TREEFAM | TREEFAM_ID | TF316913 | |||||||
| UniProt_GCRP | UniProtAcc | Q21446 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | lin | ||||||||
| Reference_allele | WBVar00089301 | ||||||||
| WBVar00089587 | |||||||||
| Allele (337) | |||||||||
| Legacy_information | Class 1 alleles (loss-of-function) n526n540ird : precocious heterochronic lineage alterations in ectoderm; abnormal development of vulva endoderm and mesoderm; abnormal cuticle formation; ES2; male more severely affected only three molts gonadal development abnormal. Similar phenotype in n536n540/Df. NA > 10 (n179ts etc.; also Class 1a n355n679ird ts (only early events precocious); Class 1b n360ts (only late events precocious). Class 2 alleles (gain-of-function) n536sd : retarded heterochronic alterations in many lineages abnormal vulval development cuticle formation supernumerary molts extra divisions in sex mesoblasts intestine etc.; gonadal lineages normal. ES3. ME0? NA2 (n355sd). For both Class 1 and Class 2 mutations late lineages are less affected if animal develops via dauer stage. | ||||||||
| See also n179, n355, n360, n407, n530, n531, n532, n534, n535, n536, n539, n540, n679, n726, n727, n837, n838, n839, n840, n841, n842 | |||||||||
| [C.elegansII] n526n540ird : lf allele (Class II, a-b-), precocious heterochronic lineage alterations in ectoderm; abnormal development of vulva,endoderm and mesoderm; abnormal cuticle formation; precocious dauer entry at L1 molt; ES2; male more severely affected, only three molts, gonadal development abnormal. Similar phenotype in n536n540/Df. OA>10: n179ts, etc.; also n355n679ird,ts (Class V, a-b+, only early events precocious); n360ts(Class III, a+b-, only late events precocious). Also gain-of-function alleles: n536sd (Class I, retarded heterochronic alterations in many lineages; abnormal vulval development, cuticle formation, supernumerary molts, extra divisions in sex mesoblasts, intestine etc.; gonadal lineages normal. ES3), n355sd(similar). Numerous intragenic revertants. For both lf and gf mutations, late lineages are less affected if animal develops via dauer stage. Cloned: two 3.5 kb transcripts, differing 5',encoding 70 kD novel proteins; antibodies stain nuclei; protein levels high in L1, reduced or absent later. Gain-of-function mutations affect3' UTR. [Ruvkun and Giusto 1989; Wightman et al. 1993; GR; VT] | |||||||||
| Strain (20) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (16) | |||||||||
| Ortholog (28) | |||||||||
| Structured_description | Concise_description | lin-14 encodes a novel protein whose activity is required for specifying the division timings of a specific group of cells during postembryonic development; lin-14 loss-of-function mutations result in the premature appearance of later larval lineages, while gain-of-function mutations result in reiteration of L1 larval stages lineages; in addition, lin-14 acts as a positive regulator of AVM, PVM, and FLP touch cell development; in regulating developmental timing, lin-14 acts, in part, by positively regulating the activity of lin-28, which encodes a cytoplasmic protein also required for proper developmental timing; at hatching, LIN-14 is detected in the nuclei of blast cells and neurons; later, from the late L1 to adult stages, LIN-14 levels are negatively regulated by translational repression mediated by lin-4, a 22-nt small temporal RNA (stRNA) that is complementary to sequences in the lin-14 3' UTR. | Paper_evidence | WBPaper00000620 | |||||
| WBPaper00001137 | |||||||||
| WBPaper00001468 | |||||||||
| WBPaper00001829 | |||||||||
| WBPaper00001848 | |||||||||
| WBPaper00003931 | |||||||||
| WBPaper00005159 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 02 Sep 2005 00:00:00 | ||||||||
| Automated_description | Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and single-stranded DNA binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; regulation of cell fate specification; and regulation of nematode larval development, heterochronic. Located in condensed nuclear chromosome. Expressed in several structures, including QL; QR; neurons; oocyte; and somatic nervous system. | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | T25C12.1a | |||||||
| T25C12.1b | |||||||||
| Corresponding_CDS_history | T25C12.1a:wp196 | ||||||||
| Corresponding_transcript | T25C12.1a.1 | ||||||||
| T25C12.1b.1 | |||||||||
| Other_sequence (11) | |||||||||
| Associated_feature | WBsf648548 | ||||||||
| WBsf663342 | |||||||||
| WBsf663343 | |||||||||
| WBsf663344 | |||||||||
| WBsf663345 | |||||||||
| WBsf663346 | |||||||||
| WBsf663347 | |||||||||
| WBsf663348 | |||||||||
| WBsf663349 | |||||||||
| WBsf663350 | |||||||||
| WBsf663351 | |||||||||
| WBsf663352 | |||||||||
| WBsf663353 | |||||||||
| WBsf663354 | |||||||||
| WBsf663355 | |||||||||
| WBsf663356 | |||||||||
| WBsf663357 | |||||||||
| WBsf663358 | |||||||||
| WBsf663359 | |||||||||
| WBsf718702 | |||||||||
| WBsf982235 | |||||||||
| WBsf1007004 | |||||||||
| WBsf1007005 | |||||||||
| WBsf1007006 | |||||||||
| WBsf1007007 | |||||||||
| WBsf1007008 | |||||||||
| WBsf1007009 | |||||||||
| WBsf1007010 | |||||||||
| WBsf1007011 | |||||||||
| WBsf1007012 | |||||||||
| WBsf1007013 | |||||||||
| WBsf1007014 | |||||||||
| WBsf1007015 | |||||||||
| WBsf1007016 | |||||||||
| WBsf1007017 | |||||||||
| WBsf1007018 | |||||||||
| WBsf1007019 | |||||||||
| WBsf1007020 | |||||||||
| WBsf1007021 | |||||||||
| WBsf1007022 | |||||||||
| WBsf1007023 | |||||||||
| WBsf1023877 | |||||||||
| WBsf1023878 | |||||||||
| WBsf1023879 | |||||||||
| WBsf1023880 | |||||||||
| WBsf1023881 | |||||||||
| WBsf1023882 | |||||||||
| WBsf1023883 | |||||||||
| WBsf1023884 | |||||||||
| WBsf1023885 | |||||||||
| WBsf1023886 | |||||||||
| WBsf1023887 | |||||||||
| WBsf1023888 | |||||||||
| WBsf236380 | |||||||||
| WBsf919695 | |||||||||
| Transcription_factor | WBTranscriptionFactor000395 | ||||||||
| Experimental_info | RNAi_result (17) | ||||||||
| Expr_pattern (13) | |||||||||
| Drives_construct | WBCnstr00000926 | ||||||||
| WBCnstr00007336 | |||||||||
| WBCnstr00007627 | |||||||||
| WBCnstr00015030 | |||||||||
| WBCnstr00015050 | |||||||||
| WBCnstr00015780 | |||||||||
| WBCnstr00015781 | |||||||||
| WBCnstr00036292 | |||||||||
| Construct_product | WBCnstr00000967 | ||||||||
| WBCnstr00007627 | |||||||||
| WBCnstr00019563 | |||||||||
| WBCnstr00019564 | |||||||||
| WBCnstr00021119 | |||||||||
| WBCnstr00021910 | |||||||||
| WBCnstr00036292 | |||||||||
| Regulate_expr_cluster | WBPaper00026952:class_A | ||||||||
| WBPaper00026952:class_B | |||||||||
| WBPaper00026952:class_C | |||||||||
| WBPaper00026952:class_D | |||||||||
| WBPaper00026952:class_E | |||||||||
| WBPaper00026952:class_F | |||||||||
| WBPaper00026952:class_G | |||||||||
| WBPaper00026952:class_H | |||||||||
| Antibody | WBAntibody00000046 | ||||||||
| WBAntibody00000337 | |||||||||
| WBAntibody00000338 | |||||||||
| WBAntibody00001031 | |||||||||
| WBAntibody00001569 | |||||||||
| WBAntibody00001873 | |||||||||
| Microarray_results (33) | |||||||||
| Expression_cluster (173) | |||||||||
| Interaction (256) | |||||||||
| WBProcess | WBbiopr:00000031 | ||||||||
| WBbiopr:00000057 | |||||||||
| WBbiopr:00000083 | |||||||||
| Map_info | Map | X | Position | 3.78431 | Error | 0.060767 | |||
| Well_ordered | |||||||||
| Positive | Inside_rearr | nDf19 | |||||||
| yDp8 | |||||||||
| yDp10 | |||||||||
| Positive_clone | PPE4 | ||||||||
| T25C12 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | 2_point | 251 | |||||||
| 492 | |||||||||
| 636 | |||||||||
| 637 | |||||||||
| 688 | |||||||||
| 3648 | |||||||||
| 3652 | |||||||||
| Multi_point (22) | |||||||||
| Pos_neg_data | 3918 | ||||||||
| 3920 | |||||||||
| 654 | |||||||||
| 668 | |||||||||
| 3155 | |||||||||
| 294 | |||||||||
| 1831 | |||||||||
| 8427 | |||||||||
| Reference (365) | |||||||||
| Method | Gene |
