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WormBase Tree Display for Gene: WBGene00001475

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Name Class

WBGene00001475SMapS_parentSequenceCHROMOSOME_V
IdentityVersion2
NameCGC_namefmi-1Person_evidenceWBPerson194
WBPerson481
Sequence_nameF15B9.7
Molecular_nameF15B9.7a
F15B9.7a.1
CE42459
F15B9.7b
CE50507
F15B9.7c
CE50392
F15B9.7b.1
F15B9.7c.1
Other_namecdh-6Person_evidenceWBPerson698
CELE_F15B9.7Accession_evidenceNDBBX284605
Public_namefmi-1
DB_infoDatabaseAceViewgene5N513
WormQTLgeneWBGene00001475
WormFluxgeneWBGene00001475
NDBlocus_tagCELE_F15B9.7
PanthergeneCAEEL|EnsemblGenome=WBGene00001475|UniProtKB=G5EDK5
familyPTHR24026
NCBIgene179788
RefSeqproteinNM_001313143.3
NM_001313142.3
NM_073855.6
SwissProtUniProtAccG5EDK5
UniProt_GCRPUniProtAccG5EDK5
OMIMgene604523
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:24WBPerson1971EventImportedInitial conversion from geneace
230 Sep 2009 14:20:01WBPerson1847EventAcquires_mergeWBGene00000398
Acquires_mergeWBGene00000398
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classfmi
Allele (194)
StrainWBStrain00040023
WBStrain00040028
RNASeq_FPKM (74)
GO_annotation (19)
Ortholog (46)
ParalogWBGene00017576Caenorhabditis elegansFrom_analysisPanther
WBGene00001980Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00022103Caenorhabditis elegansFrom_analysisPanther
WBGene00014914Caenorhabditis elegansFrom_analysisWormBase-Compara
Structured_descriptionConcise_descriptionfmi-1 encodes a highly conserved cadherin-like protein with unique domain composition of six EGF and two laminin G domains, a GPS cleavage site and seven-pass transmembrane domain; fmi-1 plays a crucial role in pioneer axon navigation as well as pioneer-mediated follower navigation; FMI-1 is required cell autonomously in pioneer and partially non-cell autonomously in the follower; different domains of FMI-1 are required for pioneer and follower navigation; mutations in fmi-1 cause strong axon navigation defects of VNC pioneer axons; HSN axons are more susceptible to changes in fmi-1 protein; LIN-17/frizzled functions together with fmi-1 in follower axon navigation; in addition, FMI-1 functions together with the CDH-4 cadherin to regulate GABAergic neuronal development; FMI-1 is expressed in neurons and localized to pioneer and follower axons during and after nervous system development; in the embryos FMI-1::GFP is found in axons in the nerve ring, the tail and along the dendrites of sensory neurons.Paper_evidenceWBPaper00037648
WBPaper00040906
Curator_confirmedWBPerson12884
WBPerson1843
Date_last_updated05 Jul 2012 00:00:00
Automated_descriptionPredicted to enable G protein-coupled receptor activity and calcium ion binding activity. Involved in anterior/posterior axon guidance and interneuron axon guidance. Located in axon. Expressed in nervous system and somatic nervous system. Human ortholog(s) of this gene implicated in hereditary lymphedema. Is an ortholog of human CELSR2 (cadherin EGF LAG seven-pass G-type receptor 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0050580Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:1850)
Molecular_infoCorresponding_CDSF15B9.7a
F15B9.7b
F15B9.7c
Corresponding_CDS_historyF15B9.7:wp138
F15B9.7:wp188
Corresponding_transcriptF15B9.7a.1
F15B9.7b.1
F15B9.7c.1
Other_sequenceCRC05304_1
JI163786.1
JI163891.1
CR04693
JI163835.1
JI163797.1
Associated_feature (36)
Experimental_infoRNAi_resultWBRNAi00066947Inferred_automaticallyRNAi_primary
WBRNAi00001265Inferred_automaticallyRNAi_primary
WBRNAi00101845Inferred_automaticallyRNAi_primary
WBRNAi00044701Inferred_automaticallyRNAi_primary
WBRNAi00000627Inferred_automaticallyRNAi_primary
WBRNAi00013361Inferred_automaticallyRNAi_primary
Expr_pattern (13)
Drives_construct (11)
Construct_product (11)
AntibodyWBAntibody00002321
Microarray_results (19)
Expression_clusterWBPaper00033065:cyc-1(RNAi)_upregulated
WBPaper00036375:enriched_in_PVD_OLL
WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
WBPaper00037950:A-class-motor-neurons_larva_enriched
WBPaper00037950:A-class-motor-neurons_larva_SelectivelyEnriched
WBPaper00037950:all-neurons_L2-larva_expressed
WBPaper00037950:BAG-neuron_blastula-embryo_expressed
WBPaper00037950:CEP-sheath-cells_Day1-adult_expressed
WBPaper00037950:coelomocytes_L2-larva_expressed
WBPaper00037950:dopaminergic-neurons_L3-L4-larva_expressed
WBPaper00037950:glr-1(+)-neurons_L2-larva_expressed
WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
WBPaper00038438:P.lumniescens_24hr_upregulated_RNAseq
WBPaper00038438:P.lumniescens_24hr_upregulated_TilingArray
WBPaper00040285:H2S_12hr_downregulated
WBPaper00042561:smg-2(RNAi)_downregulated
WBPaper00044260:1-methylnicotinamide_downregulated
WBPaper00044260:nicotic-acid_downregulated
WBPaper00044316:CH3HgCl_7.5uM_downregulated
WBPaper00044426:rotenone_24h_downregulated
WBPaper00044736:flat_dev_expression
WBPaper00045390:tunicamycin_downregulated
WBPaper00045390:ubc-9(RNAi)_downregulated
WBPaper00045420:fertilization_upregulated_transcript
WBPaper00045729:gld-2(RNAi)_downregulated
WBPaper00045861:set-2(ok952)_upregulated
WBPaper00045861:wdr-5(ok1417)_upregulated
WBPaper00046012:tdp-1(ok803)_upregulated
WBPaper00046121:ecdoderm_unique
WBPaper00046741:Garlic-Extract_upregulated_mRNA
WBPaper00047131:daf-2(e1370)_upregulated_hel-1(gk148684)-background
WBPaper00048690:gonad-male-biased
WBPaper00048988:neuron_enriched
WBPaper00048988:neuron_expressed
WBPaper00049377:MWCNT_upregulated
WBPaper00049495:starvation-refeeding_regulated
WBPaper00049498:npr-1(ur89)_regulated_4
WBPaper00049545:jmjd-3.1(+)_upregulated
WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
WBPaper00049942:HeatShock_upregulated_hsf-1(RNAi)
WBPaper00049954:BPS_upregulated
WBPaper00050163:chd-3(eh4);let-418(RNAi)_upregulated_24-cell-embryo
WBPaper00050488:adult_vs_dauer_regulated_N2_20C
WBPaper00050726:OsmoticStress_regulated_Food
WBPaper00050843:sesamin_downregulated
WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
WBPaper00050859:upregulated_pgl-1(ct131)_vs_control_day1-adult
WBPaper00050990:GABAergic-neuron_expressed
WBPaper00050990:hypodermis_expressed
WBPaper00050990:NMDA-neuron_expressed
WBPaper00051388:Glucose-diet_upregulated
WBPaper00051404:alg-1(gk214)_upregulated
WBPaper00051404:alg-2(ok304)_upregulated
WBPaper00052884:emb-4(hc60)_upregulated
WBPaper00053184:sma-4(rax3)_upregulated
WBPaper00053295:lin-22(icb38)_upregulated
WBPaper00053295:lin-22(ot267)_upregulated
WBPaper00053295:lin-22(ot269)_upregulated
WBPaper00053302:zidovudine_72h_regulated
WBPaper00053321:embryo-to-L1_downregulated_nos-1(gv5)nos-2(RNAi)_SMARTseq
WBPaper00053321:embryo-to-L1_downregulated_WT_SMARTseq
WBPaper00053321:lin-15B(RNAi)_downregulated_starved-L1_Truseq
WBPaper00053321:nos-1(gv5)nos-2(RNAi)_upregulated_starved-L1_Truseq
WBPaper00053321:PGCs_depleted_NuGen
WBPaper00053388:dauer_regulated_Cluster5
WBPaper00053606:N2_vs_elt-2(ca15);elt-7(tm840)_downregulated
WBPaper00053664:ins-11(tm1053)_upregulated
WBPaper00053713:Pheromone-induced_postdauer_vs_control_downregulated
WBPaper00053713:Starvation-induced_postdauer_vs_control_upregulated
WBPaper00053771:up_at_24h-NaCl
WBPaper00053771:up_at_dpy-7(e88)
WBPaper00054758:alg-1(gk204)_upregulated
WBPaper00055060:flr-1(RNAi)_upregulated
WBPaper00055226:ADR-2_target_N2
WBPaper00055334:DLC-1_interacting
WBPaper00055354:eat-2(ad1116)_upregulated
WBPaper00055354:Metformin_upregulated
WBPaper00055354:Psora-Allantoin_upregulated
WBPaper00055354:Rapamycin-Metformin_upregulated
WBPaper00055354:Rapamycin-Psora-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Allantoin_upregulated
WBPaper00055354:Rapamycin-Rifampicin-Psora_upregulated
WBPaper00055354:Rapamycin-Rifampicin_upregulated
WBPaper00055354:Rifampicin-Allantoin_upregulated
WBPaper00055354:Rifampicin-Psora_upregulated
WBPaper00055354:Rifampicin_upregulated
WBPaper00055981:fog-2(q71)_downregulated
WBPaper00056039:ptl-1(ok621)_upregulated
WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
WBPaper00056090:E.faecalis_upregulated_N2
WBPaper00056139:soil-microbiota_upregulated
WBPaper00056165:MINA-1_interacting_mRNA
WBPaper00056167:Cry5B_upregulated
WBPaper00056169:rrf-3(pk1426)_upregulated_embryo
WBPaper00056218:daf-16(mu86)_downregulated_Day3
WBPaper00056275:P.aeruginosa_downregulated
WBPaper00056275:P.aeruginosa_downregulated_atf-7(qd22qd130)_dependent
WBPaper00056275:P.aeruginosa_downregulated_pmk-1(km25)_dependent
WBPaper00056443:DietaryRestriction_upregulated
WBPaper00056443:sek-1(km4)_upregulated
WBPaper00056619:CEPsh_enriched
WBPaper00056826:hmc_biased
WBPaper00056868:P.aeruginosa_upregulated_smallRNA
WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
WBPaper00057347:nhr-14(tm1473)_downreglated
WBPaper00058598:mex-1(or286)_upregulated
WBPaper00058598:mex-3(eu149)_upregulated
WBPaper00058678:DAF-12_upregulated_PVD
WBPaper00058711:skn-1(lax188)_upregulated
WBPaper00058725:sftb-1(cer6)_downregulated
WBPaper00059027:neuron-synapses_depleted
WBPaper00059421:daf-1(m40);daf-3(mgDf90)_downregulated
WBPaper00059421:daf-3(mgDf90)_downregulated
WBPaper00059471:EGL-43_interacting
WBPaper00059477:hlh-2(RNAi)_regulated
WBPaper00059735:glucose_upregulated_lpin-1(RNAi)
WBPaper00059824:rnp-6(dh1127)_regulated_OP50
WBPaper00059824:rnp-6(dh1127)_regulated_S.aureus
WBPaper00059895:wounding_upregulated
WBPaper00060014:set-2(tm1630)_downregulated
WBPaper00060273:isp-1(qm150)_upregulated
WBPaper00060661:sensory-neuron_enriched
WBPaper00060811:L1_vs_adult_upregulated_neural
WBPaper00061007:HB101_upregulated
WBPaper00061007:S.aquatilis_upregulated
WBPaper00061081:E.faecalis_upregulated_N2
WBPaper00061203:let-418(n3536)_upregulated
WBPaper00061203:sin-3(tm1276)_upregulated
WBPaper00061203:spr-1(ok2144)_upregulated
WBPaper00061340:ADE
WBPaper00061340:ADF_AWB
WBPaper00061340:AIB
WBPaper00061340:AIN
WBPaper00061340:ALA
WBPaper00061340:ALN
WBPaper00061340:ASG_AWA
WBPaper00061340:ASI_parent
WBPaper00061340:AVA
WBPaper00061340:AVB
WBPaper00061340:AVD
WBPaper00061340:AVE
WBPaper00061340:AVG
WBPaper00061340:AVJ
WBPaper00061340:AVK
WBPaper00061340:AVL
WBPaper00061340:AWB
WBPaper00061340:CEPsh
WBPaper00061340:DD
WBPaper00061340:DVC
WBPaper00061340:I5
WBPaper00061340:IL1_parent
WBPaper00061340:Neuroblast_ASG_AWA
WBPaper00061340:Neuroblast_AVG_RIR
WBPaper00061340:Neuroblast_HSN_PHB
WBPaper00061340:Neuroblast_PVC_LUA
WBPaper00061340:Neuroblast_URX_CEPDx
WBPaper00061340:OLL_parent
WBPaper00061340:OLQ_parent
WBPaper00061340:Parent_of_exc_gland_AVK
WBPaper00061340:PLM_ALN_great_grandparent
WBPaper00061340:PVP
WBPaper00061340:RIA
WBPaper00061340:RIC
WBPaper00061340:RIH
WBPaper00061340:RIM
WBPaper00061340:RIS
WBPaper00061340:RIV
WBPaper00061340:RMD
WBPaper00061340:RME
WBPaper00061340:RMED
WBPaper00061340:SIA
WBPaper00061340:SIB
WBPaper00061340:SMB
WBPaper00061340:XXX
WBPaper00061341:28C_24h_upregulated
WBPaper00061341:28C_48h_upregulated
WBPaper00061479:hda-1(ne4752)_upregulated
WBPaper00061479:hrde-1(tm1200)_upregulated
WBPaper00061527:sol-1-jnk-1_18695
WBPaper00061651:AQR_enriched
WBPaper00061651:AVF_enriched
WBPaper00061651:AVJ_enriched
WBPaper00061651:DVB_enriched
WBPaper00061651:HSN_enriched
WBPaper00061651:IL2_LR_enriched
WBPaper00061651:PVW_enriched
WBPaper00061651:RMF_enriched
WBPaper00061651:VC_enriched
WBPaper00061902:camt-1(ok515)_regulated_RMG
WBPaper00061995:mter-4(syb3662syb3403)_downregulated
WBPaper00062103:neuron_enriched
WBPaper00062159:hda-2(ok1479)_upregulated
WBPaper00062193:skn-1(RNAi)_downregulated
WBPaper00062325:muscle_depleted_coding-RNA
WBPaper00062440:crh-1(n3315)_downregulated
WBPaper00062440:crh-1(syb385)_downregulated
WBPaper00062446:nhr-8(hd117)_upregulated
WBPaper00062497:xpf-1(tm2842)_upregulated
WBPaper00062672:let-418(n3536)dcp-66(RNAi)_upregulated
WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
WBPaper00064306:Agaro-oligosaccharides_upregulated
WBPaper00064661:lpd-3(ok2138)_upregulated
WBPaper00064871:hypoxia_downregulated_F2
WBPaper00065029:cadmium_upregulated
WBPaper00065096:25C_vs_20C_downregulated
WBPaper00065096:Day10_vs_Day1_upregulated
WBPaper00065149:lin-52(n771)_upregulated
WBPaper00065581:hpk-1(pk1393)_upregulated
WBPaper00065749:endu-2(tm4977)_upregulated
WBPaper00065749:Heat-Shock_downregulated_N2
WBPaper00065835:Day11_vs_Day1_upregulated
WBPaper00065841:17_0
WBPaper00065841:19_0
WBPaper00065841:25_1
WBPaper00065841:36_2
WBPaper00065841:36_3
WBPaper00065841:39_2
WBPaper00065841:39_3
WBPaper00065841:47_0
WBPaper00065841:50_0
WBPaper00065841:55_0
WBPaper00065841:60_0
WBPaper00065841:62_0
WBPaper00065841:66_0
WBPaper00065841:68_0
WBPaper00065841:68_1
WBPaper00065841:75_0
WBPaper00065841:80_0
WBPaper00065841:90_0
WBPaper00065841:94_0
WBPaper00065841:107_0
WBPaper00065841:108_0
WBPaper00065841:114_0
WBPaper00065841:118_0
WBPaper00065841:119_0
WBPaper00065841:122_0
WBPaper00065841:123_0
WBPaper00065841:130_0
WBPaper00065841:134_0
WBPaper00065841:137_0
WBPaper00065841:138_0
WBPaper00065841:139_0
WBPaper00065841:140_0
WBPaper00065841:145_0
WBPaper00065975:P-body_vs_WholeAnimal_depleted
WBPaper00065993:glp-1(e2141)_downregulated
WBPaper00066093:E.coli-purE_downregulated
WBPaper00066110:Cisplatin_upregulated_diploid
WBPaper00066110:tetraploid_vs_diploid_upregulated
cgc4386_cluster_6_5
cgc4489_group_2
WBPaper00024671:AFD_AWB_vs_unsorted_upregulated
WBPaper00025141:N2_Expressed_Genes
WBPaper00025141:unc-4::GFP_Expressed_Genes
WBPaper00029437:dcr-1_upregulated
WBPaper00030839:Larval_A_Class
WBPaper00030839:Larval_Pan_Neuronal
WBPaper00031003:0hr_muscle_depleted
WBPaper00031003:24hr_muscle_depleted
WBPaper00031003:hlh_1_enriched
WBPaper00031003:total_muscle_depleted
WBPaper00031532:Larva_Pan_Neuronal_Enriched
WBPaper00034739:N2moreDR1350
WBPaper00035227:heat_shock_regulated
WBPaper00035588:alg-1(-)_upregulated
WBPaper00036130:mir-243_up_regulated
WBPaper00036286:Pattern_H
WBPaper00040963:Q100_down
WBPaper00040963:Q200_down
WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_24h
WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
WBPaper00045263:0.1mM-paraquat_upregulated
WBPaper00045263:isp-1(qm150)_upregulated
WBPaper00045673:colistin_upregulated
WBPaper00046639:tyrosol_upregulated
WBPaper00048989:eat-2(ad465)_rapamycin_downregulated
WBPaper00057098:SiO2-nanoparticles_upregulated
[cgc6390]:Cluster_A
Interaction (26)
Anatomy_functionWBbtf0831
WBbtf0832
Map_infoMapVPosition4.81313Error0.003033
PositivePositive_cloneF15B9Inferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Mapping_dataMulti_point4295
4482
Reference (34)
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene