hmt-1 encodes a predicted transmembrane half-molecule ATP-binding cassette (ABC) transporter orthologous to Schizosaccharomyces pombe heavy metal tolerance factor 1 (SpHMT1), an ATP-dependent phytochelatin transporter; HMT-1 is required for cadmium detoxification and by homology, is predicted to promote sequestration of heavy metal-containing phytochelatins into intracellular vacuoles to protect cells from potential damage.
Enables cadmium ion transmembrane transporter activity. Involved in cadmium ion transmembrane transport; cellular detoxification of cadmium ion; and detoxification of copper ion. Located in endosome and vacuolar membrane. Expressed in coelomocyte; head neurons; intestinal cell; and tail neurons. Human ortholog(s) of this gene implicated in dyschromatosis universalis hereditaria. Is an ortholog of human ABCB6 (ATP binding cassette subfamily B member 6 (Langereis blood group)).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.