WormBase Tree Display for Gene: WBGene00002253

WBGene00002253 SMap: S_parent: Sequence: F40F4
  Identity: Version: 1
    Name: CGC_name: lbp-1 Person_evidence: WBPerson492
      Sequence_name: F40F4.3
      Molecular_name: F40F4.3
        F40F4.3.1
        CE04533
      Other_name: CELE_F40F4.3 Accession_evidence: NDB BX284606
      Public_name: lbp-1
    DB_info: Database: AceView gene XD879
        WormQTL gene WBGene00002253
        WormFlux gene WBGene00002253
        NDB locus_tag CELE_F40F4.3
        Panther gene CAEEL|WormBase=WBGene00002253|UniProtKB=Q20223
          family PTHR22725
        NCBI gene 180616
        RefSeq protein NM_076156.8
        SwissProt UniProtAcc Q20223
        UniProt_GCRP UniProtAcc Q20223
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:27 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: lbp
    Allele: WBVar01132596
      WBVar01132597
      WBVar01132598
      WBVar01132599
      WBVar01486655
      WBVar02125422
      WBVar01499636
      WBVar02047738
      WBVar01132595
    Strain: WBStrain00037446
    RNASeq_FPKM (74)
    GO_annotation: 00067527
      00067528
      00067529
      00110318
    Ortholog (44)
    Paralog: WBGene00002259 Caenorhabditis elegans From_analysis: TreeFam
      WBGene00002257 Caenorhabditis elegans From_analysis: TreeFam
      WBGene00002260 Caenorhabditis elegans From_analysis: TreeFam
      WBGene00021486 Caenorhabditis elegans From_analysis: TreeFam
      WBGene00002254 Caenorhabditis elegans From_analysis: Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00002256 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00002255 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: lbp-1 encodes a predicted secreted fatty acid binding protein (FABP) that is similar to the Ascaris suum secreted FABP As-p18; by homology, LBP-1 is predicted to function in sequestering or transporting small hydrophobic molecules such as lipids and steroid hormones; an lbp-1::gfp promoter fusion is expressed in the embryo, beginning at gastrulation, in presumptive hypodermal precursors; lbp-1::gfp hypodermal expression continues in hyp7 nuclei through hatching and is then seen only in one ventral cord neuron from the L1 to adult stages; an LBP-1::GFP fusion construct that contains the predicted LBP-1 secretory signal is secreted into the perivitelline fluid prior to hatching. Paper_evidence: WBPaper00003911
          Curator_confirmed: WBPerson1843
          Date_last_updated: 16 Jan 2008 00:00:00
      Automated_description: Predicted to enable lipid binding activity. Predicted to be located in extracellular region. Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F40F4.3
    Corresponding_transcript: F40F4.3.1
    Other_sequence (73)
    Associated_feature (12)
  Experimental_info: RNAi_result: WBRNAi00102642 Inferred_automatically: RNAi_primary
      WBRNAi00014657 Inferred_automatically: RNAi_primary
      WBRNAi00046865 Inferred_automatically: RNAi_primary
      WBRNAi00088954 Inferred_automatically: RNAi_primary
      WBRNAi00032032 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr6010
      Expr1031327
      Expr1150732
      Expr2013018
      Expr2031250
    Drives_construct: WBCnstr00003451
      WBCnstr00008651
      WBCnstr00020895
      WBCnstr00020905
      WBCnstr00020919
      WBCnstr00020920
      WBCnstr00020921
      WBCnstr00020929
      WBCnstr00021437
      WBCnstr00036358
    Construct_product: WBCnstr00036358
    Microarray_results (13)
    Expression_cluster: WBPaper00005700:secreted_protein
      WBPaper00031040:TGF-beta_adult_upregulated
      WBPaper00032031:DConiospora_downregulated_cDNA_12h
      WBPaper00032031:DConiospora_downregulated_cDNA_24h
      WBPaper00032031:DConiospora_downregulated_OligoArray_24h
      WBPaper00032425:down_in_alg-1
      WBPaper00032425:down_in_rde-4
      WBPaper00032425:down_in_zfp-1
      WBPaper00032976:non_compensated_genes
      WBPaper00033065:clk-1(qm30)_upregulated
      WBPaper00033065:cyc-1(RNAi)_downregulated
      WBPaper00035926:A.hydrophila_regulated
      WBPaper00037055:DAF-16_binding_DNA
      WBPaper00037950:all-neurons_L2-larva_expressed
      WBPaper00037950:BAG-neuron_blastula-embryo_expressed
      WBPaper00037950:bodywall-muscle_L2-larva_expressed
      WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
      WBPaper00037950:coelomocytes_embryo_enriched
      WBPaper00037950:coelomocytes_embryo_SelectivelyEnriched
      WBPaper00037950:coelomocytes_L1-larva_expressed
      WBPaper00037950:coelomocytes_L2-larva_expressed
      WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
      WBPaper00037950:GABAergic-motor-neurons_L1-larva_expressed
      WBPaper00037950:hypodermis_L3-L4-larva_expressed
      WBPaper00037950:hypodermis_larva_enriched
      WBPaper00037950:hypodermis_larva_SelectivelyEnriched
      WBPaper00037950:intestine_L1-larva_expressed
      WBPaper00037950:intestine_L2-larva_expressed
      WBPaper00037950:pharyngeal-muscle_L1-larva_expressed
      WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
      WBPaper00038213:E.coli(LF82)_72h_downregulated
      WBPaper00038215:pod-2(RNAi)_regulated
      WBPaper00038289:oocyte_protein
      WBPaper00040990:PA14_upregulated
      WBPaper00043951:insoluble_protein_day16_N2
      WBPaper00044260:1-methylnicotinamide_downregulated
      WBPaper00044260:nicotic-acid_downregulated
      WBPaper00044316:CH3HgCl_7.5uM_downregulated
      WBPaper00044426:rotenone_24h_upregulated
      WBPaper00044501:gld-1_let-7_regulated
      WBPaper00044736:flat_dev_expression
      WBPaper00045314:S.aureus-induced_N2
      WBPaper00045417:128Q-huntingtin_upreglated
      WBPaper00045521:Gender_Neutral
      WBPaper00045774:clk-1_upregulated
      WBPaper00045934:wrn-1(gk99)_upregulated
      WBPaper00045974:NSM_enriched_totalRNA_RNAseq
      WBPaper00046012:tdp-1(ok803)_upregulated
      WBPaper00046446:rapid-synthesized_YoungAdult
      WBPaper00046497:B.thuringiensis_0.1mix_upregulated_6h
      WBPaper00046497:B.thuringiensis_0.5mix_upregulated_6h
      WBPaper00046497:B.thuringiensis_upregulated_protein
      WBPaper00046795:starvation_upregulated
      WBPaper00046858:elt-2(RNAi)_upregulated
      WBPaper00047131:daf-2(e1370)_upregulated_N2-background
      WBPaper00048926:miaserin_upregulated_adult-day5
      WBPaper00048971:daf-16(mgDf50)_downregulated_L1
      WBPaper00048988:neuron_expressed
      WBPaper00049018:ham-3(RNAi)_downregulated
      WBPaper00049098:heat-induced_hrde-1(tm1200)
      WBPaper00049545:cco-1(RNAi)_upregulated
      WBPaper00049736:daf-2(e1370)_upregulated_15deg-then-25deg(12hr)
      WBPaper00049905:Age_variant_expression
      WBPaper00049920:Glucose-Diet_upregulated_N2
      WBPaper00049942:hsf-1(RNAi)_upregulated
      WBPaper00049954:BPS_upregulated
      WBPaper00050370:dpy-21(e428)_L3_upregulated
      WBPaper00050468:hlh-30-dependent_Cry5B_regulated
      WBPaper00050488:adult_vs_dauer_regulated_N2_20C
      WBPaper00050726:starvation_regulated_LowSalt
      WBPaper00050801:DAF-12_dauer_regulome
      WBPaper00050801:DAF-16_dauer_regulome
      WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
      WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
      WBPaper00050990:arcade_intestinal-valve_expressed
      WBPaper00050990:GABAergic-neuron_expressed
      WBPaper00050990:hypodermis_expressed
      WBPaper00050990:intestine_expressed
      WBPaper00050990:NMDA-neuron_expressed
      WBPaper00050990:seam_expressed
      WBPaper00051039:germline_enriched
      WBPaper00052884:emb-4(hc60)_upregulated
      WBPaper00052987:UV_upregulated_xpc-1;csb-1
      WBPaper00053184:sma-2(rax5)_upregulated
      WBPaper00053184:sma-4(rax3)_upregulated
      WBPaper00053295:lin-22(ot269)_downregulated
      WBPaper00053302:alovudine_72h_regulated
      WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
      WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq
      WBPaper00053321:PGCs_depleted_NuGen
      WBPaper00053388:dauer_regulated_Cluster2
      WBPaper00053599:mitosis_vs_meiosis_downregulated
      WBPaper00053599:oocyte_vs_mitosis_downregulated
      WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_downregulated
      WBPaper00053606:N2_vs_elt-2(ca15)_downregulated
      WBPaper00053615:SMO-1_target
      WBPaper00053713:Pheromone-induced_postdauer_vs_control_downregulated
      WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
      WBPaper00053810:daf-2(e1370)_upregulated
      WBPaper00053810:nuo-6(qm200)_upregulated
      WBPaper00053814:15C_downregulated_OP50
      WBPaper00053814:15C_downregulated_PY79
      WBPaper00055060:flr-1(RNAi)_upregulated
      WBPaper00055354:eat-2(ad1116)_downregulated
      WBPaper00055354:Rapamycin-Rifampicin_downregulated
      WBPaper00055354:Rapamycin_downregulated
      WBPaper00055354:Rifampicin-Psora_downregulated
      WBPaper00055482:Tunicamycin_upregulated
      WBPaper00055626:pry-1(mu38)_upregulated
      WBPaper00055827:daf-2(e1370)_upregulated
      WBPaper00055862:antimycin_damt-1(gk961032)_regulated
      WBPaper00055941:nuo-6(qm200)_upregulated
      WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
      WBPaper00056139:soil-microbiota_upregulated
      WBPaper00056161:hermaphrodite_enriched_siRNA
      WBPaper00056443:sek-1(km4)_upregulated
      WBPaper00056471:aak-1(tm1944);aak-2(ok524)_upregulated
      WBPaper00056826:hmc_biased
      WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
      WBPaper00057006:DietaryRestriction_downregulated
      WBPaper00057041:spc-1(cas971)_downregulated
      WBPaper00057041:unc-70(cas983)_downregulated
      WBPaper00057140:meg-3(tm4259)_meg-4(ax2026)_downregulated
      WBPaper00057161:meg-3(tm4259)_meg-4(ax2026)_downregulated_endo-siRNA_targets
      WBPaper00057162:meg-3_meg-4_downregulated_sRNA
      WBPaper00057288:Cold_downregulated_transcript
      WBPaper00058598:sin-3(tm1276)_downregulated
      WBPaper00058678:DAF-12_upregulated_PVD
      WBPaper00058725:sftb-1(cer39)_upregulated
      WBPaper00059224:tph-1(mg280)_upregulated
      WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
      WBPaper00059356:set-6(ok2195)_baz-2(tm0235)_regulated
      WBPaper00059477:hlh-2(RNAi)_regulated
      WBPaper00060084:cco-1(RNAi)_upregulated_lin-40(yth27)
      WBPaper00060358:B.thuringiensis_pathogen_regulated_N2
      WBPaper00060399:pqm-1(ok485)_upregulated_CoCl2_6hr
      WBPaper00060683:hlh-11(ko1)_downregulated
      WBPaper00060871:M.humicola-extract_1h_regulated
      WBPaper00061203:let-418(n3536)_upregulated
      WBPaper00061203:sin-3(tm1276)_upregulated
      WBPaper00061203:spr-1(ok2144)_upregulated
      WBPaper00061340:Body_wall_muscle
      WBPaper00061340:Ciliated_amphid_neuron
      WBPaper00061340:DA
      WBPaper00061340:DB
      WBPaper00061340:DD
      WBPaper00061340:DVC
      WBPaper00061340:DVC_parent
      WBPaper00061340:hmc
      WBPaper00061340:hmc_and_homolog
      WBPaper00061340:hmc_homolog
      WBPaper00061340:Intestinal_and_rectal_muscle
      WBPaper00061340:mu_int_mu_anal
      WBPaper00061340:Neuroblast_ALM_BDU
      WBPaper00061340:Neuroblast_PVC_LUA
      WBPaper00061340:Parent_of_AMsh_URB
      WBPaper00061340:PVQ_parent
      WBPaper00061340:PVR
      WBPaper00061340:XXX
      WBPaper00061340:Z1_Z4
      WBPaper00061341:28C_24h_upregulated
      WBPaper00061439:unc-30(ok613)_upregulated
      WBPaper00061527:chd-7_16664-jmjd-3.1
      WBPaper00061651:Coelomocyte_enriched
      WBPaper00061651:hmc_enriched
      WBPaper00061753:csr-1(tor159)_upregulated_25C
      WBPaper00061902:camt-1(ok515)_regulated_RMG
      WBPaper00062118:neural-HSF-1_upregulated
      WBPaper00062156:jmjd-5(zr1234)_upregulated_germline
      WBPaper00062159:hda-2(ok1479)_downregulated
      WBPaper00062325:muscle_depleted_coding-RNA
      WBPaper00062456:doxycycline_downregulated_CB4856_protein
      WBPaper00062520:qui-1(db104)_downregulated
      WBPaper00062554:MAGU-2_interacting
      WBPaper00062606:rotenone_upregulated
      WBPaper00062669:extracellular-vesicle_protein
      WBPaper00062672:dcp-66(RNAi)_upregulated
      WBPaper00062672:let-418(n3536)dcp-66(RNAi)_upregulated
      WBPaper00063930:BRD-1_interacting
      WBPaper00064055:trl-1(cas1077)_downregulated_non-starved
      WBPaper00064055:trl-1(cas1077)_downregulated_starved
      WBPaper00064071:NHR-49_interacting
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064088:Day-1-adult_vs_L4_upregulated_glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_daf-16(mu86);glp-1(e2141)
      WBPaper00064088:Day-3-adult_vs_L4_upregulated_fem-3(q20)
      WBPaper00064229:B.thuringiensis-Cry5Ba_downregulated
      WBPaper00064315:mes-4(bn73)_downregulated_EGCs
      WBPaper00064727:daf-2(e1370)_upregulated
      WBPaper00064871:hypoxia_downregulated_F2
      WBPaper00064952:Day1_vs_L4_upregulated_25C
      WBPaper00064952:Day10_vs_L4_upregulated_25C
      WBPaper00065096:25C_vs_20C_upregulated
      WBPaper00065096:Day10_vs_Day1_upregulated
      WBPaper00065096:npr-8(ok1439)_downregulated_Day10_20C
      WBPaper00065120:body-muscle-transcriptome
      WBPaper00065158:AFD_depleted
      WBPaper00065373:Cisplatin_upregulated_WT
      WBPaper00065373:sek-1(km4)_upregulated_cisplatin
      WBPaper00065623:72
      WBPaper00065623:103
      WBPaper00065835:Day5_vs_Day1_downregulated
      WBPaper00065835:mtH2S-AP39-D0-treatment_upregulated_Day5
      WBPaper00065841:1_2
      WBPaper00065841:7_2
      WBPaper00065841:7_4
      WBPaper00065841:23_0
      WBPaper00065841:38_3
      WBPaper00065841:64_0
      WBPaper00065841:102_0
      WBPaper00065841:110_0
      WBPaper00065841:110_1
      WBPaper00065945:epidermis-rpoa-2(-)_upregulated_protein
      WBPaper00065975:P-body_vs_oocyte_enriched
      WBPaper00066005:RAGA-1_degradation_somatic_upregulated
      WBPaper00066085:sin-3(syb2172)_upregulated
      WBPaper00066110:tetraploid_vs_diploid_downregulated
      cgc4386_cluster_6_2
      cgc4489_group_2
      WBPaper00005124:progesterone_10-7M_regulated
      WBPaper00024671:AFD_AWB_vs_unsorted_downregulated
      WBPaper00025032:cluster_2
      WBPaper00025141:N2_Expressed_Genes
      WBPaper00026929:sir-2.1_overexpression_regulated
      WBPaper00026952:class_F
      WBPaper00026980:intestine_enriched
      WBPaper00031003:0hr_muscle_depleted
      WBPaper00031003:24hr_muscle_depleted
      WBPaper00031003:total_muscle_depleted
      WBPaper00031060:2-deoxy-D-glucose_upregulated
      WBPaper00032062:age_regulated_genes
      WBPaper00032948:StarveUp2
      WBPaper00035227:heat_shock_regulated
      WBPaper00035873:osm-7_regulated
      WBPaper00035873:osm-8_regulated
      WBPaper00035873:osm-11_regulated
      WBPaper00036123:Fluoranthene_regulated
      WBPaper00040963:TA100_up
      WBPaper00040963:TA200_up
      WBPaper00040963:TA300_up
      WBPaper00041002:HF_3d_0.2mM_Up
      WBPaper00041002:HF_3d_2.0mM_Up
      WBPaper00041002:HQ_3d_2.0mM_Up
      WBPaper00041174:environmental
      WBPaper00041174:genotypic
      WBPaper00041174:genotypic_and_environmental
      WBPaper00041960:N2_fasting_upregulated_9hto12h
      WBPaper00041960:N2_fasting_upregulated_anytime
      WBPaper00045263:isp-1(qm150)_upregulated
      WBPaper00045263:nuo-6(qm200)_upregulated
      WBPaper00047070:N2_starvation_upregulated
      WBPaper00053236:Starvation_regulated_GR1307
      WBPaper00053236:Starvation_regulated_N2
      WBPaper00057098:SiO2-nanoparticles_upregulated
      [cgc5767]:cluster_2
      [cgc5767]:expression_class_E
      [cgc5767]:expression_class_E_pi(23_min)
      [cgc5767]:expression_class_M
      [cgc5767]:expression_class_ME
    Interaction: WBInteraction000030987
      WBInteraction000030988
      WBInteraction000135555
      WBInteraction000135556
      WBInteraction000191494
      WBInteraction000197000
      WBInteraction000204692
      WBInteraction000226453
      WBInteraction000230600
      WBInteraction000242638
      WBInteraction000249259
      WBInteraction000303932
      WBInteraction000307430
      WBInteraction000308348
      WBInteraction000321972
      WBInteraction000344096
      WBInteraction000353214
      WBInteraction000363135
      WBInteraction000375780
      WBInteraction000378310
      WBInteraction000386759
      WBInteraction000389623
      WBInteraction000389794
      WBInteraction000398335
      WBInteraction000404892
      WBInteraction000412911
      WBInteraction000419709
      WBInteraction000424209
      WBInteraction000429590
      WBInteraction000432710
      WBInteraction000434642
      WBInteraction000515506
      WBInteraction000548030
      WBInteraction000552037
      WBInteraction000577624
      WBInteraction000580118
  Map_info: Map: X Position: -10.6531
    Positive: Positive_clone: F40F4 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (16)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene