WormBase Tree Display for Gene: WBGene00001403

expand all nodes | collapse all nodes | view schema

WBGene00001403	Evidence	Paper_evidence	WBPaper00003411
	SMap	S_parent	Sequence	CHROMOSOME_IV
	Identity	Version	1
		Name	CGC_name	fbl-1
			Sequence_name	F56H11.1
			Molecular_name (24)
			Other_name	FBLN1	Accession_evidence	EMBL	AF051401
				CELE_F56H11.1	Accession_evidence	NDB	BX284604
			Public_name	fbl-1
		DB_info	Database	AceView	gene	4K309
				WormQTL	gene	WBGene00001403
				WormFlux	gene	WBGene00001403
				NDB	locus_tag	CELE_F56H11.1
				Panther	gene	CAEEL\|WormBase=WBGene00001403\|UniProtKB=O77469
					family	PTHR24039
				NCBI	gene	177788
				RefSeq	protein	NM_001306946.3
						NM_001306950.3
						NM_001028066.6
						NM_001306947.3
						NM_001306948.3
						NM_001028065.4
						NM_069293.6
						NM_001306949.2
				SwissProt	UniProtAcc	O77469
				TrEMBL	UniProtAcc	A0A061ADQ1
						A0A061AKL1
						A0A061AIV4
						A0A061ACF5
						A0A061ACI3
				UniProt_GCRP	UniProtAcc	O77469
		Species	Caenorhabditis elegans
		History	Version_change	1	07 Apr 2004 11:29:24	WBPerson1971	Event	Imported	Initial conversion from geneace
		Status	Live
	Gene_info	Biotype	SO:0001217
		Gene_class	fbl
		Allele (63)
		Strain	WBStrain00022622
			WBStrain00028706
			WBStrain00028707
			WBStrain00028708
			WBStrain00035944
			WBStrain00003953
			WBStrain00050790
			WBStrain00054900
		RNASeq_FPKM (74)
		GO_annotation (12)
		Ortholog (44)
		Structured_description	Concise_description	fbl-1 encodes proteins orthologous to the vertebrate basement membrane protein fibulin; fbl-1 activity is essential for gonad and body morphology, as well as for reproduction; fbl-1 interacts genetically with gon-1 and mig-17, which encode ADAMTS metalloproteases essential for gonad development; the FBL-1C isoform is expressed in anterior and posterior intestinal cells and localizes to the gonad and pharyngeal basement membranes; the FBL-1D isoform is expressed in some head and tail body wall muscle cells.	Paper_evidence	WBPaper00003411
						WBPaper00003910
						WBPaper00005654
						WBPaper00024609
						WBPaper00024610
					Curator_confirmed	WBPerson1843
						WBPerson567
					Date_last_updated	11 Dec 2014 00:00:00
			Automated_description	An extracellular matrix structural constituent. Involved in extracellular matrix organization; positive regulation of locomotion; and protein localization. Located in basement membrane. Expressed in ALM; GLR; basal lamina; hyp7 syncytium; and nerve ring. Is an ortholog of human FBLN1 (fibulin 1).	Paper_evidence	WBPaper00065943
					Curator_confirmed	WBPerson324
						WBPerson37462
					Inferred_automatically	This description was generated automatically by a script based on data from the WS291 version of WormBase
					Date_last_updated	29 Nov 2023 00:00:00
	Molecular_info	Corresponding_CDS	F56H11.1a
			F56H11.1b
			F56H11.1c
			F56H11.1d
			F56H11.1e
			F56H11.1f
			F56H11.1g
			F56H11.1h
		Corresponding_CDS_history	F56H11.1:wp39
			F56H11.1c:wp141
		Corresponding_transcript	F56H11.1a.1
			F56H11.1b.1
			F56H11.1c.1
			F56H11.1d.1
			F56H11.1e.1
			F56H11.1f.1
			F56H11.1g.1
			F56H11.1h.1
		Other_sequence (29)
		Associated_feature	WBsf655044
			WBsf655045
			WBsf997438
			WBsf228843
			WBsf228844
	Experimental_info	RNAi_result	WBRNAi00062661	Inferred_automatically	RNAi_primary
			WBRNAi00048771	Inferred_automatically	RNAi_primary
			WBRNAi00116170	Inferred_automatically	RNAi_primary
			WBRNAi00027780	Inferred_automatically	RNAi_primary
			WBRNAi00048773	Inferred_automatically	RNAi_primary
			WBRNAi00015848	Inferred_automatically	RNAi_primary
			WBRNAi00110311	Inferred_automatically	RNAi_primary
			WBRNAi00018168	Inferred_automatically	RNAi_primary
			WBRNAi00048772	Inferred_automatically	RNAi_primary
		Expr_pattern (13)
		Drives_construct	WBCnstr00003660
			WBCnstr00011182
			WBCnstr00011223
			WBCnstr00011224
			WBCnstr00011594
			WBCnstr00011920
			WBCnstr00036967
		Construct_product	WBCnstr00011182
			WBCnstr00011224
			WBCnstr00011920
			WBCnstr00036967
		Microarray_results (40)
		Expression_cluster	WBPaper00029359_1166
			WBPaper00029359_1197
			WBPaper00029359_1291
			WBPaper00029359_1546
			WBPaper00029359_1557
			WBPaper00029359_1599
			WBPaper00030922:glycosylated_protein
			WBPaper00033065:cyc-1(RNAi)_downregulated
			WBPaper00033065:cyc-1(RNAi)_upregulated
			WBPaper00037682:sma-2_sma-4_upregulated
			WBPaper00037950:A-class-motor-neurons_L2-larva_expressed
			WBPaper00037950:bodywall-muscle_embryo_enriched
			WBPaper00037950:bodywall-muscle_embryo_SelectivelyEnriched
			WBPaper00037950:bodywall-muscle_L1-larva_expressed
			WBPaper00037950:bodywall-muscle_L2-larva_expressed
			WBPaper00037950:coelomocytes_L1-larva_expressed
			WBPaper00037950:excretory-cell_L2-larva_expressed
			WBPaper00037950:GABAergic-motor-neurons_L2-larva_expressed
			WBPaper00037950:intestine_L1-larva_expressed
			WBPaper00037950:intestine_L2-larva_expressed
			WBPaper00037950:PVD-OLL-neurons_L3-L4-larva_expressed
			WBPaper00038438:D.coniospora_12hr_downregulated_RNAseq
			WBPaper00038438:E.faecalis_24hr_upregulated_RNAseq
			WBPaper00038438:E.faecalis_24hr_upregulated_TilingArray
			WBPaper00044260:nicotinc-acid_upregulated
			WBPaper00044316:HgCl2_20uM_upregulated
			WBPaper00044736:oscillating_dev_expression
			WBPaper00044786:emr-1(RNAi);lem-2(tm1582)_upregulated
			WBPaper00045417:128Q-huntingtin_upreglated
			WBPaper00046024:sleep_upregulated_oscillating
			WBPaper00046497:B.thuringiensis_0.1mix_downregulated_12h
			WBPaper00046497:B.thuringiensis_0.5mix_downregulated_12h
			WBPaper00048952:glucose_induced
			WBPaper00048971:daf-16(mgDf50)_upregulated_L1
			WBPaper00048988:neuron_expressed
			WBPaper00049018:swsn-2.2(RNAi)_upregulated
			WBPaper00049545:jmjd-3.1(+)_upregulated
			WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated
			WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated
			WBPaper00049942:HeatShock_downregulated_hsf-1(RNAi)
			WBPaper00049942:hsf-1(RNAi)_downregulated
			WBPaper00050053:muscle_enriched_Day4
			WBPaper00050121:mir-60(n4947)_upregulated
			WBPaper00050332:skn-1(RNAi)_downregulated
			WBPaper00050468:hlh-30-dependent_Cry5B_regulated
			WBPaper00050726:OsmoticStress_regulated_Food
			WBPaper00050859:upregulated_P-granule(-)GFP(+)_vs_control_day2-adult
			WBPaper00050859:upregulated_P-granule(-)GFP(-)_vs_control_day2-adult
			WBPaper00050903:mir-35-41(nDf50)_25C_downregulated
			WBPaper00050990:intestine_enriched
			WBPaper00050990:intestine_expressed
			WBPaper00051039:ash-2(RNAi)_regulated_intestine
			WBPaper00051039:intestine_enriched
			WBPaper00051404:alg-1(gk214)_upregulated
			WBPaper00051404:alg-2(ok304)_upregulated
			WBPaper00052856:Cadmium_regulated
			WBPaper00053184:sma-4(rax3)_upregulated
			WBPaper00053295:lin-22(ot269)_downregulated
			WBPaper00053302:zidovudine_72h_regulated
			WBPaper00053388:dauer_regulated_Cluster4
			WBPaper00053599:female_vs_male_downregulated
			WBPaper00053810:daf-2(e1370)_downregulated
			WBPaper00054192:cold-shock_downregulated
			WBPaper00054758:alg-1(gk204)_upregulated
			WBPaper00055060:flr-1(RNAi)_upregulated
			WBPaper00055354:Rapamycin-Rifampicin-Allantoin_downregulated
			WBPaper00055354:Rapamycin-Rifampicin_downregulated
			WBPaper00055354:Rifampicin-Allantoin_downregulated
			WBPaper00055354:Rifampicin_downregulated
			WBPaper00055482:Tunicamycin_downregulated
			WBPaper00055971:nhl-2(ok818)_25C_downregulated
			WBPaper00056034:pals-22(jy3)_upregulated
			WBPaper00056090:E.faecalis_upregulated_hpx-2(dg047)
			WBPaper00056161:male_enriched_siRNA
			WBPaper00056284:ints-6(t1903)_downregulated
			WBPaper00056290:hsp-6(mg585)_downregulated
			WBPaper00056290:mdt-15(mg584)_downregulated
			WBPaper00056326:zip-3(gk3164)_upregulated_P.aeruginosa-infected
			WBPaper00056443:sek-1(km4)_upregulated
			WBPaper00056550:ceh-60(ok1485)_upregulated_AdultDay4
			WBPaper00056826:hmc_biased
			WBPaper00056997:nmad-1(ok3133)_upregulated_germline_25C
			WBPaper00058598:mex-1(or286)_upregulated
			WBPaper00058598:mex-3(eu149)_upregulated
			WBPaper00058598:sin-3(tm1276)_downregulated
			WBPaper00058598:spn-4(tm291)_upregulated
			WBPaper00058691:set-2(bn129)_upregulated
			WBPaper00058711:paraquat_downregulated
			WBPaper00058711:skn-1(lax188)_upregulated
			WBPaper00058725:sftb-1(cer6)_downregulated
			WBPaper00058725:sftb-1(cer6)_upregulated
			WBPaper00059027:neuron-synapses_enriched
			WBPaper00059328:mrps-5(RNAi)_upregulated_mRNA
			WBPaper00059566:wdr-23(mac32)_upregulated
			WBPaper00059664:srbc-48(ac23)_upregulated
			WBPaper00059839:S.maltophilia_regulated
			WBPaper00060661:sensory-neuron_depleted
			WBPaper00061007:HB101_upregulated
			WBPaper00061007:S.aquatilis_upregulated
			WBPaper00061040:eat-2(ad1116)_upregulated
			WBPaper00061203:sin-3(tm1276)_upregulated
			WBPaper00061203:spr-1(ok2144)_upregulated
			WBPaper00061340:AIN
			WBPaper00061340:ASG_AWA
			WBPaper00061340:AWA
			WBPaper00061340:AWB
			WBPaper00061340:RIS
			WBPaper00061405:S.aureus_downregulated_starvation
			WBPaper00061479:hda-1(ne4752)_upregulated
			WBPaper00061479:mep-1(ne4629)_upregulated
			WBPaper00061527:ifd-1-ifp-1
			WBPaper00061527:T16H12.9-kin-9_20752
			WBPaper00062159:hda-2(ok1479)_upregulated
			WBPaper00062193:hsf-1(RNAi)_downregulated
			WBPaper00062193:skn-1(RNAi)_downregulated
			WBPaper00062325:etr-1(lq61)_downregulated
			WBPaper00062325:muscle_enriched_coding-RNA
			WBPaper00062345:bortezomib_4h_downregulated_N2
			WBPaper00062345:bortezomib_4h_downregulated_zip-1(jy13)
			WBPaper00062354:H.zoospora_6h_regulated
			WBPaper00062446:nhr-8(hd117)_downregulated
			WBPaper00064088:Day-1-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
			WBPaper00064088:Day-1-adult_vs_L4_downregulated_glp-1(e2141)
			WBPaper00064088:Day-3-adult_vs_L4_downregulated_daf-16(mu86);glp-1(e2141)
			WBPaper00064088:Day-3-adult_vs_L4_downregulated_fem-3(q20)
			WBPaper00064088:Day-3-adult_vs_L4_downregulated_glp-1(e2141)
			WBPaper00064107:lin-35(n745)_downregulated
			WBPaper00064306:Agaro-oligosaccharides_upregulated
			WBPaper00064532:pals-25(icb98)_upregulated
			WBPaper00064933:bcf-1(ylf1)_downregulated_transcript
			WBPaper00064992:Capsaicin_upregulated
			WBPaper00064992:heat-shock_upregulated
			WBPaper00065086:JU1400_N.ausubeli_regulated
			WBPaper00065086:JU1400_N.ferruginous_regulated
			WBPaper00065086:N2_N.ausubeli_regulated
			WBPaper00065096:25C_vs_20C_downregulated
			WBPaper00065096:Day10_vs_Day1_downregulated
			WBPaper00065373:Cisplatin_downregulated_WT
			WBPaper00065835:Day5_vs_Day1_downregulated
			WBPaper00065841:4_0
			WBPaper00065841:4_2
			WBPaper00065841:38_1
			WBPaper00065841:38_2
			WBPaper00065841:38_3
			WBPaper00065841:102_0
			WBPaper00065841:104_0
			WBPaper00065841:119_0
			WBPaper00065841:143_0
			WBPaper00065975:P-body_vs_oocyte_depleted
			WBPaper00065975:P-body_vs_WholeAnimal_depleted
			WBPaper00066005:RAGA-1_degradation_somatic_upregulated
			WBPaper00066062:xrep-4(lax137)_upregulated
			WBPaper00066232:ash-2(RNAi)_downregulated_WT
			cgc4489_group_4
			cgc4489_group_8
			WBPaper00024671:AFD_AWB_vs_unsorted_downregulated
			WBPaper00025141:N2_Expressed_Genes
			WBPaper00029437:dcr-1_downregulated
			WBPaper00031003:24hr_muscle_enriched
			WBPaper00031003:total_muscle_enriched
			WBPaper00034739:N2moreDR1350
			WBPaper00035227:heat_shock_regulated
			WBPaper00035873:dpy-9_regulated
			WBPaper00035873:dpy-10_regulated
			WBPaper00035873:osm-8_regulated
			WBPaper00037695:WC_5-day
			WBPaper00038172:crh-1null_up_regulated
			WBPaper00038172:tax-6null_up_regulated
			WBPaper00038231:Cry5B_1.5-fold_downregulated
			WBPaper00038231:Cry5B_1.5-fold_upregulated
			WBPaper00038231:Cry5B_2-fold_downregulated
			WBPaper00038427:lin-54_embryo_changed
			WBPaper00039866:ClassComp_daf-19_downregulated
			WBPaper00040210:Chlorpyrifos_Diazinon_24C_regulated
			WBPaper00040858:eQTL_age_regulated_aging
			WBPaper00040858:eQTL_regulated_aging
			WBPaper00040858:eQTL_regulated_old
			WBPaper00040876:mir-35_downregulated
			WBPaper00040963:TA300_up
			WBPaper00041002:HF_3d_2.0mM_Up
			WBPaper00041606:CE_X.nematophila_regulated
			WBPaper00041906:I-3690_vs_OP50_3d
			WBPaper00041939:control_vs_EtBr-exposed_48h
			WBPaper00041939:control_vs_UVC-EtBr-exposed_48h
			WBPaper00041939:EtBr-exposed_vs_UVC-exposed_48h
			WBPaper00041939:UVC-EtBr-exposed_vs_EtBr-exposed_51h
			WBPaper00044091:Bpseudomallei_repressed_2h
			WBPaper00044091:Bpseudomallei_repressed_8h
			WBPaper00044091:Bpseudomallei_repressed_12h
			WBPaper00045263:isp-1(qm150)_downregulated
			WBPaper00045263:nuo-6(qm200)_downregulated
			WBPaper00045673:colistin_upregulated
			WBPaper00045960:L1-L4-lethargus_upregulated
			WBPaper00045960:L4-lethargus_upregulated
			WBPaper00047021:MWCNT_upregulated
			WBPaper00047070:N2_starvation_upregulated
			WBPaper00047070:xpa-1_UV_downregulated
			WBPaper00048989:eat-2(ad465)_rapamycin_upregulated
			WBPaper00048989:N2_rapamycin_downregulated
			WBPaper00053236:daf-16(mgDF50)_regulated_Starved
			WBPaper00053236:Starvation_regulated_N2
			WBPaper00053550:daf-19(m86)_downregulated_3-fold-embryo
			WBPaper00057098:SiO2-nanoparticles_upregulated
			[cgc6390]:Cluster_B
			[cgc6390]:herm_soma-enriched
		Interaction (64)
	Map_info	Map	IV	Position	4.30419	Error	0.002555
		Positive	Positive_clone	F56H11	Inferred_automatically	From CDS info
						From sequence, transcript, pseudogene data
		Mapping_data	Multi_point	4280
		Pseudo_map_position
	Reference (28)
	Remark	Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.	CGC_data_submission
	Method	Gene