| WBGene00002991 | SMap | S_parent | Sequence | F17E5 |
|---|
| Identity | Version | 1 |
| | Name | CGC_name | lin-2 | Person_evidence | WBPerson261 |
| | | Sequence_name | F17E5.1 |
| | | Molecular_name | F17E5.1a |
| | | | F17E5.1a.1 |
| | | | CE27131 |
| | | | F17E5.1b |
| | | | CE27132 |
| | | | F17E5.1b.1 |
| | | Other_name | CELE_F17E5.1 | Accession_evidence | NDB | BX284606 |
| | | Public_name | lin-2 |
| | DB_info | Database (11) |
| | Species | Caenorhabditis elegans |
| | History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace |
| | Status | Live |
| Gene_info | Biotype | SO:0001217 |
| | Gene_class | lin |
| | Reference_allele | WBVar00143908 |
| | Allele (248) |
| | Possibly_affected_by | WBVar02157232 |
| | Legacy_information | e1309 : adult hermaphrodite vulvaless (penetrance 93%); ES2 (adult)/ ES1 (larvae); HME2; adult male wildtype ME3. NA13 (e1453amber (non-null lower penetrance than e1309 50% vulvaless) n105ts (penetrance 24% at 15x 90% at 25x) n768 (weak allele multiple vulval protrusions penetrance 21%) etc.). |
| | | See also e1309, e1424, e1437, e1453, n105, n167, n305, n380, n670, n674, n768, n1052, n1297, n1298 |
| | | [C.elegansII] e1309 : adult hermaphrodite vulvaless (penetrance 93%); ES2 (adult)/ ES1 (larvae); HME2; adult male wildtype ME3. NA13: e1453amb (non-null, lower penetrance than e1309, 50% vulvaless), n105ts (penetrance 24% at 15C, 90% at 25C) n768 (weak allele multiple vulval protrusions penetrance 21%), n397 (deletes most of gene), etc. Cloned: encodes predicted protein with PDZ domain,similarity to guanylate kinase, Drosophila discs large. Mutants delocalize LET-23. [Ferguson et al. 1985; SD; MT] |
| | Strain (14) |
| | RNASeq_FPKM (74) |
| | GO_annotation (26) |
| | Ortholog (43) |
| | Paralog | WBGene00006467 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00016841 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | | WBGene00021914 | Caenorhabditis elegans | From_analysis | TreeFam |
| | | | | | Panther |
| | | | | | WormBase-Compara |
| | Structured_description | Concise_description | lin-2 encodes a protein belonging to the membrane associated guanylate kinase (MAGUK) family, with several domains (L27, PDZ, SH3, and guanylate kinase) thought to assemble specific multiprotein complexes in particular regions of the cell; in vivo, LIN-2 is required for the correct localization of LET-23 (and, presumably, other membrane proteins) to specific regions of the plasma membrane. | Paper_evidence | WBPaper00000496 |
| | | | | | WBPaper00003215 |
| | | | | Curator_confirmed | WBPerson1843 |
| | | | | | WBPerson567 |
| | | | | Date_last_updated | 31 Jan 2006 00:00:00 |
| | | Automated_description | Enables insulin-like growth factor receptor binding activity. Involved in several processes, including egg-laying behavior; positive regulation of vulval development; and protein localization to membrane. Located in cell junction. Expressed in several structures, including CAN; HSN; isthmus; somatic nervous system; and vulval precursor cell. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in FG syndrome and syndromic X-linked intellectual disability Najm type. Is an ortholog of human CASK (calcium/calmodulin dependent serine protein kinase). | Paper_evidence | WBPaper00065943 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | | WBPerson37462 |
| | | | | Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase |
| | | | | Date_last_updated | 29 Nov 2023 00:00:00 |
| Disease_info | Experimental_model | DOID:0060041 | Homo sapiens | Paper_evidence | WBPaper00048837 |
| | | | | Curator_confirmed | WBPerson324 |
| | | | | Date_last_updated | 09 Feb 2018 00:00:00 |
| | Potential_model | DOID:0060807 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1497) |
| | | DOID:14711 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:1497) |
| Models_disease_asserted | WBDOannot00000474 |
| Molecular_info | Corresponding_CDS | F17E5.1a |
| | | F17E5.1b |
| | Corresponding_CDS_history | F17E5.1a:wp47 |
| | | F17E5.1b:wp47 |
| | Corresponding_transcript | F17E5.1a.1 |
| | | F17E5.1b.1 |
| | Other_sequence (49) |
| | Associated_feature (16) |
| Experimental_info | RNAi_result | WBRNAi00013468 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00030265 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00044888 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00000540 | Inferred_automatically | RNAi_primary |
| | | WBRNAi00076312 | Inferred_automatically | RNAi_primary |
| | Expr_pattern (11) |
| | Drives_construct | WBCnstr00022290 |
| | | WBCnstr00036300 |
| | Construct_product (6) |
| | Antibody | WBAntibody00000973 |
| | | WBAntibody00001507 |
| | Microarray_results (28) |
| | Expression_cluster | WBPaper00032976:dosage_compensated_genes |
| | | WBPaper00033070:Elbe_downregulated |
| | | WBPaper00033070:Rhine_downregulated |
| | | WBPaper00037950:A-class-motor-neurons_L2-larva_expressed |
| | | WBPaper00037950:A-class-motor-neurons_larva_enriched |
| | | WBPaper00037950:all-neurons_L1-larva_expressed |
| | | WBPaper00037950:all-neurons_L2-larva_expressed |
| | | WBPaper00037950:AVA-neuron_L1-larva_expressed |
| | | WBPaper00037950:AVE-neuron_embryo_enriched |
| | | WBPaper00037950:AVE-neuron_L1-larva_expressed |
| | | WBPaper00037950:BAG-neuron_blastula-embryo_expressed |
| | | WBPaper00037950:bodywall-muscle_L1-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_L2-larva_expressed |
| | | WBPaper00037950:bodywall-muscle_larva_enriched |
| | | WBPaper00037950:dopaminergic-neurons_L1-larva_expressed |
| | | WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed |
| | | WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed |
| | | WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed |
| | | WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed |
| | | WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray |
| | | WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray |
| | | WBPaper00044736:flat_dev_expression |
| | | WBPaper00045521:Oogenic |
| | | WBPaper00045861:set-2(ok952)_upregulated |
| | | WBPaper00045974:NSM_enriched_totalRNA_RNAseq |
| | | WBPaper00048923:Aging_regulated |
| | | WBPaper00048988:neuron_enriched |
| | | WBPaper00048988:neuron_expressed |
| | | WBPaper00049290:rsks-1(sv31)_upregulated |
| | | WBPaper00049545:cco-1(RNAi)_upregulated |
| | | WBPaper00049545:jmjd-3.1(+)_upregulated |
| | | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated |
| | | WBPaper00049626:UNC-75_target |
| | | WBPaper00050094:mes-6(bn66)_upregulated |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo |
| | | WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_100-cell-embryo |
| | | WBPaper00050344:AFD-neuron_enriched |
| | | WBPaper00050344:ASER-neuron_enriched |
| | | WBPaper00050488:adult_vs_dauer_regulated_N2_20C |
| | | WBPaper00050726:OsmoticStress_regulated_Food |
| | | WBPaper00050726:OsmoticStress_regulated_NoFood |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult |
| | | WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult |
| | | WBPaper00050990:body-muscle_expressed |
| | | WBPaper00050990:GABAergic-neuron_expressed |
| | | WBPaper00050990:hypodermis_expressed |
| | | WBPaper00050990:intestine_expressed |
| | | WBPaper00050990:NMDA-neuron_expressed |
| | | WBPaper00051245:body-wall-muscle_cytoplasm_expressed |
| | | WBPaper00053184:sma-4(rax3)_upregulated |
| | | WBPaper00053289:DREAM-target |
| | | WBPaper00053295:lin-22(ot269)_upregulated |
| | | WBPaper00053302:stavudine_24h_regulated |
| | | WBPaper00053302:zidovudine_72h_regulated |
| | | WBPaper00053321:mes-2(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:mes-4(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_fed-L1_Truseq |
| | | WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq |
| | | WBPaper00053388:dauer_regulated_Cluster1 |
| | | WBPaper00055334:DLC-1_interacting |
| | | WBPaper00055354:Rifampicin-Allantoin_downregulated |
| | | WBPaper00055565:AVK_enriched |
| | | WBPaper00055626:pry-1(mu38)_downregulated |
| | | WBPaper00056034:pals-22(jy3)_upregulated |
| | | WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047) |
| | | WBPaper00056284:ints-1(RNAi)_downregulated |
| | | WBPaper00056284:ints-11(RNAi)_downregulated |
| | | WBPaper00056443:sek-1(km4)_upregulated |
| | | WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated |
| | | WBPaper00056619:CEPsh_enriched |
| | | WBPaper00056809:smn-1(ok355)_upregulated |
| | | WBPaper00056826:hmc_biased |
| | | WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C |
| | | WBPaper00057140:meg-3(tm4259)_meg-4(ax2026)_downregulated |
| | | WBPaper00057288:Cold_downregulated_transcript |
| | | WBPaper00058598:mex-1(or286)_upregulated |
| | | WBPaper00058598:mex-3(eu149)_upregulated |
| | | WBPaper00058598:sin-3(tm1276)_downregulated |
| | | WBPaper00058598:spn-4(tm291)_upregulated |
| | | WBPaper00058691:sin-3(tm1276)_upregulated |
| | | WBPaper00058948:PA14_downregulated |
| | | WBPaper00058958:100mGy-irradiation-72h_upregulated |
| | | WBPaper00059027:neuron-synapses_depleted |
| | | WBPaper00059664:srbc-48(ac23)_upregulated |
| | | WBPaper00059763:neuron_expressed |
| | | WBPaper00060014:set-2(tm1630)_downregulated |
| | | WBPaper00060661:sensory-neuron_enriched |
| | | WBPaper00060811:L1_vs_adult_upregulated_neural |
| | | WBPaper00060909:atfs-1(cmh15)_downregulated |
| | | WBPaper00061203:sin-3(tm1276)_upregulated |
| | | WBPaper00061203:spr-1(ok2144)_upregulated |
| | | WBPaper00061340:AIA |
| | | WBPaper00061340:AIB |
| | | WBPaper00061340:AIM |
| | | WBPaper00061340:AVA |
| | | WBPaper00061340:AVB |
| | | WBPaper00061340:AVD |
| | | WBPaper00061340:AVE |
| | | WBPaper00061340:AVH |
| | | WBPaper00061340:AVJ |
| | | WBPaper00061340:AVK |
| | | WBPaper00061340:AWB |
| | | WBPaper00061340:IL1 |
| | | WBPaper00061340:RIA |
| | | WBPaper00061340:RIB |
| | | WBPaper00061340:RIC |
| | | WBPaper00061340:RIC_parent |
| | | WBPaper00061340:RIH |
| | | WBPaper00061340:RIM |
| | | WBPaper00061340:RIV |
| | | WBPaper00061340:RMD |
| | | WBPaper00061340:RME |
| | | WBPaper00061340:SIB |
| | | WBPaper00061340:SMB |
| | | WBPaper00061340:SMD |
| | | WBPaper00061479:hda-1(ne4752)_upregulated |
| | | WBPaper00061479:mep-1(ne4629)_upregulated |
| | | WBPaper00061527:kin-29_2839-unc-9_3883 |
| | | WBPaper00061527:sol-1-jnk-1_18695 |
| | | WBPaper00061651:SAA_enriched |
| | | WBPaper00061651:VB02_enriched |
| | | WBPaper00062103:neuron_enriched |
| | | WBPaper00062159:hda-2(ok1479)_upregulated |
| | | WBPaper00062193:skn-1(RNAi)_downregulated |
| | | WBPaper00062325:muscle_enriched_coding-RNA |
| | | WBPaper00062554:MAGU-2_interacting |
| | | WBPaper00062590:Aging_downregulated_neuron |
| | | WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20) |
| | | WBPaper00064130:Beta-Amyloid_downregulated_protein |
| | | WBPaper00064306:Agaro-oligosaccharides_upregulated |
| | | WBPaper00064315:mes-4(bn73)_upregulated_EGCs |
| | | WBPaper00064315:mrg-1(qa6200)_upregulated_PGCs |
| | | WBPaper00064716:paraquat_downregulated |
| | | WBPaper00064939:vit-5(RNAi)_upregulated |
| | | WBPaper00065096:25C_vs_20C_downregulated |
| | | WBPaper00065096:Day10_vs_Day1_downregulated |
| | | WBPaper00065158:AFD_enriched |
| | | WBPaper00065749:Heat-Shock_downregulated_endu-2(tm4977) |
| | | WBPaper00065841:6_0 |
| | | WBPaper00065841:6_1 |
| | | WBPaper00065841:6_3 |
| | | WBPaper00065841:14_0 |
| | | WBPaper00065841:14_1 |
| | | WBPaper00065841:111_0 |
| | | WBPaper00065841:115_0 |
| | | WBPaper00065841:133_0 |
| | | WBPaper00065993:glp-1(e2141)_upregulated |
| | | cgc4489_group_16 |
| | | WBPaper00024671:AFD_AWB_vs_unsorted_upregulated |
| | | WBPaper00025141:unc-4::GFP_Enriched_Genes |
| | | WBPaper00025141:unc-4::GFP_Expressed_Genes |
| | | WBPaper00026929:sir-2.1_overexpression_regulated |
| | | WBPaper00030839:Embryo_A_Class |
| | | WBPaper00030839:Embryo_Pan_Neuronal |
| | | WBPaper00031003:24hr_muscle_enriched |
| | | WBPaper00031003:hlh_1_enriched |
| | | WBPaper00031003:total_muscle_enriched |
| | | WBPaper00031532:Larva_Pan_Neuronal_Enriched |
| | | WBPaper00034661:AgNPs_downregulated |
| | | WBPaper00035588:alg-1(-)_upregulated |
| | | WBPaper00037113:Chlorpyrifos_Diazinon_16C_regulated |
| | | WBPaper00040184:hcf-1nc_sir-2.1nc_daf-2up |
| | | WBPaper00040210:Diazinon_24C_regulated |
| | | WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h |
| | | [cgc6390]:Cluster_B |
| | | [cgc6390]:herm_soma-enriched |
| | Interaction (292) |
| Map_info | Map | X | Position | 7.04058 | Error | 0.007077 |
| | Well_ordered |
| | Positive | Inside_rearr | yDp11 |
| | | Positive_clone | C43C10 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | | | F17E5 | Inferred_automatically | From sequence, transcript, pseudogene data |
| | Mapping_data | 2_point | 168 |
| | | | 280 |
| | | | 281 |
| | | Multi_point (25) |
| | | Pos_neg_data | 320 |
| | | | 686 |
| | | | 687 |
| | | | 871 |
| | | | 8424 |
| | | | 8431 |
| | | | 8443 |
| | | | 8451 |
| | | | 8457 |
| | Landmark_gene |
| Reference (172) |
| Method | Gene |
