WormBase Tree Display for Gene: WBGene00002259

WBGene00002259 SMap: S_parent: Sequence: T22G5
  Identity: Version: 1
    Name: CGC_name: lbp-7 Person_evidence: WBPerson492
      Sequence_name: T22G5.2
      Molecular_name: T22G5.2
        T22G5.2.1
        CE13984
      Other_name: CELE_T22G5.2 Accession_evidence: NDB BX284605
      Public_name: lbp-7
    DB_info: Database: AceView gene 5O359
        WormQTL gene WBGene00002259
        WormFlux gene WBGene00002259
        NDB locus_tag CELE_T22G5.2
        Panther gene CAEEL|WormBase=WBGene00002259|UniProtKB=O02323
          family PTHR11955
        NCBI gene 191701
        RefSeq protein NM_074039.2
        SwissProt UniProtAcc O02323
        UniProt_GCRP UniProtAcc O02323
        OMIM gene 170715
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:27 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: lbp
    Allele (21)
    Strain: WBStrain00037908
    RNASeq_FPKM (74)
    GO_annotation: 00027057
      00027058
      00027059
      00027060
      00027061
      00110324
    Ortholog (52)
    Paralog: WBGene00002253
      WBGene00002254
      WBGene00002255 Caenorhabditis elegans From_analysis: TreeFam
      WBGene00002256
      WBGene00002257 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00002258 Caenorhabditis elegans From_analysis: Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00002260 Caenorhabditis elegans From_analysis: TreeFam
            Inparanoid_8
            Panther
            WormBase-Compara
      WBGene00021486 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
    Structured_description: Concise_description: lbp-7 encodes a predicted intracellular fatty acid binding protein (iFABP) that is most similar to the vertebrate muscle and heart FABPs; by homology, LBP-7 is predicted to function as an intracellular transporter for small hydrophobic molecules such as lipids and steroid hormones; as loss of lbp-7 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of LBP-7 in C. elegans development and/or behavior is not yet known. Paper_evidence: WBPaper00003911
            WBPaper00005654
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable fatty acid binding activity. Predicted to be involved in fatty acid transport. Predicted to be located in cytosol and nucleus. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Charcot-Marie-Tooth disease type 1G; Down syndrome; and artery disease (multiple). Is an ortholog of several human genes including FABP3 (fatty acid binding protein 3); FABP7 (fatty acid binding protein 7); and PMP2 (peripheral myelin protein 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (11)
  Molecular_info: Corresponding_CDS: T22G5.2
    Corresponding_transcript: T22G5.2.1
    Other_sequence: CBC07626_1
      XI03466
      SSC00004_1
      GW411042.1
      SS00962
      XIC01700_1
    Associated_feature: WBsf716840
      WBsf1001903
      WBsf232840
  Experimental_info: RNAi_result: WBRNAi00095433 Inferred_automatically: RNAi_primary
      WBRNAi00035824 Inferred_automatically: RNAi_primary
      WBRNAi00102648 Inferred_automatically: RNAi_primary
      WBRNAi00053855 Inferred_automatically: RNAi_primary
      WBRNAi00019041 Inferred_automatically: RNAi_primary
      WBRNAi00088960 Inferred_automatically: RNAi_primary
      WBRNAi00063219 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1028650
      Expr1157406
      Expr2013024
      Expr2031256
    Drives_construct: WBCnstr00036352
    Construct_product: WBCnstr00036352
    Microarray_results (19)
    Expression_cluster (227)
    Interaction (12)
    WBProcess: WBbiopr:00000039
  Map_info: Map: V Position: 5.70567 Error: 0.00122
    Positive: Positive_clone: T22G5 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (12)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene